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  • 1990-1994  (6)
  • 1985-1989  (3)
  • 1990  (6)
  • 1986  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Erratum: Two- and three-body forces in the interaction of He atoms with Xe overlayers adsorbed on (0001) graphite [J. Chem. Phys. 91, 6477 (1989)] (1990)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 93 (1990), S. 4492-4492 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.459724
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  • 2
    Electronic Resource
    Electronic Resource
    Differential Activation of Monocytes in Haemodialysis Patients Exposed to Different Types of Membranes (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 31 (1990), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Peripheral blood mononuclear cells (PBMC) from haemodialysis patients treated with different types of membranes were isolated, incubated in vitro, and extracellular and cell-associated interleukin 1 (IL-1) assayed by radioimmunological methods. Extracellular IL-1 was low and not different from controls, regardless of the dialyser used. In contrast, cell-associated IL-1 was increased in patients treated with dialysers containing low-Hux Cuprophan (CU, n = 5) and polyacrylonitrile sheet membrane (AN69, n = 5), Patients treated with diaiysers containing highflux polysulphone (PS, n= 7), and polymethylmethacrylate (PMMA, n= S), exhibited no increase in cell-associated IL-l under these conditions. To elucidate the mechanism of the activation, aqueous extracts of dialysers containing CU, PS, and AN69 were tested for their ability to induce IL-1 generation in PBMC from healthy donors. Extracts from unrinsed CU-containing dialysers caused significant IL-1 synthesis and release, whereas incubation with extracts from dialysers containing PS and AN69 sheet membranes did not. Hence, although both CU and AN69 sheet type dialysers result in activation of blood monocytes the mechanism of action appears to be different. We speculate that functional signs of PBMC activation as evidenced by increased spontaneous IL-1 production observed in some patients on long-term haemodialysis may result from extractable dialyser membrane material while in other instances direct cell membrane interactions or endotoxin transfer from the dialysate may be relevant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1990.tb02758.x
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  • 3
    Electronic Resource
    Electronic Resource
    Indications for radioisotope bone scanning in staging of cervical cancer (1990)
    Springer
    Archives of gynecology and obstetrics 248 (1990), S. 21-23 
    Details
    ISSN: 1432-0711
    Keywords: Radioisotope bone scanning ; Staging examinations ; Cervical cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The total of 160 patients with newly diagnosed invasive cancer of the cervix had whole body radioisotope bone scanning during staging of their disease. 51 patients had cancer of the cervix stage I, 63 had stage II, 34 stage III and 12 stage IV (FIGO). Only in 8 of 160 patients did the bone scans indicate possible metastases and this was confirmed by X-ray examination in only one patient with stage IV disease and liver metastases. We conclude that patients with stage I and stage II carcinoma of the cervix do not need to have bone scans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02389585
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  • 4
    Electronic Resource
    Electronic Resource
    Desmin and actin associated with cytoplasmic bodies in skeletal muscle fibers: immunocytochemical and fine structural studies, with a note on unusual 18- to 20-nm filaments (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 406-414 
    Details
    ISSN: 1432-0533
    Keywords: Cytoplasmic body myopathy ; Immunohistochemistry ; Desmin ; Intermediate filaments ; Actin filaments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a fine structural and immunocytochemical study, the latter performed on semithin sections of epoxy resin embedded skeletal muscle fibers, three types of cytoplasmic bodies were identified in a case of cytoplasmic body myopathy: (1) The first type, the classical type, showed a central core and a light halo with radiating actin filaments at the periphery. (2) The second type, the spheroid body was characterized by irregularly arranged granular masses associated with intermediate filaments. Desmin immunoreactivity occurred in the central and peripheral parts, where filaments of intermediate size were visualized by electron microscopy. Desmin immunoreactivity was noted also at the Z-bands of striated annulets, within areas of disordered myofibrils, such as sarcoplasmic masses, and in atrophic muscle fibers. (3) The third type of the cytoplasmic body was composed mainly of large masses of uneven granularity and electron density. The center of this type reacted to anti-actin antibody suggesting that the 5- to 6-nm filaments, which ultrastructurally proved to be a major component, were of the actin type. By contrast, neither intermediate filaments nor actin microfilaments were found by electron microscopy in cytoplasmic bodies in a second case where no immunoreaction to desmin or actin occurred. Anti-vimentin antibody stained only the cytoplasm of endomysial cells, but not the inclusion bodies. Some other, unusual inclusions with 18- to 20-nm tubulo-filamentous structures have to be distinguished from the various types of filaments in cytoplasmic bodies. It is concluded, that pleomorphism and heterogeneity of “cytoplasmic bodies” have to be taken into consideration when classifying cytoplasmic body myopathies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307695
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  • 5
    Electronic Resource
    Electronic Resource
    Low antithrombin III in neonatal shock: DIC or non-specific protein depletion? (1986)
    Springer
    European journal of pediatrics 145 (1986), S. 500-503 
    Details
    ISSN: 1432-1076
    Keywords: Antithrombin III ; Albumin ; Shock
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Low antithrombin III (AT III) levels in shock are usually ascribed to disseminated intravascular coagulation (DIC). However, decreased activities of clotting factors and their inhibitors could reflect a generalised fall in plasma proteins rather than DIC. AT III and albumin were compared in 48 asphyxiated and non-asphyxiated newborn rabbits (pH6.70–7.30). Both AT III and albumin were markedly decreased in the sickest animals and there was a direct linear relationship between the two proteins (P〈0.001). Similar results were obtained in ten newborn infants suffering from shock and haemorrhagic diathesis. In all cases AT III and albumin were decreased below the normal range and significantly correlated (P〈0.01). Our findings suggest that AT III is not a useful diagnostic marker of DIC. Further, a similar fall of clottable and non-clottable proteins in shock questions the general assumption that the ensuing coagulopathy is due to intravascular coagulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02429051
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  • 6
    Electronic Resource
    Electronic Resource
    A fluorescence detection system for the analytical ultracentrifuge and its application to proteins, nucleic acids, and viruses (1990)
    Springer
    Colloid & polymer science 268 (1990), S. 45-54 
    Details
    ISSN: 1435-1536
    Keywords: Analyticalultracentrifuge ; fluorescencedetection ; proteins ; nucleicacids ; viruses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A fluorescence detection system was developed for the analytical ultracentrifuge Spinco model E. Fluorescence is excited by a laser beam which is focussed into the cell and illuminates an area with a dimension of 60 μm in radial direction. For scanning the laser beam is moved in radial direction. After passing the cell, the laser beam is quenched by a carbon light trap and a set of optical filters. Fluorescence emission intensity is monitored by a photomultiplier located behind the light trap and the set of filters. The sensitivity of the detection system was tested by applying it to the sedimentation analysis of proteins and nucleic acids. Bovine serum albumin (BSA) was covalently labelled with the fluorescence-dye fluorescein-isothiocyanate (FITC), and its sedimentation coefficient could be determined even if BSA was analyzed in a concentration as low as 10−10 M. Nucleic acids were labelled non-covalently by the intercalating dye ethidium bromide. Only 8 ng RNA were needed for the determination of the sedimentation coefficient. The particular advantages of the fluorescence detection system were exploited for the establishment of a new method for quantitative virus detection. To tobacco mosaic virus (TMV) a monoclonal anti-TMV antibody from mouse was bound, and to this a second, anti-mouse antibody that carried the fluorescence-label FITC was attached. Either by UV-irradiation or by incubation with glutaraldehyde, the first antibody was covalently crosslinked to TMV, and the second antibody to the first. In CsCl density centrifugation with fluorescence detection as little as 3.2 ng virus/80 μl or 6×108 virus particles/ml were recorded in a well expressed band at the corresponding buoyant density. Tenfold lower concentration would result still in a significant band. The sensitivity compares well with those of the most advanced techniques from immunology. Due to the specific labelling of viruses by antibodies it will be possible to carry out quantitative physical characterization of virus containing samples without purifying the virus. Future applications of the fluorescence detection system and of the virus detection technique are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410422
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  • 7
    Electronic Resource
    Electronic Resource
    Clinical and pharmacokinetic studies on enoxacin in ear, nose and throat infections (1986)
    Springer
    Infection 14 (1986), S. S211 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 65 Patienten, die wegen Infektionen im Hals-Nasen-Ohren-Bereich mit 400 oder 600 mg Enoxacin zweimal täglich behandelt wurden, wurde die Wirksamkeit und Verträglichkeit von Enoxacin geprüft. Bei 32 der 60 auswertbaren Patienten war das klinische Gesamtergebnis nach Enoxacin-Behandlung ausgezeichnet, bei 17 Patienten gut, bei sechs mäßig und bei fünf schlecht. Drei Patientinnen klagten über Magendruck, ein Patient über leichte Übelkeit. Bei zwei Patienten traten allergische Hautreaktionen und bei einem Patienten Gelenk- und Muskelschmerzen auf. Die pharmakokinetischen Untersuchungen ergaben hohe Enoxacin-Konzentrationen in den untersuchten Sekreten, in Eiter und Geweben, insbesondere aus Mittelohr und Nasennebenhöhlen.
    Notes: Summary The efficacy and tolerance of enoxacin were tested in 65 patients treated for ear, nose and throat infections with doses of 400 or 600 mg b.i.d. The overall clinical efficacy of enoxacin was excellent in 32, good in 17, fair in six, and poor in five out of 60 evaluable patients. Three female patients complained of stomach pressure and one man of slight nausea, two of allergic skin reactions and one of arthromyalgia. The pharmacokinetic studies showed high enoxacin concentrations in the secretions, pus, and tissues studied, especially in those of the middle ear and the sinuses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01667846
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  • 8
    Electronic Resource
    Electronic Resource
    The structure of C2H4 clusters from theoretical interaction potentials and vibrational predissociation data (1990)
    Springer
    The European physical journal 15 (1990), S. 341-351 
    Details
    ISSN: 1434-6079
    Keywords: 36.40.01 ; 33.80.Gj
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Optimized geometries and binding energies are calculated for ethene (ethylene) dimers, trimers, and tetramers based on a pairwise additive dimer potential. From these results intermolecular frequencies and relative abundancies (catchment areas) of the different isomers are obtained and compared with the results of accurate measurements of the photodissociation upon absorption of one photon of a CO2 laser in the region of thev 7 monomer absorption band at 949 cm−1. The clusters are size selected in a scattering experiment and show for a cluster size fromn=2 ton=6 a frequency maximum shifted by 3 cm−1 to the blue compared with the monomer. The result is explained by the predominance of chains and chain-like structures of the clusters in the photodissociation process. The chains consist of cross-like dimer sub-units.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01437178
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  • 9
    Electronic Resource
    Electronic Resource
    Mg2IrB2-x, ein Magnesium-Iridiumborid mit W2CoB2 -verwandter Struktur (1986)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 543 (1986), S. 89-96 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Mg2IrB2-x, a Magnesium Iridium Boride with a Structure Related to the W2CoB2-TypeThe new compound Mg2IrB2-x with a small homogeneity range determined approximately as 0,2 ≤ x ≤ 0,35 crystallizes monoclinically in the space group C2/m, Z=4 (lattice constants see Inhaltsübersicht). The structure which was solved by single crystal X-ray and powder neutron diffraction methods is related to the W2CoB2-type and contains distorted Mg4Ir2-prisms. The boron atoms are partly disordered. They are situated either inside the prisms forming pairs or with very short Ir-B distances (199 pm) on an elongated prism edge formed by two iridium atoms.
    Notes: Die neue Verbindung Mg2IrB2-x mit einem schmalen Homogenitätsbereich, der näherungsweise zu 0,2 ≤ x ≤ 0,35 bestimmt wurde, kristallisiert monoklin in der Raumgruppe C2/m, Z = 4. Bei x = 0,35 betragen die Gitterkonstanten a = 858,0(1) pm, b = 484,6(1) pm, c = 683,6(1) pm, β = 115°43′(1). Die Struktur, die mit Röntgen-Einkristall- und Pulver-Neutronenbeugungsmethoden bestimmt wurde, leitet sich vom W2CoB2-Typ ab und enthält verzerrte Mg4Ir2-Prismen. Die Boratome sind zum Teil fehlgeordnet. Sie befinden sich entweder innerhalb der Prismen und bilden Paare, oder sie liegen auf einer aufgeweiteten, aus zwei Iridiumatomen bestehenden Prismenkante, wobei sehr kurze Ir-B-Abstände ausgebildet werden (199pm).
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19865431211
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