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  • 1
    Digitale Medien
    Digitale Medien
    Intermediate Filaments: Structure, Dynamics, Function and Disease (1994)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 63 (1994), S. 345-382 
    Details
    ISSN: 0066-4154
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Chemie und Pharmazie , Biologie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.bi.63.070194.002021
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  • 2
    Digitale Medien
    Digitale Medien
    2,3,4-Tribromopyrrole from the Marine Polychaete Polyphysia crassa (1990)
    s.l. : American Chemical Society
    Journal of natural products 53 (1990), S. 703-705 
    Details
    ISSN: 1520-6025
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/np50069a028
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  • 3
    Digitale Medien
    Digitale Medien
    Quantitative Texture Analysis of Naturally Deformed Polyphase Dolomite Marbles and its Kinematic Significance (1994)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 157-162 (May 1994), p. 789-794 
    Details
    ISSN: 1662-9752
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Materialart: Digitale Medien
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/00/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.157-162.789.pdf
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  • 4
    Digitale Medien
    Digitale Medien
    Hyperechoic lesions in the basal ganglia: An incidental sonographic finding in neonates and infants (1992)
    Springer
    Pediatric radiology 22 (1992), S. 182-186 
    Details
    ISSN: 1432-1998
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Cerebral ultrasound (US) imaging was performed as a screening procedure in approximately 3,600 neonates and infants over a period of 18 months. Hyperechoic lesions in the basal ganglia and thalamic region were detected incidentally in 15 of these patients. Clinical diagnoses included cytomegalovirus infection, asphyxia, rotavirus infection, prematurity, amniotic infection, dysmorphic stigmata, hyperbilirubinemia, congenital heart disease, and diabetic fetopathia. Lesions showed a single punctate (n=5), multiple punctate (n=8), or stripe-like pattern (n=2), with no disease-specific distribution. Computed tomography performed in two of the 15 patients was normal. Lesions resolved within four to seven months in four of eleven cases who had follow-up studies, whereas echogenicities persisted in the remaining seven patients over a period of observation ranging between one to 15 months. Our results indicate that hyperechoic lesions in the basal ganglia and thalamic region may be associated with congenital infections and asphyxia, but could indicate some other unknown pathology. No correlation was found between the morphology of foci and both clinical diagnosis and results of follow-up studies.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02012490
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  • 5
    Digitale Medien
    Digitale Medien
    Choroid plexus cysts: A normal finding on ultrasound (1992)
    Springer
    Pediatric radiology 22 (1992), S. 410-412 
    Details
    ISSN: 1432-1998
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Within a period of 2.5 years, cystic structures in the choroid plexus were encountered at cerebral sonography in 70 neonates and babies (45 male, 25 female; 18 premature babies). Their prevalence in patients examined during the first 4 weeks of life (n=55) was 3%. The size of the cysts ranged from 1–4 and, rarely, up to 7 mm. They were mostly solitary and unilateral. Follow-up sonograms over periods up to 13 months showed that most of the cysts perisisted unchanged. A few disappeared (n=7), while distinct increase in size was observed in 1 case. Since no additional sonographic changes were observed and none of the patients displayed any neurological abnormalities and no association existed with any other, particularly chromosomal, disease, such plexus cysts are postulated to represent a normal sonographic finding and do not require follow-up.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02013498
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  • 6
    Digitale Medien
    Digitale Medien
    Recombinant immunoblot in the serodiagnosis of Lyme borreliosis (1993)
    Springer
    Medical microbiology and immunology 182 (1993), S. 255-270 
    Details
    ISSN: 1432-1831
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A recombinant immunoblot was developed for detection of IgM and IgG antibodies in patients with Lyme borreliosis. The recombinant antigens were the chromosomal-encodedBorrelia burgdorferi proteins p100, the flagellin and an internal flagellin fragment thereof as well as the plasmid-encoded outer surface proteins A (OspA) and C (OspC). A panel of 144 sera from patients with Lyme borreliosis (erythema migrans,n = 31; neuroborreliosis state II,n = 60; Lyme arthritis,n = 24 and acrodermatitis chronica atrophicans,n =19) have been investigated and the results have been compared to the immunofluorescence absorption test (IFA-ABS) and to two different enzyme-linked immunosorbent assays [the flagellin ELISA and a newly developed ELISA (OGP-ELISA)]. The two ELISAs were comparable in sensitivity, whereas the IFA-ABS was less sensitive for IgM antibody but equally sensitive for IgG antibody detection. Immunoblot analysis revealed that IgG antibodies are mainly reactive with p 100 and the internal flagellin fragment (sensitivity 51% and 32%, respectively) and rarely with OspC (14%). All patients with late Lyme borreliosis had IgG antibodies against the p100. IgM antibodies were predominantly directed against OspC (43%) and in a lower extent against the internal flagellin fragment and p100 (15% and 13%, respectively). The complete flagellin was not useful due to a high number of unspecific reactions with control sera and the OspA was only exceptionally reactive in Lyme borreliosis patients. The sensitivity of IgM antibody detection could be increased in cases with early Lyme borreliosis from 46% to 65% when the OspC blot was performed in addition to the flagellin ELISA, or from 56% to 65% when performed in addition to the OGP-ELISA. The recombinant blot is, therefore, a valuable diagnostic test to increase sensitivity of early antibody detection and is regarded as a valuable confirmatory test also in late disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00579624
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  • 7
    Digitale Medien
    Digitale Medien
    Renin-angiotensin system and myocardial collagen matrix remodeling in hypertensive heart disease: in vivo and in vitro studies on collagen matrix regulation (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. S35 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Myocardial fibrosis ; Arterial hypertension ; Cardiac renin-angiotensin system ; ACE inhibition
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The interstitial space of the myocardium is composed of nonmyocyte cells and a highly organized collagen network which serves to maintain the architecture and mechanical behavior of the myocardial walls. It is the myocardial collagen matrix that determines myocardial stiffness in the normal and structurally remodeled myocardium. In hypertensive heart disease, the heterogeneity in myocardial structure, created by the altered behavior of nonmyocyte cells, particularly cardiac fibroblasts which are responsible for collagen synthesis and degradation, explains the appearance of diastolic and/or systolic dysfunction of the left ventricle that leads to symptomatic heart failure. Several lines of evidence suggest that circulating and myocardial renin-angiotensin systems (RAS) are involved in the regulation of the structural remodeling of the nonmyocyte compartment, including the cardioprotective effects of angiotensin converting enzyme (ACE) inhibition that was found to prevent myocardial fibrosis in the rat with renovascular hypertension. In cultured adult rat cardiac fibroblasts angiotensin II was shown to directly stimulate collagen synthesis and to inhibit collagenase activity, which is the key enzyme for collagen degradation, that would lead to collagen accumulation. In the spontaneously hypertensive rat, an appropriate experimental model for primary hypertension in man, left ventricular hypertrophy could be regressed and abnormal myocardial diastolic stiffness due to interstitial fibrosis could be restored to normal by inhibition of the myocardial RAS. These antifibrotic or cardioreparative effects of ACE inhibition that occurred irrespective of blood pressure normalization may be valuable in reversing left ventricular diastolic dysfunction in hypertensive heart disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00180074
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  • 8
    Digitale Medien
    Digitale Medien
    Serum concentration of soluble intercellular adhesion molecule 1 in chlamydial infection in diabetes mellitus type II (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 806-806 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Diabetes mellitus type II ; Soluble ICAM-I ; Chlamydia trachomatis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00190323
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  • 9
    Digitale Medien
    Digitale Medien
    Dynamical and thermal aspects of relativistic heavy-ion collisions (1991)
    Springer
    The European physical journal 340 (1991), S. 287-295 
    Details
    ISSN: 1434-601X
    Schlagwort(e): 25.70.−z ; 25.70.Np
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Within a covariant BUU-approach we simulate heavyion collisions at various bombarding energies from 400 MeV/u to 1 GeV/u. We evaluate locally the energymomentum tensorT μv (x), and extract pressures, energydensities and temperatures. The connection of these thermodynamical quantities to experimental observables and their sensitivity to the equation of state is discussed. Furthermore, we investigate the question of local equilibration and evaluate the entropy produced in these reactions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01294677
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  • 10
    Digitale Medien
    Digitale Medien
    Azithromycin versus penicillin V for the treatment of early lyme borreliosis (1993)
    Springer
    Infection 21 (1993), S. 367-372 
    Details
    ISSN: 1439-0973
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Bei einer randomisierten Multicenter-Therapiestudie erhielten 32 Patienten mit Erythema migrans (EM) 10 Tage lang täglich 500 mg Azithromycin und 33 Patienten 3x täglich 1 Mill. IE Penicillin V. Die Nachbeobachtungszeit betrug 17 (3–32) Monate. Die klinischen Erscheinungen heilten bei 20 (62%) der mit Azithromycin und 17 (51%) der mit Penicillin V behandelten Patienten innerhalb von vier Wochen und bei 25 (78%) der mit Azithromycin beziehungsweise 28 (85%) der mit Penicillin V behandelten Patienten innerhalb von drei Monaten nach Therapiebeginn vollständig ab, ohne erneut zu einem späteren Zeitpunkt aufzutreten (kein signifikanter Unterschied). Die klinischen Folgeerscheinungen waren nur leichter Art. Es handelte sich z. B. um Arthralgien, Kopfschmerzen, Abgeschlagenheit, Nackensteife und Paraesthesien. Durch Azithromycin kam es zu einer signifikant schnelleren Abheilung des EM als durch Penicillin V (p〈0.001). Signifikant mehr Patienten mit ausgeprägteren als mit milden Initialerscheinungen hatten einen erhöhten IgM-Antikörper-Titer vor Therapiebeginn (p〈0.001). Meistens gering- bis mäßiggradige Nebenwirkungen fanden sich bei 12 mit Azithromycin und fünf mit Penicillin V behandelten Patienten (p〈0.05). Azithromycin ist offensichtlich ähnlich wirksam wie Penicillin V bei der Behandlung der frühen Lyme-Borreliose, aber Azithromycin scheint das EM schneller abzuheilen.
    Notizen: Summary In a randomized multicenter therapeutic trial, 32 patients with erythema migrans received oral azithromycin 500 mg once daily and 33 patients received phenoxymethylpenicillin (penicillin V) 1 million U three times daily for 10 days. Follow-up was for a median of 17 (range 3–32) months. Four weeks after initiation of therapy, 20 (62%) patients given azithromycin and 17 (51%) patients given penicillin V were completely free of all signs and symptoms and did not develop new ones subsequently (no significant difference). Three months after initiation of therapy, the corresponding figures were 25 (78%) azithromycin and 28 (85%) penicillin V recipients (no significant difference). There were only minor sequelae such as arthralgia, headache, fatigue, stiff neck and dysesthesia. Azithromycin led to a significantly faster resolution of the erythema migrans than penicillin V (p〈0.001). Significantly more patients with more severe compared with mild initial disease had an elevated IgM antibody titer prior to therapy (p〈0.001). Usually mild to moderate side effects occurred in 12 patients given azithromycin and five patients given penicillin V (p〈0.05). Azithromycin appears to be as effective as penicillin V for the treatment of early Lyme borreliosis and it seems to clear the erythema migrans more promptly.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01728915
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