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  • Artikel: DFG Deutsche Nationallizenzen  (7)
  • 2000-2004
  • 1995-1999  (7)
  • 1980-1984
  • 1999  (4)
  • 1997  (3)
  • 1
    Digitale Medien
    Digitale Medien
    Specific Changes of Urinary Excretion of Cross-Linked N-Telopeptides of Type I Collagen in Pre- and Postmenopausal Women: Correlation with Other Markers of Bone Turnover (1997)
    Springer
    Calcified tissue international 60 (1997), S. 317 -322 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Key words: Type I collagen — N-telopeptides — Bone resorption — Pyridinolines — Menopause.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Abstract. Urinary excretion of cross-linked N-telopeptide of type I collagen (NTx) has been reported to be a specific marker of bone resorption [18]. We assessed a new immunoassay for NTx as an indicator of changes in bone resorption caused by spontaneous menopause and compared cross-sectionally the levels of urinary NTx, hydroxylysylpyridinoline (HP), lysylpyridinoline (LP), hydroxyproline (OH-Pr), other serum biochemical indices, and lumbar spine and proximal femur bone mineral density (BMD). Eighty-one Japanese women aged 22–77 participated in this study; 36 were premenopausal and 45 were postmenopausal. Urinary HP, LP, and NTx stayed at low levels in the premenopausal period and rose 21%, 30%, and 67% in the postmenopausal period, respectively. The rise in LP and NTx was statistically significant (P 〈 0.01), suggesting that NTx is mostly released from bone matrix when bone resorption is accelerated. When premenopausal women were divided into two age groups and postmenopausal women were divided into two groups according to years since menopause (YSM) there were significant differences in LP and NTx between women 〈4 YSM and women aged 〈40 and those women aged 41+ (P 〈 0.01 and P 〈 0.05, respectively). A significant 110% increase in urinary NTx and a 48% increase in urinary LP were observed in postmenopausal women compared with age-matched premenopausal women aged 45–55. All biochemical markers other than serum PTH correlated significantly with each other (r = 0.243–0.858, P 〈 0.05–0.0001). Urinary NTx inversely correlated with lumbar spine BMD. When postmenopausal women were divided into three groups, the correlation between bone resorption and formation markers in women 0-1 YSM was greater than in women 2–10 YSM and in women 11 + YSM, indicating that resorption and formation are coupled at the early postmenopausal period. We conclude that urinary NTx is responsive to changes in bone metabolism caused by estrogen deficiency and may be a more sensitive and specific marker than HP, LP, or OH-Pr in the early postmenopausal years.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002239900235
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  • 2
    Digitale Medien
    Digitale Medien
    An aldose redutase inhibitor prevents the intimal thickening in coronary arteries of galactose-fed beagle dogs (1999)
    Springer
    Diabetologia 42 (1999), S. 1404-1409 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Keywords Aldose reductase inhibitor, polyol pathway, diabetic macroangiopathy, galactose.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Aims/hypothesis. Although increased polyol pathway activity has been implicated in the pathogenesis of diabetic microangiopathy, the relation with diabetic macroangiopathy remains unclear. Galactose feeding is known to stimulate the polyol pathway and to develop abnormalites similar to those in diabetic microangiopathy. Our study was conducted to investigate whether an activation of polyol pathway by long-term treatment with galactose produced morphological changes in coronary arteries of dogs and the effect of an aldose reductase inhibitor, epalrestat, was also studied.¶Methods. Dogs received either normal chow or chow containing 30 % galactose with or without epalrestat given orally (20 or 50 mg · kg–1). After 44 months, morphometric analyses of coronary arteries were carried out and the galactitol contents in aortas were measured.¶Results. The ratio of areas of the intimal layer to those of the medial layer, an indicator of intimal thickening, was statistically significantly increased in galactose-fed dogs compared with control dogs. Galactose-fed dogs had a remarkable accumulation of galactitol in their aortas. These morphological and biochemical deficits were reduced by treatment with epalrestat.¶Conclusion/interpretation. This report morphologically shows diabetes-like macrovascular abnormalities in galactosaemic animals, suggesting that polyol pathway hyperactivity is closely related to the development of diabetic macroangiopathy, which could be prevented by aldose reductase inhibition. [Diabetologia (1999) 42: 1404–1409]
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001250051310
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  • 3
    Digitale Medien
    Digitale Medien
    Early Postmenopausal Bone Loss is Prevented by Estrogen and Partially by 1α-OH-vitamin D3: Therapeutic Effects of Estrogen and/or 1α-OH-vitamin D3 (1999)
    Springer
    Calcified tissue international 65 (1999), S. 16-22 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Key words: Estrogen — 1α(OH)D3— Early postmenopause — Lumbar spine BMD — Femoral neck BMD.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Abstract. A total of 79 Japanese women who were within 5 years of menopause were randomly assigned 1α-hydroxyvitamin D3 [1α(OH)D3] 1.0 μg/day, conjugated estrogens 0.625 mg/day, a combination of both, or control (no treatment). Lumbar spine and proximal femur bone mineral density (BMD) and biochemical indices were monitored over 2 years. In the 1α(OH)D3-treated group, there was a nonsignificant decrease in lumbar spine BMD compared with controls, and no significant loss in the femoral neck compared with controls. In the estrogen-treated group, there was a nonsignificant increase in spine BMD (+2.17% in the first year and +1.71% in the second year), and no loss in femoral neck BMD. The combination of conjugated estrogens +1α(OH)D3 was more effective in increasing BMD in the spine (+3.68% in the first year and +3.63% in the second year) and femur (+2.56% in the first year and +4.44% in the second year) BMD. There was a significant difference in lumbar spine BMD in both the first and second years between the combination-treated group and the 1α(OH)D3-treated and control groups (P 〈 0.01). Serum osteocalcin (OC) significantly decreased in the combination-treated group (−23.8% in the first year) and the estrogen-treated group (−37.6% and −41.2% at 6 and 18 months, respectively), and serum alkaline phosphatase (Alp) decreased significantly in the first year in the combination-treated (−31.5%), estrogen-treated (−27.3%), and 1α(OH)D3-treated (−7.9%) groups, whereas serum OC increased (+45.4% in the first year) in women without treatment. The results of this study indicate that early postmenopausal bone loss in the femoral neck is prevented by conjugated estrogens, 1α(OH)D3, or both, whereas bone loss in the spine is not prevented by 1α(OH)D3. Estrogen proves effective in preventing early postmenopausal bone loss by markedly inhibiting bone turnover. Moreover, a synergistic bone-sparing effect can be expected when estrogen is administered concomitantly with 1α(OH)D3 rather than when used alone.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002239900651
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  • 4
    Digitale Medien
    Digitale Medien
    Aortic Dissection in an Infant Caused by Intraaortic Balloon Pumping (1999)
    Springer
    Pediatric cardiology 20 (1999), S. 373-374 
    Details
    ISSN: 1432-1971
    Schlagwort(e): Key words: Aortic dissection — Intraaortic balloon pumping — Infant
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. The case of an 8-month-old boy with aortic dissection caused by intraaortic balloon pumping is reported. The balloon was inserted during an operation for the anomalous origin of the left coronary artery. It is important to realize the potential risk of aortic dissection even in infants and to select an appropriately sized balloon. Modification of the balloon for use in infants is necessary.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002469900489
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  • 5
    Digitale Medien
    Digitale Medien
    Nucleoprotein gene analysis of fixed and street rabies virus variants using RT-PCR (1997)
    Springer
    Archives of virology 142 (1997), S. 1787-1796 
    Details
    ISSN: 1432-8798
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary.  A simple and rapid single-step reverse transcriptase-polymerase chain reaction (RT-PCR) was used to investigate the nucleoprotein (N) gene of 11 rabies viruses. A conserved set of RT-PCR primers was designed to amplify the most variable region in the N gene. N gene regions were amplified from 6 fixed laboratory viruses, 4 street viruses from dogs in Thailand, and a horse in Zambia. Sequences of the amplified products, together with the database of 91 additional sequences, were analyzed by using PILEUP program of the GCG package. The rabies viruses grouped into at least 9 distinct clusters by 〈90% nucleotide similarity of the N gene region: I (4 isolates, USA), II (2 isolates, South America), III (3 isolates, Africa), IV (52 strains, Europe, Middle East, Africa and South America), V (16 isolates, North America and Arctic), VI (17 isolates, Africa), VII (1 isolate, Africa), VIII (6 isolates, Thailand and Malaysia) and IX (1 isolate, Sri Lanka). A unique group of rabies viruses from Thailand and clusters of isolates corresponding to their geographic origin also were determined. The simple and rapid single-step RT-PCR proved to be useful for identifying rabies viruses, and for grouping the viruses into clades by sequence analysis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s007050050197
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  • 6
    Digitale Medien
    Digitale Medien
    Genetic Variation in the VP7 Gene of Human Rotavirus Serotype 3 (G3 Type) Isolated in China and Japan (1997)
    Springer
    Archives of virology 142 (1997), S. 1481-1489 
    Details
    ISSN: 1432-8798
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary.  Sequence analysis of the VP7 gene was performed on twenty-one human isolates of serotype 3 related-rotavirus in China and Japan. The five Chinese isolates were found to be not similar to the 16 Japanese isolates and to SA11 (simian rotavirus). The Chinese isolates, especially CHW2 and CH-32, were different from the major serotype 3 human isolates. AU-1 and 02/92 which previously showed a wider spacing between RNA segments 10 and 11 by RNA polyacrylamide gel electrophoretic analysis, were more closely related to each other and could be differentiated from the other Chinese and Japanese isolates. For these reasons, serotype 3 viruses were considered to be intra-serotypically more heterologous than serotype 1, 2 and 4 viruses.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s007050050174
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  • 7
    Digitale Medien
    Digitale Medien
    Investigation of chlorophylls as a scavenger of manganese(II) and zinc(II) using a radiotracer technique (1999)
    Springer
    Journal of radioanalytical and nuclear chemistry 242 (1999), S. 533-536 
    Details
    ISSN: 1588-2780
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Energietechnik
    Notizen: Abstract Uptake of manganese(II) and zinc(II) by chlorophylla (Chl) was investigated using a radiotracer technique in order to elucidate its ability of scavenging metals released into the soil environment. Two possibilities were considered for the metal uptake: (1) substitutional complexation with Chl and (2) inclusion of the metals into Chl aggregates. It was found that manganese(II) was not trapped appreciably by both Chl itself and its aggregates. Magnesium of Chl was exchanged with zinc(II) in aqueous phase giving Zn−Chl at pH values higher than 7. Zinc(II) was found to be trapped by Chl aggregates depending on the pH of the aqueous phase.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02345588
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