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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 111 (1986), S. 157-159 
    ISSN: 1432-1335
    Keywords: Experimental colorectal carcinoma ; Autochthonous tumor model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Chemically induced (autochthonous) tumors in the rodent are thought to be the best models at hand to obtain results transferable to the clinical situation. Four different autochthonous tumor models: 1,2-dimethylhydrazine, N-methylnitrosourea (MNU), N-methyl-N-nitro-nitrosoguanidine (MNNG), and N-nitroso-acetoxymethyl-methylamine (AMMN) which are used worldwide for etiological and therapy studies of colon cancer are compared for tumor biology and clinical relevance. The four tumor models of colon carcinoma described in the rat are different in growth, invasion, and metastases. The choice of the selected tumor model for experimental investigations of colon cancer should depend on the clinical question.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 804-804 
    ISSN: 1435-2451
    Keywords: Traumatic hemobilia ; Trauma of the liver ; Upper gastrointestinal bleeding ; Traumatische Hämobilie ; Leberverletzung ; Obere G.I.—Blutung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Symptome einer Hämobilie sind in der Trias von Sandblom zusammengefaßt: Blutung aus dem G.I.-Trakt, Ikterus, abdominelle Schmerzen. Die Blutung nach Trauma wird durch ein Arteriogramm, evtl. durch ein CT nachgewiesen. Die Hämobilie nach Leberpunktion ist schwach und zeigt sich durch einen cholestatischen Ikterus. Die Diagnostik erfolgt über eine Cholangiografie (retrograd transpapillär oder percutan transhepatisch). Die Behandlung der Blutung erfolgt durch arterielle Embolisation oder arterielle Ligatur (interparenchymatös, Lobärarterie, A. hepatica propria). Bei Verschluß-Ikterus wird endoskopisch canaliculär desobliteriert. Die Hämobilie nach Drainage schwindet meist nach Entfernung des T-Drains.
    Notes: Summary Hemobilia presents with the triad of biliary colic, obstructive jaundice and occult or gross intestinal bleeding. Bleeding after trauma is diagnosed by arteriography. Hemobilia following liver biopsy is manifested by obstructive jaundice and is diagnosed by transhepatic or retrograde endoscopic cholangiography. The bleeding should be treated by transarterial embolization, direct ligation of the bleeding point in the liver, or proximal ligation of an upstream branch of the hepatic artery. Obstructive jaundice is treated by retrograde removal of the canalicular obstruction. Hemobilia following T tube implantation vanishes in most cases after removal of the tube. Liver resection is required only in rare cases. Of our nine patients seven were saved by this regimen. Two died postoperatively, due to the extent of the liver trauma and associated injury to other organs.
    Type of Medium: Electronic Resource
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