ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
By the use of absorption, partition and paper chromatography as well as counter-current distribution 18 pure crystalline cardenolides (B, γ, C, δ, D, E, F, G, H, I, K, L N, 0, P, π, ς and Q) and a further crystalline KEDDE-positive compound (A) were isolated after fermentation of the seeds of Nerium oleaizder L. The compounds H, I and e were identified with known genins; namely Digitoxigenin (H), Oleandrigenin (I) and Gitoxigenin (ς). Of the remaining 15 compounds, 14 were found to be glycosides composed of the 4 genins H, I, ς and 16-Anhydro-gitoxigenin with the following sugars: L-Oleandrose, D-Diginose, D-Samentose and D-Digidose. 10 of these glycosides have previously been isolated in pure form. They are: Digistroside (γ), Oleandrin (C), Cryptograndoside A (d), 16-Anhydro-desacetyl-cryptograndoside A (D), Odoroside A (E), Desacetyl-oleandrin (K), Desacetyl-cryptograndoside A (L), Odoroside H (0), 16-Anhydro-strospeside (n) and Strospeside (Q). The other 4 are new compounds whose structures were elucidated and which were named as follows: Nerigoside (F), 16-Anhydro-desacetyl-nerigoside (G), Desacetyl-nerigoside (N) and Neritaloside (P).
Additional Material:
29 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19590420339
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