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  • 1
    Electronic Resource
    Electronic Resource
    A dynamic study of domain formation mechanism during thermomagnetic recording based on micro-Hall effect measurements : The 40th annual conference on magnetism and magnetic materials (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 5700-5702 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A method for analyzing the dynamics of domain formation during the thermomagnetic recording process has been developed based on the extraordinary Hall effect. A magnetic domain is written at the center of a cross-shaped magneto-optical sample having an area of 5×5 μm2, and the Hall voltage is monitored during the recording process. As far as domain nucleation is concerned, we find that the temperature gradient around the transition region (i.e., the region whose temperature is between the critical temperature for magnetization reversal and the Curie point) is very important. Under the conditions of high power and short pulse-width laser, a domain can form only during the cooling period. However, it is possible for a domain to form during the heating cycle under a low power, long pulse laser beam. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.362222
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  • 2
    Electronic Resource
    Electronic Resource
    Evanescent-field amplification in Nd3+-doped fluoride planar waveguide (1996)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 69 (1996), S. 2012-2014 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Planar channel waveguides of rare-earth doped fluoride glass are demonstrated with single mode excitation and propagation losses below 3 dB/cm. The waveguide core was fabricated by Ag+–Na+ molten salt ion exchange process in a borosilicate glass (BGG31), and a Nd3+-doped ZBLAN glass was used as a cladding. A 0.45 dB signal amplification at 1.064 μm was observed in the fabricated 1 cm long waveguide, and a 0.9 dB amplification is expected at the emission peak (1.049 μm). Modeling results show 2.5 dB/cm potential gain with the improvement in surface flatness of ZBLAN glass. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.116863
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  • 3
    Electronic Resource
    Electronic Resource
    A patient with plaque-stage mycosis fungoides has successfully been treated with long-term administration of IFN-γ and has been in complete remission for more than 6 years (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary We report the successful treatment of a patient with plaque-stage mycosis fungoides with long-term and intravenous administration of recombinant human interferon-γ (IFN-γ) and discuss the possible mechanisms of this therapy.A 55-year-old female patient had been resistant to existing treatments and had suffered repeated exacerbations over a 5-year period. Four weeks after initiation of 2 × 106U/day of IFN-γ. a 〉 10% decrease in the affected surface area was noted. Twenty-two weeks after the administration of 228 × 106U of IFN-γ, complete remission (CR) was obtained. The CR continued for 13 weeks, but this was followed by an exacerbation. The second CR was obtained after the IFN-γ dosage was increased to 16 × 106U/week. The dosage was then gradually reduced by 2–4 × 106U every 2 or 3 months. She was treated with a total dose of 2814 × 106 of IFN-γ. She has been followed up for more than 6 years, and there has been no recurrence of mycotic skin lesions nor any visceral involvement. During therapy, no serious side-effects were noted.Long-term administration of IFN-γ is useful for the treatment of patients with intractable mycosis fungoides. A gradual decrease in the dose of IFN-γ is important for maintaining remission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.d01-752.x
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  • 4
    Electronic Resource
    Electronic Resource
    MR imaging enhancement with superparamagnetic iron oxidein chronic liver disease: influence of liver dysfunction andparenchymal pathology (1996)
    Springer
    Abdominal imaging 21 (1996), S. 318-323 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Superparamagnetic iron oxide—MR imaging, contrast agent—Liver cirrhosis, hepatocellular carcinoma.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Purpose: To analyze the influence of liver dysfunction and parenchymal pathology on the accumulation of superparamagnetic iron oxide (SPIO). Methods: We evaluated MR images of 13 patients having small hepatic neoplasms before and after administration of SPIO (10 μmol/kg). Biopsy and laboratory data confirmed the presence of severe cirrhosis in two patients, mild cirrhosis in four, chronic hepatitis in five, and normal livers in two. Degrees of liver dysfunction or liver parenchymal pathology were correlated with reductions in signal intensity of the liver and spleen after administration of SPIO. Signal intensity reduction was evaluated using a 1.5 Tesla MR unit. Results: Response to SPIO of the liver and spleen did not correlate with liver parenchymal pathology, although reductions in signal intensity of the liver were somewhat small in severely cirrhotic livers. There were slight correlations between signal intensity alterations of the liver and laboratory data such as the indocyanine green retention rate (correlation coefficient 0.47), albumin (0.36), total bilirubin (0.36), and serum glutamic oxaloacetic transaminase (GOT) (0.46). Signal intensity reduction of spleen did not correlate with liver function tests except for serum GOT. In patients with cirrhosis, heterogeneous structures were detected in the nontumorous portions of the liver. However, these did not prevent the diagnosis of small hepatomas. Conclusion: The uptake of SPIO showed some correlation with liver function but not with chronic liver parenchymal pathology. SPIO provided sufficient contrast between tumor and surrounding liver parenchyma among patients with chronic liver disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900072
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  • 5
    Electronic Resource
    Electronic Resource
    The Effect of Tamoxifen on Bone Metabolism and Skeletal Growth is Different in Ovariectomized and Intact Rats (1996)
    Springer
    Calcified tissue international 59 (1996), S. 271-276 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Antiestrogen — Biochemical markers — Bone mineral density — Osteocalcin — Pyridinoline.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. The effects of tamoxifen (TAM) treatment on bone metabolism and skeletal growth were studied in sexually mature intact or ovariectomized (OVX) rats. Experiment 1 was designed to observe the effects of TAM on bone metabolism and skeletal growth in intact rats and included two groups: (1) intact plus vehicle and (2) intact plus TAM. Experiment 2 was designed to investigate the effects of TAM on OVX rats and included the other two groups: (3) OVX plus vehicle and (4) OVX plus TAM. Serum calcium osteocalcin and urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) were measured serially before and after TAM treatment for 6 weeks in order to monitor bone turnover. Bone mineral density (BMD) and bone mineral content (BMC) of excised right femora and lumbar vertebrae were determined by dual energy X-ray absorptiometry (DXA). To examine the effect of TAM on skeletal growth, the conventional parameters of femora and the histology of right tibiae were also measured. TAM did not induce significant change in the biochemical markers in intact rats during the 6-week experiment. Bone mass and skeletal growth were not changed by TAM treatment in intact rats. However, TAM treatment reduced the increase in serum osteocalcin and urinary pyridinium cross-links from 1 week to 6 weeks postovariectomy in the OVX rats. TAM inhibited the skeletal growth in OVX rats, because TAM treatment shortened femoral length and decreased the cell number in the growth plate in OVX rats in this study. Our findings indicate that TAM exerts an effect of estrogen agonist on bone metabolism and skeletal growth in OVX rats, however, it does not affect them in intact rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900122
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  • 6
    Electronic Resource
    Electronic Resource
    MR signal intensity of the perirolandic cortex in the neonate and infant (1996)
    Springer
    Neuroradiology 38 (1996), S. 578-584 
    Details
    ISSN: 1432-1920
    Keywords: Key words Child's brain ; Magnetic resonance imaging ; Myelination ; Brain development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our purpose was to study the magnetic resonance (MR) signal intensity of the perirolandic gyri perinatally and to correlate it with the histological findings in formalin-fixed brains, focusing on myelination. MRI of 20 neurologically normal neonates and infants, of 37–64 weeks postconception (PCA), were studied retrospectively. We reviewed four formalin-fixed brains of infants 37–46 weeks PCA microscopically. The posterior cortex of the precentral gyrus (P-PRE) and the anterior cortex of the postcentral gyrus (A-PST) had different signal intensity from the adjacent surrounding cortex. On T 1-weighted images P-PRE and A-PST gave higher signal 41–44 weeks PCA; on T 2-weighted images, they gave lower signal 37–51 weeks PCA. Histological examination revealed very little myelination of the nerve fibres within both the P-PRE and the A-PST, while considerable myelination was present in the internal capsule and central corona radiata. The changes in signal intensity in the perirolandic gyri may reflect not only the degree of myelination but also the more advanced development of the nerve cells, associated with rapid proliferation and formation of oligodendroglial cells, synapses and dendrites. They could be another important landmark for brain maturation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00626104
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  • 7
    Electronic Resource
    Electronic Resource
    MR signal intensity of the perirolandic cortex in the neonate and infant (1996)
    Springer
    Neuroradiology 38 (1996), S. 578-584 
    Details
    ISSN: 1432-1920
    Keywords: Child's brain ; Magnetic resonance imaging ; Myelination ; Brain development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our purpose was to study the magnetic resonance (MR) signal intensity of the perirolandic gyri perinatally and to correlate it with the histological findings in formalinfixed brains, focusing on myelination. MRI of 20 neurologically normal neonates and infants, of 37–64 weeks postconception (PCA), were studied retrospectively. We reviewed four formalin-fixed brains of infants 37–46 weeks PCA microscopically. The posterior cortex of the precentral gyrus (P-PRE) and the anterior cortex of the postcentral gyrus (A-PST) had different signal intensity from the adjacent surrounding cortex. On T1-weighted images P-PRE and A-PST gave higher signal 41–44 weeks PCA; on T2-weighted images, they gave lower signal 37–51 weeks PCA. Histological examination revealed very little myelination of the nerve fibres within both the P-PRE and the A-PST, while considerable myelination was present in the internal capsule and central corona radiata. The changes in signal intensity in the perirolandic gyri may reflect not only the degree of myelination but also the more advanced development of the nerve cells, associated with rapid proliferation and formation of oligodendroglial cells, synapses and dendrites. They could be another important landmark for brain maturation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00626104
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  • 8
    Electronic Resource
    Electronic Resource
    Chronic dexamethasone administration decreases noradrenaline-stimulated, but not serotonin-stimulated, phosphoinositide metabolism in the rat brain (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 353 (1996), S. 616-620 
    Details
    ISSN: 1432-1912
    Keywords: Key words Dexamethasone ; Glucocorticoids ; Phosphoinositide metabolism ; α1-Adrenoceptors ; 5-HT2-receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The present study was undertaken to investigate the effects of chronic administration of dexamethasone on the noradrenaline- and serotonin-stimulated (5-HT-stimulated) phosphoinositide metabolism in hippocampus and frontal cortex of the rat brain. For determination of phosphoinositide metabolism, slices from selected regions of the rat brain (hippocampus or frontal cortex) were loaded with myo- [3H] inositol and stimulated with the agonists (noradrenaline or 5-HT) in the presence of LiCl (7.5 mM). Administration of dexamethasone (1 mg/kg/day) every 2nd day for 14 days markedly reduced the noradrenaline-stimulated phosphoinositide metabolism in the rat hippocampus (IP1: 60% of the control value). In the rat frontal cortex, the noradrenaline-stimulated phosphoinositide metabolism was less depressed by the chronic administration of dexamethasone (IP1: 84% of the control value). However, the chronic administration of dexamethasone did not affect the 5-HT-stimulated phosphoinositide metabolism in the rat brain. The binding characteristics of α1-adrenoceptors and 5-HT2A receptors were unaffected by the chronic treatment with dexamethasone. These results indicate that chronic administration of dexamethasone induces regional and neurotransmitter-specific changes of phosphoinositide metabolism in rat brain. The results suggest that the reduction of noradrenaline-stimulated phosphoinositide metabolism is due to modification of the intracellular signal transduction system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167180
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  • 9
    Electronic Resource
    Electronic Resource
    Radiology in Japan (1996)
    Springer
    European radiology 6 (1996), S. 104-104 
    Details
    ISSN: 1432-1084
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00619973
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  • 10
    Electronic Resource
    Electronic Resource
    Randomized study of immediate and delayed adverse reactions to iotrolan and non-ionic monomers (1996)
    Springer
    European radiology 6 (1996), S. S14 
    Details
    ISSN: 1432-1084
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00556672
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