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  • Articles: DFG German National Licenses  (10)
  • Magnetic resonance imaging  (6)
  • Gelatinase A  (4)
  • Human brain  (3)
  • 1
    Electronic Resource
    Electronic Resource
    White matter microglia produce membrane-type matrix metalloprotease, an activator of gelatinase A, in human brain tissues (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 421-424 
    Details
    ISSN: 1432-0533
    Keywords: Key words Membrane-type matrix metalloprotease ; Gelatinase A ; Human brain ; Microglia ; β-Amyloid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Membrane-type matrix metalloprotease (MT-MMP) is an activator of gelatinase A (MMP-2), which has previously been found in carcinoma cells. We examined non-neurological and Alzheimer's disease brain tissues for MT-MMP by immunohistochemistry and in situ hybridization. The anti-MT-MMP antibodies gave positive staining of brain microglial cells in all the brain tissues. Positively stained microglia were found only in the white matter. The cells producing MT-MMP protein were also shown to be white matter microglia. These results provide further evidence that activated gelatinase A, which may be a processing enzyme for degradation of β-amyloid protein, may be produced in white matter microglia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294800
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    White matter microglia produce membrane-type matrix metalloprotease, an activator of gelatinase A, in human brain tissues (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 421-424 
    Details
    ISSN: 1432-0533
    Keywords: Membrane-type matrix metalloprotease ; Gelatinase A ; Human brain ; Microglia ; β-Amyloid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Membrane-type matrix metalloprotease (MT-MMP) is an activator of gelatinase A (MMP-2), which has previously been found in carcinoma cells. We examined non-neurological and Alzheimer's disease brain tissues for MT-MMP by immunohistochemistry and in situ hybridization. The anti-MT-MMP antibodies gave positive staining of brain microglial cells in all the brain tissues. Positively stained microglia were found only in the white matter. The cells producing MT-MMP protein were also shown to be white matter microglia. These results provide further evidence that activated gelatinase A, which may be a processing enzyme for degradation of β-amyloid protein, may be produced in white matter microglia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294800
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Expression of the membrane-type 3 matrix metalloproteinase (MT3-MMP) in human brain tissues (1998)
    Springer
    Acta neuropathologica 96 (1998), S. 347-350 
    Details
    ISSN: 1432-0533
    Keywords: Key words Membrane-type 3 matrix metalloproteinase ; Gelatinase A ; Human brain ; Microglia ; Reverse ; transcriptase-polymerase chain reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Membrane-type 3 matrix metalloproteinase (MT3-MMP) is a novel MT-MMP which has a transmembrane domain at the C terminus, and mediates activation of pro-gelatinase A, just as does MT1-MMP. Previously, we reported that MT1-MMP was expressed on microglial cells only in the white matter [Yamada T, Yoshiyama Y, Sato H, Seiki M, Shinagawa A, Takahashi M (1995) Acta Neuropathol 90 : 421–424]. In the present study of both non-neurological and Alzheimer brain tissues, we examined the localization of MT3-MMP by immunohistochemistry. Anti-MT3-MMP antibodies gave positive staining of microglial cells in all brain tissues. Positively stained microglia were found not only in the white matter but also in the gray matter. Reverse transcriptase-polymerase chain reaction for MT3-MMP mRNA showed the same amount of expression in gray and white matters, while that for gelatinase A and MT1-MMP mRNA expressed much higher in the white matter than in the gray matter. These results suggest that MT3-MMP may play a role on microglial cells, although its role may be different from MT1-MMP in the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050904
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Selective localization of gelatinase A, an enzyme degrading β-amyloid protein, in white matter microglia and in Schwann cells (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 199-203 
    Details
    ISSN: 1432-0533
    Keywords: Gelatinase A ; β-Amyloid ; Microglia ; Alzheimer's disease ; Schwann cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gelatinase A is an enzyme capable of cleaving soluble β-amyloid protein (βAP), and may function as an α-secretase to produce secretory forms of amyloid precursor protein. We examined gelatinase A immunoreactivity in the brains and posterior roots of neurologically normal, lacunar stroke, Alzheimer disease (AD), amyotrophic lateral sclerosis, progressive supranuclear palsy and myasthenia gravis cases. The gelatinase A antibody stained only microglial cells in the white matter in all the brain tissues. In AD brain, the reactive microglia located in the center of classical senile plaques, as well as in other microglial cells in the gray matter, showed no immunoreactivity. Gelatinase A in white matter microglial cells may play a role in preventing local deposition of βAP. In the posterior root, Schwann cells had positive immunoreactivity. As with other metalloproteases, gelatinase A in Schwann cells may play an antiproliferative role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309334
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Differential diagnosis of extra-axial intracranial tumours by dynamic spin-echo MRI (1995)
    Springer
    Neuroradiology 37 (1995), S. 522-525 
    Details
    ISSN: 1432-1920
    Keywords: Brain neoplasms ; Magnetic resonance imaging ; Neuroma ; Meningioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dynamic MRI was performed on 22 patients with extra-axial intracranial tumours. Serial images were obtained every 30 s for 3 min using a spin-echo sequence (TR 200, TE 15 ms) after rapid injection of Gd-DTPA, 0.1 mmol/kg body weight. The contrast medium enhancement ratio (CER) was correlated with the histology of the tumours. Meningiomas and extra-axial metastases showed a sharp rise, then a gradual decline. Although both had a definite early peak of CER, metastases showed a more rapid decline. Neuromas and extra-axial lymphoma showed a slow, steady increase with no peak within 180 s. This study indicates that the CER is helpful in the differentiation of extra-axial tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593708
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Differential diagnosis of extra-axial intracranial tumours by dynamic spin-echo MRI (1995)
    Springer
    Neuroradiology 37 (1995), S. 522-525 
    Details
    ISSN: 1432-1920
    Keywords: Key words Brain neoplasms ; Magnetic resonance imaging ; Neuroma ; Meningioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dynamic MRI was performed on 22 patients with extra-axial intracranial tumours. Serial images were obtained every 30 s for 3 min using a spin-echo sequence (TR 200, TE 15 ms) after rapid injection of Gd-DTPA, 0.1 mmol/kg body weight. The contrast medium enhancement ratio (CER) was correlated with the histology of the tumours. Meningiomas and extra-axial metastases showed a sharp rise, then a gradual decline. Although both had a definite early peak of CER, metastases showed a more rapid decline. Neuromas and extra-axial lymphoma showed a slow, steady increase with no peak within 180 s. This study indicates that the CER is helpful in the differentiation of extra-axial tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593708
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Multiple haemorrhagic brain metastases from papillary thyroid cancer (1997)
    Springer
    Neuroradiology 39 (1997), S. 198-202 
    Details
    ISSN: 1432-1920
    Keywords: Key words Brain metastasis hemorrhagic ; Papillary thyroid cancer ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a 40-year-old woman, who initially developed cerebellar symptoms, with multiple hemorrhagic brain metastases from a papillary thyroid cancer. Intracranial masses gave heterogeneous high signal on T 1-weighted and T 2-weighted images, hemosiderin rims on the latter. Some of the tumors showed contrast enhancement. Metastatic thyroid cancer is a consideration in a patient with multiple hemorrhagic masses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050393
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Dynamic MRI of meningiomas and schwannomas: is differential diagnosis possible? (1997)
    Springer
    Neuroradiology 39 (1997), S. 633-638 
    Details
    ISSN: 1432-1920
    Keywords: Key words Meningioma ; Schwannoma ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied 23 patients with meningiomas and 14 with schwannomas using dynamic spin-echo (TR/TE 200/15 ms) MRI. Histologically the meningiomas were classified according to the 1993 WHO classification. Serial images were obtained every 30 s for 210 s after rapid injection of gadopentetate dimeglumine (0.1 mmol/kg). The contrast-enhancement ratio (CER) was divided into three patterns; a sharp rise with a peak within 60 s (A), a relatively rapid increase with a peak between 60 and 210 s (B), a slow increase without a peak (C). The patterns were correlated with the histology of the tumors. The signal intensities of the tumours on T2-weighted images were also analyzed and correlated with the dynamic patterns. Meningiomas had more varied dynamic patterns than schwannomas. Almost half of the meningiomas showed pattern A, and one third pattern C. Of six meningothelial meningiomas showed pattern A; all schwannomas and fibrous meningiomas showed pattern C. Various patterns were observed in transitional meningiomas. Of the 8 meningiomas showing pattern C, only one gave high signal on T2-weighted images, and could not be differentiated from the schwannomas. Thus, one third of meningiomas could not be differentiated from schwannomas by the dynamic contrast enhancement alone. However, when this was combined with the signal intensity on T2-weighted images, most meningiomas could be differentiated from schwannomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050482
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    MR signal intensity of the perirolandic cortex in the neonate and infant (1996)
    Springer
    Neuroradiology 38 (1996), S. 578-584 
    Details
    ISSN: 1432-1920
    Keywords: Key words Child's brain ; Magnetic resonance imaging ; Myelination ; Brain development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our purpose was to study the magnetic resonance (MR) signal intensity of the perirolandic gyri perinatally and to correlate it with the histological findings in formalin-fixed brains, focusing on myelination. MRI of 20 neurologically normal neonates and infants, of 37–64 weeks postconception (PCA), were studied retrospectively. We reviewed four formalin-fixed brains of infants 37–46 weeks PCA microscopically. The posterior cortex of the precentral gyrus (P-PRE) and the anterior cortex of the postcentral gyrus (A-PST) had different signal intensity from the adjacent surrounding cortex. On T 1-weighted images P-PRE and A-PST gave higher signal 41–44 weeks PCA; on T 2-weighted images, they gave lower signal 37–51 weeks PCA. Histological examination revealed very little myelination of the nerve fibres within both the P-PRE and the A-PST, while considerable myelination was present in the internal capsule and central corona radiata. The changes in signal intensity in the perirolandic gyri may reflect not only the degree of myelination but also the more advanced development of the nerve cells, associated with rapid proliferation and formation of oligodendroglial cells, synapses and dendrites. They could be another important landmark for brain maturation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00626104
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    MR signal intensity of the perirolandic cortex in the neonate and infant (1996)
    Springer
    Neuroradiology 38 (1996), S. 578-584 
    Details
    ISSN: 1432-1920
    Keywords: Child's brain ; Magnetic resonance imaging ; Myelination ; Brain development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our purpose was to study the magnetic resonance (MR) signal intensity of the perirolandic gyri perinatally and to correlate it with the histological findings in formalinfixed brains, focusing on myelination. MRI of 20 neurologically normal neonates and infants, of 37–64 weeks postconception (PCA), were studied retrospectively. We reviewed four formalin-fixed brains of infants 37–46 weeks PCA microscopically. The posterior cortex of the precentral gyrus (P-PRE) and the anterior cortex of the postcentral gyrus (A-PST) had different signal intensity from the adjacent surrounding cortex. On T1-weighted images P-PRE and A-PST gave higher signal 41–44 weeks PCA; on T2-weighted images, they gave lower signal 37–51 weeks PCA. Histological examination revealed very little myelination of the nerve fibres within both the P-PRE and the A-PST, while considerable myelination was present in the internal capsule and central corona radiata. The changes in signal intensity in the perirolandic gyri may reflect not only the degree of myelination but also the more advanced development of the nerve cells, associated with rapid proliferation and formation of oligodendroglial cells, synapses and dendrites. They could be another important landmark for brain maturation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00626104
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    Paper (German National Licenses)
    Fulltext
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