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  • 1985-1989  (6)
  • 1970-1974  (1)
  • 1985  (6)
  • 1974  (1)
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  • 1985-1989  (6)
  • 1970-1974  (1)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Expression of A and B Types of Monoamine Oxidase in Differentiated Neuroblastoma Hybrid Cells (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 44 (1985), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The total activities of monoamine oxidase (MAO) and the ratio of type B/type A activities were determined in mouse neuroblastoma N1E-115 cells, and in NX31T and NG108-15 hybrid cells derived from mouse neuroblastoma × rat sympathetic ganglion hybrid or mouse neuroblastoma × rat glioma hybrid cells. N1E-115 and NX31T cells possessed type A activities exclusively, although NG108-15 cells showed both type A (65–90%) and type B (10–35%) MAO activities. The activity of type A MAO in NX31T and N1E-115 cells was relatively constant during culturing periods in the presence or absence of dibutyryl cyclic AMP (Bt2cAMP), whereas total MAO activity and the ratio of type B MAO/type A MAO in NG108-15 cells increased as a function of culture periods. Prostaglandin E1 (PGE1) and theophylline, the best known combination to increase intracellular cyclic AMP content of NG108-15 cells, caused similar increases of MAO and of the type B/type A ratio in NG108-15 cells. The results suggest that MAO activity and expression of MAO B activity are regulated in NG108-15 cells in a cyclic AMP-dependent manner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1985.tb12879.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Tryptophan hydroxylase activity in the brains of controls and parkinsonian patients (1985)
    Springer
    Journal of neural transmission 62 (1985), S. 107-115 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The activity of tryptophan hydroxylase was measured in nine regions of human brains from controls and patients with Parkinson's disease, striato-nigral degeneration, Shy-Drager syndrome and progressive supranuclear palsy by high performance liquid chromatography with fluorescence detection. The regional distribution of the enzyme activity in control brains was similar to that of serotonergic neurons; relatively high activity was found in the raphe nucleus, locus coeruleus and substantia nigra. The activity in the thalamus in Parkinson's disease and that in the locus coeruleus, raphe nucleus and substantia nigra in striato-nigral degeneration were significantly lower than that of controls (p〈0.05). In most other brain regions in parkinsonian patients the activity was relatively lower than that of controls except the caudate nucleus and nucleus accumbens where the activity was relatively higher than that of controls. Marked decrease in the enzyme activity in various brain regions was observed in striato-nigral degeneration, Shy-Drager syndrome, and progressive supranuclear palsy. These results suggest that the activity of tryptophan hydroxylase in serotonergic neurons is reduced in the brains of parkinsonian patients and of patients with degenerative nervous diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01260420
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Monitoring of circadian fluctuations of N-acetylserotonin in the rat pineal body by differential pulse voltammetry (1985)
    Springer
    Journal of neural transmission 62 (1985), S. 321-329 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Circadian fluctuations of the electrochemical signal appearing at + 270 mV (peak 3) recorded from the pineal body of freely moving rats were first monitored for 24 hours using thein vivo voltammetry technique. The peak 3 height increased after injection of pargyline and S-adenosyl-L-homocysteine but decreased after injection of NSD-1015, while probenecid did not cause any change. Under a 12/12 hours light-dark cycle, the peak 3 height represented circadian fluctuations, similar to those of N-acetyltransferase activity, which were higher in the dark than in the light period. These data suggest that the compound responsible for peak 3 in the pineal body is essentially due to extracellular N-acetylserotonin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01252245
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Collagenase-like peptidase activity in serum from patients with rheumatoid arthritis (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 487-488 
    Details
    ISSN: 1420-9071
    Keywords: Rheumatoid arthritis ; peptidase ; collagen-like
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The activities of collagenase-like peptidase, estimated by using (succinyl-Gly-Pro-Leu-Gly-Pro-Leu-Gly-Pro)-4-methyl-coumaryl-7-amide as substrate, and of dipeptidyl-aminopeptidase IV were decreased in the sera from patients with rheumatoid arthritis. Both enzymes bring about the degradation of peptides derived from collagen. A significant positive correlation was observed between the activities of the two serum peptidases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966162
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A 24-hour rhythm in human serum dopamine-β-hydroxylase activity (1974)
    Springer
    Cellular and molecular life sciences 30 (1974), S. 605-607 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Nachweis, dass die Dopamin-β-Hydroxylase im menschlichen Serum einen Tag-Nacht-Rhythmus aufweist, wobei die Nachtaktivität im Verhältnis zu derjenigen des Tages reduziert ist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01921498
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Quantitative immunofluorescence of tyrosine hydroxylase in the adrenal medulla of spontaneously hypertensive rats (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1054-1055 
    Details
    ISSN: 1420-9071
    Keywords: Quantitative immunofluorescence ; tyrosine hydroxylase ; adrenal medulla ; SHR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The amount of tyrosine hydroxylase protein in the adrenal medulla, which was estimated by a quantitative immunofluorescence method, was higher in spontaneously hypertensive rats than in normotensive control Wistar-Kyoto rats at 4 and 16 weeks of age before and after the development of hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01952140
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of short-term swimming stress and diazepam on 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) levels in the caudate nucleus: an in vivo voltammetric study (1985)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 331 (1985), S. 23-26 
    Details
    ISSN: 1432-1912
    Keywords: In vivo voltammetry ; Swimming stress ; DOPAC ; 5-HIAA ; Diazepam
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of swimming stress on dopaminergic and serotonergic neurons were studied by an in vivo voltammetry technique. 3,4-Dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) levels in rat striatum were measured by differential pulse voltammetry with an electrochemically treated carbon fiber electrode. Exposure to swimming stress for 1 to 10 min to the animal increased the DOPAC and 5-HIAA peaks, which depended on the length of stress. Pretreatment of the rats with diazepam (10 mg/kg, i.p.) prevented completely the stress-induced increase in DOPAC levels but only partially reduced the increase in 5-HIAA levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498848
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    Paper (German National Licenses)
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