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  • 1985-1989  (3,339)
  • 1988  (1,899)
  • 1986  (1,440)
  • Analytical Chemistry and Spectroscopy  (2,244)
  • Engineering  (1,095)
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Material
Years
  • 1985-1989  (3,339)
Year
Keywords
  • 101
    Electronic Resource
    Electronic Resource
    S. J. Gaskell (Ed.) Mass spectrometry in biomedical research John Wiley & Sons, Chichester, 492 pages (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 357-357 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150610
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  • 102
    Electronic Resource
    Electronic Resource
    Masthead (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988) 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150701
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  • 103
    Electronic Resource
    Electronic Resource
    Letter to the editors (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 465-465 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150810
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  • 104
    Electronic Resource
    Electronic Resource
    The applicability of evacuated serological tubes for the collection of breath for isotopic analysis of CO2 by isotope ratio mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 467-472 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Stable isotope ratio mass spectrometry was used for the analysis of 13C and 18O in CO2 of human breath collected in evacuated serological tubes (Vacutainer® and Venoject®) and in gas sample bottles. There was a 1-2‰0 difference between the δ13CPDB values obtained from breath CO2 collected in gas bottles and that collected in two batches of Vacutainer. δ18OPDB differed between Vacutainers and gas bottles by as much as 14%0 and standard deviations within the two batches of Vacutainer were 0.7 and 1.8%0. The poor reproducibility and accuracy for the δ18OPDB values was caused by the presence of a contaminant which originated from the rubber septa of the Vacutainers. The results show that it is not possible to obtain δ18OPDB values with a high degree of accuracy or precision for breath samples collected in Vacutainers. However, with selection of less contaminated or re-evacuated batches, δ13CPDB analysis of breath CO2 in Vacutainers may provide acceptable accuracy and precision. δ13CPDB and δ18OPDB values measured in breath collected in non-sterile Venoject tubes were also significantly different from those obtained with gas bottles. However, the accuracy and precision of these determinations were considerably better than in sterilized Vacutainer tubes. As a result of these comparisons it is concluded that gas bottles are necessary for the full accuracy and precision of stable isotope ratio analysis mass spectrometers to be exploited in breath CO2 analysis. However, automated analysis of breath CO2 collected in non-sterile Venoject tubes will provide an accuracy and precision that is suitable for most biological studies.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150902
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  • 105
    Electronic Resource
    Electronic Resource
    The quantification of synthetic corticosteroids using isotope dilution gas chromatography negative chemical ionization mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 479-483 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Prednisolone, dexamethasone and betamethasone were labelled with deuterium via a simple synthetic procedure and used as internal standards in the gas chromatographic/mass spectrometric analysis of the corresponding undeuterated compounds. The mass spectrometer was used in the negative chemical ionization mode, which gave fragmentation of the methoxime trimethylsilyl ether derivatives favourable for their quantification. The method was applicable to the quantification of synthetic corticosteroids contained in human aqueous humour in the 0.1-10-ng range.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150904
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  • 106
    Electronic Resource
    Electronic Resource
    Masthead (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988) 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151001
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  • 107
    Electronic Resource
    Electronic Resource
    Capillary column isobutane chemical ionization mass spectrometry of mustard and related compounds (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 553-564 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Capillary column isobutane chemical ionization was found to be an excellent method for the mass spectral characterization of mustard, other sulfur vesicants and related compounds. Interpretation of [M + H]+ and fragmentation ion information afforded by this technique enabled the identification of many previously unreported mustard impurities. The developed methodology was applied to the analysis of an Iran/Iraq soil sample suspected to have been contaminated with mustard. Mustard and 17 other mustard related impurities were identified and characterized in this sample under electron impact and isobutane chemical ionization conditions.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151008
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  • 108
    Electronic Resource
    Electronic Resource
    Masthead (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988) 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151101
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  • 109
    Electronic Resource
    Electronic Resource
    Use of ion-molecule reactions for selected reaction monitoring in gas chromatographic/tandem mass spectrometric analyses in two model systemsPresented at the 34th Annual Conference on Mass Spectrometry and Allied Topics, Cincinnati, Ohio, June, 1986. (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 583-588 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The use of ion-molecule reactions with NH3 for selected reaction monitoring (SRM) in gas chromatographic/tandem mass spectrometric analysis is demonstrated for 2-methoxyethanol and chlorobenzene in methanol and urine. In the former, the reaction [CH3OC2H4]+ + NH3 → [H2NC2H4]+ + CH3OH was followed; in the latter, the reaction [C6H5Cl]+· + NH3 → [C6H5NH3]+ + Cl·. Increased selectivity and an improvement in sensitivity by factors of up to five were observed when compared to conventional SRM analyses that used collisionally activated decompositions on NH3. SRM analyses with a triple quadrupole tandem mass spectrometer using ion-molecule reactions rather than collisionally activated decompositions have been found to be more sensitive and more selective in two model systems.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151102
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  • 110
    Electronic Resource
    Electronic Resource
    Errata (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 635-635 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151109
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  • 111
    Electronic Resource
    Electronic Resource
    Determination of boldenone sulfoconjugate and related steroid sulfates in equine urine by high-performance liquid chromatography/tandem mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 283-289 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Sulfoconjugated anabolic steroids were separated by micro-bore high-performance liquid chromatography. The eluent was introduced into the atmospheric pressure ion source of the triple-quadrupole mass spectrometer via an ion spray liquid chromatograph/mass spectrometer interface operated in the negative ion mode. The limit of detection was 10 pg on-column by selected ion monitoring of the molecular ion and the response increased linearly over a concentration range of 2.4 orders of magnitude. Following work-up by a liquid-solid extraction procedure of equine urine samples, full-scan daughter ion spectra of boldenone sulfate could be obtained up to 17 days after a therapeutic dose of boldenone undecylenate to a horse.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150508
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  • 112
    Electronic Resource
    Electronic Resource
    Laser desorption/fourier transform ion cyclotron resonance mass spectrometry: Digoxin, digitoxin, and their reduced and sugar-hydrolyzed metabolites (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 295-302 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Mass spectra of digoxin and digitoxin (the most widely prescribed drugs for treatment of congestive heart failure) and a complete set of their 14 dihydro- and sugar-hydrolyzed metabolites have been obtained via laser desorption/ionization with a Fourier transform ion cyclotron resonance (LD/FT/ICR) mass spectrometer. The most intense peak is typically the pseudomolecular [M + K]+ ion, but fragment ions corresponding to loss of 1--3 sugars and hydroxyls are also observed. LD/FT/ICR mass spectra for all 16 compounds were produced with a single set of sample and spectrometer parameters. No matrix peaks are present. Finally, LD/FT/ICR provides dynamic mass accuracy within ≈5 ppm throughout a mass range of 404 〈 m/z 〈 819.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150510
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  • 113
    Electronic Resource
    Electronic Resource
    Conjugation reactions of polyaromatic quinones to mono- and bisglutathionyl adducts: Direct analysis by fast atom bombardment mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 329-332 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The conjugation products of several reactive quinones with glutathione have been identified by fast atom bombardment mass spectrometry. Appropriate conditions have been developed which enabled the direct, dynamic mass spectral analysis of spontaneous, as well as glutathione transferase catalysed conjugation reactions. Applications to a series of quinones provided the direct detection and differentiation of the formation of mono- and bisglutathionyl adducts between regioisomeric quinone substrates in that only 1,4-quinones yielded bisglutathionyl adducts, which were not observed for the 1,2-isomers.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150605
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  • 114
    Electronic Resource
    Electronic Resource
    Collisional spectroscopy in structural characterization of melanins 2 - laser desorption experiments on bio- and synthetic tryptophan melaninsFor part 1 see Ref. 13. (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 353-355 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Melanins1 are naturally occurring macromolecules whose structural complexity appeared evident from the first researches of Quilico.2 Their structural characterization remains a difficult problem, mainly due to the physico-chemical properties of such compounds. Melanins are insoluble in organic solvents as well as aqueous solutions and are infusible. Consequently the traditional chemical degradation and physicochemical methods such as ultraviolet, infrared, 1H and 13C nuclear magnetic resonance, ESR (electron spin resonance), XPS (X-rays photoelectron spectroscopy) and X-ray diffraction have led, until now, to limited information on melanin chemical structure1,3.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150608
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  • 115
    Electronic Resource
    Electronic Resource
    Automated measurement of the concentration and 13C enrichment of carbon dioxide in breath and blood samples using the finnigan MAT breath gas analysis system (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 365-367 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The operation and performance of the Finnigan MAT automated Breath Gas Analysis System for the routine analysis of 13C breath tests taken in 20-ml Vacutainers is described. Up to four samples per hour can be analysed with a standard deviation of δ13C of 〈0.05%o being achieved over the range 10-50 μmol CO2. The equipment can also be used for the automatic measurement of the concentration and 13C enrichment of CO2 derived from carbonate or bicarbonate solutions, including blood and other physiological fluids.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150703
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  • 116
    Electronic Resource
    Electronic Resource
    Identification of a biliary metabolite of cisapride (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 323-328 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Radiolabeled cisapride was administered orally to male Wistar rats. The drug was metabolized extensively, resulting in the formation of a large number of urinary and faecal metabolites. In bile-cannulated rats a major metabolite was excreted with the bile whose structure could not be elucidated with the aid of the registered electron impact and desorption chemical ionization spectra. Therefore the biliary metabolite was subjected to extensive analytical procedures combining fast atom bombardment mass spectrometry, thermospray liquid chromatography/mass spectrometry, nuclear magnetic resonance and ultraviolet analysis. The results of this study allowed the identification of the biliary metabolite as the O-sulphate of metabolically formed 3′-hydroxycisapride.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150604
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  • 117
    Electronic Resource
    Electronic Resource
    In vivo metabolism of the n-propyl homologues of delta-8- and delta-9-tetrahydrocannabinol in the mouse (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 403-410 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: n-Propyl-delta-8-tetrahydrocannabinol (n-propyl-delta-8-THC and n-propyl-delta-9-THC were synthesized by condensation of (1S)-cis-verbenol with 5-n-propyl-1,3-dihydroxybenzene and administered to male Charles River CD-1 mice. Hepatic merabolites were isolated by solvent extraction and chromatography on Sephadex LH-20 and identified by gas chromatography/mass spectrometry. Seven metabolites were identified from each cannabinoid. Metabolism was similar to that previously observed from the pentyl homologues, with the major biotransformation pathway being the production of 11-hydroxy-propyl-THCs and their oxidation to carboxylic acid metabolites. Other metabolites were mainly hydroxylated derivatives of these compounds and the corresponding 11-alcohol. Less hydroxylation at C(8) was found with n-propyl-delta-9-THC than with the pentyl homologue, and the monohydroxy metabolite, 8-alpha-hydroxy-n-propyl-delta-9-THC, was not observed, even though it was a prominent metabolite from delta-9-THC itself. Hydroxylation occurred in the side-chain at C(2′).
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150708
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  • 118
    Electronic Resource
    Electronic Resource
    Ion chemistry of a gas chromatographic/mass spectrometric ion abundance calibrant (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 429-439 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Mass and ion abundance calibration of gas chromatograph/mass spectrometer responses is essential for the production of good data. In 1975, ion abundance criteria based on the mass spectrum of decafluorotriphenylphosphine (DFTPP) were proposed to standardize quadrupole mass spectra against magnetic sector spectra. This paper reports an investigation of DFTPP ion chemistry with the determination of the effects of some gas chromatograph/mass spectrometer operating parameters on the mass spectrum of DFTPP. New ion abundance criteria are proposed and discussed in relation to the findings of this investigation.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150804
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  • 119
    Electronic Resource
    Electronic Resource
    Measurement of 13C-glucose oxidation rate using mass spectrometric determination of the CO2: Ar ratio and spirometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 447-451 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A new method was developed and validated for measuring the CO2 concentration in the breath by mass spectrometric analysis. Argon, an inert gas that is present in air in a constant concentration of 0.923%, was used as an internal standard. By determining the ratio of CO2 (mass 44) to Ar (mass 40) in a breath sample, it was possible to read the CO2 concentration from a standard curve, relating CO2 concentration to CO2: Ar ratio. By combining mass spectrometric determination of CO2 concentration in breath with spirometric measurement of expired volumes, the CO2 production was determined in 67 subjects at rest. The mean value was 8.86 mmol kg-1 h-1, but there was considerable interindividual variation. This new method was applied to glucose oxidation studies in 10 normal subjects, 10 post-gastrectomy patients and 7 obese type II diabetic subjects. Measurement of the 13CO2 exhalation with quantitative determination of CO2 production allowed more accurate determination of the CO2 excretion rate in relation to blood levels of glucose, insulin and free fatty acids than assuming the constant CO2 production of 300 mmol unit body surface-1 h-1 or 9 mmol kg-1 h-1. It also resulted in a better discrimination between normal subjects and diabetics.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150806
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  • 120
    Electronic Resource
    Electronic Resource
    Masthead (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988) 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150901
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  • 121
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    Characterization of doxylamine and pyrilamine metabolites via thermospray/mass spectrometry and tandem mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 501-508 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Analysis of doxylamine N-oxide and pyrilamine N-oxide as synthetic standards and biologically derived metabolites by thermospray mass spectrometry (TSP/MS) provided [M + H]+ ions for each metabolite. TSP/tandem mass spectrometry (TSP/MS/MS) of the [M + H]+ ions provided fragment ions characteristic of these metabolites. In addition, TSP mass spectrometry and TSP/MS/MS analysis of ring-hydroxylated N-desmethyldoxylamine, N-desmethylpyrilamine and O-dealkylated pyrilamine is also reported. A fragmentation pathway for analysis by MS/MS of pyrilamine and its metabolites is also proposed. The results demonstrate the utility of TSP/MS for biologically derived metabolites of pyrilamine and doxylamine.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150907
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  • 122
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    A rapid and sensitive method for the determination of γ-hydroxybutyric acid and trans-γ-hydroxycrotonic acid in rat brain tissue by gas chromatography/mass spectrometry with negative ion detection (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 521-524 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: γ-Hydroxybutyric acid (GHB) and trans-γ-hydroxycrotonic acid (HCA) together with their respective internal standards were derivatized to give the pentafluorobenzyl esters of the N-tert-butyldimethylsilyl derivatives. These compounds give, under electron capture conditions, very simple negative ion mass spectra. A very sensitive and specific assay for GHB and HCA in brain tissue (detection limit of about 5 pg per injection) using gas chromatography/negative ion mass spectrometry is described. The average levels measured in the whole brain were 1.10 ± 0.18 nmol GHB/g wet weight and 0.18 ± 0.02 nmol HCA/g wet weight.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151002
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  • 123
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    Negative ion mass spectra of dihydropyridine calcium-channel blockers (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 525-528 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The negative ion mass spectra of some dihydropyridine analogues of nifedipine are studied; they show a fragmentation which is highly dependent on the position of the nitro group on the phenyl ring: 3′-nitro derivatives give essentially the molecular anion, whereas 2′-nitro derivatives lose successively H2O, RO and O. In addition, (2,1,3-benzoxadiazol-4-yl) derivatives show essentially a [M—ROH]- peak. Possible pathways for these fragmentations are given.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151003
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  • 124
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    A determination of the positions of disulphide bonds in Paim I, α-amylase inhibitor from Streptomyces corchorushii, using fast atom bombardment mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 541-546 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Paim I, a protein α-amylase inhibitor, is a single-chain polypeptide which consists of 73 amino acids, including 4 half-cystine residues. The positions of disulphide bonds in Paim I have been determined with the combination of enzymatic digestion and fast atom bombardment (FAB) mass spectrometry. Denatured Paim I was digested to peptides with Staphylococcus aureus V8 protease. These peptides were subjected to FAB mass spectrometry, with or without isolation by high-performance liquid chromatography. The positions of disulphide bonds in Paim I were determined from the relative molecular masses of the peptides containing a disulphide bond and by the enzyme specificity of S. aureus V8 protease. It is deduced that Paim I has two disulphide bridges at Cys(8)-Cys(24) and Cys(42)-Cys(70).
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151006
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  • 125
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    Constant neutral loss spectra of small peptides (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 577-581 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151011
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  • 126
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    Stable isotope dilution method using thermospray liquid chromatography/mass spectrometry for quantification of daily cortisol production in humans (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 603-608 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A thermospray high-performance liquid chromatography/mass spectrometry method for the separation and quantification of cortisol in human serum has been developed. The technique does not require derivatization, allows for both qualitative and quantitative determinations, provides increased specificity not available from conventional high-performance liquid chromatography, and has a detection limit of 5 pmol on-column. This isotope dilution mass spectrometry method, using d3-cortisol as an internal standard, allows precise determinations even at low isotopic ratios (2%-5 mole%). Evidence that this technique can be applied to the quantification of serum cortisol and to the determination of daily cortisol production in humans is presented.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151105
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    Masthead (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988) 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150501
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  • 128
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    Comparison of methanol thermospray (filament on) and direct chemical ionization mass spectrometry to the study of biologically active steroids (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 253-255 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A series of biologically active steroids was analyzed by both, ‘filament on’ thermospray using 100% methanol as the mobile phase with ammonium acetate as buffer, and direct chemical ionization with NH3 gas. The mass spectra obtained were very similar. Addition of pyridine instead of ammonium acetate showed selectivity in adding to the steroid molecule.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150504
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  • 129
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    Distinction of α- and β-aspartyl and α- and γ-glutamyl peptides by fast atom bombardment/tandem mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 399-402 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A fast atom bombardment/collisional activation/linked-scan at constant B/E (tandern mass spectrometric) method is described which can distinguish between α- and β-aspartyl and α- and μ-glutamyl underivatized peptides. The method is based upon differences in loss of CO from aspartyl or glutamyl B-fragment ions (IB) in these isomers which are rationalized from the stability of the resultant A-fragment ions (IA). It was observed that the ratio of IB:IA which was used in this determination was dependent upon the collision cell pressure. The higher the collision cell pressure, the larger the difference between the IB: IA ratios for these linkages.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150707
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  • 130
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    Masthead (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988) 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150801
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  • 131
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    Direct stereochemical assignment of sugar subunits in naturally occurring glycosides by low energy collision induced dissociation. Application to papulacandin antibiotics (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 441-446 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A tandem mass spectrometric method is described which allows the assignment of stereochemistry to fragment ions comprising intact sugar subunits of larger glycosides without chemical degradation and product isolation by chromatography. The approach relies on the mass selection of the ‘sugar ion’ of interest followed by analysis of stereoselective fragmentation induced by low-energy collisional activation. The daughter ion spectra provide configurational fingerprints of the selected sugar ions which can be matched for identity with reference spectra obtained from suitable precursors of known stereochemistry. Glucose, mannose and galactose furnished the required set of the most important reference ions. By using peracetyl (and perdeuterioacetyl) derivatives, galactose was readily identified as the glycosidic sugar constituent of the (known) antibiotic papulacandin B and a further (unknown) congener.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150805
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  • 132
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    Calculation of the relative frequencies of stable isotope labelled and unlabelled molecules in a gas chromatographic peak using gas chromatography/mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 473-478 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method is described for the calculation of stable isotope enrichments from the mass spectra of organic compounds obtained by gas chromatography/mass spectrometry. Correction factors for the natural abundance of stable isotopes account for the probabilities of observing more than one stable isotope atom in a molecule and these are particularly significant when analysing trimethylsilyl derivatives containing 29Si, 30Si and 13C. It was demonstrated that 15N-labelled molecules, as well as 13C-labelled molecules, elute earlier than their unlabelled analogues in a gas chromatographic peak, and thus enrichment values should be calculated from sample scans taken at regular intervals throughout the peak.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150903
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  • 133
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    ‘Revised’ mass spectral identification of 2-amino-4-(5-nitro-2-furyl)thiazole metabolites (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 495-499 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The electron ionization mass spectra of 2-amino-4-(5-nitro-2-furyl)thiazole metabolites obtained from microsomal incubations and chemical syntheses were studied. The identities of the metabolites were established by chemical ionization, high resolution, and metastable measurements. The compounds studied showed multiple modes of cleavage, skeletal rearrangements and hydrogen back-transfer.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150906
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  • 134
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    Analysis of the polycyclic aromatic compounds of diesel fuel by gas chromatography with ion-trap detection (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 517-519 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Capillary column gas chromatography combined with ion-trap detector mass spectrometry was used in the identification of 85 constituents of the polycyclic aromatic hydrocarbon fraction of diesel fuel. The main constituents are an extensive range of alkylnaphthalenes; alkylated tetrahydronaphthalenes, benzothiophens, dibenzothiophens biphenyls, fluorenes and phenanthrenes were also identified. Chromatographic retention indices for these compounds were determined to calibrate retention data for routine analysis with flame-ionization detection, and to identify positions of alkyl substitution.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150909
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  • 135
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    An extraction-derivatization method suitable for the analysis of biogenic amines by gas chromatography negative ion mass spectrometryPart 1 in the series: The Analysis of Biogenic Amines and their Metabolites by Gas Chromatography/Mass Spectrometry. (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 535-539 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An extraction-derivatization method suitable for the analysis of subnanogram amounts of biogenic amines in aqueous solution has been developed. The most satisfactory procedure for the analysis of these compounds was reaction with 3,5-ditrifluorobenzoylchloride (DTFMBCl) in phosphate buffer at pH 7.2 followed by extraction of the resultant amide esters into ethyl acetate. This was followed by hydrolysis of the phenolic ester functionalities by shaking the organic layer with 10 M ammonium hydroxide. The phenolic and alcoholic hydroxyl groups were then reacted with bistrimethylsilylacetamide and the trimethylsilyl-DTFMB amides were then analysed by gas chromatography/mass spectrometry in the negative ion chemical ionization mode with methane as reagent gas. The limits of detection for these derivatives was 〈1 pg and the method was readily applicable to the extraction and analysis of 0.5 ng of a given biogenic amine.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151005
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  • 136
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    A selected ion monitoring assay for tributyltin and its degradation productsThis work was presented, in part, at the 34th Annual Conference of the American Society for Mass Spectrometry, Cincinnati, Ohio, 1986. (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 565-569 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Tributyltin (TBT) is a biocide which has been shown to enter the aquatic environment by release from antifouling paints. TBT is acutely toxic to some marine organisms at concentrations near 1 μg I-1 and physiological changes may occur at low nanogram per liter concentrations. Gas chromatography/mass spectrometry (GC/MS) (methane chemical ionization) has been used for identification (full scanning) and quantification (selected ion monitoring) of TBT, dibutyltin (DBT) and monobutyltin (MBT). The butyltins were extracted from environmental water samples with hexane/0.2% tropolone and derivatized with hexyl magnesium bromide to form hexylbutyltins. Selected ion monitoring was at m/z 319 (TBT) and m/z 347 (DBT, MBT and tripentyltin, the internal standard). Calibration curves prepared in natural water were linear and detection limits were 〈2 ng I-1, GC/MS and GC with flame photometric detection were compared as quantification methods for environmental samples and were shown to give similar results at the low nanogram per liter levels.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151009
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  • 137
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    Identification of flavonoid glycosides isolated from plants by fast atom bombardment mass spectrometry and gas chromatography/mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 589-594 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Three flavonoid glycosides isolated from plants were identified using fast atom bombardment mass spectrometry and gas chromatography/mass spectrometry. In the latter studies, electron impact and ammonia chemical ionization were used.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151103
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  • 138
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    Laser desorption/Fourier transform mass spectrometry of steroids (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 609-613 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Mass spectra of six representative underivatized steroids and three parent hydrocarbons were obtained using laser desorption/Fourier transform (LD/FT) mass spectrometry. The carbonyl steroids, with the exception of aldosterone, yielded abundant [M + H]+ ions. For cholesterol, a major fragment ion was that corresponding to dehydration. The hydrocarbons produced [M + H]+, M+ and [M - H]+ ions, in addition to expected alkyl cleavage ions including those resulting from methyl loss. The LD/FT mass spectra of all were qualitatively similar to electron ionization spectra, but showed somewhat less fragmentation.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151106
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  • 139
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    Analysis of glutathione conjugates and related compounds by thermospray mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 623-633 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A series of 17 cysteine, N-acetyl cysteine, glutathione, and N-trifluoroacetyl glutathione conjugates have been prepared, and their thermospray (TSP) spectra have been recorded in the positive and negative ion modes. The compounds undergo extensive fragmentation, which primarily occurs at the carbon-sulfur bonds. For most of the compounds, positive ion TSP is more sensitive than negative ion thermospray. Probably due to the thermal lability of these adducts, the quality of the spectra obtained are dependent on source conditions, requiring fine control of the vaporization/desolvation process.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151108
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    Forthcoming events (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 685-685 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151208
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  • 141
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    In vivo metabolism of the methyl homologues of delta-8-tetrahydrocannabinol, delta-9-tetrahydrocannabinol and abn-delta-8-tetrahydrocannabinol in the mouse (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 389-398 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Methyl-delta-8-tetrahydrocannabinol (methyl-delta-8-THC), methyl-delta-9-THC and abn-methyl-delta-8-THC were synthesized by condensation of orcinol and (1S)-cis-verbenol and were administered to male Charles River CD-1 mice. Extracted hepatic metabolites were isolated by chromatography on Sephadex LH-20 and examined by gas chromatography/mass spectrometry as trimethylsilyl (TMS), (2H9)TMS and methyl ester/TMS derivatives. In addition, metabolic fractions were reduced with lithium aluminium deuteride to convert carboxylic acids to alcehols for structural correlation. Metabolites from methyl-delta-8-THC were similar with respect to the positions substituted to those produced by higher homologues; the major metabolite was methyl-delta-8-THC-11-oic acid. abn-Methyl-delta-8-THC was metabolized in a different manner. The location of the aromatic methyl group at the position adjacent to ring fusion appeared to inhibit metabolism at C(11) to a considerable extent and also to reduce the amount of the resulting alcohol from being oxidized to a carboxylic acid. This caused other metabolic pathways to become dominant, with the result that a compound containing a hydroxy group at the gem-methyl position was the major metabolite. Hydroxylation at this position has not been confirmed with any other cannabinoid, although it is thought to result in trace concentrations of hydroxy metabolites from some compounds. Metabolism of methyl-delta-9-THC was also similar to that of the higher homologues, with the exception that less metabolism occurred at C(8) and a higher percentage of the total metabolic fraction was accounted for by the 11-oic acid metabolite. Minor metabolites were mainly dihydroxy compounds and hydroxylated derivatives of delta-9-THC-11-oic acid.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150706
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  • 142
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    Packed column supercritical fluid chromatography/mass spectrometry using a thermospray source in the filament-on mode (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 105-109 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Combined packed column supercritical fluid chromatography/mass spectrometry has been effected using a thermospray ion source in the filament-on mode. If organic modifiers are used with carbon dioxide as the supercritical mobile phase, chemical ionization mass spectra are obtained. With carbon dioxide electron impact type mass spectra are obtained. The potential of the system is illustrated with studies of mixtures of carbamate and organochlorine pesticides and a crude ergot fermentation extract.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150208
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  • 143
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    The identification of biologically important thiols (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 123-128 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A new mass spectral method has been developed and used to identify biologically important thiols. This method is based upon the use of C-14 labeled N-para-bromophenylmaleimide (BPM) to selectively derivatize thiols. The isotopic label facilitates the isolation and purification of trace quantities of the maleimide thiol adducts by high performance liquid chromatography (HPLC) with radioactivity detection. The use of the bromine atom in the thiol derivative greatly enhances the detectability of the parent and fragment ions containing the BPM moiety because of the generation of the characteristic N + 2 doublet ions. Several examples of the use of this method to identify non-volatile thiol peptides such as glutathione (GSH) and homoglutathione (hGSH) by fast atom bombardment mass spectrometry (FAB-MS) are described in this report.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150302
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    Determination of melatonin in blood plasma, using capillary gas chromatography and electron impact medium-resolution mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 249-252 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Determination of the low concentrations (〈10-100 pg ml-1) of melatonin in blood plasma by gas chromatography/mass spectrometry has previously required the use of negative ionization (electron capture) mass spectrometry, a technique particularly delicate to set up. We show that a general-purpose medium-resolution instrument gives adequate sensitivity in electron impact mode, when used with a capillary gas chromatographic column-switching device. A straightforward extraction procedure gives good specificity, and the limit of useful measurement is better than 10 pg per 1 ml sample.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150503
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  • 145
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    Identification and quantification of halogenated and non-halogenated octylphenol polyethoxylate residues by gas chromatography/mass spectrometry using electron ionization and chemical ionization (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 275-282 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Residues of octylphenol polyethoxylates (OPEO) are frequently found in wastewater effluents. OPEO are commonly used surfactants. The polyethoxy chain of OPEO may be shortened or carboxylated during biological wastewater treatment and the aromatic ring chlorinated or brominated during wastewater disinfection with chlorine. Mass spectral data obtained using electron ionization (EI) and chemical ionization (CI) are presented which positively characterize these residues. For CI, methane was used as the reactant gas and protonated molecular ions were observed. The most prominent ions formed under EI resulted from benzylic cleavage while the prominent ions formed under CI resulted from alkyl ion displacement and olefin displacement. EI and CI mass spectra are summarized and fragmentation mechanisms are proposed. Response factors are presented for quantitative analysis by single ion monitoring.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150507
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  • 146
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    Determination of pyrrolizidine alkaloid metabolites from mouse liver microsomes using tandem mass spectrometry and gas chromatography/mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 265-273 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The rapid and sensitive identification and quantification of important pyrrolizidine alkaloid metabolites using tandem mass spectrometry (MS/MS) and gas chromatography/mass spectrometry (GC/MS) is described. Identifications of N-oxide and hydrolytic metabolites of the pyrrolizidine alkaloids senecionine and monocrotaline in extracts of mouse hepatic microsomal incubations were accomplished by comparing collisionally activated decomposition/mass-analyzed ion kinetic energy spectra of specific ions from microsomal extracts with spectra obtained from synthetic standards of suspected metabolites. Trace amounts of the toxic metabolite dihydropyrrolizine (DHP) were observed by GC/MS of trimethylsilyl (TMS) derivatives, but the amounts present in hepatic microsomal extracts were below the MS/MS limit of detection. Quantitative determinations of senecionine N-oxide were performed by fast atom bombardment MS/MS. Suppression of N-oxide ionization by other substances in the extracts was judged to be minimal. The TMS derivatives of the metabolites senecic acid, monocrotalic acid and DHP were quantified using capillary GC/MS. Results from the study demonstrate that the relative contributions of the three major pathways of pyrrolizidine alkaloid metabolism (N-oxidation, hydrolysis and oxidation to pyrrolic compounds) can be assessed using a single analytical instrument and minimal sample preparation.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150506
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    Forthcoming events (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 303-303 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150511
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  • 148
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    Masthead (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988) 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150601
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  • 149
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    Nucleophilic reactions between biological conjugates and tetraalkylammonium ion pair reagents during desorption chemical ionization (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 571-576 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Tetraalkylammonium salts, commonly used as ion pair reagents in chromatography, were found to react with biological conjugates under desorption chemical ionization conditions in a mass spectrometer. The reactions occur for aromatic glucuronide and glucoside conjugates using solid samples loaded on the direct exposure probe. Evidence is presented that several mechanisms contribute to the degradative alkylation of benzo(a)pyrene glucuronide. This undesirable process can be prevented by using ammonium or trialkylammonium instead of tetra-alkylammonium salts in the chromatographic separation. Nucleophilic attack on the tetraalkylammonium cations in the energized condensed phase was found to occur also for some simpler aromatic compounds.
    Additional Material: 5 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200151010
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  • 150
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    A rapid method for the structural characterization of sulphated phlorotannins by negative ion fast atom bombardment mass spectrometry and acetylation on the target (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 595-602 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method for a rapid and direct structural determination of sulphated phlorotannins has been developed by using a combination of negative ion fast atom bombardment mass spectrometry and acetylation on the target. The structural variations of sulphated phlorotannins include: (i) the number of monomeric phloroglucinol units involved; (ii) the mode of their connectivity; (iii) the orientation of hydroxy groups on aromatic carbon atoms; (iv) the presence of the substituents other than hydroxy groups on aromatic carbon atoms; and (v) the number of sulphate esters on the hydroxy groups. Additionally, the acidic protons on the sulphate groups can be easily substituted by sodium or potassium cations, depending on the mode of isolation. In the negative ion mode, several ions were observed and a determination of molecular size and molecular parameters (i)-(v) appeared to be rather speculative. After adding diluted hydrochloric acid to the sample in order to substitute alkali ions for protons, the hydrolysis of sulphate groups has been observed. The acetylation on the target, however, represents a rapid method to observe the molecular ions, and from the mass differences the molecular parameters can be easily calculated. This procedure also demonstrates the general possibility of studying rapid chemical reactions by fast atom bombardment mass spectrometry.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151104
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    Masthead (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988) 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151201
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  • 152
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    The use of alkoxycarbonyl derivatives for the mass spectral analysis of drug-thioether metabolites. Studies with the cysteine, mercapturic acid and glutathione conjugates of acetaminophen (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 637-647 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Alkoxycarbonyl derivatives of the cysteine-, N-acetylcysteine- and glutathione conjugates of acetaminophen have been prepared in aqueous buffer solutions and their chromatographic and mass spectrometric properties examined. Structurally informative fragmentation patterns of the cysteine- and N-acetylcysteine derivatives were obtained when their methyl esters were subjected to analysis by direct insertion chemical ionization (CH4) mass spectrometry, although field desorption and liquid secondary ion mass spectrometric techniques were required in order to obtain satisfactory spectral data for derivatives of the glutathione adduct. Treatment of ethoxycarbonyl derivatives of the three acetaminophen metabolites with N-methyltrifluoroacetamide-based silylating reagents led to the formation of a common volatile product which was ideally suited to analysis by gas chromatography/electron impact mass spectrometry. A mechanism is proposed for the formation of this novel derivative, which appears to possess a benzo-1,3-thioxalane structure, and its mass spectral characteristics are reported. Finally, the utility of alkoxycarbonyl derivatives for the analysis of drug - thioether conjugates in biological fluids is discussed in terms of their advantages for aqueous phase derivatization, purification by high-performance liquid chromatography and characterization by mass spectrometry.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151202
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  • 153
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    Bromo- and bromochloro-polynuclear aromatic hydrocarbons, dioxins and dibenzofurans in municipal incinerator fly ash (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 669-676 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A fly ash sample found to contain polychlorinated dioxins and dibenzofurans was analyzed for brominated analytes. Bromochloro-polynuclear aromatic hydrocarbons, dioxins and dibenzofurans, as well as bromo PAH were found in ppt to ppb concentrations. Analytical results were confirmed by high-resolution mass spectrometric accurate mass determinations and by tandem mass spectrometry.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151205
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  • 154
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    Fast atom bombardment mass spectrometry of protected peptide segments (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 681-684 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151207
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  • 155
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    Characterization of glutathione conjugates by fast atom bombardment/tandem mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 615-621 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The collisionally activated decomposition of [M + H]+ ions, generated by fast atom bombardment (FAB) of glutathione conjugates, has been studied by tandem mass spectrometry (MS/MS) using hybrid sector/quadrupole instruments. Abundant fragments of diagnostic utility were present in the daughter ion spectra. Common fragmentation modes were observed but their relative importance was strongly dependent on the nature of the conjugated species. As an example of a general approach to the characterization of glutathione conjugates in biological samples, the acetaminophen-glutathione conjugate was identified in rat bile, following coadministration of (2H0)- and (2H3)acetaminophen, using the experimental sequence: (i) conventional FAB mass spectrometric analysis, (ii) MS/MS using constant neutral loss (129 u) scanning to identify parent ions corresponding to glutathione conjugates, (iii) MS/MS to yield daughter ion spectra of parents so identified and corresponding to (2H0)- and (2H3)-labeled conjugates.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151107
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  • 156
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    FAB and tandem mass spectrometry for endorphin- and ACTH peptides of molecular weight to 2000 (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 649-657 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Four β-endorphins (β-endorphin 6-17, 2-17, 1-16, and 1-17) and two adrenocorticotropic hormone (ACTH) peptides (ACTH 1-10 and (1-16)-NH2) were studied by using fast atom bombardment coupled with tandem mass spectrometry. The capability to reproduce metastable ion and collisionally activated decomposition spectra on two different commercial sector mass spectrometers in two different laboratories was found to be acceptable (deviations in relative abundance are less than ± 50%). The endorphin peptides fragment metastably or upon collisional activation to give abundant B-series ions as well as Y-series ions, whereas Y-series ions are the principal ionic species produced upon the desorption by fast atom bombardment. The ACTH peptides also fragment to give Y-series ions, but of relatively low abundance compared to those from the endorphins. For both sets of peptides, high-energy collisionally activated decomposition and metastable ion decomposition daughter ion spectra are precise, structurally informative - even for peptides up to m/z 2000 - and complementary to spectra of daughter ions produced by desorption ionization alone.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151203
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  • 157
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    Time domain absorbing boundary condition in Layered media (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 115-128 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: An absorbing boundary condition for simple layered media is presented. The method enables the modelling of open space radiation and scattering problems when the source (or scatterer) and a plane interface between two media are both located within the finite-difference or finite-element region. The projection operator method is used to take into account the presence of reflected waves at the media interface. The derivation of the projection operator is presented for one, two and three dimensions. Examples of electromagnetic radiation and scattering in two dimensions are presented to illustrate the numerical implementation and validity of the new absorbing boundary condition.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010207
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    Optimal control and stochastic estimation: Theory and applications, M. J. Grimble and M. A. Johnson; Wiley, Chichester, 1988. Vol. 1, No. of pages: 582, Price: £65.00, ISSN: 0471-905933. Vol. 2, No. of pages: 424, Price: £50.00, ISSN: 0471-912654 (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 129-130 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010208
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  • 159
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    A design method for partial-response filters (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 131-136 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: A design method for filters having duobinary signal pulses as impulse response is presented.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010302
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  • 160
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    Spectral technique in electronic circuit analysis (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 137-151 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010303
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  • 161
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    A new time-domain model for spontaneous emission in semiconductor lasers and its use in predicting their transient response (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 153-164 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Spontaneous emission noise power, although small in magnitude, affects many aspects of the semiconductor laser's operation. An accurate model has been developed for it for use in the transmission-line laser model (TLLM), which is a time-domain, wideband, dynamic, non-adiabatic semiconductor laser model. The effects of approximations used in other dynamic laser models are then investigated by comparison with the results from the TLLM. The study shows that the representation of this noise power has an important bearing on the damping of modelled transient oscillations.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010304
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  • 162
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    Call for papers (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 171-171 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010306
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  • 163
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    Radio frequency simulation of a complex printed circuit board layout by the quasi-static boundary element method (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 165-170 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: A method for analysing the electrical effect of a set of conducting strips is presented. This method is applied to modelling the electrical behaviour of conducting tracks on a printed circuit board (PCB). Unlike most other published work, this analysis is not restricted to the case where the tracks are parallel. The problem is formulated in terms of an admittance matrix. A boundary element method incorporating image theory is used to produce a system of linear equations. These are solved to yield the required admittance matrix, which can then be incorporated into a standard circuit analysis package. Comparisons between measured and predicted circuit performance for a complex layout show close agreement up to at least 1 GHz.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010305
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  • 164
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    Editorial (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 173-174 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010402
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  • 165
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    High-frequency propagation on nonuniform multiconductor transmission lines in uniform media (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 175-188 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: The asymptotic form, for high frequencies, of the equations of propagation on a nonuniform N-conductor transmission line is considered. Under the assumption of perfect conditions in uniform, isotropic media, all N propagation velocities are the same, but the characteristic impedance matrix is allowed to vary with position along the line. Closed-form solutions are obtained for some cases of interest.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010403
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  • 166
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    Two-dimensional numerical simulation of short-gate-length gaAs MESFETs and application to the travelling gunn domain phenomenon (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 19-30 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: The Boltzmann transport equation is used to derive a set of conservation equations which is capable of describing the electron transport phenomena in a single-valley semiconductor. These conservation equations are averaged over the different valleys of the conduction band to develop another set of equations that can be used to describe accurately the electron transport phenomena in a multi-valley semiconductor, such as GaAs, using the equivalent single-electron gas model whose characteristics are the average weighted characteristics of the constituent gases. The nonstationary effects are included by using energy dependent mobility and electron temperature functions. This program is used to simulate a GaAs MESFET with a 0·5 μm gate length and a 0.2 μm thick active layer. The active layer is doped at 1017 cm-3. A travelling Gunn domain is observed between the gate and the drain. The domain oscillation frequency is much higher than the normal operating frequency of the MESFET. The domain formation's dependence on the gate bias and the active layer thickness are also presented.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010105
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    Masthead (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988) 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010201
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  • 168
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    Application of the symmetrized transmission-line matrix method to the cold modelling of magnetrons (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 61-70 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Two- and three-dimensional electromagnetic resonance calculations have been performed on rising-sun magnetron structures. These calculations have been made using the transmission-line matrix method. Cylindrical coordinates have been used in order to facilitate modelling of the essentially cylindrical device. Recent improvements to the TLM technique, such as the development of the symmetric condensed node for electromagnetics, have been fully exploited. The numerical procedure is described, the modelling process is discussed, and the results obtained are evaluated in comparisons with corresponding empirical data.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010108
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  • 169
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    Characterization of coupled finlines by generalized transverse resonance method (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 45-59 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: The conventional transverse resonance method, which has been widely used for the approximate characterization of a number of guiding structures and leaky wave antennas, is formulated in a generalized form. The transverse resonance viewpoint combined with the generalized matrix representation of discontinuities yields a rigorous transverse equivalent circuit of the guiding structure.This technique is used to compute the characteristics of both symmetrical and asymmetrical double slot unilateral finlines in terms of phase constant and characteristic impedance of the dominant as well as higher-order modes. Numerical aspects of this method are discussed.In a double-slot finline structure, a coupled-mode regime is established with the onset of the first higher-order mode in addition to the dominant quasi-TEM mode. Symmetrical structures are simply modelled in terms of even and odd mode characteristics, but a more general coupled-line model, in terms of the C-mode and the II-mode must be applied to asymmetrical coupled finlines.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010107
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    Peter Bruce Johns 1938-1988 (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 71-72 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010202
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  • 171
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    Transmission-line modelling of nonlinear reactive components and mutual inductances (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 85-91 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Transmission-line models (TLMs) for nonlinear reactive components and mutual inductances are derived. The model for nonlinear reactive components is shown to be an improvement on the previous one. TLM results with the mutual inductance model are compared with the exact solution, and good agreement is found.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010204
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  • 172
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    A hybrid modelling technique for underwater acoustic scattering (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 189-206 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: A numerical method using impulse analysis of a transmission-line matrix is used to model the scattering of underwater acoustic waves. The method is demonstrated by observation of plane and curved wavefronts travelling through the medium, and by plane wavefronts being scattered by a reflecting boundary.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010404
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  • 173
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    Radar cross-section reduction studies of partially open cavity structures (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 207-220 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Shooting and bouncing rays (SBR) is a numerical method based on geometric optics developed to compute the electromagnetic scattering from jet inlets and partially open cavity structures. This method is used to study the effects of shaping on the radar cross-section (RCS) of cavities. Two cylindrical cavity structures are analysed: one with a uniform circular cross-section, and the other with a non-uniform cross-section varying from a triangular shape to a circular shape. By bending the longitudinal axis of a cylindrical cavity, a significant reduction in RCS at near axial incidence can be achieved.
    Additional Material: 19 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010405
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  • 174
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    Masthead (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988) 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010101
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  • 175
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    Editorial (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 1-1 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010102
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  • 176
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    The modelling of multiaxial discontinuities in quasi-planar structures with the modified TLM method (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 7-17 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: The principal features of the modified TLM method such as the asymmetrical condensed node, graded mesh and dispersion characteristics, are briefly presented. Its general application to multiaxial discontinuities in quasi-planar structures is described, and the modelling of bilateral finline T-junctions is demonstrated in particular.
    Additional Material: 15 Ill.
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    URL: http://dx.doi.org/10.1002/jnm.1660010104
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    Some thoughts on the numerical modelling of electromagnetic processes (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 3-6 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: The use of models in giving meaning to sense data is described. It is shown that models are essential to human understanding, but that there are no uniquely ‘best’ models. This leads to the discussion of the design of suitable models for engineering use. The role of physical and mathematical models is mentioned, and attention is drawn to geometrical and physical features. It is stated that numerical methods have overriding advantages, one of which is the possibility of numerical experimentation. The modelling of vector fields is discussed and attention is drawn to the ideas of differential geometry which attach the vector field to the space in which it acts. It is shown that variational methods, together with numerical experiments, can be used to derive invariant parameters which give both global and local information about electromagnetic systems in a particularly economical method of computation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010103
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  • 178
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    Coupling between electromagnetic fields and multiconductor transmission systems using TLM (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 31-43 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: The coupling between incident electromagnetic fields and lossless multiconductor transmission systems is studied using transmission-line modelling-(TLM) and the impedance parameters of the transmission system. This calculation is a two-stage procedure:firstly, the field problem is solved, with no conductors present, to give the incident fields; secondly, the multiconductor transmission-line problem is solved using equivalent voltage and current sources representing coupling from the incident fields. Comparison of these results with previously published work shows excellent agreement. The numerical model presented is particularly suitable for studying electromagnetic compatibility problems.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010106
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  • 179
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    A discrete model of substitutional-interstitial diffusion in the Czochralski growth of semiconductor crystals (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 73-83 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: A discrete model is developed to describe the diffusion of dopant/impurity in a single semiconductor crystal during Czochralski growth. The basic diffusion mechanism is assumed to be substitutional-interstitial interchange for the impurity, together with self-diffusion of the host atoms. In particular, the model incorporates the complicated conditions that result from the simultaneous growth and diffusion taking place at the crystal/melt interface. The high temperature dependence of the process is also taken into account, together with possible vacancy production to counteract vacancy depletion. The numerical model is explicit in time, and conditions for convergence and stability are considered. Results are presented for chromium doping of growing gallium arsenide crystals, and compared with published experimental data.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010203
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  • 180
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    New one- and two-dimensional algorithms for the transient simulation of semiconductor devices (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 93-102 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: One- and two-dimensional algorithms for the transient simulation of semiconductor devices are presented which incorporate a solenoidal total current. The paper includes results from one-dimensional simulation of a p-n junction, including forward-to-reverse bias switching and also switching and also switch-on into high injection in an asymmetric structure. A discretization scheme for the two-dimensional formulation is described with details on handling voltage driven terminals and the associated boundary conditions.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010205
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  • 181
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    Thermal modelling using ASTEC3 software (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 103-113 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: This paper describes the application of ASTEC3, a general purpose analogue electronic circuit simulation package, to the analysis of thermal properties of given structures. The modelling of each system is considered for both conduction and convection mechanisms, radiation being assumed to play a very minor role in heat dissipation from most electrical circuits. A procedure is given for the modelling of one-, two- and three-dimensional thermal problems which is then used for the simulation of relatively simple examples. The results obtained with ASTEC3 are compared with results determined by using more traditional and independent techniques.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010206
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  • 182
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    Masthead (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988) 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010301
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  • 183
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    The use of orthogonal curvilinear meshes in TLM models (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988), S. 221-238 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: The development of numerical models to describe physical problems with irregular boundaries frequently involves the use of very fine or variable Cartesian meshes when a more descriptive mesh might be appropriate. This paper describes the application of the transmission line matrix (TLM) technique to the analysis of orthogonal curvilinear mesh problems. Although very high levels of accuracy are possible, the computational efficiency may be reduced owing to the stub admittance factor, S, and the need for an accurate evaluation of the transmission line parameters.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010406
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  • 184
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    Masthead (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 1 (1988) 
    Details
    ISSN: 0894-3370
    Keywords: Engineering ; Electrical and Electronics Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jnm.1660010401
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  • 185
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    Splitless injection in capillary supercritical fluid chromatography (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 16-20 
    Details
    ISSN: 0935-6304
    Keywords: Supercritical fluid chromatography ; Splitless injection ; Capillary columns ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A splitless injection technique, allowing 0.5 μl injections on 50 μm i.d. columns, has been developed.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110106
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  • 186
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    Isomer-specific separation and quantitation of tetrachlorodibenzo-p-dioxins by HRGC and HRGC/MS (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 9-12 
    Details
    ISSN: 0935-6304
    Keywords: Gas chromatography, GC ; GC/MS ; Dioxins ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method is described for the determination of 22 tetrachlorodibenzo-p-dioxin isomers at the low part-per-trillion (ppt) level. High resolution, narrow bore, open tubular columns (OTCs) with 100 μm i.d. can achieve better separations than presently used 320 or 250 μm i.d. columns in about half the total time. Relative retention times and response factors for all 22 TCDD isomers are presented for the electron capture detection and for the molecular ion mass of individual isomers under electron impact ionization with selected ion monitoring (SIM).
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110104
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  • 187
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    Capillary gas chromatography of amino acids as their tert-butyldimethylsilyl derivatives in the analysis of serum amino acids in metabolic diseases (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 12-16 
    Details
    ISSN: 0935-6304
    Keywords: Gas chromatography, GC ; Capillary column ; Amino acids ; Derivatization ; Serum ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Reaction of amino acids with N-methyl-N-(tert-butyldimethylsilyl)trifluoroaceamide (MTbSTFA) in acetonitrile affords good yields of amino acid derivatives with excellent gas chromatographic and mass spectrometric properties. The single-step derivatization procedure is highly reproducible. The TBDMS amino acids are stable at room temperature for at least three days. Only a single peak is observed for each amino acid. The procedure allows simultaneous analysis of asparagine and glutamine together with other serum amino acids. Separation is achieved on a borosilicate glass capillary coated with OV-1. The mass spectra of the TBDMS amino acids possess characteristic diagnostic ions. These properties were used in the sensitive detection by GC-MS and SIM-GC-MS of GABA and pipecolic acid in the serum of a newborn suspected of a Zellweger-type syndrome, which could not be detected by other methods.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110105
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  • 188
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    Determination of serum metabolic profiles of bile acids by microcolumn liquid chromatography/laser-induced fluorescence (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 20-24 
    Details
    ISSN: 0935-6304
    Keywords: Capillary column liquid chromatography ; Laser-induced fluorescence ; Serum bile acids ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method for the determination of individual free and conjugated bile acids in serum using microcolumn liquid chromatography coupled with a laser-induced fluorescence detector is described. Bile acids are separated into free/glycine-conjugate and taurine-conjugate fractions using a Sep-Pak SIL cartridge. The taurine-conjugated bile acid fraction is subjected to enzymatic hydrolysis. Subsequently, free and conjugated bile acids are labeled using 4-(bromomethyl)-7-methoxycoumarin as a fluorogenic reagent, producing stable derivatives that can be excited by the 325 nm line of a He/Cd laser. Prior to their fluorimetric detection, the individual components of a bile acid serum profile are separated by reversed-phase microcolumn liquid chromatography.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110107
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  • 189
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    Practical aspects of mixed mobile phases in capillary supercritical fluid chromatography (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 25-29 
    Details
    ISSN: 0935-6304
    Keywords: Capillary supercritical fluid chromatography ; Mixed mobile phases ; Practical aspects ; Equilibration times ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Studies of mixed mobile phases in supercritical fluid chromatography must include consideration of a number of factors. Phase equilibria and critical parameters of a mixed fluid are very important in both the solvent delivery system and in the chromatographic column. The effects of pressure and temperature on retention with mixed mobile phases were studied and compared to estimated density values. System equilibration times with regard to pressure, temperature, and composition were studied. A mixed mobile phase was applied to the analysis of a high-molecular-weight metalloporphyrin.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110108
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  • 190
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    On-line extraction and separation by supercritical fluid chromatography with packed columns (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 38-42 
    Details
    ISSN: 0935-6304
    Keywords: SFC ; Fluid extraction ; FID detection ; Packed columns ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The application of fluid extraction in combination with fluid chromatography with packed column and flame ionization detection is described. Fluid chromatographic equipment is shown. Applications of this system to drug characterization are demonstrated.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110111
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  • 191
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    Use of small diameter WCOT columns for ultra-high resolution GC/MS (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 69-72 
    Details
    ISSN: 0935-6304
    Keywords: Ultra-high resolution GC ; Reduced diameter capillary columns ; Capillary direct GC/MS ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: For clinical and environmental analyses utilizing capillary gas chromatography/mass spectrometry (GC/MS), increased sensitivity and speed of analysis are highly desirable. These performance advantages are realized using a WCOT column of 100 μm i.d. as compared to the more conventional 200 μm i.d. capillary columns. The improved sensitivity of capillary direct GC/MS with the 100 μm i.d. column for the confirmation of drugs of abuse will be demonstrated. For environmental analysis, the superior efficiency and resolution of the 100 μm i.d. column can be employed for the separation of priority pollutants. This approach is more amenable to capillary direct GC/MS providing a more effective interface to the mass spectrometer. As a result improved sensitivity and a considerable decrease in analysis time is achieved over that obtained with the larger diameter environmental specialty phase columns.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110118
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  • 192
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    Direct sample injection in supercritical fluid chromatography with packed fused silica column (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 81-84 
    Details
    ISSN: 0935-6304
    Keywords: Supercritical fluid chromatography, SFC ; Packed fused silica column ; Direct sample injection ; Extraction ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A direct sample injection technique was developed for supercritical fluid chromatography in a packed capillary column, with carbon dioxide as mobile phase and a flame ionization detector. The method allowed solutions, neat liquids, and even solids to be introduced as samples. Also, extraction with supercritical carbon dioxide was combined with this method to separate polymer additives.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110121
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  • 193
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    Multi-element selective radio frequency plasma detector for capillary gas chromatography (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 75-81 
    Details
    ISSN: 0935-6304
    Keywords: Capillary gas chromatography ; Element selective detection ; Radio frequency plasma ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A radio frequency plasma detector for element specific detection in gas chromatography is described. The detector is comprised of a radio frequency (300 kHz) discharge between electrodes in helium, and utilizes a low-resolution emission spectrometer to monitor selected spectral emission lines produced when the helium discharge decomposes and excites the atomic constituents in the chromatographic column effluent. The spectrometer is tuned to an atomic emission line in the near-infrared portion of the spectrum, and the emission intensity from the discharge region of a selected line is used to monitor the concentration of the element producing that line. Acceptable detector sensitivity was achieved by the use of a high-throughput optical system. Selectivity was achieved by a combination of correct line selection, plasma and carrier gas purification, and plasma gas doping.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110120
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  • 194
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    Quality test of a mechanical switching valve for two-dimensional open tubular gas chromatography (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 85-89 
    Details
    ISSN: 0935-6304
    Keywords: Gas chromatography, GC ; Two-dimensional system ; Mechanical switching valve ; Heart-cutting ; Grob test ; Aroma fractions ; GC-GC/sniffing ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A commercially available mechanical micro switching valve has been tested for inertness. The test mixtures used were a modified Grob test and a solution consisting of eight typical aroma compounds, both at the 2-ng level. Cryogenic focusing of the sample after chromatography including one passage through the valve revealed that irreversible interaction of some test substances with valve components was rather small. A composite main peak of a chromatogram from a fruit juice aroma exhibiting a “mixed odor” was selectively transferred (heart-cutting) to a second column and resolved into three peaks. GC-GC/sniffing assigned a minor peak to a substance formerly hidden under the composite peak. Separate heating of the valve during temperature programming of the column was found to be unnecessary.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110122
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  • 195
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    Enantiomer separation of 2-halocarboxylic acid esters by chiral complexation gas chromatographyDedicated to Professor Ernst Bayer on the occasion of his 60th birthday (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 89-93 
    Details
    ISSN: 0935-6304
    Keywords: Gas chromatography, GC ; Capillary columns ; glass ; Complexation GC ; Chiral complexation GC ; Enantiomer separation ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The enantiomer separation of 2-halocarboxylic acid esters on two chiral nickel(II) bis-((perfluoroacyl)terpeneketonates) by complexation gas chromatography is described. The quantitative entiomer separation of branched 2-halocarboxylic acid esters is achieved with nickel (II) bis (3-(heptafluorobutanoyl)(1R, 2S)-pinan-4-onate) 1 while unbranched 2-halocarboxylic acid esters are preferably separated on nickel(II) bis(3-(heptafluorobutanoyl)-(1S)-10-methylenecamphorate) 2. The metal chelates 1 and 2 are accessible in both enantiomeric forms allowing the determination of the enantiomeric excess (ee) effective and reliable.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110123
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  • 196
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    Determination of Broxaterol in Plasma by Coupled HPLC-GC (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 99-102 
    Details
    ISSN: 0935-6304
    Keywords: Gas chromatography, GC ; Liquid chromatography, HPLC ; Coupled HPLC-GC ; Human plasma ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: For the analysis of broxaterol 1-(3-bromoisoxazol-5-yl)-2-(tert-butylamino)ethanol in human plasma and urine an on-line HPLC-GC apparatus was used applying the “concurrent solvent evaporation” technique described in previous studies. Broxaterol is quantitatively determined by capillary GC with ECD detection, after extraction from plasma and derivatization. The detection limit of 0.03 ng/ml permits pharmacokinetic studies in man after oral and intravenous administration of the drug.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110125
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  • 197
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    Analysis of pharmaceuticals and other solutes of biochemical importance by supercritical fluid chromatography (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 94-98 
    Details
    ISSN: 0935-6304
    Keywords: Supercritical fluid chromatography ; Retention time and peak area reproducibility ; Converging-diverging restrictors ; Cyclosporin ; ionophores ; fat-soluble vitamins ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The feasibility of using supercritical fluid chromatography (SFC) for analysis of polar and/or ionic analytes of interest to the pharmaceutical industry is described. Specifically, the analyses of cyclopsporin (a cyclic undecapeptide), several ionophores, and a group of fat-soluble vitamins are illustrated. The separation of group of fat-soluble vitamins is evaluated on two bonded stationary phases, DB-5 (95% dimethyl-5%-diphenylpolysiloxane) and DB-WAX (Carbowax 20M type, “bonded”). Lastly, a new restrictor technology known as a converging-diverging restrictor is described.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110124
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  • 198
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    Determination of the calcium entry blocker verapamil in plasma by capillary gas chromatography with on-column injection (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 103-106 
    Details
    ISSN: 0935-6304
    Keywords: Capillary gas chromatography ; Plasma ; Verapamil ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A specific, sensitive, and accurate assay for quantitation of verapamil has been developed. The method involves a single extraction step with n-heptane, followed by evaporation at room temperature under nitrogen. 0.1 μl of the extract was injected into a capillary column coated with crosslinked 5% phenylmethylsilicone. The column separated verapamil, norverapamil, and its internal standard within 15 minutes using temperature programming from 90 to 290°C. The lower limit of detection was 1 ng/ml for verapamil. The calibration curve was linear in the concentration range (5-300 ng/ml). Plasma concentration data from dogs receiving intravenous verapamil infusion are presented.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110126
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  • 199
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    Determination of soil fumigants in air using tandem capillary gas chromatography after charcoal trapping (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 106-110 
    Details
    ISSN: 0935-6304
    Keywords: Gas chromatography ; Tandem capillaries ; Charcoal trapping ; Soil fumigants ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Soil fumigants, like 1,3-dichloropropene and metham-sodium (forming methyl isothiocyanate) diffuse into the atmosphere, thus presenting a hazard to people in the surroundings. A method is described in which a large volume (50 μl) of extractant, used to desorb the compounds from charcoal, is injected into a GC, equipped with two capillary columns. By way of Deans switching, the solvent is separated from the compounds of interest. Modification of a GC sampler makes unattended analyses possible.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110127
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  • 200
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    Cyclodextrins and their derivatives as stationary phases in GC capillary columns (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 110-113 
    Details
    ISSN: 0935-6304
    Keywords: Gas chromatography, GC ; Capillary column ; Cyclodextrin stationary phase ; Isomer separation ; Enantiomer pair separation ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110128
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