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  • 1
    Electronic Resource
    Electronic Resource
    Epistasis in Maize (Zea mays L.) III. Comparison of Single and Three-Way Crosses for Forage Traits (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 98 (1987), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The importance of epistasis for forage performance and quality traits was studied in early maturing European maize (Zea mays L.) breeding materials. Sixty-six three-way crosses (3W), 33 of the flint x (dent · dent) and 33 of the dem × (flint · flint) type, were compared with the mean of their respective non-parental single crosses (〈inlineGraphic alt="inline image" href="urn:x-wiley:01799541:PBR185:PBR_185_mu1" location="equation/PBR_185_mu1.gif" extraInfo="missing"/〉) using data obtained in six environments. For each of the 11 traits examined, at least 6 out of the 66 three-way crosses displayed significant (P 〈 0.05) epistatic deviations, calculated as 〈inlineGraphic alt="inline image" href="urn:x-wiley:01799541:PBR185:PBR_185_mu1" location="equation/PBR_185_mu1.gif" extraInfo="missing"/〉– 3W. Averaged over crosses and environments, epistatic deviations were highly significant (P 〈 0,31] for 8 trails, but of minor importance except for grain yield. In general, the variance of epistatie deviations was appreciably smaller than the variance of genotype × environment interactions. Highly significant correlations occurred among epistatie deviations for silking date, dry matter content of ear, and dry matter yield of grain and stover. The reliability of predicting the performance of three-way crosses from 2W as opposed to assessing them directly was investigated as a function of the number of test environments. Disturbing e fleets of epistasis on prediction only became important under intense testing (〉 3 or 4 environments), With fewer test environments, both procedures were almost equivalent, due to a smaller influence of genotype × environment interaction on the 〈inlineGraphic alt="inline image" href="urn:x-wiley:01799541:PBR185:PBR_185_mu1" location="equation/PBR_185_mu1.gif" extraInfo="missing"/〉 values, Epistasis is concluded to be of minor importance with regard to the optimum type of hybrid for forage use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0523.1987.tb01115.x
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  • 2
    Electronic Resource
    Electronic Resource
    Cushing-Syndrom — ein Leitsymptom bei Bronchuskarzinoid (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 314-322 
    Details
    ISSN: 1432-1440
    Keywords: Ectopic ACTH production ; Peripheral bronchial carcinoid ; Cushing's syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bilateral adrenalectomy was performed in a 27-year-old male because of Cushing's syndrome. After 7 years a peripheral bronchial carcinoid was diagnosed; ACTH values went back to normal only after removal of the carcinoid. In the literature, there are 31 case reports on bronchial carcinoids associated with Cushing's syndrome. The Cushing's syndrome precedes the diagnosis of a tumor for months to years in at least half of the cases. Most of these patients first underwent adrenalectomy and/or hypophysectomy for their primarily endocrine symptoms and signs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727520
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  • 3
    Electronic Resource
    Electronic Resource
    Investigations of the estrogen (ER-ICA-test) and the progesterone receptor in the prostate and prostatic carcinoma on immunohistochemical basis (1988)
    Springer
    Virchows Archiv 412 (1988), S. 387-391 
    Details
    ISSN: 1432-2307
    Keywords: Estrogen ; Progesterone receptor ; Immunohistochemistry ; Prostate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Estrogen (ER) and Progesterone receptors (PR) were demonstrated immunohistochemically on frozen sections from 11 prostatectomy and 7 cystoprostatectomy specimens in the nuclei of various cell types. The periglandular fibrocytes and smooth muscle cells were extensively positive, the interglandular stromal cells were only partly so. Normal basal cells stained focally positive, hyperplastic basal cells stained extensively. The glandular secretory epithelium and atrophic glands were negative. The same findings were obtained in hyperplastic nodules. Both ER and PR also occurred in the urothelium of central prostatic ducts and of the prostatic urethra. The fibrous stroma around the ejaculatory ducts and seminal vesicles was extensively positive while the epithelium was negative. The smooth musculature of the seminal vesicles was only partly positive. On large field sections, the ER as well as the PR were numerically equally distributed throughout the inner zone of the prostate and the prostate proper. 12 prostatic carcinomas (G I–G III) were ER- and PR-negative. Estrogens may contribute to nodular hyperplasia by triggering a stromal proliferation with a secondary inductive epithelial growth. Obviously they do not act directly on prostatic carcinoma but inhibit growth via the hypophyseal-testicualr axis. The biological significance of the PR in the prostate is unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00750267
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  • 4
    Electronic Resource
    Electronic Resource
    Islet transplantation with 15-Deoxyspergualin (1987)
    Springer
    Diabetologia 30 (1987), S. 678-678 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00277329
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  • 5
    Electronic Resource
    Electronic Resource
    Prolongation of graft survival in allogeneic islet transplantation by (−) 15-deoxyspergualin in the rat (1987)
    Springer
    Diabetologia 30 (1987), S. 38-40 
    Details
    ISSN: 1432-0428
    Keywords: 15-Deoxyspergualin ; pancreatic islets ; graft survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of 15-Deoxyspergualin, a novel drug which has been described to have anti-tumour activity, on allogeneic graft survival (Dark Agouti ⇀ Lewis rats) after pancreatic islet transplantation was tested. A marked prolongation of graft survival could be shown using doses of 1.0, 2.5 and 5.0mg Deoxyspergualin/kg on day 0 until day +9 post transplantation. A maximum of 55.6 days (average) survival time was observed using 2.5mg/kg Deoxyspergualin compared to 5.2±0.6 days without immunosuppression. Using the chemiluminescence reaction of recipient monocytes after islet transplantation, a marked suppression of the monocyte system exceeding the treatment period could be observed. Since, in contrast to cyclosporin, B-cell toxicity could not be shown, the new drug seems to be a hopeful step towards successful allogeneic islet transplantation for treatment of diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01788905
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  • 6
    Electronic Resource
    Electronic Resource
    Increased detectability of somatic changes in the DNA from human tumours after probing with “synthetic” and “genome-derived” hypervariable multilocus probes (1989)
    Springer
    Human genetics 〈Berlin〉 84 (1989), S. 35-40 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary DNA fingerprinting with two minisatellite (33.15, M13) and two simple repeat probes [(GACA)4, (CAC)4/ (GTG)5] was performed to screen for somatic changes in the DNA from various solid human tumours in comparison with constitutional DNA from the same patient. Loss of bands or changes in band intensitities were observed. Together the probes 33.15 and (CAC)5/(GTG)5 detected deviating fingerprint patterns in 63% of the colorectal carcinomas investigated. In mammary and stomach carcinomas, only 1/11 and 2/11 tumours, respectively, showed differences with either of the three probes, 33.15, (GACA)4 and (CAC)5/(GTG)5.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210667
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  • 7
    Electronic Resource
    Electronic Resource
    Optimum prediction of three-way crosses from single crosses in forage maize (Zea mays L.) (1987)
    Springer
    Theoretical and applied genetics 74 (1987), S. 339-345 
    Details
    ISSN: 1432-2242
    Keywords: Epistasis ; Genotype x environment inter-actions ; Forage maize breeding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Three-way cross means were predicted with formulae involving linear functions of general (GCA) and specific combining ability (SCA) effects estimated from single-cross factorials between genetically divergent populations. Data from an experiment with 66 single-cross and 66 three-way cross forage maize (Zea mays L.) hybrids was used for comparing the prediction formulae. The genotypic correlation (r) between observed and predicted three-way crosses increased with increasing χ, the weighting factor of SCA effects, for plant height and ear dry matter (DM) content. It displayed slightly convex curves for total and stover DM yield, ear percentage, and metabolizable energy content of stover. For Jenkins' method B, r was considerably less than 1.0 for all traits, indicating the presence of epistasis. The square root of heritability (hĜ) of the predicted means decreased with increasing χ, the reduction being small with a greater number of test environments. Using the product r·hĜ as a criterion of efficiency, none of the prediction methods was consistently superior and the differences among them were rather small (〈 7.5%) for all traits, irrespective of the number of test environments. We recommend evaluating the GCA of a greater number of lines from each parent population in testcrosses with a small number of elite lines from the opposite population. All possible three-way or double crosses between both sets of lines should be predicted by Jenkins's method C. This procedure allows one to select with a higher intensity among the predicted hybrids and thus should increase the genetic gain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274716
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  • 8
    Electronic Resource
    Electronic Resource
    334. Temporäre occlusion des pankreasganges mit einem modifizierten fibrinkleber (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 944-945 
    Details
    ISSN: 1435-2451
    Keywords: Pancreatic autotransplantation ; Temporary duct occlusion ; Fibrin sealant ; Aprotinin ; Pankreasautotransplantation ; Temporäre Gangblockade ; Fibrinocclusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach Pankreaskopfresektionen bzw. nach Pankreasautotransplantationen am Schwein wurde der Pankreasgang mit einem modifizierten Fibrinkleber verschlossen. Die Fibrinocclusion erzeugt keine Pankreatitis. Die exokrine Akivität des Organs kann bis zu drei Tagen unterbrochen werden. Diese Zeitspanne genügt für ein ungestörtes Einheilen von Pankreasanastomosen. Langzeitbeobachtungen zeigen eine ungestörte Funktionstüchtigkeit des endokrinen und des exokrinen Pankreas. Diese neue Technik verbindet die Vorteile der Gangocclusion mit denen der Gangdrainage.
    Notes: Summary The pancreatic duct of pigs was occluded with a modified fibrin glue following resection of the head of the pancreas or autotransplantation of the left pancreatic segment. Occlusion with liquid fibrin glue did not induce pancreatitis. Following the injection, the exocrine activity was interrupted for 3 days. This allowed time for healing of the pancreas anastomoses to the gut to occur. Three months later, all animals had normal exocrine and endocrine activities. This new technique combines the advantages of permanent duct occlusion with those of duct drainage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298119
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  • 9
    Electronic Resource
    Electronic Resource
    362. Ein neues Modell der autologen Pankreastransplantation am Schwein. Induktion des Diabetes durch regionale Streptozotocinapplikation (1986)
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 865-866 
    Details
    ISSN: 1435-2451
    Keywords: Segmental pancreatic autotransplantation ; Regional streptozotocin application ; Pankreasautotransplantation ; Regionale Streptozotocinapplikation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir entwickelten ein neues Modell der autologen Pankreastransplantation am Schwein. Das linke Pankreassegment wird als Transplantat entnommen, während der Pankreaskopf verbleibt und die exokrine Funktion aufrechterhält. Sein endokriner Anteil wird über eine regionale Streptozotocinapplikation ausgeschaltet. Das Autotransplantat wird an die Iliacagefäße angeschlossen und je nach Protokoll mit einer Jejunostomie bzw. mit Ethibloc® versorgt. In diesem neuen Modell können alle technischen Fragen der Pankreastransplantation am diabetischen Tier unter Ausschluß von Abstoßungsvorgängen untersucht werden.
    Notes: Summary A new model of pancreatic autotransplantation was developed in pigs. The left pancreatic segment was removed and used as an autograft. The head of the pancreas was left in place in order to maintain normal exocrine function. Its endocrine part, however, was ablated by regional streptozotocin infusion into the pancreaticoduodenal artery. The autograft was transplanted onto the right iliac vessels and its exocrine part either occluded using Ethibloc® or anastomosed with a jejunal Roux-en-y-loop. In this new model, all technical problems of pancreatic transplantation can be investigated in a diabetic animal without interference as a result of rejection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274682
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