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  • Articles: DFG German National Licenses  (2)
  • Brain banking  (1)
  • Survival  (1)
  • 1
    ISSN: 1432-0533
    Keywords: Astrocytoma ; Macrophage ; Lymphocyte ; Mononuclear cells ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Frozen samples from 92 malignant astrocytomas were stained with a panel of monoclonal antibodies directed against macrophages and lymphocytes. A follow-up to death was available on 68 cases which form the basis of this study. Large numbers of macrophages were found in all cases; T lymphocytes, mostly of the CD8 phenotype were also seen in moderate numbers in 70% of cases. CD4-positive cells were present in small numbers in 32% and B cells were seen in only 8% of cases. Analysis of the survival showed no demonstrable correlation between the numbers of macrophages or CD4 lymphocytes and survival. The survival curves for parencymal CD8 infiltration diverged after 9 months suggesting increased survival for those patients without such an infiltration but the difference failed to reach statistical significance (P=0.37). No correlation between lymphocytic cuffing and survival was seen after studying all paraffinembedded material. We conclude that there is no significant statistical correlation between survival and the various types of mononuclear cell infiltrating malignant astrocytomas.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-1463
    Keywords: Brain banking ; post mortem research ; schizophrenia ; affective disorders ; European consensus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The sophisticated analysis of and growing information on the human brain requires that acquisition, dissection, storage and distribution of rare material are managed in a professional way. In this publication we present the consensus of the European work group 〉European Dementia and Schizophrenia Network〈, granted by the BIOMED I project of the EU, on minimal neuropathological and clinical requirements to include brains of patients with schizophrenia and affective disorders in post mortem studies. The description of clinical prerequisites in different EU countries and institutions is followed by a consensus on tissue handling, a consensus on minimal neuropathological criteria and a consensus on minimal clinical diagnostic criteria including clinical vignette, family, social, educational/professional and general medical histories, general physical history including neurostatus, neurological, psychiatric, medication and general pathological histories, psychostatus, laboratory tests and a history provided by family/health care giver questionaire. This publication should give help to interconnect different European brain bank centers on a basis of standarized protocols.
    Type of Medium: Electronic Resource
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