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  • 1
    Electronic Resource
    Electronic Resource
    Temperaturabhängigkeit von Stoffwechselgrößen in der perfundierten Rattenleber (1976)
    Springer
    Research in experimental medicine 168 (1976), S. 57-64 
    Details
    ISSN: 1433-8580
    Keywords: Liver perfusion ; hypothermia ; Q10 values of various metabolic processes ; activation energies ; Leberperfusion ; Hypothermie ; Q10-Werte verschiedener Stoffwechselprozesse ; Aktivierungsenergien
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Experimente mit perfundierten Rattenlebern haben gezeigt, daß verschiedene Stoffwechselprozesse (Glycolyse, Fructolyse, Glycogenolyse, Ketogenese, CO2-Produktion, oxydative Pyruvatdecarboxylierung, Gluconeogenese) eine unterschiedliche Temperaturabhängigkeit haben. Diese Temperaturabhängigkeit kann sich außerdem bei Übergang in einen anderen Temperaturbereich ändern. Die Q10-Werte lagen zwischen 1, 7 und 25 und entsprechen in erster Näherung Aktivierungsenergien von 38 bis 216 kJ/Mol.
    Notes: Summary The temperature dependence of various metabolic processes (glycolysis, fructolysis, glycogenolysis, ketogenesis, CO2-production, oxidative decarboxylation of pyruvate and gluconeogenesis) was studied in perfused rat livers. The processes measured differed with respect to their temperature dependence. Moreover, the sensitivity towards changes in temperature differed depending on the temperature range. Q10 values were found between 1, 7 and 25 corresponding to values for activation energies between 38 and 216 kJoule/Mol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851733
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  • 2
    Electronic Resource
    Electronic Resource
    Pancreatic autotransplantation in the pig: variations in epigastric arterial blood supply (1989)
    Springer
    Transplant international 2 (1989), S. 193-198 
    Details
    ISSN: 1432-2277
    Keywords: Pancreas transplantation, in the pig ; Experimental pancreas transplantation, pig, anatomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A major problem in pancreatic autotransplantation is the vascular supply of the left segment, which serves as the graft. We therefore examined the arterial blood supply of the epigastric organs in 36 German landrace pigs. In 19 pigs (anatomical variation 1) there was a pancreatic branch of the splenic artery supplying the left segment. After splenectomy the splenic artery could be used as the graft-supplying vessel. In 14 pigs (anatomical variation 2) the arterial branch for the left segment was the first branch out of the hepatic artery distal to the coeliac trunk. In these cases a splenohepatic bypass was performed to ensure delivery of the blood to the epigastric organs. Thereafter, the proximal part of the hepatic artery could be used as the vessel supplying the graft. The left segment could not be used for autotransplantation in 3 pigs (anatomical variation 3) because of the atypical vascular supply. During the 6-month observation period, no malfunction of the epigastric organs was evident.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02414533
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  • 3
    Electronic Resource
    Electronic Resource
    334. Temporäre occlusion des pankreasganges mit einem modifizierten fibrinkleber (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 944-945 
    Details
    ISSN: 1435-2451
    Keywords: Pancreatic autotransplantation ; Temporary duct occlusion ; Fibrin sealant ; Aprotinin ; Pankreasautotransplantation ; Temporäre Gangblockade ; Fibrinocclusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach Pankreaskopfresektionen bzw. nach Pankreasautotransplantationen am Schwein wurde der Pankreasgang mit einem modifizierten Fibrinkleber verschlossen. Die Fibrinocclusion erzeugt keine Pankreatitis. Die exokrine Akivität des Organs kann bis zu drei Tagen unterbrochen werden. Diese Zeitspanne genügt für ein ungestörtes Einheilen von Pankreasanastomosen. Langzeitbeobachtungen zeigen eine ungestörte Funktionstüchtigkeit des endokrinen und des exokrinen Pankreas. Diese neue Technik verbindet die Vorteile der Gangocclusion mit denen der Gangdrainage.
    Notes: Summary The pancreatic duct of pigs was occluded with a modified fibrin glue following resection of the head of the pancreas or autotransplantation of the left pancreatic segment. Occlusion with liquid fibrin glue did not induce pancreatitis. Following the injection, the exocrine activity was interrupted for 3 days. This allowed time for healing of the pancreas anastomoses to the gut to occur. Three months later, all animals had normal exocrine and endocrine activities. This new technique combines the advantages of permanent duct occlusion with those of duct drainage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298119
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  • 4
    Electronic Resource
    Electronic Resource
    362. Ein neues Modell der autologen Pankreastransplantation am Schwein. Induktion des Diabetes durch regionale Streptozotocinapplikation (1986)
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 865-866 
    Details
    ISSN: 1435-2451
    Keywords: Segmental pancreatic autotransplantation ; Regional streptozotocin application ; Pankreasautotransplantation ; Regionale Streptozotocinapplikation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir entwickelten ein neues Modell der autologen Pankreastransplantation am Schwein. Das linke Pankreassegment wird als Transplantat entnommen, während der Pankreaskopf verbleibt und die exokrine Funktion aufrechterhält. Sein endokriner Anteil wird über eine regionale Streptozotocinapplikation ausgeschaltet. Das Autotransplantat wird an die Iliacagefäße angeschlossen und je nach Protokoll mit einer Jejunostomie bzw. mit Ethibloc® versorgt. In diesem neuen Modell können alle technischen Fragen der Pankreastransplantation am diabetischen Tier unter Ausschluß von Abstoßungsvorgängen untersucht werden.
    Notes: Summary A new model of pancreatic autotransplantation was developed in pigs. The left pancreatic segment was removed and used as an autograft. The head of the pancreas was left in place in order to maintain normal exocrine function. Its endocrine part, however, was ablated by regional streptozotocin infusion into the pancreaticoduodenal artery. The autograft was transplanted onto the right iliac vessels and its exocrine part either occluded using Ethibloc® or anastomosed with a jejunal Roux-en-y-loop. In this new model, all technical problems of pancreatic transplantation can be investigated in a diabetic animal without interference as a result of rejection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274682
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  • 5
    Electronic Resource
    Electronic Resource
    73. Gastroduodenale Ulcera im Kindesalter (1983)
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 405-407 
    Details
    ISSN: 1435-2451
    Keywords: Ulcerations in childhood ; Etiology ; Therapy ; Ulcus im Kindesalter ; Ätiologie ; Therapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ulcera im Kindesalter werden in den meisten Fällen erst mit dem Eintreten von Komplikationen, Blutung oder Perforation, erkannt. Am häufigsten sind Ulcerationen bei Risikoneugeborenen. Im Vorschulalter sind Ulcera am seltensten, während sie zur Pubertät hin wieder zunehmen. Schmerzen sind erst bei älteren Kindern pathognomisch. Wir berichten über 16 Fälle, 9 Kinder konnten konservativ behandelt werden, 7 Kinder mußten wegen Blutung, Perforation oder Versagen der konservativen Therapie operiert werden. Eine konservative Behandlung des Ulcusleidens sollte den Vorrang haben.
    Notes: Summary Peptic ulcerations of the stomach or the duodenum in childhood occur infrequently and are only recognized when perforations or hemorrhages occur. Peptic ulcerations are mostly seen in premature or sick infants. In preschool children ulcerations are seldom diagnosed, whereas in older children primary ulcerations are seen with increasing frequency. Pain becomes pathognomic only in older children. We report of 16 cases 7 of which had to be operated upon. Surgical treatment is only indicated in uncontrolled hemorrhage, perforations or failure of conservative therapy. Conservative treatment should include regular feeding, cimetidine and psycho-social therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01275898
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  • 6
    Electronic Resource
    Electronic Resource
    359. Gewebekonzentration von Doxorubicin in tumortragenden Rattenlebern nach hypothermer in vivo Perfusion (1986)
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 864-864 
    Details
    ISSN: 1435-2451
    Keywords: Hypothermic liver perfusion ; Cytotoxic drug ; Tissue concentration ; Hypotherme Leberperfusion ; Cytostaticaspiegel ; Walkertumore
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir untersuchten die Frage, ob es gelingt, mit einer hypothermen Leberperfusion therapeutisch wirksame Cytostaticakonzentrationen im Gewebe zu erzeugen. In Lebern von SD Ratten wurden durch direkte Zellinoculation Walker Tumore erzeugt. Die Lebern wurden in situ mit verschiedenen Konzentrationen von Doxorubicin hypotherm perfundiert. Die Konzentrationen im tumortragenden Gewebe korrelierten direkt mit der Perfusionsdauer und der Perfusatkonzentration. Die hypothermen Cytostaticaperfusionen haben einen deutlichen therapeutischen Effekt. Ein entscheidender Vorteil des vorgestellten hypothermen Verfahrens ist der geringere apparative Aufwand bei vergleichbarem therapeutischen Effekt.
    Notes: Summary We were interested whether hypothermic drug perfusion would yield an effective concentration of a cytotoxic drug in tumor-bearing rat livers. Walker tumors were inoculated by a single injection of diluted cells into one liver lobe. The livers were perfused in situ with various concentrations of doxorubicin. The concentrations found in the liver correlated well with the perfusion time and the drug concentration in the perfusate. The hypothermic isolated liver perfusions showed a marked therapeutic effect. A major advantage of this approach is the simplicity of the hypothermic perfusion device compared with normo- or hyperthermic devices with a similar therapeutic effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274679
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