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  • Electronic Resource  (3)
  • Establishment  (1)
  • Keywords: Germ cell tumor; syncytiotrophoblastic giant cell; human chorionic gonadotropin (hCG); outcome.  (1)
  • meningioma  (1)
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  • Electronic Resource  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    A continuous cell line (KK-2) from a supratentorial primitive neuroectodermal tumor (1992)
    Springer
    Acta neuropathologica 84 (1992), S. 52-58 
    Details
    ISSN: 1432-0533
    Keywords: Primitive neuroectodermal tumor ; Cell line ; Characterization ; Establishment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tumor tissue located in the occipital lobe with hemorrhage was obtained from a 19-year-old patient. Histological examination indicated it to consist of undifferentiated small, round cells without neuronal or glial differentiation, and possibly to be a type of primitive neuroectodermal tumor. The tumor cells were cultured for 3 years and a continuous cell line (KK-2) was established. KK-2 was transplantable to nude mice. With immunocytochemistry, neuron-specific enolase, protein gene product 9.5, vimentin, TUJ1 (a monoclonal antibody specific for neuron-associated class III β-tubulin isotype) and 6H7 (a monoclonal antibody to NCAM produced by us) were detected. None of the following could be found: glial fibrillary acidic protein, S-100 protein, neurofilament and synaptophysin, calcitonin gene-related peptide, gastrin releasing peptide corticotropin-releasing factor, substance P, somatostatin, chromogranin, aromatic l-amino acid decarboxylase and tyrosine hydroxylase. The original tumor and KK-2 cells obtained after 3 years of culture and transplants in nude mice displayed essentially the same ultrastructural and immunohistochemical characteristics. KK-2 cells showed no differentiation to mature neuronal, glial or ependymal cells. This cell line may possibly serve as a useful model for studying cellular differentiation of human neuroectodermal tumors and normal neuronal development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427215
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cerebral Germinoma with Syncytiotrophoblastic Giant Cells: Feasibility of Predicting Prognosis Using the Serum hCG Level (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 975-978 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Germ cell tumor; syncytiotrophoblastic giant cell; human chorionic gonadotropin (hCG); outcome.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  As the biological behaviour of germinoma with syncytiotrophoblastic giant cells (STGC) is not well established, the present study was undertaken to ascertain the prognostic significance of serum hCG level in affected patients. Of a total of 23 cases studied, 12 patients were regarded as pure germinomas and 11 were germinomas with STGC. All but one of the former demonstrated an excellent outcome. The exception developed subarachnoid metastases, but the tumour disappeared on radiation therapy and the patient is enjoying a normal social life 13 years after the initial treatment. With the germinoma complicated by STGC, 3 cases showed local recurrence which were followed by a poor outcome. Their pretreatment hCG levels were 15.0, 26.0 and 29.6 mIU/ml respectively. The study showed a tendency, in germinomas with STGC, for a positive association between serum hCG, and the likelihood of a poor outcome. Germinomas with STGC and serum hCG levels higher than 15 mIU/ml thus have a high recurrence rate, and more aggressive treatment is indicated for the affected patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050404
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Invasive meningioma: A tumour with high proliferating and “recurrence” potential (1995)
    Springer
    Acta neurochirurgica 136 (1995), S. 127-131 
    Details
    ISSN: 0942-0940
    Keywords: Argyrophilic nucleolar organizer regions (AgNORs) ; invasiveness ; meningioma ; proliferating cell nuclear antigen (PCNA)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A study was undertaken to investigate the correlation between histological invasiveness and proliferating potential and clinical recurrence in meningioma. In 39 meningiomas, the histological findings at the tumour-brain interface zone were classified into 3 types, consisting of 29 cases of non-invasion (NON), 7 cases of nodular invasion (NOD), and 3 cases of intermingled invasion (INT). Proliferating cell nuclear antigen (PCNA) and argyrophilic nucleolar organizer region (AgNOR) indices were studied. PCNA indices (mean±standard error) of NON, NOD, and INT were 1.7±0.1%, 5.2±0.5%, and 7.5±0.7%, respectively, and the AgNOR indices (dot number/nucleus) were 1.50±0.03, 2.00±0.04, and 2.22±0.07, respectively. Significant differences were found among the three types in both parameters. Clinically, tumour recurrence was observed in 1/29 NON, 4/7 NOD, and 2/2 INT cases, indicating a higher incidence of recurrence in invasive meningiomas (NOD plus INT). Four of 32 patients who underwent gross total removal of the tumours showed recurrence, and all of these four tumours were invasive meningiomas. The results of the present study showed that tumour invasiveness as measured by PCNA + AgNOR indices correlated well with high proliferative potential and clinical recurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410613
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    Paper (German National Licenses)
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