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  • Articles: DFG German National Licenses  (17)
  • 1985-1989
  • 1970-1974  (17)
  • 1965-1969
  • 1940-1944
  • 1890-1899
  • 1830-1839
  • 1970  (17)
  • Electron Microscopy
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  • Articles: DFG German National Licenses  (17)
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Years
  • 1985-1989
  • 1970-1974  (17)
  • 1965-1969
  • 1940-1944
  • 1890-1899
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  • 1
    Electronic Resource
    Electronic Resource
    Polygonal crystalline structures in human ependymoma cells (1970)
    Springer
    Acta neuropathologica 15 (1970), S. 359-362 
    Details
    ISSN: 1432-0533
    Keywords: Ependymoma ; Polygonal Crystalline Structures ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Polygonale kristalline Strukturen fanden sich in Lysosomen der Zellen eines menschlichen Ependymoms. Die von der granulären Matrix der Lysosomen gut abgegrenzten Strukturen waren aus regelrecht in Abständen von 150–160 Å angeordneten Formationen aufgebaut, in denen dichte und weniger dichte Schichten abwechselten. Diese waren in einer der drei Achsen angeordnet und bildeten rechteckige, tetragonale oder hexagonale Gebilde.
    Notes: Summary Polygonal crystalline structures were found in the lysosomes of human ependymoma cells, well demarcated from the granular matrix of the lysosomes. They were composed of a regular spacing at an interval of 150–160 Å of alternating dense and less dense layers, orientated along one to three axes and forming rectilinear, tetragonal, or hexagonal arrays.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684733
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  • 2
    Electronic Resource
    Electronic Resource
    Electron microscopic observations of sural nerve in familial opticoacoustic nerve degeneration with polyneuropathy (1970)
    Springer
    Acta neuropathologica 15 (1970), S. 114-127 
    Details
    ISSN: 1432-0533
    Keywords: Opticoacoustic Nerve Degeneration ; Polyneuropathy ; Hypertrophic Changes ; Nerve Biopsy ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es werden die elektronenmikroskopische Befunde der Nervenbiopsie eines Patienten mit familiärer optikoakustischer Nervendegeneration und Polyneuropathie mitgeteilt. Diese Krankheit, die noch nicht klinisch abgerenzt ist, ähnelt der Charcot-Marie-Tooth-Krankheit wie auch der Refsumschen Krankheit. Eine hypertrophische Neuropathie mit Zwiebelschalenstrukturen wurde festgestellt. Die Zwiebelschalenstruktur erscheint oft bedingt durch eine abnorme Verlängerung der Schwann-Zellbasalmembran, die manchmal den Zwiebelschalenkern ringförmig einwickelt. Es wurden auch Degeneration der Markscheide und des Achsencylinders, unbedeutende Remyelinisierungsvorgänge und unspezifische Lipoid-Ablagerungen im Cytoplasma der Schwann-Zellen beobachtet. Abnorme Einschlüsse in den Schwann-Zellen, pathologische Ablagerungen im Endoneurium wie auch andere spezifische Befunde wurden nicht festgestellt. Die Befunde wurden als Frühveränderungen einer chronischen Neuropathie interpretiert.
    Notes: Summary Electron microscopic data are presented on a sural nerve biopsy from a patient with familial opticoacoustic nerve degeneration with polyneuropathy. This disease is not yet defined clinically, but is similar to Charcot-Marie-Tooth disease and Refsum's disease. Examination showed a hypertrophic neuropathy with onion-bulb formations. There was often abnormal elongation or an occasional circle of the basement membrane of a Schwann cell around the core of the onion-bulb. Degeneration of the myelin sheath and the axon, very rare remyelinative changes, and non-specific lipid deposits in the Schwann cell cytoplasm were observed. Unusual inclusions in the Schwann cells or accumulations in the endoneurium were not observed. Specific findings were not found in this study. These findings were considered to be those of the early changes of a chronic neuropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685265
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  • 3
    Electronic Resource
    Electronic Resource
    The fine structure of plaques fibromyéliniques in ulegyria and in status marmoratus (1970)
    Springer
    Acta neuropathologica 14 (1970), S. 304-311 
    Details
    ISSN: 1432-0533
    Keywords: Electron Microscopy ; Plaques Fibromyéliniques ; Ulegyria and Status Marmoratus ; Myelinated Astrocyte-like Processes ; Hypermyelinization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Le cas d'un garçon âgé de 12 ans avec antécédant traumatique périnatal et porencéphalie encéphaloclastique est rapporté. L'étude au microscope électronique de zônes d'ulégyrie et d'état marbré montrent que les plaques fibromyéliniques présentes dans ces régions sont essentiellement constituées de prolongements fibrillaires d'origine probablement astrocytaire, entourés de lamelles myéliniques. L'hypermyélinisation de certains de ces prolongements est également présente. Ces observations plaident en faveur d'une activité régénératrice excessive de la part des cellules gliales myélinoformatrices.
    Notes: Summary A 12 year old boy with a history of perinatal injury resulting in encephaloclastic porencephaly is described. Electron microscopic examination of the plaques fibromyéliniques in areas of ulegyria and status marmoratus revealed that they mainly consist of fibrillated processes, apparently of astrocytic origin, surrounded by myelin lamellae. Hypermyelinization of some of these processes was also present. These observations suggest excessive regenerative activity on the part of myelin-forming glial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685786
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  • 4
    Electronic Resource
    Electronic Resource
    Ultrastructural study of a nerve and muscle biopsy from a case of “subacute myelo-optico-neuropathy” (1970)
    Springer
    Acta neuropathologica 16 (1970), S. 17-24 
    Details
    ISSN: 1432-0533
    Keywords: Subacute Myelo-Optico-Neuropathy ; Peripheral Nerve ; Muscle ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Von einem Patienten mit peripherer Nervenlähmung, die einer schweren Diarrhoe folgte, wurden Biopsien vom N. suralis und vom M. quadriceps femoris elektronenmikroskopisch untersucht. Die Markscheiden der peripheren Nervenfasern waren geschwollen und in Degeneration begriffen. Die Axone der markhaltigen Nervenfasern zeigten beginnende Degeneration; auch an den Schwannschen Zellen wurde Degeneration beobachtet. Bemerkenswerte Befunde am Muskel waren Unregelmäßigkeiten des Z-Bandes und Verschwinden der dicken Fasern. In allen Teilen der Muskel waren die Glykogengranula beträchtlich vermehrt. Diese Befunde zeigen, daß im vorliegenden Fall nicht nur die peripheren Nerven, sondern auch die Muskeln geschädigt worden waren. Die Muskelveränderungen stellen einen neuen Befund bei subakuter myelo-optischer Neuropathie dar.
    Notes: Summary N. suralis and M. quadriceps femoralis, taken from a patient with peripheral nerve paralysis following severe diarrhoea, were examined by electron microscopy. In the nerve fibres myelin sheaths were swollen and degenerated: axons in myelinated fibres also were degenerated. Degeneration was also observed in Schwann cells. In muscle the noteworthy findings were focal irregularity of Z-bands and disappearance of thick filaments. In all parts of the muscle, glycogen granules were remarkably increased in number. These findings reveal that in the present case there was damage not only to peripheral nerve but also to muscle. The changes in the muscle are a new observation in subacute myelooptico-neuropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686959
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrastructure of sural nerve in a case of arsenical neuropathy (1970)
    Springer
    Acta neuropathologica 16 (1970), S. 233-242 
    Details
    ISSN: 1432-0533
    Keywords: Electron Microscopy ; Sural Nerve ; Arsenical neuropathy ; Wallerian Degeneration ; Onion Bulb
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es werden die elektronenmikroskopischen Beobachtungen und Zupf-befunde an der Nervenbiopsie eines Patienten mit Arsenneuropathie mitgeteilt. Die Zupf-methode und die mit Toluidinblau gefärbte Epon-präparate zeigten eine Verminderung der markhaltigen Achsencylinder und Veränderungen nach Art der Wallerschen Degeneration. Elektronenmikroskopische Befunde zeigten Markscheidenzerstörungen mit Achsencylinder-degeneration und Verlust bemarkter Axone sowie häufige degenerative Veränderungen im Cytoplasma der Schwann-Zellen. Keine Hinweise auf segmentale Demyelinisation, aber seltene zwiebelschalenähnliche Strukturen mit Schwann-Zellproliferation wurden beobachtet. Außerhalb der zwiebelschalenähnlichen Strukturen war keine wesentliche Verbreitung der Basalmembran und Vermehrung von Kollagenfasern sowie keine Phagocytose vorhanden. Diese Befunde werden im wesentlichen als Folge der Wallerschen Degeneration betrachtet. Es werden einige Betrachtungen über die ungewöhnlichen zwiebelschalenähnlichen Strukturen angestellt.
    Notes: Summary Examination of electron microscopical and teased preparations of a biopsied sural nerve from a patient with arsenical neuropathy is reported. Teased preparations and toluidine blue stained epon sections showed a decrease in the number of myelinated fibres and Wallerian degeneration. Electron microscopy revealed destruction of myelin sheaths, further disintegration associated with degeneration or disappearance of myelinated axons and numerous degenerative changes in the Schwann cell cytoplasm. There was no evidence of segmental demyelination. Occasional onion-bulb-like structures, however, associated with proliferation of Schwann cells, were observed. Obvious elongation of the basement membrane, except in an onion-bulb-like structure, or collagen fibril proliferation or evidence of phagocytosis was not found. These findings are considered to correspond mainly with Wallerian degeneration. Some consideration as given to the unusual onion-bulb-like structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687363
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  • 6
    Electronic Resource
    Electronic Resource
    Experimental organic mercury poisoning — Pathological changes in peripheral nerves (1970)
    Springer
    Acta neuropathologica 15 (1970), S. 45-55 
    Details
    ISSN: 1432-0533
    Keywords: Organic Mercury Compound ; Peripheral Nerve ; Minamata Disease ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Organische Quecksilberverbindungen schädigen im Nervensystem zunächst die peripheren Nerven. Dabei werden die sensiblen Fasern bevorzugt betroffen: es kommt zur Proliferation und Degeneration der Schwannschen Zellen sowie zu starken Veränderungen an Markscheiden und Axonen. Vermehrte Schwannsche Zellen und Makrophagen bewirken die Beseitigung und Verdauung degenerierter Markscheiden und Axone. Die Veränderungen an markhaltigen Nervenfasern beginnen hauptsächlich am Ranvierschen Schnürring. Organisches Quecksilber schädigt in einer bestimmten Dosierung ausschließlich die peripheren Nerven. Diese Befunde lassen vermuten, daß bei Patienten mit organischen Quecksilbervergiftungen mitunter nur Symptome von Schäden an sensiblen Nerven auftreten können.
    Notes: Summary Organic mercury firstly affects peripheral nerves all over the nervous system. In peripheral nerves, pathological changes are selectively observed in sensory nerve fibres and are as follows: Swelling and degeneration of Schwann cells, noticeable changes in both myelin sheaths and axons. Proliferating cells such as Schwann cells and macrophages may be acting the role of removal and digestion of degenerated myelin and axon. The pathological changes in myelinated fibres tend to begin at the nodes of Ranvier. With the quantity of organic mercury which was administered, only peripheral nerves were injured. From this point of view, we speculate that, of the neurological signs, only sensory disturbance might be found in some of the patients poisoned by organic mercury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690688
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  • 7
    Electronic Resource
    Electronic Resource
    Zur Feinstruktur der experimentell-allergischen Neuritis beim Kaninchen (1970)
    Springer
    Acta neuropathologica 14 (1970), S. 261-283 
    Details
    ISSN: 1432-0533
    Keywords: Allergic Neuritis ; Electron Microscopy ; Mononuclear Cells ; Demyelination ; Remyelination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Kaninchen mit einer experimentell-allergischen Neuritis (EAN) wurden 8 Tage bis 4 Monate nach der Injektion einer Emulsion aus heterologem Nervengewebe mit Freundschem Adjuvans phasenkontrast- und elektronenmikroskopisch untersucht. Im akuten Stadium der Demyelinisation ist eine Beteiligung von mononucleären Infiltratzellen am Vorgang der Entmarkung peripherer Nervenfasern in der gleichen Weise nachweisbar, wie es Lampert (1969) bei der EAN von Ratten dargestellt hat. Da die Markscheidenschäden jedoch nicht immer in unmittelbarem Kontakt mit den Infiltratzellen auftreten, sind humorale Faktoren, die möglicherweise von den Infiltratzellen ausgeschieden werden, als Ursache der Markscheidenschäden nicht mit Sicherheit auszuschließen. Der weitere Abbau der geschädigten Markscheiden findet dann sowohl in den zu Makrophagen transformierten Infiltratzellen als auch in den proliferierenden Schwann-Zellen statt. Ausnahmsweise dominieren unter den Infiltratzellen auch bei der einfachen experimentell-allergischen Neuritis neutrophile Leukocyteninfiltrate; sie kommen in Zusammenhang mit anderen Zeichen einer schweren Störung der Gefäßnervenschranke wie Erythrodiapedesen und Fibrinexsudaten im fortgeschrittenen Stadium der Gewebsschädigung vor. Auf Axonläsionen und die im Ausheilungsstadium der EAN vorkommenden Zwiebelschalenformationen sowie die wiederholt beobachteten Gruppen regenerierter, von einer gemeinsamen Basalmembran gebündelter Nervenfasern wird kurz hingewiesen.
    Notes: Summary Rabbits with experimental allergic neuritis (EAN), induced by intradermally injected emulsified heterologous antigen together with Freund's adjuvant, were investigated by phase and electron microscopy 8 days to 4 months after the injection. Early lesions of the myelin sheaths in EAN can be demonstrated to occur in close contact with infiltrated mononuclear cells as has been reported by Lampert (1969) in rats. Yet since myelin lesions are not always restricted to areas of immediate contact with infiltrated mononuclear cells, it cannot be excluded that humoral factors, possibly excreted by the infiltrated cells, may initiate the myelin lesions. Further breakdown of myelin sheaths takes place in proliferating Schwann cells as well as in infiltrated mononuclear cells. Occasionally, neutrophilic leucocytes predominate among the cellular infiltrates. They occur together with erythrodiapedesis, and fibrinous exsudates in areas of severance of the blood-nerve barrier. Axonal lesions, and during remyelination, “onion bulb” formation were also seen as a sequence of the demyelinating lesions. Also, bundles of small regenerated nerve fibers enclosed by a single basement membrane were repeatedly observed in areas with remyelinated nerve fibers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685783
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  • 8
    Electronic Resource
    Electronic Resource
    Secretory ependymoma of the filum terminale (1970)
    Springer
    Acta neuropathologica 15 (1970), S. 240-250 
    Details
    ISSN: 1432-0533
    Keywords: Ependymoma ; Electron Microscopy ; Secretory Granules ; Histochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ein unikales Ependymom des Filum terminale mit intracytoplas-matischen Sekretgranula wurde licht- und elektronenmikroskopisch nachgewiesen. Auffallende strukturelle und histochemische Änlichkeiten bestehen zwischen den Sekretionsprodukten des Tumors und denen im sekretorischen System des Endabschnittes des Rückenmarks bei Fischen. Die Funktion und der Wirkungsort des Sekretionsproduktes sind unbekannt.
    Notes: Summary An unique ependymoma of the filum terminale with intracytoplasmic secretory granules has been identified by light and electron microscopy. A striking structural and histochemical similarity exists between the tumor secretory product and that found in the secretory system present in the terminal portion of the spinal cord of the fish. The function and site of action of the secretory product is unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686770
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  • 9
    Electronic Resource
    Electronic Resource
    The examination of isolated nerve fibres by light and electron microscopy, with observations on demyelination proximal to neuromas (1970)
    Springer
    Acta neuropathologica 16 (1970), S. 177-186 
    Details
    ISSN: 1432-0533
    Keywords: Isolated Nerve Fibres ; Electron Microscopy ; Demyelination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird eine Technik zur Isolierung peripherer Nervenfasern durch Auffasern und nachfolgende licht-undd elektronenmikroskopische Untersuchung beschrieben. Diese Technik wurde zum Studium ungewöhnlich geschwollener Fasern angewandt, die proximal der Läsion bei durchschnittenen Nerven von Ratten beobachtet wurden. Diese Fasern wurden als das Ergebnis der Demyelinisation bereits remyelinisierter Segmente dargestellt.
    Notes: Summary A technique is described for isolating peripheral nerve fibres by teasing and subsequently examining them by light and electron microscopy. The technique was applied to the study of unusual swollen fibres observed central to the lesion in transected nerves in rats. These were shown to be the result of the demyelination of already remyelinated segments of the fibre.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687357
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  • 10
    Electronic Resource
    Electronic Resource
    An unusual structure in Kuru brain (1970)
    Springer
    Acta neuropathologica 15 (1970), S. 288-292 
    Details
    ISSN: 1432-0533
    Keywords: Electron Microscopy ; Kuru ; Inclusion ; Cytoplasmic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In Fällen von Kuru wurden im Cytoplasma von ansonst normalen Purkinjezellen Strukturen mit strahlendichten Balkenmustern gefunden. Solche sind auch in geringerer Zahl im Axoplasma von Nervenfasern sowohl im menschlichen wie auch im Schimpansenmaterial vorhanden. Sie weisen eine zarte Punktstruktur auf sind und eng mit intracellulären Membranprofilen verbunden.
    Notes: Summary Within the cytoplasm of otherwise normal Purkinje cells barred structures have been found in cases of Kuru. They are also present in small numbers in axoplasm of nerver fibres, both in human and chimpanzee material. They present a discrete punctate structure and are closely associated with intracellular membranous profiles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686775
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  • 11
    Electronic Resource
    Electronic Resource
    La dystrophie neuroaxonale infantile ou maladie de Seitelberger (1970)
    Springer
    Acta neuropathologica 15 (1970), S. 327-350 
    Details
    ISSN: 1432-0533
    Keywords: Neuroaxonal Dystrophy Infantile ; Electron Microscopy ; Spheroids ; Smooth Endoplasmic Reticulum ; Mitochondria ; Seitelberger's Disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs rapportent 2 cas de DNAI.Le tableau clinique, d'évolution mortelle en 2 ans, associe un arrêt du développement psycho-moteur, des signes pyramidaux et extrapyramidaux, un nystagmus pendulaire avec atrophie optique. L'étude en microscopie optique définit:—les aspects morphologiques, la nature glycolipoprotéique et la répartition topographique des sphéroïdes, électivement disposés dans les structures médullaires, bulbo-protubérantielles et cérébelleuses, phylogénétiquement les plus anciennes, —l'atrophie du cortex cérébelleux, —la surcharge soudanophile avec état dysmyélinique du pallidum, —la dégénérescence des voies afférentes et efférentes des fibres longues de la moelle, du tronc cérébral et des voies optiques.L'étude en microscopie électronique précise la structure des sphéroïdes composés d'amas membrano-tubulaires et cisternaux, des corps denses amorphes ou lamellés, multigranuleux, pseudo-cristallins ou multivésiculaires et de mitochondries pathologiques. La formation de ce matériel est liée à l'hyperplasie du réticulum endoplasmique lisse et à l'accumulation de mitochondries anormales dans les péricaryons neuronaux, les prolongements dendro-axonaux, les culs de sacs synaptiques. Les auteurs rapprochent leurs constatations de faits semblables observés en pathologie humaine et expérimentale.
    Notes: Summary Two cases of INAD are reported. Clinical features with fatal issue within 2 years, are characterized by psychomotor retardation, pyramidal and extrapyramidal signs, pendular nystagmus with bilateral atrophia of optic discs.Light microscopy shows:—the morphology of spheroids, their glycolipoproteid component and their elective distribution in medulla, brain-stem and cerebellum, phylogenetically the oldest parts of the CNS—a cerebellar cortical atrophia—sudanophilic fatty deposits associated to status dysmyelinatus of pallidum—a degeneration of pyramidal, spinocerebellar tracts and optic pathways.Electron microscopy in the two cortical biopsies allows to specify the internal structure of spheroids made of membrano-tubular and interconnected aggregates, amorphous and lamellar electron-dense bodies, multigranular bodies, cristalline-like inclusions, multivesicular bodies and involved mitochondria. That complex material represents an overproduction of smooth endoplasmic reticulum and abnormal mitochondria located in neuronal perikarya, axons, dendrites and enlarged synaptic bulbs. These pathological findings are compared to those already described in human and experimental cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684731
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  • 12
    Electronic Resource
    Electronic Resource
    Electron microscopic study on a case of idiocy: Astrocytes and mental deficiency (1970)
    Springer
    Acta neuropathologica 16 (1970), S. 25-34 
    Details
    ISSN: 1432-0533
    Keywords: Mental Deficiency ; Astrocytes ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einem Fall von Schwachsinn ohne starke somatische und neurologische Symptome wurde eine Biopsie der Frontalwindung vorgenommen und das Material elektronenmikroskopisch untersucht: Bei Fehlen eines cerebralen Abbauprozesses fanden sich Einschlußkörperchen im Cytoplasma der Astrocyten und eine abnorme Zunahme der Lipofuscingranula im Cytoplasma der Nevenzellen. Diese Einschlußkörperchen erwiesen sich aus geschädigtem ergastoplasmischen Reticulum und RNP-Körperchen bestehend. Aus diesen Befunden wurde geschlossen, daß die physiologische Funktion der Astrocyten infolge einer Störung des Protein-Metabolismus in den Astrocyten beeinträchtigt war; außerdem war die Funktion der Nervenzellen durch die Zunhme der Lipofuscingranula sekundär gestört. Es scheint, daß die Veränderungen eng mit dem Schwachsinn zusammenhingen und daß die intellektuellen Funktionen teilweise von der Funktion der Gliazellen abhängen.
    Notes: Summary A biopsy of a frontal gyrus from a case of idiocy, without gross bodily symptoms or neurological signs, was examined by electron microscopy. The results of this examination were as follows: there was no destructive process in the cerebral tissue but inclusions were seen in the cytoplasm of the astrocytes and there was an abnormal increase in lipofuscin granules, in the cytoplasm of the nerve cells. The inclusions consisted of damaged endoplasmic reticulum and RNP granules. From these findings, it was considered that the physiological function of the astrocytes was disturbed, as the result of a disturbance in protein metabolism and that the function of the nerve cells was also disturbed, with an increase in lipofuscin granules. These changes seem to be intimately concerned with mental deficiency and part of intellectual function seems to depend on the functions of the glia cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686960
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  • 13
    Electronic Resource
    Electronic Resource
    The ultrastructure of ring fibres in dystrophic muscle (1970)
    Springer
    Acta neuropathologica 16 (1970), S. 161-172 
    Details
    ISSN: 1432-0533
    Keywords: Muscular Dystrophy ; Quadriceps Muscle ; Ring Fibres ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine Biopsie des M. vastus lateralis bei einem 49 jährigen Mann mit langsam progressiver Myopathie mit isoliertem Befall der Mm. quadriceps wurde untersucht. Es fanden sich zahlreiche atrophische Fasern und Ringbinden. Die atrophischen Fasern zeigten Zunahme an Glykogen und Mitochondrien sowie Verlust der Myofibrillen als geringere Läsionen sowie Fragmentierung und grobe Desorganisation der Myofilamente in den stärker betroffenen Fasern. Ausstülpungen der Basalmembran ragten aus ihrer Oberfläche vor. Phagocyten traten in wenigen degenerierten Fasern und in den Basalmembranschläuchen auf. Alle untersuchten Ringbinden hatten einen intakten Längskern mit einem eng anliegenden zirkulären Band von Myofibrillen. Schwere Veränderungen, wie sie in den atrophischen Fasern vorlagen, waren in den Ringbinden nicht anzutreffen. Die degenerativen Veränderungen beschränkten sich auf die umgebenden Myofibrillen, die Verlust der Myofilamente verschiedenen Grades sowie Anhäufungen von Glykogen und Mitochondrien aufwiesen. Die Verff. sind der Meinung, daß die Ringbinden originäre Strukturen und keine Artefakte durch Fixation oder bioptische Eingriffe darstellen.
    Notes: Summary A biopsy was taken from the vastus lateralis of a man of 49 years with slowly progressive myopathy largely confined to the quadriceps muscles. Both atrophic fibres and ring fibres were numerous. The atrophic fibres showed increase in glycogen and mitochondria and loss of myofilaments as the lesser changes, with fragmentation and gross disorganisation of myofilaments in the more severely affected fibres. Folds of basement membrane projected from their surfaces. Phagocytes occurred in a few degenerate fibres and in basement membrane tubes. All the ring fibres examined had an intact longitudinal core with a closely applied encircling band of myofibrils. Severe changes of the type found in the atrophic fibres were not seen in the ring fibres. Degenerative changes were confined to the circumferential myofibrils, which presented loss of myofilaments of varying degree and aggregations of glycogen and mitochondria. We believe that ring fibres are genuine structures and are not artefacts produced either by fixation or by the biopsy procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687671
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  • 14
    Electronic Resource
    Electronic Resource
    The ultrastructure of medulloblastomas (1970)
    Springer
    Acta neuropathologica 16 (1970), S. 271-284 
    Details
    ISSN: 1432-0533
    Keywords: Medulloblastoma ; Electron Microscopy ; Arachnoid Sarcoma ; Lymphocyte-Like Cells ; Dark Cells ; Histogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 9 Medulloblastome wurden elektronenmikroskopisch untersucht. Sie zeigten eine relativ einheitliche histologische und cytologische Struktur. Die Tumorzellen haben eine wechselnde Form, wenig Organellen und in der Regel zahlreiche cytoplasmatische Fortsätze. In Gewebspartikeln, die nach der vorherigen lichtmikroskopischen Untersuchung aus dem Tumorzentrum stammten, wurden keine Zellen mit glialer oder neuronaler Differenzierung beobachtet. Nur in den am Tumorrand gelegenen Infiltrationszonen, wo die Tumorgrenze nicht mehr sicher zu bestimmen war, fanden sich gliale oder neuronale Zellelemente. — Das Medulloblastom hat die wesentlichen morphologischen Kriterien der kleinzelligen Sarkome und des embryonalen Gewebes. Deren gemeinsames Charakteristicum, daß sie nämlich keine speziellen Differenzierungen besitzen, ist auch eine spezifische Eigenschaft des Medulloblastoms.
    Notes: Summary 9 medulloblastomas were investigated by electron microscopy. They all showed a rather unique histological and cytological structure. The cells were differently shaped, had in general many cytoplasmic processes and only few organells. Special differentiations which would have made tumour elements look like glial or neural cells were not observed when the tissue samples under investigation were carefully selected by light microscopical examination. Glial or neural elements were found only in infiltration zones where no clear distinction between pre-existing cerebellar and tumourous tissues could be made by conventional histological investigation. Medulloblastomas have essentially the same appearance as parvicellular sarcomas or embryonic tissues. Their common characteristic, viz. that they usually show no special differentiation, is also the most specific quality of medulloblastomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686892
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  • 15
    Electronic Resource
    Electronic Resource
    Infantile neuroaxonal dystrophy: Cortical axonic and presynaptic changes (1970)
    Springer
    Acta neuropathologica 16 (1970), S. 342-352 
    Details
    ISSN: 1432-0533
    Keywords: Neuroaxonal Dystrophy, Infantile ; Cortical Biopsy ; Spheroid-Like Axons ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ein 21/2 Jahre altes arabisches Mädchen (Eltern Cousins 2. Grades) bot seit dem 1. Lebensjahr progressive psychomotorische Retardierung. Eine Hirnrindenbiopsie ergab normale lichtoptische Verhältnisse, während elektronenoptisch reichlich schollenartige Axonauftreibungen gefunden wurden. Ihr Inhalt setzte sich aus vesico-tubulärem Material oder aus dicht gepacktem filamentösen Material zusammen. Synapsen waren zwischen den Sphäroiden und anderen neuronalen Somata sowie Dendriten nachweisbar. In den Mitochondrien und Sphäroiden fanden sich kristalline Strukturen. Es wird vermutet, daß die “neuroaxonale Dystrophie” durch Rindenbiopsie diagnostiziert werden kann.
    Notes: Summary A 21/2 year old girl who, since the age of 1 year presented, a progressive psychomotor retardation. A cortical biopsy appeared normal by light microscopy, but by electron microscopy an abundance of dilated spheroid-like axons were found. They contained either vesiculo-tubular material or densly packed filamentous material. Synapses were demonstrated between the spheroids and other neuronal bodies or dendrites. Crystalline like material was observed within mitochondria and the spheroids. It is suggested that Neuroaxonal dystrophy may be diagnosed by cortical brain biopsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686897
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  • 16
    Electronic Resource
    Electronic Resource
    The differentiation of two types of intrafusal fibres in rabbit muscle spindles (1970)
    Springer
    Pflügers Archiv 317 (1970), S. 187-197 
    Details
    ISSN: 1432-2013
    Keywords: Muscle Spindles ; Intrafusal Muscle Fibres ; Electron Microscopy ; Rabbit ; Muskelspindel ; Intrafusalen Muskelfasern ; Elektronenmikroskopie ; Kaninchen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The ultrastructure of muscle spindles in deep lumbrical muscles of adult rabbit has been investigated. Contrary to findings obtained by previous authors at the light microscope, indicating morphologic uniformity of intrafusal fibre type in rabbit spindles, two populations of intrafusal muscle fibres have been detected. 2. The first type of fibres is made by myofibrils which have a thick Z line and lack a distinct M line. These fibres are also characterized by the apparent fusion of fibrillar fields due to the paucity of the sarcoplasm, which contains very little glycogen. The mitochondria are scattered and of small size. The sarcoplasmic reticulum is poorly developed and the triads are quite rare. These fibres resemble the nuclear bag fibres of cat muscle spindles. 3. The second type of fibres is made by myofibrils which have a thin Z line and a prominent M line. There is a great separation of the fibrillar fields as a result of abundant sarcoplasm which contains large accumulation of glycogen and ribosomes. The mitochondria are densely distributed and of large size. The sarcoplasmic reticulum is well developed and the triads are rather numerous. These fibres resemble the nuclear chain fibres of cat muscle spindles. 4. The demonstration of two types of intrafusal muscle fibres in rabbit spindles may account for the duality of physiological responses obtained from these receptor organs in this animal species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00586503
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  • 17
    Electronic Resource
    Electronic Resource
    The morphology of the toad urinary bladder: A stereoscopic and transmission electron microscopical study (1970)
    Springer
    Cell & tissue research 109 (1970), S. 297-305 
    Details
    ISSN: 1432-0878
    Keywords: Bladder ; Bufo marinus ; Transport ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The appearance of the mucosal cell layer of the isolated urinary bladder of the toadBufo marinus, has been examined using stereoscopic and conventional transmission electron microscopy. Three cell types can be identified in surface view, these are granular cells, mitochondriarich cells and goblet cells. Cell boundaries between granular cells are clearly defined by membranous folds along their margins. Although no changes are seen in the stereoscopic electron micrographs when the granular cells are made permeable to water by vasopressin, the changes observed on transmission electron micrographs include swelling of cell bodies and nuclei, filling of intercellular channels with water, and the appearance beneath the mucosal cell membrane surface of electron dense granules. Differences between the appearance of the bladder mucosal cells by the two methods of electron microscopical examination are due largely to water loss when the tissue is freeze dried prior to stereoscopic examination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02226903
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