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  • 1
    Electronic Resource
    Electronic Resource
    The cost of atopic dermatitis in the Netherlands: an international comparison (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background Only a few international studies have assessed the economic burden of atopic dermatitis (AD), and no costs-of-illness study for AD has been done for the Netherlands. Objectives To estimate the incidence, prevalence and health-care costs of AD in the Netherlands and to put these in an international perspective. Methods We conducted a retrospective cohort study by using the data of an information system of general practitioners (GPs). To calculate the health-care costs at the primary care level we assessed medical resources utilization. We assessed the costs of patients with more severe AD from a retrospective study of patient files at the department of dermatology of a general hospital. We compared our results with costs-of-illness studies for other countries. Results The overall general population incidence and prevalence of AD were 0·8% and 2·3%, respectively. The incidence and prevalence were high among children until the age of 6 years, respectively, 3·1% and 11·3%, but decreased rapidly thereafter. The total mean health-care costs per patient were US$71. The most significant costs were due to visits to the GP (US$32) and medication, mostly corticosteroids (US$21). Young children were treated more often with emollients alone. Only 7·8% of patients were referred to a specialist. The mean costs for these patients were US$186. Costs-of-illness studies for Australia, Germany, the U.K., the U.S.A. and the Netherlands suggested that the costs associated with AD vary considerably across countries. Estimates of the costs-of-illness for AD ranged from US$71 in the Netherlands to US$2559 in Germany per patient due to variation in the study population (GP vs. hospital) and the number of cost components included. Studies that included costs due to the time spent on treatment had relatively high estimates. Conclusions The prevalence and incidence of AD are high among young children. In general, the health-care costs for AD were low. Patients' out-of-pocket costs were relatively high.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.04964.x
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  • 2
    Electronic Resource
    Electronic Resource
    Rapid release of volatile fission products from solid uranium tetrafluoride
    Amsterdam : Elsevier
    Inorganic and Nuclear Chemistry Letters 9 (1973), S. 519-525 
    Details
    ISSN: 0020-1650
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0020-1650(73)80184-9
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  • 3
    Electronic Resource
    Electronic Resource
    Investigation of steroid-CBG (transcortin)-interactions with fluorescent 4,6,8 (14) - triene - 3 - one steroids
    Amsterdam : Elsevier
    Steroids 52 (1988), S. 419-420 
    Details
    ISSN: 0039-128X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0039-128X(88)90176-6
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  • 4
    Electronic Resource
    Electronic Resource
    Successful Surgery of Multiple Recurrent Basal Cell Carcinomas Guided by Photodynamic Diagnosis (1997)
    Springer
    Aesthetic plastic surgery 21 (1997), S. 437-439 
    Details
    ISSN: 1432-5241
    Keywords: Key words: Basal cell carcinomas—Photodynamic diagnosis—Aminolevulinic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We describe a 56-year-old Caucasian man with history of multiple regressed basal cell carcinomas. During the last 20 years approximately 200 histologically proven basal cell carcinomas preferentially localized on the face were surgically treated. Several large skin grafts were necessary to cover the extensive tissue defects on the face and scalp. Although all excised tissues were histologically proven to be basal cell carcinomas with tumor-free margins, new tumors developed in proximity to the skin graft margins. The dissemination of the new tumors made it difficult to perform additional invasive operation procedures without influencing the cosmetic result. Thus, we used photodynamic diagnosis to improve detection and demarcation of the neoplastic tissues. This procedure facilitated surgical planning and enabled primary in toto excisions. Surgical trauma and a number of interventions were thus minimized with the consequence of improved cosmetic and functional results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002669900153
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  • 5
    Electronic Resource
    Electronic Resource
    Der Normalverlauf der Keuchhustenerkrankung als Maszstab zur Beurteilung von Heilversuchen (1935)
    Springer
    Journal of molecular medicine 14 (1935), S. 1036-1039 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Auf Grund von Beobachtungen an 100 medikamentös unbehandelten jungen Keuchhustenkindern wurde der Umfang der täglichen Schwankungen in der Zahl der Hustenanfälle und der Verlauf der Anfallshäufigkeitskurve und ihre Streuungen während des gesamten Krankheitsverlaufes festgestellt. Es wurde nachgewiesen, daß die Schwankungen des Krankheitsverlaufes beim Keuchhusten ungewöhnlich groß sind und infolgedessen nur sehr selten Gelegenheit gegeben ist, in der üblichen Weise vorzugehen und ausreichend große, unter gleichen Umweltsbedingungen gehaltene Gruppen behandelter und unbehandelter Kinder für die Beurteilung eines Heilversuches miteinander zu vergleichen. Daher wurde eine „Normal-Verlaufskurve“ des Keuchhustens aufgestellt und gezeigt, auf welche Weise sie vorteilhaft als Grundlage zur Beurteilung therapeutischer Versuche benutzt werden kann.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01760749
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  • 6
    Electronic Resource
    Electronic Resource
    Therapeutische Optionen zur Behandlung von Fersendefekten (2000)
    Springer
    Der Chirurg 71 (2000), S. 311-318 
    Details
    ISSN: 1433-0385
    Keywords: Keywords: Foot and ankle defects – Microvascular flaps – Plastic surgery. ; Schlüsselwörter: Weichteildefekt – Ferse – gestielte Lappen – freie Lappen.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Einleitung: Eine Defektdeckung im Fersenbereich stellt aufgrund der besonderen anatomischen und physiologischen Anforderungen eine Herausforderung dar. Das Vorgehen ist bislang nicht klar strukturiert. Patienten und Methode: Die Daten von 52 Patienten, vorzugsweise Männer, im Alter von 49 Jahren, wird in einer retrospektiven Analyse dargestellt. In 48 % war der Defekt Folge eines Traumas. 37 % der Defekte lagen im Bereich der Vollbelastungszone. Ergebnisse: Zur Defektdeckung wurden 59 operative Eingriffe, darunter eine Hauttransplantation in 16, eine lokale Lappenplastik in 3, eine gestielte Lappenplastik in 14 und eine freie mikrovaskuläre Lappenplastik in 17 Fällen durchgeführt. Eine Amputation erfolgte bei 4 Patienten. Komplikationen traten bei 18 Patienten auf. Schlußfolgerungen: Anhand der eigenen Ergebnisse und unter Berücksichtigung der aktuellen Literatur wurde ein Algorithmus zum therapeutischen Vorgehen entwickelt, der ein strukturiertes Vorgehen erlaubt, aber auch die Notwendigkeit vielfältiger plastischer Deckungsalternativen zeigt.
    Notes: Abstract. Introduction: The treatment of soft tissue defects of the foot and ankle region remains a challenge, because special anatomical and physiological properties have to be considered. Patients and methods: The data of 52 patients, who were treated between 1994 and 1998, were analyzed. 48 % were posttraumatic defects and were located in the weight bearing zone in 37 %. Results: Fifty-nine procedures were used, including skin transplantation in 16 patients, local flaps in 3 cases, regional flaps in 14 cases, and microvascular procedures in 17 cases. Amputation was required in 4 patients. The overall success rate was 92 %. Complications occurred in 18 patients. Conclusions: Using these data and evaluation of the actual literature lead to the development of an algorithm for the treatment of defects in this area. The modern armamentarium of plastic surgery offers the possible different treatment modalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050052
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  • 7
    Electronic Resource
    Electronic Resource
    Neue Clathrate vom Typ Ge38A8X8 mit A=P, As, Sb und X=Cl, Br, J (1972)
    Springer
    Naturwissenschaften 59 (1972), S. 420-420 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00623136
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  • 8
    Electronic Resource
    Electronic Resource
    Development of self-perceived risk behaviour and psychosomatic symptoms in adolescents: a longitudinal approach
    Amsterdam : Elsevier
    Journal of Adolescence 10 (1987), S. 291-308 
    Details
    ISSN: 0140-1971
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0140-1971(87)80005-2
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  • 9
    Electronic Resource
    Electronic Resource
    Histamine release during induction of anaesthesia and preparation for operation in patients undergoing general surgery: Incidence and clinically severe cases (1992)
    Springer
    Inflammation research 36 (1992), S. C149 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Histamine release events were shown in a prospective randomized controlled trial in patients undergoing elective general surgery with an extraordinarily high incidence: 73 per cent. This high incidence was explained by several factors: — the sample size which was much greater than in previous studies — the improved plasma histamine assay — the precise definition of histamine release in clinical conditions and its measurement at the top of Bateman functions — the standardized induction of anaesthesia and preparation of the surgical patient — and finally the considerable number of cancer patients since more than 60% of the reactions 〉5 ng/ml occurred in this group which comprised only 20% of the study population. Two cases of life-threatening anaphylactoid reactions occurred in this trial corresponding to an incidence of 1 per cent. This was — again — very high compared to previous epidemiological studies. Both cases were again cancer patients and occurred in the placebo group — information given by the external study advisory group for further treatment of the individual patient. The data on the high incidence of histamine release including the high incidence of life-threatening reactions favourrationally a preoperative H1 −+H2-prophylaxis with the drugs used in this study: dimetindene and cimetidine. The question of the incidence was one of the unsettled problems which led to this trial. Analysis of the first 180 patients already answered this question more than we had ever expected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01997321
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  • 10
    Electronic Resource
    Electronic Resource
    Cardiorespiratory disturbances following antibiotic prophylaxis in general surgery: Reasons for a complex reappraisal of a common problem (1997)
    Springer
    Inflammation research 46 (1997), S. 71-72 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050085
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