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  • Articles: DFG German National Licenses  (38)
  • 1985-1989  (26)
  • 1975-1979  (12)
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  • Articles: DFG German National Licenses  (38)
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Years
Year
  • 11
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 33 (1977), S. 923-925 
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 33 (1977), S. 925-928 
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 33 (1977), S. 2911-2913 
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 35 (1979), S. 247-249 
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 45 (1989), S. 150-152 
    ISSN: 1420-9071
    Keywords: Dopamine ; vasorelaxation ; human ; pulmonary arteries ; DA1 receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Dose-dependent relaxations were induced by dopamine in human pulmonary arteries that had been contracted with prostaglandin F2α without α-adrenergic blocking agents. The dopamine-induced relaxation was inhibited by haloperidol and fluphenazine, but not by domperidone, suggesting that this relaxation was mediated via DA1 receptors.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 121 (1976), S. 279-285 
    ISSN: 1432-1076
    Keywords: Tryptic activity ; Chymotryptic activity ; Stool ; Prematures ; Sucklings ; Infants ; Diarrhoea ; Constipation ; Enteric bacteria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bakterienproteasen verschiedener untersuchter Stämme der Proteus-, Pseudomonas aeruginosa-, Coli-, Streptococcus faecalis- und Bakteroidesgruppe stören die verwendeten Methoden zur Bestimmung der tryptischen und chymotryptischen Aktivität im Stuhl nicht. Beide innerhalb der Kollektive gemessenen Enzymaktivitäten folgen einer logarithmisch normalen Verteilung. Für die tryptische Aktivität liegt die untere Grenze der einfachen Standardabweichung in den Altersgruppen bei 51%, die obere bei 129% der Mittelwerte, entsprechend 60 und 170% für die chymotryptische Aktivität. Während für die chymotryptische Aktivität keine Unterschiede zwischen den 10 Altersgruppen mit insgesamt 157 weitestgehend gesunden Kindern bestehen, lassen sich für die tryptische Aktivität signifikante Differenzen zwischen der Gesamtgruppe der Frühgeborenen und älteren Kindern nachweisen. Auch die intraindividuellen täglichen Schwankungen der Enzymaktivitäten sind hoch und nur bei “Flaschenkindern” mit gleichbleibender Nahrung geringer. Bei Frühgeborenen und ganz jungen Säuglingen überwiegt die chymotryptische Aktivität, in späterem Alter die tryptische. Der Einfluß beschleunigter und verlangsamter Darmpassage auf die Streuung der Werte wird bei leichter Dyspepsie bzw. Obstipation als annähernd entsprechenden Modellen geprüft, wobei Vorbehalte bei der Interpretation dieser Untersuchungen zu machen sind. Die Beeinflussung der Enzymaktivitätswerte durch beide Passagestörungen geht nicht über die einfache Standardabweichung der jeweiligen Kontrollgruppe hinaus. Passagezeit und Nahrungseinfluß gehen neben anderen Faktoren in die Streuung der Enzymaktivitätswerte ein. Die starke Streuung der Aktivitätswerte im Rahmen der Altersgruppen setzt der Aussagekraft des Verfahrens engere Grenzen.
    Notes: Abstract Measurement of tryptic and chymotryptic activity in the faeces was not disturbed by bacterial proteolytic activity of different bacteria such as proteus, pseudomonas, coli, enterococci, bacteroides. Both activities within a group follow a logarithmic normal distribution. Lower limit of the standard deviation is 51%, upper limit 129% for tryptic activity, respectively 60 and 170% for chymotryptic activity. There were no differences in chymotryptic activity between the 10 age groups comprising 157 healthy children, whereas a significant difference could be found for tryptic activity between prematures and older children. Daily fluctuations of the enzyme activities are quite high in the same individual, and only reduced in “bottlefed” infants with constant nutrition. In prematures and very young infants chymotryptic activity predominates, later tryptic activity. Influence of increased and decreased bowel movements on deviation of the data was tested. There was, however, no real alteration of enzyme activity due to the bowel dysfunction beyond the standard deviation of the control groups. But passage time and nutrition have to be considered beside other factors in the wide distribution of the enzyme activities and the latter limits the value of this method.
    Type of Medium: Electronic Resource
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  • 17
    ISSN: 1432-1076
    Keywords: Prematures ; Infants ; Children ; Cystic fibrosis ; Dystrophy ; Diagnosis ; Therapy ; Pancreatic enzyme substitution ; Fecal fat ; Digestion ; Feces ; Tryptic activity ; Chymotryptic activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Unter gewissen Voraussetzungen ist die Bestimmung der tryptischen, besonders aber der chymotryptischen Aktivität im Stuhl vor allem während der ersten 4–6 Lebenswochen als wichtige Maßnahme in der Diagnostik der Mucoviscidosis anzusehen. Nach Absetzen des Pankreasenzympräparates fällt die tryptische und chymotryptische Aktivität des Stuhles Mucoviscidosis-kranker Kinder ab. Nach Verabfolgung des Präparates steigt die Enzymaktivität in Abhängigkeit von der Höhe der Dosis an und erreicht die Aktivitätswerte altersentsprechender gesunder Kinder. Ein Vergleich zwischen der proteolytischen Aktivität und dem Fettgehalt des Stuhles im Rahmen von Untersuchungsperioden ohne Gabe des Pankreasenzympräparates und bei unterschiedlicher Dosierung des Präparates läßt eine signifikante Korrelation der beiden Parameter vermissen. Es ist nicht erlaubt, aus einer hohen proteolytischen Aktivität des Stuhles auf eine entsprechend verminderte Fettausscheidung zu schließen, da sich fäkale proteolytische Aktivität und Fettausscheidung nicht umgekehrt proportional zueinander verhalten. Man kann deshalb die Höhe der proteolytischen Aktivität im Stuhl von Mucoviscidosis-Patienten nicht als allgemeinen Maßstab für die gesamte Verdauungsleistung bei Pankreasenzymsubstitution betrachten.
    Notes: Abstract Under certain conditions the determination of the tryptic activity, especially of the chymotryptic activity in the feces mostly of infants in the first 4–6 weeks of life is considered to be an important step in the diagnosis of cystic fibrosis. The tryptic and chymotryptic activity in the feces of children with cystic fibrosis declines when the substitution of pancreatic enzymes is stopped. On resubstitution, the activity rises in relation to the dose and attains the activity related to age as found in healthy children. A comparison of the proteolytic activity with the fat content of the feces during the study period without the enzyme substitution and during the period when the enzyme dosage varied showed no significant correlation. It is not possible to postulate a poor excretion of fats merely from the high proteolytic activity of the feces because the fecal proteolytic activity and the fat excretion are not inversely proportional to one another. For this reason, one cannot conclude that the grade of the proteolytic activity in the feces of patients with cystic fibrosis is a yardstick for the total digestive process when they are under pancreatic enzyme substitution.
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 145 (1986), S. 347-350 
    ISSN: 1432-1076
    Keywords: Auditory brainstem response ; Newborn ; Intracranial haemorrhage ; Neonatal asphyxia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Auditory brainstem response (ABR) was used to assess possible brainstem damage in 76 neonates with asphyxia and intracranial haemorrhage (ICH). Fifty-eight neonates had ICH, 52 had neonatal asphyxia and 34 of these patients had both. Eighty-nine percent of the patients with neonatal asphyxia showed some abnormal patterns in response, the major one being an increase in the threshold of wave V. In the ICH group, abnormal patterns were observed in 62.5%, among whom the prolongation of the I–V interpeak latency (IPL) and of wave V latency was seen more frequently than the increase of threshold of wave V. In the case of neonatal asphyxia associated with ICH, both the prolongation of the latency and the increase of threshold were observed equally. These abnormalities of ABR were associated with worsening clinical condition and conversely normalized gradually following the improvement of the underlying disease. Especially the I–V IPL, wave V latency and the threshold of wave V could serve as indicators of the treatment.
    Type of Medium: Electronic Resource
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  • 19
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Computed tomographic (CT) scans were obtained from eight infants and young children with herpes simplex virus encephalitis. In two cases the initial scan showed diffuse edematous changes as a mass effect without laterality. Unilateral localized low attenuation in the initial scan was evident 4 days after the onset in one patient, and high attenuation in the initial scan appeared on the 6th day in another patient, but in general, it was not possible to establish an early diagnosis of herpes simplex virus encephalitis from CT scan. In the longitudinal study the calcification with ventriculomegaly appeared in 3 of 5 survivors, and gyriform calcification in 2 of 3 patients, respectively. The appearance of multicystic encephalomalacia was evident in one patient 6 months after the onset of neonatal herpes simplex encephalitis. It is shown that the CT findings of neonates and young children with herpes simplex encephalitis are different from those of older children and adults, and the importance of longitudinal CT studies was stressed in clarifying the pathophysiology of the central nervous system involvement in survivors.
    Type of Medium: Electronic Resource
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  • 20
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of caecal duplication in a 36-h-old neonate is described. The patient presented with vomiting and an abdominal mass and the barium enema finding was initially suggestive of intussusception. At laparotomy a duplication cyst completely obstructing the lumen was found. This was considered to have given the radiological picture simulating intussusception.
    Type of Medium: Electronic Resource
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