ISSN:
1432-0533
Keywords:
BB-Wistar rat
;
Diabetic distal symmetric neuropathy
;
Axonal degeneration
;
Teased fibers
;
Ultrastructure
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The distal, symmetric polyneuropathy of the spontaneously diabetic BB-Wistar rat was studied ultrastructurally and by means of teased fiber preparations. Ultrastructural findings consisted of malorientation of the axonal cytoskeleton, followed by axonal atrophy, secondary myelin breakdown and distal Wallerian degeneration. This sequence of structural changes could be confirmed by scoring of pathological abnormalities and morphometric evaluation of teased fibers. Distal sensory nerve fibers were affected earlier and more severely than motor fibers.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00692696
