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  • 1
    ISSN: 1432-2277
    Keywords: Pancreas transplantation, in the pig ; Experimental pancreas transplantation, pig, anatomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A major problem in pancreatic autotransplantation is the vascular supply of the left segment, which serves as the graft. We therefore examined the arterial blood supply of the epigastric organs in 36 German landrace pigs. In 19 pigs (anatomical variation 1) there was a pancreatic branch of the splenic artery supplying the left segment. After splenectomy the splenic artery could be used as the graft-supplying vessel. In 14 pigs (anatomical variation 2) the arterial branch for the left segment was the first branch out of the hepatic artery distal to the coeliac trunk. In these cases a splenohepatic bypass was performed to ensure delivery of the blood to the epigastric organs. Thereafter, the proximal part of the hepatic artery could be used as the vessel supplying the graft. The left segment could not be used for autotransplantation in 3 pigs (anatomical variation 3) because of the atypical vascular supply. During the 6-month observation period, no malfunction of the epigastric organs was evident.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 944-945 
    ISSN: 1435-2451
    Keywords: Pancreatic autotransplantation ; Temporary duct occlusion ; Fibrin sealant ; Aprotinin ; Pankreasautotransplantation ; Temporäre Gangblockade ; Fibrinocclusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach Pankreaskopfresektionen bzw. nach Pankreasautotransplantationen am Schwein wurde der Pankreasgang mit einem modifizierten Fibrinkleber verschlossen. Die Fibrinocclusion erzeugt keine Pankreatitis. Die exokrine Akivität des Organs kann bis zu drei Tagen unterbrochen werden. Diese Zeitspanne genügt für ein ungestörtes Einheilen von Pankreasanastomosen. Langzeitbeobachtungen zeigen eine ungestörte Funktionstüchtigkeit des endokrinen und des exokrinen Pankreas. Diese neue Technik verbindet die Vorteile der Gangocclusion mit denen der Gangdrainage.
    Notes: Summary The pancreatic duct of pigs was occluded with a modified fibrin glue following resection of the head of the pancreas or autotransplantation of the left pancreatic segment. Occlusion with liquid fibrin glue did not induce pancreatitis. Following the injection, the exocrine activity was interrupted for 3 days. This allowed time for healing of the pancreas anastomoses to the gut to occur. Three months later, all animals had normal exocrine and endocrine activities. This new technique combines the advantages of permanent duct occlusion with those of duct drainage.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1435-2451
    Keywords: Segmental pancreatic autotransplantation ; Regional streptozotocin application ; Pankreasautotransplantation ; Regionale Streptozotocinapplikation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir entwickelten ein neues Modell der autologen Pankreastransplantation am Schwein. Das linke Pankreassegment wird als Transplantat entnommen, während der Pankreaskopf verbleibt und die exokrine Funktion aufrechterhält. Sein endokriner Anteil wird über eine regionale Streptozotocinapplikation ausgeschaltet. Das Autotransplantat wird an die Iliacagefäße angeschlossen und je nach Protokoll mit einer Jejunostomie bzw. mit Ethibloc® versorgt. In diesem neuen Modell können alle technischen Fragen der Pankreastransplantation am diabetischen Tier unter Ausschluß von Abstoßungsvorgängen untersucht werden.
    Notes: Summary A new model of pancreatic autotransplantation was developed in pigs. The left pancreatic segment was removed and used as an autograft. The head of the pancreas was left in place in order to maintain normal exocrine function. Its endocrine part, however, was ablated by regional streptozotocin infusion into the pancreaticoduodenal artery. The autograft was transplanted onto the right iliac vessels and its exocrine part either occluded using Ethibloc® or anastomosed with a jejunal Roux-en-y-loop. In this new model, all technical problems of pancreatic transplantation can be investigated in a diabetic animal without interference as a result of rejection.
    Type of Medium: Electronic Resource
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