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  • 1
    Electronic Resource
    Electronic Resource
    Unspecific white matter lesions: prevalence, number and distribution in cranial MRI (1992)
    Springer
    European radiology 2 (1992), S. 154-158 
    Details
    ISSN: 1432-1084
    Keywords: White matter lesions ; Cerebrovascular disease ; Magnetic resonance imaging ; Brain infarction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To establish data about prevalence, number and topography of “unspecific” white matter lesions as seen on MRI, the T2-weighted MRI scans of 83 patients with hyperintense focal white matter changes were reviewed. Patients with known inflammatory central nervous system disease were excluded. There was an approximately linear increase in prevalence and number of lesions with age. Prevalence ranged from 18% in the third decade to over 90% in those over 70 years. We found a close correlation with concomitant periventricular hyperintensity. However, rating of Virchow-Robin spaces did not correlate with the number of white matter lesions. Both hemispheres were involved nearly equally with a minimal non-significant right side preponderance. Lesions showed a strong predilection for the frontal and parietal paraventricular “watershed” areas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171404
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cranial MRI and CT in patients with left atrial myxoma (1992)
    Springer
    Neuroradiology 34 (1992), S. 57-61 
    Details
    ISSN: 1432-1920
    Keywords: Cardiac myxoma ; Stroke ; Cerebrovascular disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Six of 12 patients with histologically verified left atrial myxoma showed CT and MRI evidence of ischemic lesions of varying size and location, predominantly in the left hemisphere.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588434
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Die Bedeutung der Bestimmung von Antikörpern gegen Acetylcholinreceptoren in der Diagnostik der Myasthenia gravis (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 937-942 
    Details
    ISSN: 1432-1440
    Keywords: Myasthenia gravis ; Acetylcholine-receptor ; Acetylcholine-receptor antibodies ; Autoimmune disease ; Plasmapheresis ; Myasthenia gravis ; Acetylcholin-Receptor ; Acetylcholin-Receptor-Antikörper ; Autoimmunerkrankung ; Plasmapherese
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 65 Patienten mit Myasthenia gravis (MG) wurden Antikörper gegen Acetylcholin-Receptoren (ACh-R) in der IgG-Fraktion des Patienten-Serums bestimmt (Immunpräzipitations-Assay mit125Jod-α-Bungarotoxin und menschlichem ACh-R als Antigen). Bei 91% der Patienten zeigte sich eine erhöhte Antikörper-Konzentration bis zum 500fachen des oberen Referenzbereichs. Eine Kontrollgruppe von 77 Patienten mit anderen gesicherten Autoimmunerkrankungen oder positiven Antikörpern gegen Muskulatur wies in keinem Fall erhöhte ACh-R-Antikörper-Konzentrationen auf. Damit ist der in-vitro Nachweis von ACh-R-Antikörpern ein empfindlicher und hochspezifischer Test für die Diagnostik der MG. Der Test eignet sich ebenfalls für die Verlaufskontrolle unter Therapie mit Immunsuppressiva oder Plasmapherese. Immunfluoreszenz-Untersuchung auf Antikörper gegen Muskelgewebe ist für die MG-Diagnostik weniger empfindlich und nicht spezifisch.
    Notes: Summary The sera of 65 patients with myasthenia gravis (MG) were analysed for antibodies against the nicotinic acetylcholine receptor (ACh-R) using an immunoprecipitation assay (125I-α-bungarotoxin bound to human ACh-R as antigen). In 91% of MG sera elevated antibody titers were found ranging up to 500 times reference values. A control group of 77 patients showing various autoimmunological phenomena had ACh-R antibody concentrations within the reference range. The demonstration of antibodies against ACh-R provides a sensitive and highly specific tool for the diagnosis of MG. In addition, the test is helpful in following patients under treatment with immunosuppressive drugs or plasmapheresis. Antibodies against striated, smooth, or heart muscle (indirect immunofluorescence test) are much less sensitive and nonspecific for the diagnosis of MG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01478550
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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