ISSN:
1432-0878
Keywords:
Substantia nigra
;
Rat
;
Incorparation of 3H-Dopamine, 3H-Serotonin and 3H-Norepinephrine
;
Axo-dendritic Synapses
;
Autoradiography
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary In autoradiographies of substantia nigra in rat, it has been observed that after intraventricular injections of 3H-dopamine and 3H-norepinephrine respectively the silvergrains are accumulated in nigra neurons and their dendritic branches. The incorporation was more pronounced in the case of 3H-norepinephrine than 3H-dopamine. This seems to indicate that exogenous norepinephrine may have stronger affinity to nigra neurons and their dendrites than exogenous dopamine. In addition, some 3H-dopamine and 3H-norepinephrine labelled nerve terminals were observed in axo-dendritic synapses. In contrast to these data, 3H-5HTP and 3H-5HT administration showed almost all silver grains accumulated in the neuropil when observed in light microscopic autoradiography. Electron micrographs further reveal that the incorporation of 3H-5HTP and 3H-5HT was mostly within axo-dendritic boutons with more frequent dense core vesicles. These data again strongly suggest that substantia nigra receives a large number of serotoninergic fibres forming axo-dendritic synapses which may play an important role in modulation of substantia nigra function.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00330222
