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Digitale Medien

Influence of prednisolone on antipyrine elimination in patients with obstructive lung disease (1987)

Loft, S. ; Simonsen, K. ; Evald, T. ; [weitere]

Springer

European journal of clinical pharmacology 33 (1987), S. 89-91

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Details

ISSN: 1432-1041

Schlagwort(e): antipyrine ; prednisolone ; pharmacokinetics ; obstructive lung disease ; hepatic drug metabolism

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary The influence of prednisolone on the elimination of antipyrine has been investigated. The one-sample antipyrine clearance was estimated in 23 outpatients with obstructive lung disease before and after treatment with prednisolone 30 or 50 mg/day for 7 days. During prednisolone administration antipyrine clearance decreased from 54.9±14.8 to 51.7±14.6 ml/min (mean±SD; p〈0.05). The results indicate that prednisolone decreases the rate of antipyrine elimination, but not to an extent suggesting a clinically important change in hepatic drug metabolism.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00610387

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