ISSN:
1432-2072
Keywords:
γ2-MSH
;
Naloxone
;
Opiate dependence
;
Taste preference conditioning
;
Taste aversion
;
Withdrawal motivation
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A two flavour, unbiased, taste preference conditioning procedure was used to test for possible motivating effects of γ2-MSH. Three training trials failed to produce any significant effect with doses ranging from 2.4 to 40 μg/ ICV infusion in drug-naive, non-operated or placebo-implanted rats. However, in rats made dependent by SC implantation of a morphine pellet 4 days earlier 15 μg γ2-MSH/infusion produced a taste aversion that was comparable to that produced by infusion of a low dose of the competitive opioid receptor antagonist naloxone (0.32 μg). The findings confirm with a conditioning procedure and with opiate-dependent animals the naloxone-like effects of γ2-MSH. They also suggest that this endogenously-located peptide may acquire an aversive property as a result of chronic morphine treatment.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00634469
