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  • 11
    Electronic Resource
    Electronic Resource
    The effect of drugs on serum histidine levels in rheumatoid arthritis (1983)
    Springer
    Rheumatology international 3 (1983), S. 145-149 
    Details
    ISSN: 1437-160X
    Keywords: Anti-rheumatoid ; Drugs ; Histidine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Groups of 15 patients with active rheumatoid arthritis were treated for 24 weeks with zinc sulphate, trien, captopril, clozic in two doses or a combination of d-penicillamine and hydroxychloroquine. Serum histidine levels were monitored along with measures of disease activity including C-reactive protein, plasma viscosity, articular index, grip strength and early morning stiffness. Zinc sulphate and trien were found to be ineffective while the other drugs all showed evidence of second-line action. Serum histidine was found to improve during successful therapy. The possible cause of low serum histidine and its response to therapy is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541592
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    The distribution of zinc, cadmium, lead and copper within the woodlouse Oniscus asellus (Crustacea, Isopoda) (1982)
    Springer
    Oecologia 54 (1982), S. 227-232 
    Details
    ISSN: 1432-1939
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The concentrations of zinc, cadmium, lead and copper have been determined in the hepatopancreas, hindgut and rest of the body tissues of Oniscus asellus collected from eight sites in the U.K. The hepatopancreas is by far the most important storage organ of heavy metals, particularly cadmium, and at each site, contains a mean of at least 89% of the total body load of this element. Specimens of Oniscus asellus from contaminated sites may contain concentrations of zinc, cadmium, lead and copper in the hepatopancreas of about 1%, 0.5%, 2.5% and 3% of the dry weight respectively, which are among the highest so far recorded in the soft tissues of any animal. There is a significant positive correlation between the mean relative dry weight of the hepatopancreas of Oniscus asellus and the concentrations of zinc or cadmium in leaf litter from all eight sites. It is suggested that animals from sites which are contaminated heavily with zinc or cadmium have a large hepatopancreas because this enables them to ‘de-toxify’ a greater amount of the metal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00378396
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    Paper (German National Licenses)
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  • 13
    Electronic Resource
    Electronic Resource
    Absence of exercise-induced hypoglycaemia in Type I (insulin-dependent) diabetic patients during maintenance of normoglycaemia by short-term, open-loop insulin infusion (1982)
    Springer
    Diabetologia 23 (1982), S. 337-342 
    Details
    ISSN: 1432-0428
    Keywords: Type I diabetes ; exercise ; open-loop insulin infusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To assess the risk and possible mechanisms of hypoglycaemia during moderate exercise in Type I (insulin-dependent) diabetic patients receiving constant insulin infusion, five insulin-dependent male diabetic patients were exercised 18 h after their last meal and 30 h after their last injection of intermediate acting insulin. Intravenous insulin was initially delivered via a closed-loop infusion system programmed to lower mean blood glucose from 11.3 ± 1.8 to 4.8 ± 0.4 mmol/l over approximately 3.5 h. Blood glucose was then maintained at this level for 4 h. At this time, the closed-loop infusion was discontinued and replaced by an open-loop system. The average amount of insulin infused per min during the 4 h normoglycaemic closed-loop period was calculated and this amount was infused at a constant rate during both a 30 min period of exercise on a bicycle ergometer (approximately 65% maximum oxygen uptake) and a 30 min rest period which followed. Five nondiabetic males served as control subjects. Despite significantly higher free insulin concentrations (p 〈 0.05) and identical preexercise blood glucose concentrations, blood glucose rose during exercise only in the diabetic group (0.5 ± 0.2 mmol/l; p 〈 0.01). Changes in the serum concentrations of lactate, glycerol, glucagon, cortisol, non-esterified fatty acids and growth hormone were similar in the two groups and did not account for the increment of blood glucose in the diabetic patients. Beta-hydroxybutyrate concentrations were, however, higher in the diabetic patients at the onset of exercise (p 〈 0.01) and decreased significantly more than the control subjects during exercise. We conclude that exercise under these conditions in diabetic patients is not attended by hypoglycaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253741
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  • 14
    Electronic Resource
    Electronic Resource
    A new case of satellited Yq chromosome (1982)
    Springer
    Human genetics 〈Berlin〉 61 (1982), S. 277-277 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296462
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    Paper (German National Licenses)
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  • 15
    Electronic Resource
    Electronic Resource
    Unusual pericentric inversion inv(9)(p13q11) in a phenotypically normal family (1983)
    Springer
    Human genetics 〈Berlin〉 64 (1983), S. 100-100 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00289491
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  • 16
    Electronic Resource
    Electronic Resource
    Gas chromatography in open rectangular channels with large aspect ratios (1982)
    Springer
    Chromatographia 16 (1982), S. 98-102 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; Rectangular channel ; Efficiency ; Capacity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Gas chromatographic experiments have been performed in a truly rectangular channel with a 60∶1 cross-sectional aspect ratio, constructed according to the field-flow fractionation technology. It is shown that the peak broadening is controlled by the thickness of the channel while the maximum load is determined by the largest cross-sectional dimension. However, even with its elongated configuration, the side walls contribute significantly to the band broadening of solutes with a high diffusivity. Good agreement is found between the experimental plate height data and the recent theoretical calculations of Golay [13] taking into account the side-wall effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02258877
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  • 17
    Electronic Resource
    Electronic Resource
    Lithium as a non-radioactive tracer for roots of intercropped species (1982)
    Springer
    Plant and soil 64 (1982), S. 203-208 
    Details
    ISSN: 1573-5036
    Keywords: Barley ; Field beans ; Intercropping ; Lithium ; Rooting depth ; Tracers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary A technique is described for investigating the rooting pattern of species when intercropped, using Lithium as a non-radioactive tracer. The technique was tested on pure stands and mixtures of barley (Hordeum sativum) and field beans (Vicia faba), with 10% LiCl solution placed at depths of 0, 10, 25 and 62 cm. Pure stands of the two crops had similar patterns of Li uptake with depth. Growing the crops in mixture did not significantly change the pattern of Li uptake with depth, but did change total uptake. The Li uptake (m−2) by both species was reduced in mixtures, and was further reduced when the observed species was sown later than the other. The value of non-radioactive tracers, especially Li, in intercropping studies is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02184251
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  • 18
    Electronic Resource
    Electronic Resource
    Quantum chemical structure-activity relationships on β-carbolines as natural monoamine oxidase inhibitors (1983)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 23 (1983), S. 1643-1652 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The electron density and the molecular electrostatic potential of the β-carbolines are studied using ab initio STO-3G wave functions. The analysis was done from the point of view of a previous model built with monoamine oxidase substrates and irreversible inhibitors. The results confirm the usefulness of the model and make it possible to propose new precision to the molecular electrostatic potential patterns needed to have monoamine oxidase inhibitory activity.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560230445
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  • 19
    Electronic Resource
    Electronic Resource
    Quantum chemical study of the molecular patterns of MAO inhibitors and substrates (1983)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 23 (1983), S. 1627-1641 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Similarities and differences between mitochondrial monoamine oxidase (MAO) substrates and inhibitors (both A and B types) are considered, studying quantitatively two molecular properties: electron density and molecular electrostatic potential (MEP). The following molecules are considered: substrates: PHEA, BZA, tele-N-methyl-histamine, phenylethanolamine, phenylpropylamine, tryptamine, dopamine, phenoxylethylamine, noradrenaline, serotonin, and p-nitro-phenylethanolamine; inhibitors: Deprenil, Clorgyline, and Lilly 51641 (only the moiety involved in the A-B differentiation is considered). The wave functions needed to calculate the analyzed properties are of ab initio quality, and have been calculated in analogous conformations, all near the energetic minima. Electron densities distributions are qualitatively compared by means of a correlation coefficient defined over the whole space. Otherwise, patterns of the possible zones of electrostatic interactions are described by means of the distances and angles between minima, in order to differentiate MAO-A and MAO-B substrates. The results reproduce efficiently the experimental classification and enable us to predict the type of enzymatic action of molecules not yet experimentally classified.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560230444
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    Paper (German National Licenses)
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  • 20
    Electronic Resource
    Electronic Resource
    Polymer analysis by fractionation with on-line light scattering detectors (1982)
    Springer
    Chromatographia 15 (1982), S. 426-432 
    Details
    ISSN: 1612-1112
    Keywords: Polymer analysis ; Molecular weight distribution ; Steric exclusion chromatography ; Field-flow fractionation ; Light scattering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The classical method for the determination of the molecular weight distribution (MWD) curve of a polymer requires fractionation according to the molecular weight and prior calibration of the separator. It is shown that the use of a dual detection system which includes a molecular mass sensitive detector eliminates the need for prior calibration. The principles of operation of a low-angle light scattering photometer, working as such a detector, are presented, as well as the basic equations for determination of the MWD curve from the elution curve and of the average molecular weights. Then the performances of the light scattering photometer are discussed with special emphasis on the various sources of errors and unaccuracies in these determinations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02261602
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