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Digitale Medien

Toxicological evaluation of cyclosporin A (1983)

Ryffel, B. ; Donatsch, P. ; Madörin, M. ; [weitere]

Springer

Archives of toxicology 53 (1983), S. 107-141

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Details

ISSN: 1432-0738

Schlagwort(e): Cyclosporin A ; Animal toxicity ; Carcinogenicity ; Teratogenicity ; Mutagenicity ; Immunosuppression

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Toxicological studies in a variety of different animal species have shown that cyclosporin A (CS-A) is a unique immunosuppressant, since it does not cause myelotoxic, teratogenic, mutagenic, or carcinogenic effects. This is undoubtedly due to the fact that CS-A produces its immunosuppressive effects by a specific action on T lymphocytes rather than by a cytotoxic mechanism. The incidence of acute inflammatory lesions was also not significantly higher in treated animals than in controls. Clear-cut organ toxicity only occurred in rats and cynomolgus monkeys, where at high doses nephro- and hepatotoxicity were observed.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00302721

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