ISSN:
1432-0533
Keywords:
Senile plaques
;
Methenamine silver stain
;
Alzheimer-type dementia
;
Down's syndrome
;
Amyloid β protein
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We have developed a new methenamine silver (MS) stain for detecting diffuse plaques distinctively on paraffin-embedded tissue sections of Alzheimer-type dementia, Down'n syndrome, and mentally normal aged brains. This rapid and easy method selectively labels amyloid-related component of senile plaques, but not of kuru plaques found in Gerstmann-Sträussler syndrome. Our MS stain shows almost the same staining pattern as that of the β protein immunostaining with formic acid pretreatment. Therefore, new MS stain is appropriate to routine or screening studies for senile plaques including diffuse plaques.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00296119
