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  • Digitale Medien  (15)
  • Myoelectric control  (6)
  • Cadmium  (3)
  • Cell & Developmental Biology  (3)
  • X-ray absorption spectroscopy  (3)
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Materialart
  • Digitale Medien  (15)
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  • 1
    Digitale Medien
    Digitale Medien
    Renal cadmium content in the West of Scotland (1983)
    Springer
    Urological research 11 (1983), S. 285-290 
    Details
    ISSN: 1434-0879
    Schlagwort(e): Trace metals ; Cadmium ; Kidney cortex ; Ischaemic heart disease ; Medulla
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The trace element content of kidneys has been documented in very few international centres. Significant differences can be demonstrated between the cortical and medullary levels of calcium, zinc and cadmium. For the West of Scotland the values for the latter are similar to those found in Scandinavia. There are significantly higher cadmium contents in subjects who smoke and who have evidence of ischaemic heart disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00256348
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  • 2
    Digitale Medien
    Digitale Medien
    The effects of treatment on the hypercalciuria of chronic cadmium poisoning (1979)
    Springer
    Urological research 7 (1979), S. 285-289 
    Details
    ISSN: 1434-0879
    Schlagwort(e): Cadmium ; Iron ; Bendrofluazide ; Hypercalciuria Hyperzincuria ; Treatment
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Cadmium induces a variety of effects on kidney tubules including hypercalciuria. This is accompanied by hyperzincuria. The present work shows that both of these biochemical abnormalities can be corrected but where a state of cadmium-induced-anaemia exists urine zinc and calcium excretion do not follow the expected parallel course in response to iron therapy as they do with bendrofluazide.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00256610
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  • 3
    Digitale Medien
    Digitale Medien
    Histological and ultrastructural changes in rat kidney following cadmium injection (1977)
    Springer
    Urological research 5 (1977), S. 15-20 
    Details
    ISSN: 1434-0879
    Schlagwort(e): Cadmium ; Kidney ; Ultrastructure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Cadmium injection in rats affects the genito-urinary system. The renal effects are generally considered to be mainly tubular. Light microscopy of 29 specimens confirms cellular damage in the glomeruli with changes in glomerular capillaries. Electron microscopic changes in the glomeruli confirm changes in the podocytes, thickening of the basement lamina, the occurrence of electron dense deposits in association with the capillary endothelium with platelet and polymorphonuclear cell accumulations which suggests opening of the endothelial junction of the glomerular vessels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00257111
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  • 4
    Digitale Medien
    Digitale Medien
    X-ray absorption spectroscopic analysis of Fe(II) and Cu(II) forms of a herbicide-degrading α-ketoglutarate dioxygenase (1999)
    Springer
    JBIC 4 (1999), S. 122-129 
    Details
    ISSN: 1432-1327
    Schlagwort(e): Key words α-Ketoglutarate dioxygenase ; TfdA ; X-ray absorption spectroscopy ; Extended X-ray absorption fine structure ; 2 ; 4-Dichlorophenoxyacetic acid
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract  The first step in the degradation of 2,4-dichlorophenoxyacetic acid (2,4-D) by Ralstonia eutropha JMP134 is catalyzed by the α-ketoglutarate (α-KG)-dependent dioxygenase TfdA. Previously, EPR and ESEEM studies on inactive Cu(II)-substituted TfdA suggested a mixture of nitrogen/oxygen coordination with two imidazole-like ligands. Differences between the spectra for Cu TfdA and α-KG- and 2,4-D-treated samples were interpreted as a rearrangement of the g–tensor principal axis system. Herein, we report the use of X-ray absorption spectroscopy (XAS) to further characterize the metal coordination environment of Cu TfdA as well as that in the active, wild-type Fe(II) enzyme. The EXAFS data are interpreted in terms of four N/O ligands (two imidazole-like) in the Cu TfdA sample and six N/O ligands (one or two imidazole-like) in the Fe TfdA sample. Addition of α-KG results in no significant structural change in coordination for Cu or Fe TfdA. However, addition of 2,4-D results in a decrease in the number of imidazole ligands in both Cu and Fe TfdA. Since this change is seen both in the Fe and Cu EXAFS, loss of one histidine ligand upon 2,4-D addition best describes the phenomenon. These XAS data clearly demonstrate that changes occur in the atomic environment of the metallocenter upon substrate binding.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s007750050295
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  • 5
    Digitale Medien
    Digitale Medien
    Structural evidence for a common zinc binding domain in archaeal and eukaryal transcription factor IIB proteins (2000)
    Springer
    JBIC 5 (2000), S. 276-283 
    Details
    ISSN: 1432-1327
    Schlagwort(e): Key words Transcription factor IIB ; Metalloprotein ; Zinc finger ; Gene transcription ; X-ray absorption spectroscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract X-ray absorption spectroscopy has been used to compare the metal coordination of the N-terminal zinc binding domain of eukaryal human transcription factor (TF) IIB to the previously reported structure of archaeal Pyrococcus furiosus (Pf) TFB. Full length and N-terminal fragments for both PfTFBand human TFIIB were cloned, expressed, and purified. The [C10H] variant of PfTFB was constructed to resemble the metal binding motif of higher eukaryal TFIIB proteins by mutating the second cysteine ligand to a histidine. All five proteins bind zinc in a 1 :1 ratio. Zn X-ray absorption spectroscopy of human TFIIB and [C10H]PfTFB mutant are consistent with ZnS3(N,O) ligation, and further suggest that the N/O ligand is an imidazole.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s007750050372
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  • 6
    Digitale Medien
    Digitale Medien
    A transcription factor IIB homolog from the hyperthermophilic archaeon Pyrococcus furiosus binds Zn or Fe in an N-terminal Cys4 motif (1996)
    Springer
    JBIC 1 (1996), S. 162-168 
    Details
    ISSN: 1432-1327
    Schlagwort(e): Key words TFIIB ; Metalloprotein ; Zinc finger ; Gene transcription ; X-ray absorption spectroscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract  The gene for an archaeal homolog of the eukaryotic transcription factor TFIIB has been cloned from the marine hyperthermophilic archaeon Pyrococcus furiosus and overexpressed in Escherichia coli. This TFB gene displays a sequence that is identical to a gene sequence in P. woesei. A gene for the 49-residue N-terminal domain of TFB that contains a putative C-X2-C-X15-C-X2-C metal-binding motif was subcloned and overexpressed as TFB-NTD. Purification of the TFB-NTD gene product yields Zn- and Fe-containing forms, which have been characterized by mass spectrometry and UV-visible, electron paramagnetic resonance, and X-ray absorption (XAS) spectroscopies. Only the Zn form of the TFB holoprotein has been (partially) purified, and it has been characterized by XAS. All spectroscopic characteristics are consistent with a nearly tetrahedral MS4 metal-binding site made up of the four cysteine residues in the N-terminal domain. The relatively greater thermal stability of the Zn form suggests that TFB may be a Zn-containing protein involved in archaeal transcription.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s007750050035
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  • 7
    Digitale Medien
    Digitale Medien
    Axial and paraxial influences on limb morphogenesis (1991)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 208 (1991), S. 367-379 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: Previous studies by Stephens and McNulty and Strecker and Stephens have demonstrated that foil barriers placed between the mesonephros and lateral plate at stages 12 to 15 inhibited limb development, but foil barriers placed between the neural tube and somites at stages 11 to 12 resulted in limbs with normal skeletal patterns. It was concluded that some influence present in the paraxial region of the embryo at stages 11 to 15 is necessary for normal limb development. The present study was undertaken to localize that influence more precisely. Foil barriers were placed in the lateral edge of the somites or segmental plate of stage 10 to 15 chick embryos. Barriers placed into stage 13 to 15 embryos resulted in chicks with normal limbs, but barriers placed into stage 10 to 11 embryos resulted in chicks with defective limbs. Barriers inserted just lateral to Hensen's node at stages 6 to 8 resulted in embryos with defective or absent wings. We also grafted stage 4 to 9 presumptive limb territories with and without Hensen's node. Explants without Hensen's node formed limb-like structures in 1% of the cases. Explants with Hensen's node formed limb-like structures in 27% of the cases. When barriers were implanted and a node was placed on the lateral side of the barrier, limbs formed in 40% of the cases. These data suggest a medial to lateral progression of some as yet unknown morphogenetic influence necessary for normal limb development and we hypothesized that the influence may initially emanate from Hensen's node.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1052080310
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  • 8
    Digitale Medien
    Digitale Medien
    Operator error in multistate myoelectric control systems (1978)
    Springer
    Medical & biological engineering & computing 16 (1978), S. 296-301 
    Details
    ISSN: 1741-0444
    Schlagwort(e): Error analysis ; Myoelectric control
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Beschreibung / Inhaltsverzeichnis: Sommaire Un système de commandes myoélectriques est celui, où le fonctionnement d'un dispositif est contrôlé par le potentiel électrique produit par la contraction volontaire d'un muscle. Ces systèmes sont surtout employés pour la commande de membres artificiels. Les premiers types de systèmes de commande était empiriques, mais de récents travaux ont produit des bases théoriques, pouvant prédire leur performance. Ceci devrait pouvoir améliorer les systèmes déjà existants, et rendre possible le développement de prothèses plus complexes.
    Kurzfassung: Zusammenfassung Bei einem myoelektrischen Steuersystem wird der Betrieb eines Geräts durch ein elektrisches Potential gesteuert, das durch freiillige Kontraktion eines Muskels erzeugt wird. Diese Systeme wurden hauptsächlich zur Kontrolle künstlicher Glieder verwendet. Frühere Entwürfe des Steuersystems waren empirisch, jedoch wurden kürzlich einige theoretische Grundlagen erarbeitet, die ihre Leistung vorbestimmen können. Dieses wird zur Verbesserung der bestehenden Systeme führen und die Entwicklung mehr komplexer Prothesen wahrscheinlicher machen.
    Notizen: Abstract A myoelectric control system is one in which the operation of a device is controlled by the electric potential produced by voluntary contraction of a muscle. These systems have been used mainly for the control of artificial limbs. Early design of the control systems was empirical, but recent work has provided some theoretical basis for predicting their performance. This should lead to improvements in existing systems and make feasible the development of more complex prostheses.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02442431
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  • 9
    Digitale Medien
    Digitale Medien
    Sensory-feedback system compatible with myoelectric control (1980)
    Springer
    Medical & biological engineering & computing 18 (1980), S. 65-69 
    Details
    ISSN: 1741-0444
    Schlagwort(e): Electrocutaneous stimulation ; Myoelectric control ; Prosthetics ; Sensory feedback
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Progress in the development of a system to provide sensory feedback of the pinch force of an artificial hand is described. Design criteria relating to electrocutaneous stimulation and compatibility with myoelectric control are discussed. Details of a practical system, presently in use by two amputees prior to full-scale clinical evaluation, are presented.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02442481
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  • 10
    Digitale Medien
    Digitale Medien
    A biphasic pulse burst generator for afferent nerve stimulation (1987)
    Springer
    Medical & biological engineering & computing 25 (1987), S. 77-80 
    Details
    ISSN: 1741-0444
    Schlagwort(e): Myoelectric control ; Nerve stimulator ; Pulse burst ; Sensory feedback
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02442825
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