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  • 1
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1981)
    Springer
    Helgoland marine research 34 (1981), S. 507-522 
    Details
    ISSN: 1438-3888
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01995922
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1983)
    Springer
    Helgoland marine research 36 (1983), S. 473-483 
    Details
    ISSN: 1438-3888
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983461
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Tolbutamide does not alter insulin requirement in Type 1 (insulin-dependent) diabetes (1984)
    Springer
    Diabetologia 27 (1984), S. 8-12 
    Details
    ISSN: 1432-0428
    Keywords: Tolbutamide ; insulin ; euglycaemic glucose clamp ; β cell ; Type 1 diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined whether tolbutamide has any acute or short-term effects on insulin action in Type 1 (insulin-dependent) diabetes. A euglycaemic glucose clamp was performed in seven Type 1 diabetic patients without clinical insulin resistance by infusing glucose at a constant rate of 0.01 mmol·kg-1·min-1 for 3 h together with a simultaneous insulin infusion using an ‘artificial pancreas’. The insulin infusion rate required to maintain blood glucose at 6.7 mmol/l at a set low glucose infusion rate provides an index of insulin action in vivo. The euglycaemic clamp was performed on 3 separate days in the same patient: (1) in the basal state; (2) during simultaneous intravenous tolbutamide infusion of 0.5 g/h, and (3) after treatment with 2.5 g tolbutamide/day for 6 days in addition to insulin. The insulin infusion rate needed to maintain the set blood glucose level did not differ significantly between the three experimental conditions (1.2±0.2 versus 1.3±0.3 versus 1.2±0.3 U/h). Plasma glucagon, growth hormone, non-esterified fatty acid and glycerol levels did not differ between control or sulphonylurea treatment studies. The results suggest that tolbutamide does not exert any acute or short-term effects on insulin action in vivo in Type 1 diabetes. Our results do not provide support for the idea that this agent is a clinically useful adjunct to insulin in such patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253493
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Assessment of an algorithm for the artificial B-cell using the normal insulin-glucose relationship in diabetic dogs and men (1980)
    Springer
    Diabetologia 18 (1980), S. 97-107 
    Details
    ISSN: 1432-0428
    Keywords: Artificial B-cell ; algorithm ; glucose-insulin relationship ; regression analysis ; insulin secretion ; insulin half-life ; human diabetes mellitus ; experimental diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin secretion rates after glucose loading were calculated from peripheral venous IRI concentrations considering half life and distribution space of exogenous insulin in normal men and dogs. The coefficients of multiple linear regression analysis between insulin secretion rates and plasma glucose (level and order and rate of change) were used as algorithm parameters in glucose-controlled insulin infusions. These were carried out in each dog based on individual estimations before the induction of diabetes but in the diabetic patients based on values derived from a group of normal subjects. Using this formula, nearly normal patterns of glucose and of insulin were observed in diabetic men and dogs under basal conditions and after IV glucose loading but not after meals. This algorithm enables selection of the parameters prospectively. The effect of a parameter combination depends on insulin sensitivity and it should be appropriately adapted. In the diabetic patients there was no predictable influence of the brittle or stable characteristics of the disease nor of insulin antibodies on the glucose curves obtained with glucose controlled insulin infusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290484
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  • 5
    Electronic Resource
    Electronic Resource
    Evaluation of insulin resistance during inhibition of endogenous insulin and glucagon secretion by somatostatin in non-obese subjects with impaired glucose tolerance (1981)
    Springer
    Diabetologia 21 (1981), S. 192-197 
    Details
    ISSN: 1432-0428
    Keywords: Insulin resistance ; somatostatin infusion ; C-peptide ; insulin ; pancreatic glucagon ; growth hormone ; non-esterified fatty acids ; impaired glucose tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin resistance was studied in seven non-obese male subjects with impaired glucose tolerance and four healthy, age and body-weight matched male control subjects by means of a continuous intravenous infusion of somatostatin, glucose and insulin over 150 min. Glucose tolerance was evaluated by means of a 2-h glucose infusion test. Endogenous insulin (C-peptide), growth hormone, and glucagon secretion were suppressed by somatostatin in both groups. Steady-state plasma insulin and glucose levels were achieved between 90–135 min. Since similar steady-state levels of exogenous insulin were achieved, the resulting steady-state plasma glucose level provided a direct estimate of the ability of insulin to dispose of the infused glucose. The glucose levels were higher in subjects with impaired glucose tolerance with values of 14.6 ± 1.8 mmol/1 compared with 5.1 ± 1.2 mmol/1 in control subjects (p 〈 0.01), thus indicating insulin resistance. There was a direct correlation between the steady-state plasma glucose level and glucose tolerance suggesting that the degree of glucose intolerance is proportional to the degree of insulin resistance. These results revealed that decreased insulin sensitivity is found in non-obese subjects with impaired glucose tolerance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252653
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Absorption rates of subcutaneously injected insulin in the dog as calculated from the plasma insulin levels by means of a simple mathematical model (1983)
    Springer
    Diabetologia 24 (1983), S. 196-201 
    Details
    ISSN: 1432-0428
    Keywords: Dog ; insulin therapy ; mathematical model ; soluble insulin ; depot insulin ; absorption ; subcutaneous
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The appearance rate of insulin (calculated insulin secretion rate) in the circulating blood after subcutaneous injection was estimated in diabetic dogs from serial measurements of immunoreactive insulin concentrations using a simple mathematical model based on the insulin half-life and the distribution space. In the case of highly purified monocomponent porcine insulin, maximum concentrations occurred after 30–60 min. The duration of insulin appearance was dose-dependent and the rate of appearance could be described by a bi-exponential function. It was linearly dose-dependent but the effect on glycaemia showed saturation kinetics. The action of the injected dose on the fasting glycaemia diminished when the appearance rate became 〈0.3 mU · kg-1 · min-1. Fractional dose recovery was between 70% and 90% and was not different between depot and regular insulin. Appearance kinetics were not significantly affected by the initial glycaemia. The model presented provides a means for quantitative characterization of different insulin preparations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00250161
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  • 7
    Electronic Resource
    Electronic Resource
    Investigation about methods of quantitative evaluation of DTA curves (1977)
    Springer
    Journal of thermal analysis and calorimetry 12 (1977), S. 59-68 
    Details
    ISSN: 1572-8943
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Résumé L'étude porte sur la comparison des méthodes les plus connues d'exploitation cinétique des courbes ATD. Du point de vue de l'exactitude et de la compensation des erreurs, on établit que les méthodes de Borchardt et Daniels, de Coats et Redfern ainsi que de Šatava et Škvara peuvent être recommandées pour l'étude des réactions irréversibles simples en cinétique homogène. Dans la seconde partie, on décrit la méthode d'intégration exponentielle complète qui supprime totalement le caractère approximatif de la méthode de Coats et Redfern.
    Abstract: Zusammenfassung Die Untersuchung beschäftigt sich mit dem Vergleich der bekanntesten kinetischen Auswerteverfahren für DTA-Kurven. Unter Beachtung der Genauigkeit und des Fehlerausgleiches wird festgestellt, daß die Methoden von Borchardt und Daniels, Coats und Redfern sowie Šatava und Škvara besonders empfehlenswert sind, wenn man einfache irreversible Reaktionen auf der Grundlage der Homogenkinetik auswerten will. — Im zweiten Teil wird die Methode des vollständigen Exponentialintegrals beschrieben, die den Näherungscharakter in dem praktikablen Verfahren von Coats und Redfern aufhebt. Dadurch wird es wieder theoretisch exakt.
    Notes: Abstract The investigation gives a comparison of the best-known kinetic evaluation methods for DTA curves. With regard to accuracy and error-compensation, the methods of Borchardt and Daniels, Coats and Redfern and Šatava and Škvara in particular are to be recommended if simple irreversible reactions are to be evaluated on the basis of homogeneous kinetics. The complete exponential integral method is described which totally eliminates the approximative character of the practical procedure of Coats and Redfern. Hence, it becomes theoretically exact again.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01909856
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1980)
    Springer
    Helgoland marine research 34 (1980), S. 237-250 
    Details
    ISSN: 1438-3888
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01984043
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1979)
    Springer
    Helgoland marine research 32 (1979), S. 582-589 
    Details
    ISSN: 1438-3888
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02277995
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    Paper (German National Licenses)
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