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  • Articles: DFG German National Licenses  (3)
  • Cyclic GMP  (1)
  • Extracorporeal plasma treatment  (1)
  • LDL apheresis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Beeinflussung von atrialem natriuretischen Peptid (ANP) und zyklischem GMP durch Hämofiltration und Hämodialyse (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 940-945 
    Details
    ISSN: 1432-1440
    Keywords: Atrial natriuretic peptide ; Cyclic GMP ; Hemodialysis ; Hemofiltration ; Ultrafiltration ; Atriales natriuretisches Peptid ; zyklisches GMP ; Hämodialyse ; Hämofiltration ; Ultrafiltration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 7 chronisch niereninsuffizienten Patienten, die regelmäßig hämofiltriert (HF) wurden, erfolgten während der Behandlung periodische Bestimmungen von ANP and c-GMP. Um den Einfluß des Blutreinigungsverfahrens auf die Veränderungen der Plasmakonzentrationen dieser Hormone zu untersuchen, wurde bei den Patienten eine Hämodialyse (HD) mit identischer Ultrafiltration und Behandlungsdauer durchgeführt. Bei beiden Behandlungsverfahren wurde ein gleichartiger kontinuierlicher Abfall von ANP und c-GMP beobachtet. Nach Kopf-Tieflagerung wegen Hypotonie unter HD stiegen die ANP und c-GMP Werte akut an. Bei einem anderen Patienten wurde gleichfalls ein akuter Anstieg während der HD beim Auftreten einer Tachyarrhythmia absoluta beobachtet. Diese Befunde zeigen, daß die Freisetzung von ANP bei chronischer Niereninsuffizienz nicht verändert ist. Da eine enge Beziehung zwischen Intravasalvolumen und der Höhe des Plasma ANP besteht, kann die regelmäßige Bestimmung dieses Hormons zur Beurteilung des Hydratationszustandes terminal niereninsuffizienter Patienten herangezogen werden.
    Notes: Summary ANP and c-GMP concentrations in 7 patients with chronic renal failure (CRF) undergoing regular hemofiltration (HF) were determined. After switching to hemodialysis (HD) under identical ultrafiltration and treatment time no significant difference of the ANP and c-GMP profiles was detected, suggesting that the type of treatment does not affect ANP and c-GMP plasma levels. In both procedures a continuous decrease of ANP and c-GMP was observed. Head down tilting to compensate hypotension during HD was immediately followed by an increase in ANP and c-GMP during ultrafiltration. An acute onset of tachyarrhythmia absoluta during HD was also accompanied by a rise in ANP plasma concentrations. This demonstrates that ANP secretion is not altered in patients with CRF. Since ANP plasma levels closely correlate with intravascular volume, periodic determination of this hormone in HD/HF patients may provide diagnostic information to detect volume overload.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728958
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Acute and long-term effects of low-density lipoprotein apheresis on the serum concentrations of vitamins E and A (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 123-128 
    Details
    ISSN: 1432-1440
    Keywords: LDL apheresis ; Vitamin E ; Vitamin A ; α-Tocopherol ; Retinol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serum α-tocopherol and retinol concentrations were followed in four heterozygous adults and one homozygous child with familial hypercholesterolemia being treated by regular low-density lipoprotein (LDL) apheresis. Approximately 50% of plasma α-tocopherol was eliminated during a single apheresis procedure in the heterozygous adults, while a complete elimination of this vitamin along with LDLs was observed in the homozygous child. Absolute losses of α-tocopherol amounted to 13.4–22.5 mg/apheresis and are equivalent to the recommended dietary intake for 1.5 to 2 days. Despite these losses, no changes were observed either in serum α-tocopherol levels or in the ratio of α-tocopherol/total serum lipids after 12 months regular apheresis treatment. Serum retinol concentrations only showed a small decrease on apheresis, there being apparently no specific elimination of this vitamin. The absolute losses ranged from 42–422 µg/apheresis and were, therefore, much lower than the recommended dietary intake of the equivalent of 1500 µg retinol/day. It is concluded that no extra supplementation of these vitamins is required during LDL-apheresis therapy, although it may be advisable to monitor vitamin E status in patients on long-term, intensive therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01774226
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Selective removal of low density lipoproteins (LDL) by precipitation at low pH: First clinical application of the HELP system (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 161-168 
    Details
    ISSN: 1432-1440
    Keywords: Hypercholesterolemia ; Low-density lipoproteins ; Heparin precipitation ; Extracorporeal plasma treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The first clinical application of a new extracorporeal procedure (HELP) for the selective elimination of low-density lipoproteins by heparin precipitation at acid pH is described. Plasma, obtained by filtration of whole blood through a 0.2 µ filter, is continuously mixed with an equal volume of an acetate buffer (pH 4.85) containing heparin. After removal of the precipitated heparin complex by filtration, excess heparin is adsorbed to a specially developed filter and the clear plasma filtrate is subject to bicarbonate dialysis/ultrafiltration to restore physiologic pH and remove excess fluid. The calculated efficiency for the elimination of low-density lipoproteins from plasma by HELP is 100% and is therefore comparable to conventional plasmapheresis. The HELP system shows a high degree of specificity with over 80% of total protein being returned to the patient. Over 130 treatment procedures have now been performed. Patient compliance and acceptance have been excellent and no major complications have been observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728226
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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