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  • 1
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Rat cerebral cortex slices were incubated in vitro with [3H]dopamine (DA) or [3H]noradrenaline (NA) (10−7M), superfused by fresh buffer and stimulated by an electric field. The stimulation-induced overflow of [3H]DA and [3H]NA was determined.In slices from untreated rats about 16 ng [3H]NA/g tissue was formed from [3H]DA, corresponding to about 5 per cent of the endogenous NA concentration. Stimulation markedly enhanced the overflow of [3H]NA. The [3H]NA newly formed from [3H]DA was overflowing to a greater extent than [3H]NA previously taken up from the incubation medium, indicating a preferential release of newly synthesized transmitter. The stimulation-induced overflow of [3H]DA and [3H]NA was increased in slices of rats pretreated with a tyrosine hydroxylase inhibitor (H44/68). It seems that depletion of the endogenous NA stores of central NA neurons by tyrosine hydroxylase inhibition makes the [3H]cate-cholamines more available for release. Pretreatment of the rats with the DA-β-hydroxylase inhibitors FLA63 or FLA69 considerably diminished the formation of [3H]NA from [3H]DA. Stimulation markedly enhanced the overflow of [3H]DA indicating that DA can act as a ‘false transmitter’ in central NA neurons after DA-β-hydroxylase inhibition.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0196-9781
    Keywords: Chromogranin A ; Chromogranin B ; Pheochromocytoma (human)
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Regulatory Peptides 13 (1985), S. 41-52 
    ISSN: 0167-0115
    Keywords: calcium ; neuropeptide Y ; nifedipine ; noradrenaline ; surgical stress ; vasoconstriction
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0303-7207
    Keywords: (Ovary) ; Adenylate cyclase ; Adrenaline ; Catecholamine ; Corpus luteum model ; LH ; Noradrenaline
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 6 (1982), S. 757-764 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Le diagnostic d'aldostéronisme primitif repose sur la constatation d'un niveau faible de rénine plasmatique de d'un taux élevé et irréductible d'aldostérone. La tomodensitométrie et le dosage veineux sélectif représentent les méthodes électives de localisation. Lorsque le malade présente une tumeur unilatérale l'adrénalectomie, de préférence par voie postérieure ou par voie latérale, est indiquée. Chez les sujets dont l'aldostéronisme correspond à une hyperplasie surrénalienne bilatérale, le traitement par la spironolactone est préférable à la chirurgie, encore que le traitement des hyperplasies macronodulaires prête à controverse.
    Notes: Abstract The diagnosis of primary aldosteronism is based upon low plasma renin and elevated unsuppressible aldosterone. Computerized tomography and selective venous sampling are the most accurate methods of localization. In patients with an aldosteronoma, unilateral adrenalectomy is performed preferably via the posterior or flank approach. Patients with bilateral adrenal hyperplasia are treated with spironolactone rather than surgery, although controversy exists regarding the management of patients with macronodular hyperplasia.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 7 (1983), S. 385-389 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les modifications de la concentration dans le plasma de la catécholamine et de la gastrine ainsi que les modifications de la secrétion d'acide gastrique après repas d'épreuve simulé ont été étudiées chez 7 malades atteints d'ulcère duodénal avant la vagotomie hypersélective et 6 semaines après celle-ci. La sécrétion basale et le pic de la sécrétion acide furent réduits après la vagotomie hypersélective. Les concentrations de la noradrénaline plasmatique qui étaient élevées chez les ulcéreux revirent à la normale après l'intervention. En revanche, les taux de l'adrénaline plasmatique qui étaient voisins de la normale avant l'intervention ne varièrent pas après celle-ci. Les taux de la gastrine plasmatique furent sensiblement plus élevés après la vagotomie hypersélective. Cette étude permet d'affirmer que le repas d'épreuve simulée ne produit pas de modification significative des taux de la catécholamine et de la gastrine plasmatique avant ou après vagotomie hypersélective, mais, en revanche, l'intervention est suivie de la diminution du taux de la noradrénaline. On peut conclure de l'ensemble de ces faits que la noradrénaline est impliquée dans la genèse de la maladie ulcéreuse ou qu'elle en constitue le reflet.
    Abstract: Abstracto Los cambios en las concentraciones plasmáticas de catecolamina y de gastrina y en la secreción de ácido gástrico en respuesta a una comida fantasma (sham feeding), fueron investigados en 7 pacientes con Úlcera duodenal (DU) antes y 6 semanas después de vagotomía altamente selectiva (HSV). Tanto la secreción basal como la secreción pico en respuesta a una comida fantasma modificada, fueron reducidas en forma significativa por la HSV. Las concentraciones plasmáticas de noradrenalina se encontraban elevadas en pacientes con UD, pero descendieron a valores normales después de HSV. Las concentraciones plasmáticas de adrenalina estuvieron dentro de límites normales y no cambiaron después de HSV. Las concentraciones basales de gastrina se hallaron significativamente más altas después de HSV que antes. La comida fantasma modificada no causó cambios significativos en las concentraciones plasmáticas de catecolamina y de gastrina, ni pre ni postoperatoriamente. Se concluye que la noradrenalina está involucrada en, o es un reflejo de la enfermedad ulcerosa duodenal.
    Notes: Abstract The changes in plasma catecholamine and gastrin concentrations and gastric acid secretion in response to modified sham feeding were investigated in 7 duodenal ulcer (DU) patients before and 6 weeks after highly selective vagotomy (HSV). Both basal and peak acid secretion in response to modified sham feeding were significantly reduced by HSV. Basal plasma noradrenaline concentrations were elevated in DU patients but fell to normal values after HSV. Plasma adrenaline concentrations were within the normal range and did not change after HSV. Basal gastrin concentrations were significantly higher after HSV than before. Modified sham feeding caused no significant changes in plasma catecholamine and gastrin concentrations either pre- or postoperatively. It is concluded that noradrenaline is involved in, or reflects, DU disease.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 19 (1963), S. 580-581 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Sympathische Ganglien wurden mit einer spezifischen und besonders empfindlichen histochemischen Methode zum Nachweis gewisser Monoamine studiert. Die meisten Zellkörper der Ganglienzellen enthalten im Cytoplasma mehr oder weniger einer primären Monoamine, wahrscheinlich Noradrenalin. In prävertebralen Ganglien wurden auch adrenerge Nevenendigungen nachgewiesen, die synaptische Verbindungen mit den Ganglienzellen eingehen.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0167-0115
    Keywords: adrenal gland ; adrenaline ; neuropeptide Y ; pheochromocytoma tumors
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Regulatory Peptides 1 (1980), S. S57 
    ISSN: 0167-0115
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0428
    Keywords: Adrenaline ; insulin resistance ; diabetes mellitus ; counterregulatory hormones ; the Somogyi phenomenon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin resistance was assessed after an intravenous infusion of adrenaline (50 ng·kg−1·min−1) or saline (control study) given between 08.00 and 08.30 hours in nine patients with Type 1 (insulin-dependent) diabetes mellitus. The blood glucose level during a somatostatin (100μg/h)-insulin (0.4mU·kg−1·min−1)-glucose (4.5 mg·kg−1·-min−1)-infusion-test performed between 1030 and 14.30 hours served as an indicator of the total body insulin resistance. Blood glucose was maintained around 7 mmol/l between 08.00 and 10.30 hours by a constant infusion of regular insulin (0.57 mU·kg−1· min−1) and a variable infusion of a 20% glucose solution. The infusion of adrenaline raised plasma adrenaline to 2.7±0.3 nmol/l (mean±SEM) at the end of the infusion; thereafter it returned to its basal level within 30 min. The plasma levels of free insulin, glucagon, cortisol and growth hormone were similar in the adrenaline and the control studies from 08.00 to 14.30 hours. In comparison with the control study the infusion of adrenaline decreased the need for intravenous glucose significantly over the initial 2 h. Furthermore, during the somatostatin-insulin-glucose infusion test the blood glucose rose significantly (p〈0.05) over the initial 2h; thereafter no significant differences between the two studies were seen. It is concluded that a short term infusion of adrenaline, resembling the adrenergic hormone response to hypoglycaemia, induces a diabetogenic effect which subsides within 6 h after omission of the adrenaline infusion.
    Type of Medium: Electronic Resource
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