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  • 1
    Electronic Resource
    Electronic Resource
    Mycobacterium kanasii infection limited to skin and lymph node in a patient with AIDS (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 15 (1990), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The case of a 36-year-old HIV-1-positive patient is presented. After an episode of Pneumocystis carinii pneumonia and cytomegalovirus retinitis a pruritic lesion developed on the thigh with subsequent intracutaneous abscess formation and regional lymph-node enlargement. Mycabacterium kansasii was demonstrated in lymph-node and abscess material. With a tuberculostatic triple-drug regimen the lesions resolved completely. Cutaneous involvement in the course of non-tuberculous mycobacterium in the acquired immunodeficiency syndrome is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1990.tb02144.x
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  • 2
    Electronic Resource
    Electronic Resource
    Beeinflussung von Gasaustausch und Metabolismus durch unterschiedliche Hämodialyseverfahren (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 806-813 
    Details
    ISSN: 1432-1440
    Keywords: Acetatehemodialysis ; Bicarbonatehe-modialysis ; Pulmonary gasexchange ; Cardiopulmonary instability ; pCO2 in dialysate ; Hypoxia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We compared the effects of various dialysate composition on pulmonary and transdialyzer gas exchange in patients during hemodialysis. Under acetate hemodialysis there was a permanent loss of CO2 (45–68 ml/min) into the dialysate resulting in a significant decrease of arterial pO2, which can be explained by a reduced alveolar ventilation. The pulmonary oxygen uptake increased up to +20% during treatment, reflecting rising energy metabolism and possibly increased cardiopulmonary instability. Using different concentrates for bicarbonatehemodialysis we saw a moderate to clinical relevant uptake of CO2 (40–60 ml/min) from the dialysate into the blood of the patients, cause the pCO2 in the dialysate varied between 45 and 115 mmHg. Bicarbonate hemodialysis with high pCO2-levels in the dialysate led to hyperventilation and markedly increased oxygen consumption. In critically ill hemodialysis patients the pathophysiologic effects on pulmonary gas exchange of either acetatehemodialysis and bicarbonatehemodialysis with high pCO2 can explain the higher incidence of severe complications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01796270
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  • 3
    Electronic Resource
    Electronic Resource
    Visceral leishmaniasis in an HIV-infected patient: Clinical features and response to treatment (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 793-796 
    Details
    ISSN: 1432-1440
    Keywords: Leishmaniasis ; HIV infection ; AIDS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report the case of 43-year-old homosexual patient with HIV infection and a history of travel to the Far East in whom visceral leishmaniasis was the first infectious complication. Symptoms were fever, malaise, weight loss, hepatosplenomegaly, generalized lymphadenopathy, and oral thrush. Laboratory abnormalities included a slight elevation of liver enzymes, impairment of liver function tests, leukocytopenia, anemia, hypergammaglobulinemia, and markedly depressed CD4 + -cell counts. Despite initially successful treatment with pentavalent antimony, a relapse of leishmaniasis occurred after 7 months. Eradication of the infection was not achieved. Treatment was continued as a palliative chronic suppressive treatment with fortnightly pentamidine infusions. The clinical course was complicated by legionella pneumonia and the development of rapidly progressing Kaposi's sarcoma. The case is presented in detail, and the influence of HIV infection on the course of leishmaniasis is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01744270
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  • 4
    Electronic Resource
    Electronic Resource
    A novel variety of atypical pneumocystis carinii infection after long-term prophylactic pentamidine inhalation in an AIDS patient: large lower lobe pneumocystoma (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 310-313 
    Details
    ISSN: 1432-1440
    Keywords: HIV infection ; AIDS ; Pneumocystis carinii pneumonia ; Pentamidine inhalation ; Prophylaxis ; Pneumocystoma ; Nodular infiltrates ; Pulmonary masses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Atypical pulmonary manifestations of Pneumocystis carinii infection and fair numbers of extrapulmonary and disseminated infections have lately been documented in patients with human immunodeficiency virus infection treated prophylactically with inhalative pentamidine. We report the case of a 32-year-old homosexual patient who was assessed for complaints of night sweats, weight loss, and progressive malaise. The patient denied any respiratory tract symptoms such as cough, sputum production, pleuritic chest pain, or shortness of breath. Chest X-ray revealed two large round noncavitating lesions in the lower lobe of the right lung. Pneumocystomas were diagnosed by fine-needle aspiration. A 3-week course of intravenous high-dose cotrimoxazole resulted in amelioration of symptoms but no change in the radiographic appearance of the pulmonary lesions. Four months later the patient is alive and stable and is being treated with pentamidine inhalation of 300 mg per 2 weeks and two tablets of pyrimethamine sulfadoxine per week.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00184733
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  • 5
    Electronic Resource
    Electronic Resource
    The prognostic value of hypocholesterolemia in hospitalized patients (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 939-943 
    Details
    ISSN: 1432-1440
    Keywords: Hypocholesterolemia ; Hospital mortality ; Prognostic parameter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clinical observations show that severe illness often leads to hypocholesterolemia. To verify this finding and to define the relationship between serum cholesterol and a patient's prognosis, a study was conducted in two large hospital populations. Of 24,000 and 61,463 adult patients (populations I and II) an average of 3.8% and 3.6% died in hospital, respectively. The mean serum cholesterol levels of patients who died was significantly lower than that of those who survived (163.6 mg/dl versus 217.8 mg/dl;P 〈 0.0001). The average cholesterol of surviving patients was similar to that of 6,543 healthy controls. During hospitalization serum cholesterol levels of ≤ 100 mg/dl were encountered in 1.2% and 3.6% of patients of populations I and II, respectively. The mortality of these hypocholesterolemic patients was about tenfold higher than average and showed a strong, inverse, linear relationship with serum cholesterol concentrations. Patients whose serum cholesterol level dropped to less than 45 mg/dl did not survive. These data show that in severely ill patients serum cholesterol may decline to very low concentrations, and the prognosis is reflected by the degree of hypocholesterolemia, which thus may serve as a clinically useful prognostic parameter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00577732
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  • 6
    Electronic Resource
    Electronic Resource
    Pneumococcal parotitis and cervical lymph node abscesses in an HIV-infected patient (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 1037-1040 
    Details
    ISSN: 1432-1440
    Keywords: Human immunodeficiency virus infection ; Streptococcus pneumoniae ; Parotitis ; Lymph node abscess ; Cotrimoxazole
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The case of a 33-year-old patient with rapid onset of bilateral parotid gland and lymph node abscesses is described. The patient was positive for human immunodeficiency virus 1 and presented with a history of interstitial lymphocytic pneumonia and pneumococcal meningitis prior to admission. The patient received cotrimoxazole as primary prophylaxis againstPneumocystis carinii pneumonia. Fine needle aspiration from the abscesses yieldedStreptococcus pneumoniae. Penicillin G treatment in combination with surgical drainage of the lesions led to healing with minimal residual lymph node enlargement. No relapse was noted until 12 months after presentation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00577751
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  • 7
    Electronic Resource
    Electronic Resource
    Successful treatment ofToxoplasma gondii myocarditis in an AIDS patient (1994)
    Springer
    European journal of clinical microbiology & infectious diseases 13 (1994), S. 500-504 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Central nervous system disease due toToxoplasma gondii is a common cause of morbidity and mortality in patients with the acquired immunodeficiency syndrome. Cardiac toxoplasmosis, however, has been described in only a limited number of cases. In a 45-year-old patient with symptoms suggestive of myocarditis,Toxoplasma gondii was detected in myocardial tissue obtained by biopsy. After the institution of appropriate antiprotozoal therapy, the patient recovered. This patient is believed to be the first patient to survive biopsy-proven myocarditis caused byToxoplasma gondii. Cardiac toxoplasmosis should be ruled out in HIV-infected patients presenting with high fever and/or cardiorespiratory symptoms and exhibiting serologic evidence of prior exposure toToxoplasma gondii as determined by a positive IgG EIA, especially if the CD4+ count is low and no systemicPneumocystis carinii pneumonia prophylaxis has been administered. A high index of clinical suspicion and, if necessary, invasive diagnostic tests, including myocardial biopsies, are most important in making the correct diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01974642
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  • 8
    Electronic Resource
    Electronic Resource
    Herpes simplex virus type-2 ulcers resistant to acyclovir in an AIDS patient — Successful treatment with foscarnet (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 274-278 
    Details
    ISSN: 1432-1440
    Keywords: Herpes simplex virus ; Acyclovir resistance ; Foscarnet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The case of a 25-year-old homosexual man with large inguinal and perianal ulcers is reported. He had been pretreated extensively with acyclovir. Herpes simplex virus (HSV) was identified in the ulcer tissue byin-situ hybridization. No clinical improvement with acyclovir but a prompt response to foscarnet was noted. In a relapse after 11 weeks an acyclovir-resistant HSV type 2 was isolated. Again, a prompt response to foscarnet was noted. The case is presented in detail, and the clinical impact of resistance of HSV to acyclovir is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01666854
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  • 9
    Electronic Resource
    Electronic Resource
    Book reviews (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 451-451 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180058
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  • 10
    Electronic Resource
    Electronic Resource
    Antiviral and immunological effects of escalating low doses of zidovudine in HIV-positive patients (1993)
    Springer
    European journal of clinical microbiology & infectious diseases 12 (1993), S. 618-621 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty-eight patients with different stages of HIV infection who had not undergone antiretroviral pretreatment were treated with an escalating dose regimen of zidovudine (4 weeks 2 × 50 mg, 4 weeks 2×100 mg, 4 weeks 2×250 mg). CD4+ cell counts and p24 antigen levels were monitored every four weeks. Twenty-one patients were evaluable. p24 antigen levels showed a significant decrease after four weeks (p〈0.01, Sign test, Wilcoxon matched pairs test) that was sustained until week 12 without a further significant decrease. CD4+ cell counts increased significantly within the first four weeks (p〈0.01, Sign test, Wilcoxon matched pairs test). This increase was sustained until week 12 but no further significant increase was noted. Mean corpuscular erythrocyte volume values increased significantly after week 4 and continued to rise until week 12. These results demonstrate antiretroviral activity of a very low zidovudine dose, however low doses should not be used for treatment unless the clinical efficacy is shown to be equivalent to that of standard doses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01973641
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