ISSN:
1433-8726
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary We report the efficacy and toxicity of combined methotrexate, vinblastine, 4′-epirubicin and cisplatin (M-VEC) for the treatment of advanced urothelial tract tumors in 58 evaluable patients. Histologically, the patients had pure transitional-cell carcinoma (89.7%), squamous-cell carcinoma (8.6%) and anaplastic carcinoma (1.7%). Locally advanced disease (pT3-4 N0 M0) was present in 22 patients (37.9%); pelvic lymphnode metastases (pT3-4 N1-3 M0), in 20 (34.5%); and metastatic disease, in 16 (27.6%). Response was observed in 72.3% of the patients, with complete remission achieved by 51.7%. Response rates and survival were influenced by histological subtype and tumor stage. Squamous-cell carcinoma did not respond to M-VEC chemotherapy. There was one drug-related death (1.7%); otherwise, toxicity was mild to moderate. Adverse effects included cardiac toxicity (9%), mucositis (5.1%), nadir sepsis (1.7%) and renal failure (1.7%) in a small number of patients.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01576278
