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  • 1
    Electronic Resource
    Electronic Resource
    A preparation from bovine colostrum in the treatment of HIV-positive patients with chronic diarrhea (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 42-45 
    Details
    ISSN: 1432-1440
    Keywords: AIDS ; Diarrhea ; Bovine colostrum ; Cryptosporidiosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a prospective, open, uncontrolled study 25 patients infected with the human immunodeficiency virus with chronic refractory diarrhea and either confirmed cryptosporidiosis (n=7) or absence of demonstrable pathogenic organisms (n =18) were treated with a daily oral dose of 10 g of an immunoglobulin preparation from bovine colostrum over a period of 10 days. Among the 7 patients with cryptosporidiosis, this treatment led to complete remission in 3 and partial remission in 2. Among the 18 patients with diarrhea and negative stool culture, complete remission of diarrhea was obtained in 7 and partial remission in 4. In the remaining 2 patients with cryptosporidiosis and the 7 patients with diarrhea but no demonstrable pathogens treatment produced no significant improvement of the diarrhea. Subsequent doubling of the Lactobin dose (2 × 10 g daily) in 8 of the nonresponders led to complete remission in one case and at least partial remission in a further 4 patients. Treatment of refractory diarrhea with 10 g immunoglobulins from bovine colostrum per day constitutes an important therapeutic approach and led to complete (40%) or partial (24%) remission of diarrhea in 64% of the patients described here.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210962
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  • 2
    Electronic Resource
    Electronic Resource
    Treatment of atypical leishmaniasis with interferon γ resulting in progression of Kaposi's sarcoma in an AIDS patient (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 1041-1047 
    Details
    ISSN: 1432-1440
    Keywords: Acquired immunodeficiency syndrome ; Human immunodeficiency virus ; Leishmania donovanii ; Visceral leishmaniasis ; Kala-azar ; Intestinal pathogens ; Kaposi's sarcoma ; Parasites ; Parasitic pathogens ; Interferon-γ
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Visceral leishmaniasis (kala-azar) affecting HIV-infected patient is being reported in increasing frequency. A 40-year-old German bisexual patient with full-blown AIDS is described who presented with Kaposi's sarcoma, epigastric pain, diarrhea, and weight loss but without fever.Leishmania amastigotes were initially found in biopsies from stomach, duodenum, and a cutaneous Kaposi's sarcoma lesion but were later also recovered from bone marrow and lymph node. The patient received three courses of a combination of pentavalent antimony and interferon-γ. In addition to the common side effects such as fever, thrombocytopenia, and elevated amylase and lipase, a vivid progression of the Kaposi's sarcoma was noted. Tumor progression was temporally closely associated with treatment with interferon-γ. Because this phenomemon has also been observed in other patients, we advise caution when using interferon-γ in patients with Kaposi's sarcoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00577752
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  • 3
    Electronic Resource
    Electronic Resource
    A novel variety of atypical pneumocystis carinii infection after long-term prophylactic pentamidine inhalation in an AIDS patient: large lower lobe pneumocystoma (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 310-313 
    Details
    ISSN: 1432-1440
    Keywords: HIV infection ; AIDS ; Pneumocystis carinii pneumonia ; Pentamidine inhalation ; Prophylaxis ; Pneumocystoma ; Nodular infiltrates ; Pulmonary masses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Atypical pulmonary manifestations of Pneumocystis carinii infection and fair numbers of extrapulmonary and disseminated infections have lately been documented in patients with human immunodeficiency virus infection treated prophylactically with inhalative pentamidine. We report the case of a 32-year-old homosexual patient who was assessed for complaints of night sweats, weight loss, and progressive malaise. The patient denied any respiratory tract symptoms such as cough, sputum production, pleuritic chest pain, or shortness of breath. Chest X-ray revealed two large round noncavitating lesions in the lower lobe of the right lung. Pneumocystomas were diagnosed by fine-needle aspiration. A 3-week course of intravenous high-dose cotrimoxazole resulted in amelioration of symptoms but no change in the radiographic appearance of the pulmonary lesions. Four months later the patient is alive and stable and is being treated with pentamidine inhalation of 300 mg per 2 weeks and two tablets of pyrimethamine sulfadoxine per week.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00184733
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  • 4
    Electronic Resource
    Electronic Resource
    Pneumococcal parotitis and cervical lymph node abscesses in an HIV-infected patient (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 1037-1040 
    Details
    ISSN: 1432-1440
    Keywords: Human immunodeficiency virus infection ; Streptococcus pneumoniae ; Parotitis ; Lymph node abscess ; Cotrimoxazole
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The case of a 33-year-old patient with rapid onset of bilateral parotid gland and lymph node abscesses is described. The patient was positive for human immunodeficiency virus 1 and presented with a history of interstitial lymphocytic pneumonia and pneumococcal meningitis prior to admission. The patient received cotrimoxazole as primary prophylaxis againstPneumocystis carinii pneumonia. Fine needle aspiration from the abscesses yieldedStreptococcus pneumoniae. Penicillin G treatment in combination with surgical drainage of the lesions led to healing with minimal residual lymph node enlargement. No relapse was noted until 12 months after presentation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00577751
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  • 5
    Electronic Resource
    Electronic Resource
    Mycobacterium kanasii infection limited to skin and lymph node in a patient with AIDS (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 15 (1990), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The case of a 36-year-old HIV-1-positive patient is presented. After an episode of Pneumocystis carinii pneumonia and cytomegalovirus retinitis a pruritic lesion developed on the thigh with subsequent intracutaneous abscess formation and regional lymph-node enlargement. Mycabacterium kansasii was demonstrated in lymph-node and abscess material. With a tuberculostatic triple-drug regimen the lesions resolved completely. Cutaneous involvement in the course of non-tuberculous mycobacterium in the acquired immunodeficiency syndrome is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1990.tb02144.x
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  • 6
    Electronic Resource
    Electronic Resource
    Risk factors for severe disease due to Toxoplasma gondii in HIV-positive patients (1993)
    Springer
    European journal of epidemiology 9 (1993), S. 633-637 
    Details
    ISSN: 1573-7284
    Keywords: Toxoplasmosis ; HIV infection ; Risk factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objective of this study was to assess the risk of toxoplasmosis in HIV-positive subjects as a basis for primary prophylaxis. A retrospective chart review of 400 consecutive patients was carried out and clinical and laboratory markers at first presentation and follow-up data on the occurrence of toxoplasmosis were recorded. Independent variables were identified, laboratory parameters were stratified, and estimates for the risk of toxoplasmosis and the impact of different variables on its occurrence were made using conventional statistical methods. An increased risk of toxoplasmosis was strongly associated with a positive Toxoplasma gondii IgG EIA in conjunction with a CD4+ cell cont below 0.15/nl (the estimated risk of toxoplasmosis was 20% and 35% after 12 and 24 months, respectively) or a history of one or more opportunistic infections (the estimated risk was 12% and 30% after 12 and 24 months, respectively). Toxoplasma gondii-seropositive patients with CD4+ cell counts below 0.15/nl and those with antecedent opportunistic infections are most likely to develop toxoplasmosis and thus might benefit from primary prophylaxis. The risk of disease probably outweighs the risk of medication in these subjects. Prospective clinical trials are needed to define the optimal choice of drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00211438
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  • 7
    Electronic Resource
    Electronic Resource
    Visceral leishmaniasis in an HIV-infected patient: Clinical features and response to treatment (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 793-796 
    Details
    ISSN: 1432-1440
    Keywords: Leishmaniasis ; HIV infection ; AIDS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report the case of 43-year-old homosexual patient with HIV infection and a history of travel to the Far East in whom visceral leishmaniasis was the first infectious complication. Symptoms were fever, malaise, weight loss, hepatosplenomegaly, generalized lymphadenopathy, and oral thrush. Laboratory abnormalities included a slight elevation of liver enzymes, impairment of liver function tests, leukocytopenia, anemia, hypergammaglobulinemia, and markedly depressed CD4 + -cell counts. Despite initially successful treatment with pentavalent antimony, a relapse of leishmaniasis occurred after 7 months. Eradication of the infection was not achieved. Treatment was continued as a palliative chronic suppressive treatment with fortnightly pentamidine infusions. The clinical course was complicated by legionella pneumonia and the development of rapidly progressing Kaposi's sarcoma. The case is presented in detail, and the influence of HIV infection on the course of leishmaniasis is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01744270
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  • 8
    Electronic Resource
    Electronic Resource
    Herpes simplex virus type-2 ulcers resistant to acyclovir in an AIDS patient — Successful treatment with foscarnet (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 274-278 
    Details
    ISSN: 1432-1440
    Keywords: Herpes simplex virus ; Acyclovir resistance ; Foscarnet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The case of a 25-year-old homosexual man with large inguinal and perianal ulcers is reported. He had been pretreated extensively with acyclovir. Herpes simplex virus (HSV) was identified in the ulcer tissue byin-situ hybridization. No clinical improvement with acyclovir but a prompt response to foscarnet was noted. In a relapse after 11 weeks an acyclovir-resistant HSV type 2 was isolated. Again, a prompt response to foscarnet was noted. The case is presented in detail, and the clinical impact of resistance of HSV to acyclovir is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01666854
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  • 9
    Electronic Resource
    Electronic Resource
    A case of disseminatedMycobacterium bovis infection in an AIDS patient (1995)
    Springer
    European journal of clinical microbiology & infectious diseases 14 (1995), S. 226-229 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The first case of disseminatedMycobacterium bovis infection with meningitis in an AIDS patient is reported. A 54-year-old male HIV-positive patient was admitted for evaluation of fever, weight loss, inappetence, fatigue and malaise.Mycobacterium bovis (non-BCG) was isolated from blood, bone marrow, stool, urine, sputum, abdominal lymph nodes and cerebrospinal fluid. Antituberculous therapy using a five-drug regimen plus steroids resulted in complete recovery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02310361
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  • 10
    Electronic Resource
    Electronic Resource
    Successful treatment ofToxoplasma gondii myocarditis in an AIDS patient (1994)
    Springer
    European journal of clinical microbiology & infectious diseases 13 (1994), S. 500-504 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Central nervous system disease due toToxoplasma gondii is a common cause of morbidity and mortality in patients with the acquired immunodeficiency syndrome. Cardiac toxoplasmosis, however, has been described in only a limited number of cases. In a 45-year-old patient with symptoms suggestive of myocarditis,Toxoplasma gondii was detected in myocardial tissue obtained by biopsy. After the institution of appropriate antiprotozoal therapy, the patient recovered. This patient is believed to be the first patient to survive biopsy-proven myocarditis caused byToxoplasma gondii. Cardiac toxoplasmosis should be ruled out in HIV-infected patients presenting with high fever and/or cardiorespiratory symptoms and exhibiting serologic evidence of prior exposure toToxoplasma gondii as determined by a positive IgG EIA, especially if the CD4+ count is low and no systemicPneumocystis carinii pneumonia prophylaxis has been administered. A high index of clinical suspicion and, if necessary, invasive diagnostic tests, including myocardial biopsies, are most important in making the correct diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01974642
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