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  • Electronic Resource  (12)
  • 1980-1984  (5)
  • 1960-1964  (4)
  • 1925-1929  (3)
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Material
  • Electronic Resource  (12)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Predictive animal testing for photocontact allergenicity (1980)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 103 (1980), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this investigation was to establish a standardized animal model to predict the photoallergenic potential of new chemical compounds. In a first series of experiments the main factors influencing the induction of photoallergenicity were evaluated (induction concentration, pH of the test solution, pretreatment of the irradiation site with sodium lauryl sulphate, additional use of adjuvant injections and routes of administration). Osram Ultravitalux lamps were utilized for these studies.In a second series of experiments a Xenon 6000 W radiation source was used. Positive results were obtained with well known photosensitizers, as, for instance, the halogenated salicylanilides, as well as with so-called weak photoallergens (e.g. bithionol, sulphanilamide) by stimulating the animals' immune system with Freund's complete adjuvant.The photoallergenic compounds were at the same time tested for their contact allergenic potential in the optimization test.A standard procedure for the predictive photoallergenicity assay in guinea-pigs is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1980.tb01681.x
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  • 2
    Electronic Resource
    Electronic Resource
    Evaluation of the photocontact allergenic potential of 6-methylcoumarin in the guinea pig (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 6 (1980), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 6-Methylcoumarin was tested in a new animal model developed for the predictive evaluation of photocontact allergenic potential. Negative results were obtained and these are discussed with respect to inherent limitations of the animal model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1980.tb04930.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Astronomische Mitteilungen (1925)
    Springer
    Naturwissenschaften 13 (1925), S. 347-348 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01558939
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Astronomische Mitteilungen (1927)
    Springer
    Naturwissenschaften 15 (1927), S. 855-856 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01505093
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  • 5
    Electronic Resource
    Electronic Resource
    Astronomische Mitteilungen (1928)
    Springer
    Naturwissenschaften 16 (1928), S. 474-476 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01504856
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  • 6
    Electronic Resource
    Electronic Resource
    Histochemical and Homogenization Studies of Mitochondrial α-Glycerophosphate Dehydrogenase in the Nervous System (1961)
    [s.l.] : Nature Publishing Group
    Nature 191 (1961), S. 718-719 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the presence of reduced menadione (A"3H2), tetrazolium salts are reduced to formazan pigment. This reaction, which is non-enzymic4, renders histo-chemically visible the reduction of K3 by its reductase. Formazan formation by A"3H2 occurred above pH 6-1 and at neutral and slightly alkaline pH; ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/191718a0
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    What can specific behavioural testing procedures contribute to the assessment of neurotoxicity in laboratory animals? (1984)
    Springer
    Inflammation research 14 (1984), S. 131-138 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Subchronic testing of laboratory animals in accordance with present regulatory guidelines involves maximum exposure with the chemical under investigation and serves for the evaluation of systemic toxicity as well as of lesions in organs and organ systems, including neurotoxicity. The primary assessment of neurotoxicity is essentially based on the overall observation of animal behaviour in the course of the customary toxicity studies and on the subsequent neuropathological evaluation with contemporary techniques. Under this maximum exposure the absence of symptoms and signs of neural abnormalities indicates that the material testd would be devoid of neurotoxicity. Any overt or suspicious symptoms for neurotoxicity appearing in the course of subchronic testing may be further characterized with additional functional tests such as neurological examination, electrodiagnostics and possibly with specific behavioural tests. The subsequent neuropathological investigation would have to be expanded to include a detailed evaluation of all neural structures possibly related with the above functional derangements. In case of relevant neurotoxicity subsequent specific behavioural tests might include the evaluation of complex neural functions such as integrated psycho-neuro-motor activity and memory. These behavioural tests might help to explain neurotoxicity and to assess behaviour at low levels of exposure. The implementation of such specific behavioural testing procedures beyond the scope of routine toxicity studies would require a group of investigators capable to earry out appropriate tests. The introduction of such testing will therefore have to be evaluated competitively regarding costs versus the advantages offered by the refinement of the other testing procedures for neurotoxicity including the neuropathological techniques. The performance of behavioural tests without preceding or concomitant toxicological evaluation is not considered to be a feasible approach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966846
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of hydroxyurea on postnatal growth and behaviour of rats (1980)
    Springer
    Inflammation research 10 (1980), S. 389-393 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hydroxyurea was administered intraperitoneally to pregnant albino rats in a single dose of 2000 mg/kg on day 14 of gestation. Both the perinatal and postnatal mortality rates of the progeny were increased and their weight gain reduced. Exploratory locomotion of 32-day-old rats, calculated by means of an ‘activity index’, was significantly reduced. The treatment had no effect on the brain weight. The fertility of the progeny was not impaired.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01971445
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  • 9
    Electronic Resource
    Electronic Resource
    Modelle für Reaktionen zwischen organischen und mineralischen Substanzen im Boden (1960)
    Springer
    Cellular and molecular life sciences 16 (1960), S. 38-40 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Low molecular siloxanes, silicagel, aluminium oxide, permutite, and perlite were dissolved by ammoniacal catechol solution. Silicagel was also dissolved by othero-diphenols. Low molecular silicon organic ester or complex compounds were crystallised from the reaction products of silicagel with catechol and 2,3-naphthalenediol. On orthoclase an insoluble brown cover was formed. The reaction ofo-diphenols with silicates may be important in soil formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02201792
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  • 10
    Electronic Resource
    Electronic Resource
    Substantivity and other factors responsible for formazan patterns in dehydrogenase histochemistry (1961)
    Springer
    Cellular and molecular life sciences 17 (1961), S. 136-141 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Es wurden substantive Eigenschaften verschiedener Mono- und Ditetrazoliumsalze gegenüber Gewebebestandteilen im Schnittpräparat untersucht. Ditetrazole werden im allgemeinen stärker vom Gewebe adsorbiert als Monotetrazole. Ausnahmen bilden Monotetrazole mit polaren Substituenten oder Azobenzol-Resten in 3-Stellung. Ditetrazole mit elektronegativen Gruppen in 2-Stellung werden stark von Lipoprotein-Strukturen adsorbiert und zeigen in Modellexperimenten Substantivität für ungesättigte Lipoide. An verschiedenen Beispielen wird die Bedeutung substantiver Tetrazol-Eigenschaften für die Lokalisation von Dehydrogenaseaktivität im Schnittpräparat dargelegt. Die Lokalisation enzymatisch gebildeten Formazans ist im Falle von substantivem Tetrazol ein Ausdruck für die Adsorption der Farbstoffvorstufe an bestimmte Gewebekomponenten. Im Falle von nichtsubstantivem Monotetrazol besteht die Möglichkeit zur Bestimmung von Orten intrazellulärer Enzymaktivität ohne unspezifische Anfärbung von Gewebsbestandteilen. Die Bedeutung der stark voneinander abweichenden Eigenschaften von in der Histochemie gebräuchlichen Tetrazoliumsalzen für die Darstellung intra-und extramitochondrialer Aktivität wird diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02160833
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