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Antibodies to brain tissue in sera of schizophrenic patients (1993)

Henneberg, Alexandra E. ; Ruffert, Silvia ; Henneberg, Hans-Joachim ; [et al.]

Springer

European archives of psychiatry and clinical neuroscience 242 (1993), S. 314-317

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ISSN: 1433-8491

Keywords: Schizophrenia ; Pathogenesis ; Autoimmune disease

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The sera of 30 patients suffering from schizophrenia (DSM III) and 30 neurological controls were tested for antibrain antibodies in a blind indirect immunofluorescence assay. We found IgG- and IgM-binding in the sera of 22 patients, but only 4 out of the 30 age- and sex-matched controls. The binding was mainly directed to neurons from the frontal cortex and septal area, areas, which are regarded as important in the development of schizophrenic illness. These preliminary data are presented, to encourage other immunological studies in schizophrenia research.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02190392

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