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  • 11
    Electronic Resource
    Electronic Resource
    Occurrence of tetrodotoxin in the starfishAstropecten latespinosus (1984)
    Springer
    Cellular and molecular life sciences 40 (1984), S. 1395-1396 
    Details
    ISSN: 1420-9071
    Keywords: Astropecten latespinosus ; starfish ; tetrodotoxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A toxin causing paralysis was detected in the starfishAstropecten latespinosus. The toxin was purified by a method consisting of charcoal treatment and chromatography on CM-Sephadex C-25 and Bio-Rex 70. The toxin was identified as tetrodotoxin by its behavior in thin-layer chromatography and electrophoresis and its1H-NMR spectrum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951908
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  • 12
    Electronic Resource
    Electronic Resource
    Inhibition of brain enolases by acrylamide and its related compounds in vitro, and the structure-activity relationship (1984)
    Springer
    Cellular and molecular life sciences 40 (1984), S. 971-972 
    Details
    ISSN: 1420-9071
    Keywords: Rat brain ; Enolase ; acrylamide ; acrylamide derivatives ; neurotoxicity ; structure-activity relationship
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Acrylamide and its related compounds inhibited brain enolases in vitro independently of their neurotoxicity. The inhibitory potency was a function of the binding constants of the compounds for phenylalanine. The binding constant for tryptophan was higher in neurotoxic compounds than in non-neurotoxic ones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01946464
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    Paper (German National Licenses)
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  • 13
    Electronic Resource
    Electronic Resource
    Different responses of the isolated canine coronary artery superfused with blood or Krebs-Henseleit solution (1984)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 327 (1984), S. 156-158 
    Details
    ISSN: 1432-1912
    Keywords: Canine coronary artery ; Superfusion media ; Nifedipine ; Ca2+-channels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Responses of ring segments of the isolated canine coronary artery superfused with arterial blood from a donor dog were compared with responses of segments superfused with Krebs-Henseleit (K-H) solution. KCl (1–30 mg) caused contraction in a dose-dependent manner both in K-H solution- and in blood-superfused preparation. However, CaCl2 (1–100 mg) and nifedipine (0.1–30 μg) contracted and relaxed, respectively, only blood-superfused preparation but not K-H solution-superfused one. These results show that even in the same region of the coronary artery, different superfusates result in different responses to contracting or relaxing agents. This difference may be explained by the idea that Ca2+-channels are activated and endow basal tension in blood-superfused preparations, but not in K-H solution-superfused ones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500911
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    Paper (German National Licenses)
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  • 14
    Electronic Resource
    Electronic Resource
    Anti-neutrophil cytoplasmic antibody in patients with systemic lupus erythematosus is unrelated to clinical features (1997)
    Springer
    Clinical rheumatology 16 (1997), S. 70-75 
    Details
    ISSN: 1434-9949
    Keywords: Disease Activity Index ; Anti-Myeloperoxidase Antibody ; Anti-Lactoferrin Antibody ; Lupus Nephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the incidence, the specificity and clinical significance of positivity for serum anti-neutrophil cytoplasmic antibody (ANCA) in 31 patients with systemic lupus erythematosus (SLE), the indirect immunofluorescence (IIF) technique and enzyme-linked immunosorbent assay (ELISA) were used to measure ANCA. Purified myeloperoxidase (MPO), lactoferrin (LF), cathepsin-G (CTG) and elastase (HLE) served as ANCA antigens for ELISA. Thirteen (42%) of the 31 SLE patients showed positivity for perinuclear, but not cytoplasmic, ANCA by IIF. Five of 31 sera were positive for MPO, 10 for LF, 1 for CTG and 0 for HLE by ELISA. Patients positive for ANCA had a higher score of SLE disease activity index (SLEDAI) than those without ANCA. There was no correlation between ANCA positivity, clinical manifestations, or organic involvement. While the ANCA in patients with SLE reflected disease activity, it was unrelated to organic involvement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02238766
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    Paper (German National Licenses)
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  • 15
    Electronic Resource
    Electronic Resource
    Age-related changes in the compound action potentials of the eighth nerve in guinea pigs (1997)
    Springer
    European archives of oto-rhino-laryngology and head & neck 254 (1997), S. 145-149 
    Details
    ISSN: 1434-4726
    Keywords: Eighth nerve compound action potential ; Aging effects ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The eighth nerve compound action potential (CAP) in 95 guinea pigs was measured using click stimuli to investigate age-related changes in their neural auditory thresholds. The animals were separated into three groups: group A (n = 43, 86 ears; 2–4 months old); group B (n = 29; 58 ears, 13–15 months old); and group C (n = 23; 46 ears, 23–25 months old). With increasing age, a gradual elevation of CAP thresholds was clearly seen among the three groups. The negative peak (N1) latencies of the CAP were prolonged, and the N1 amplitudes of the CAP decreased. There were significant differences in N1 latencies among the three groups and in N1 amplitudes between groups A and B, and between groups A and C. However, the rate of decline of the thresholds as well as the input-output function curves of the CAP varied in some of the oldest animals, suggesting that there were some individual differences in degenerative aging processes of the auditory system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471279
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    Paper (German National Licenses)
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  • 16
    Electronic Resource
    Electronic Resource
    Mitochondrial DNA and nuclear DNA indicate that the Japanese Fasciola species is F. gigantica (1997)
    Springer
    Parasitology research 83 (1997), S. 220-225 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract For elucidation of the taxonomic status of the Japanese Fasciola species, whole mitochondrial DNA of Fasciola hepatica from Australia, F. gigantica from Malaysia, and Fasciola sp. from Japan was digested with three four-base-cutting endonucleases: HinfI, MspI, and RsaI. The resulting digestion patterns showed that for each enzyme there were some bands specific for each geographical isolate and that the Japanese Fasciola sp. shared more bands with F. gigantica than with F. hepatica. Nucleotide sequences of two regions, the second internal transcribed spacer (ITS2) of the nuclear ribosomal RNA cluster and mitochondrial cytochrome c oxidase subunit I (COI), were also compared among them. The ITS2 sequence was highly conserved among the three isolates. F. gigantica and the Japanese Fasciola sp. were identical, but they differed from the Australian F. hepatica at six sites, one of which was a deletion. The COI sequence was less conserved but implied a similar relationship between the isolates. There seems no reason to regard the Japanese Fasciola sp. as anything other than a strain of F. gigantica.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004360050237
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    Paper (German National Licenses)
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