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  • 11
    Electronic Resource
    Electronic Resource
    PET reflections (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 293-294 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186657
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  • 12
    Electronic Resource
    Electronic Resource
    Comparison of PET, SPET, neuropsychological and morphological findings in vascular dementia (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 348-349 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728777
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  • 13
    Electronic Resource
    Electronic Resource
    Dual-head gamma camera 2-[fluorine-18]-fluoro-2-deoxy-d-glucose positron emission tomography in oncological patients: effects of non-uniform attenuation correction on lesion detection (1999)
    Springer
    European journal of nuclear medicine 26 (1999), S. 818-823 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Dual-head gamma camera ; Positron emission tomography ; Attenuation correction ; Oncological patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of this study was to evaluate a dual head coincidence gamma camera (DH-PET) equipped with single-photon transmission for 2-[fluorine-18]-fluoro-2-deoxy-d-glucose (FDG) imaging in oncological patients. Forty-five patients with known or suspected malignancies, scheduled for a positron emission tomography (PET) scan, were first studied with a dedicated ring PET and subsequently with DH-PET. All patients underwent measured attenuation correction using germanium-68 rod sources for ring PET and caesium-137 sources for DH-PET. Ring PET emission scan was started 64±17 min after intravenous administration of 235±42 MBq FDG. DH-PET emission followed 160±32 min after i.v. FDG. Attenuation-corrected and non-attenuation-corrected images were reconstructed for ring PET and DH-PET. The image sets were evaluated independently by three observers blinded to clinical data and to results of conventional imaging. Attenuation-corrected ring PET as the standard of reference depicted 118 lesions, non-attenuation-corrected ring PET 113 (96%) lesions, and attenuation-corrected DH-PET and non-attenuation-corrected DH-PET, 101 (86%) and 84 (71%) lesions, respectively (P〈0.05). The lesion detection rate of attenuation-corrected and non-attenuation-corrected DH-PET was almost similar for lesions 〉20 mm, whereas attenuation correction increased the detection rate from 60% to 80% for lesions ≤20 mm (P〈0.01). A patient-based analysis revealed concordant results relative to attenuation-corrected ring PET for non-attenuation-corrected ring PET, attenuation-corrected DH-PET and non-attenuation-corrected DH-PET in 42 (93%), 36 (80%) and 31 (69%) patients, respectively. Differences might have influenced patient management in two (4%), six (13%) and ten (22%) patients, respectively. In conclusion, measured attenuation correction markedly improves the lesion detection capability of DH-PET. With measured attenuation correction the diagnostic performance of DH-PET is closer to that of dedicated ring PET.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590050454
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  • 14
    Electronic Resource
    Electronic Resource
    Computerized tomography and nuclear imaging of the liver (1978)
    Springer
    European journal of nuclear medicine 3 (1978), S. 71-80 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was performed to comparatively assess the diagnostic accuracy of computerized tomography (CT) and nuclear liver-scanning in detecting and defining circumscript and diffuse liver diseases in 83 patients. Presence or absence of liver diseases was assessed based on the results of invasive diagnostic procedures such as biopsy, laparoscopy, laparotomy, and/or autopsy. The percentage of true negative diagnoses was 94% for CT and 91% for static gamma-imaging (n=33). With a rate of 94% true positive diagnoses, CT proved to be superior to gamma imaging with radiocolloids (81% true positives) in diagnosing circumscript liver diseases (n=31). In addition, CT was superior to nuclear imaging regarding discrimination of number and size of space-occupying lesions within the liver. In contrast to nuclear screening, CT scans were pathognomonic to some circumscript liver diseases such as cysts, metastates, and perhaps echinococciasis. This was also true for obstructive jaundice. Nuclear imaging, because it reflects a sort of liver function, was superior with cirrhosis, whereas CT showed only alterations in the size and shape of the liver and spleen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251627
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  • 15
    Electronic Resource
    Electronic Resource
    Effects of physical stress and pharmacologically induced coronary dilation on myocardial and non-myocardial 201Thallium-uptake (1978)
    Springer
    European journal of nuclear medicine 3 (1978), S. 19-27 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract After subtraction of the 201Tl background radioactivity which was obtained from the paracardiac region, left ventricular (LV)-201Tl net uptake at rest correlated with (1) the LV-muscle mass and therefore with (2) the LV-oxygen consumption. In normal LV, after maximum coronary dilation with dipyridamole, LV-201Tl net uptake increased little more than LV-oxygen consumption but by factor of 2.27 less than was coronary vascular reserve. In coronary heart disease (c.h.d.), dipyridamole caused a significantly smaller increase of LV-201Tl uptake (factor 1.16) than in normal LV myocardium (factor 1.76). This correlated well with the severity of the disease. Therefore, in maximum coronary dilation passive transport mechanisms may be responsible for augmented uptake and changed LV distribution of 201Tl which depends on the perfusion pattern. In exercise, the 201Tl-background radioactivity decreased from 54% (at rest) to 35% in normal patients and to 44% in c.h.d. Stressed thigh muscles accumulated 201Tl 4.72-fold more than at rest. Therefore, it is still questionable if the myocardium during exercise receives enough 201Tl to be labelled maximum. Since the LV-201Tl count rates in c.h.d., measured over the maximum uptake area were increased to the same amount as in normal myocardium neither in coronary dilation nor during exercise, the validity of using the maximum LV-201Tl uptake as a reference for the minimum one under these conditions is problematic.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253473
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  • 16
    Electronic Resource
    Electronic Resource
    Evaluation of myocardial function with the 201Thallium scintimetry in various diseases of the heart (1976)
    Springer
    European journal of nuclear medicine 1 (1976), S. 125-136 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To assess the validity of the quantitative 201Tl scintimetry in various diseases of the heart (coronary heart disease with and without myocardial infarction, non-coronary cardiomyopathy, scleroderma heart disease and asymmetric septal hypertrophy with IHSS), the 201Tl myocardial uptake values for five standardized projections (a) were correlated with the grade of LAD stenosis, (b) the pattern of myocardial wall motion and (c) were compared with the 201Tl uptake values derived from normal patients. Significant reduction (c) of 201Tl myocardial uptake could in individual cases be evaluated in acute myocardial infarction (95%), in dys-and akinesia (90%), in hypokinesia (71%), in scleroderma heart disease (50%), in non-coronary cardiomyopathy (50%) as well as in normokinesia (28%) when associated with LAD stenosis. The mean values (b) of 201Tl uptake in normo-and hypokinesia significantly differed between these two groups and from those evaluated in dys-and akinesia. The latter group showed the lowest 201Tl uptake values computed which in some cases were very close to the mean mediastinal 201Tl uptake. The correlation (a) of individual 201Tl values demonstrated that 201Tl distribution in the myocardium is not only equivalent to myocardial “perfusion” but is corresponding with the myocardial function. In non-coronary cardiomyopathy reduced 201Tl values sometimes could not be separated from values in coronary heart disease (and myocardial infarction). A regional increase of myocardial mass as in septal hypertrophy correlated well with an augmented 201Tl uptake when referred to the 201Tl storage in the mediastinum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257958
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  • 17
    Electronic Resource
    Electronic Resource
    Reduced technetium 99m labelled NCA-95/CEA-antibody uptake in liver due to gentle antibody reconstitution (1990)
    Springer
    European journal of nuclear medicine 17 (1990), S. 38-41 
    Details
    ISSN: 1619-7089
    Keywords: Monoclonal antigranulocyte antibody ; NCA-95-specific antibody ; Bone marrow scintigraphy ; Antibody liver uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of reconstituting a murine monoclonal IgG1 antibody kit with pertechnetate technetium 99m on antibody distribution in the liver, spleen and sternal bone marrow of patients was examined. The99mTc-labelled antibody used is directed against nonspecific cross-reacting antigen (NCA-95) and carcinoembryonic antigen (CEA) and has been successfully applied for imaging tissue inflammation and bone marrow scanning. Radioactivity uptake was determined in the liver, spleen, bone marrow and a precordial background region in a consecutive series of 25 patients, examined with an antibody preparation, routinely radiolabelled according to the manufacturer's recommendations and in 14 patients, in whom the antibody was reconstituted with special care, avoiding bubble formation and dropping of buffer into the antibody-containing vial. Gentle compared with routine antibody reconstitution caused a highly significant reduction of the antibody uptake in the liver, as determined by count densities, normalized to injected dose and acquisition time (13.2 ± 5.5 vs 20.1 ± 6.0 cpm per pixel, x±SID,P=0.008). The liver to background ratio was reduced from 3.4 ± 1.4 to 1.9 ±0.5 (P 〈 0.001). Spleen, sternal bone marrow and precordial background count rates were not significantly affected. These results clearly demonstrate that gentle antibody reconstitution can decrease non-specific antibody uptake in the liver by 34% ± 6.4% (x ± SEM). Thus, scan quality is improved, and the potential deleterious camouflage of underlying structures is avoided.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00819402
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  • 18
    Electronic Resource
    Electronic Resource
    A comparison of maximal exercise and dipyridamole thallium-201 planar gated scintigraphy (1992)
    Springer
    European journal of nuclear medicine 19 (1992), S. 826-826 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00182828
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  • 19
    Electronic Resource
    Electronic Resource
    Improvement of bone scintigraphy by quantitative evaluation compared with X-ray studies and iliac crest biopsy in malignant disease (1983)
    Springer
    European journal of nuclear medicine 8 (1983), S. 342-345 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bone marrow biopsy of the iliac crest was performed on 268 patients (124♂; 144♀). Of these patients 206 had haematological systemic disorders (HSD) or carcinoma and suspected bone involvement, which was confirmed by biopsy on 66 patients. Bone biopsy was performed not longer than 3 weeks after X-ray examination and bone scintigraphy which, combined, had already raised the suspicion of skeletal involvement in 55% of the 66 patients with skeletal involvement diagnosed by biopsy. Additional quantitative evaluation of the bone scans using bone to soft tissue ratios was able to increase the overall accuracy to 67% in that group. Additional quantitative assessment of the scan yielded considerably more effective bone scintigraphy, particularly in cases with visually normal patterns. Available equipment should therefore be used in scintigraphic bone imaging on a routine basis. It was shown that the various methods of examination, i.e. X-ray, biopsy and scintigraphy with both visual and quantitative evaluation provide their own individual values for the final diagnosis. Therefore, if one of the methods shows a negative result, bone involvement is not excluded and the others should be used for confirmation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253542
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  • 20
    Electronic Resource
    Electronic Resource
    Nuclear imaging in loosening of hip-joint endoprostheses (1988)
    Springer
    Archives of orthopaedic and trauma surgery 107 (1988), S. 288-292 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 28 patients with surgically proved loosening of hip-joint endoprostheses and 42 patients without loosening between 2 and 12 years after implantation and without clinical or radiological signs of loosening we performed clinical evaluation, and radiographs, a three-phase bone scan, and a 111indium-labeled leukocyte scan (ILLS). The sensitivity of radiographs in the group with loosening of hip-joint endoprostheses in the femoral as well as in the acetabular component was only about 50%, while the specificity was almost 100%. With a combination of radiographs and ILLS we reached a sensitivity in the acetabular component of 100% and in the femoral component of 88%, but specificities of only 57% in the acetabular component and 40% in the femoral component were found. We found that the ILLS is a very helpful method of examination to detect loosening of hip-joint arthroplasties in doubtful cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451509
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