Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Large-area ion source combining microwaves with inductively coupled plasma : The 8th international conference on ion sources (2000)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 71 (2000), S. 716-718 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The semiconductor industry is growing rapidly and requires high technologies for nano-structure devices. Ion sources for manufacturing the next-generation semiconductor devices have been studied from the viewpoint of applications to material processing, such as ion beam assisted deposition, ion beam etching, and ion implantation. Recently, large-area ion sources which extract broad ion beams with multiapertures have come to be required not only for processing the size-growing wafers but also for industrial applications to nonsemiconductor materials. However, the uniformity of plasma density over the multiaperture electrodes has not met the requirements yet. We suggest a new method to improve the uniformity by superposing microwaves to an inductively coupled plasma source. Distributions of ion species in the plasma are measured with a quadrupole mass spectrometer which can be moved in vacuum perpendicularly to the beam extraction. The distributions of both plasma density and ion species in the source plasma as well as their properties over a large area are being studied and discussed. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1150271
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Improvement of microwave ion source for higher B+ ion current : The 8th international conference on ion sources (2000)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 71 (2000), S. 713-715 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Microwave ion sources have many advantages over dc-discharge ion sources, such as long lifetime and high current for most ion species. But B+ ion current has been the only disadvantage. Here we experimentally study how to get higher B+ ion current by optimizing the shape and volume of the source chamber as well as by increasing the secondary electron emissivity of the chamber wall. We carry out the experiment with regard to the maximum ion beam, lifetime, and dynamic range of the beam current for various ion species. Then, we compare the data with those of the Bernas-type ion source that has been widely used in semiconductor manufacturing factories. As a result of the improvement, the performance of all the above-mentioned aspects of the microwave ion source exceed those of the Bernas-type ion source. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1150270
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Poor response to interferon treatment for chronic hepatitis C in human immunodeficiency virus-infected haemophiliacs (2000)
    Oxford UK : Blackwell Science Ltd
    Haemophilia 6 (2000), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We performed a pilot study to evaluate the factors associated with response to interferon (IFN) therapy for chronic hepatitis C (CHC) with human immunodeficiency virus (HIV) coinfected haemophiliacs. Seven haemophiliacs, coinfected with HIV and hepatitis C virus (HCV), received 9 mega-units (MU) of natural IFN-alpha daily during the first 2 weeks and then three times a week for 22 weeks, all injected subcutaneously. Six patients were receiving zidovudine (AZT) 600 mg day−1 and didanosine (ddI) 200 mg day−1 during IFN therapy. This treatment was safe and well tolerated. Four patients had no detectable serum HCV-RNA at the end of therapy, but long-term, none of the seven patients achieved a sustained response, i.e. undetectable serum HCV-RNA with persistently normal serum alanine aminotransferase (ALT) 6 months after therapy. IFN did not affect CD4-positive cell counts. Most of our patients had high HCV-RNA loads and/or low CD4 counts, both unfavourable markers for IFN therapy. In conclusion, IFN therapy did not eradicate HCV from haemophiliacs coinfected with HIV.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2516.2000.00444.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Mechanical Properties of Tungsten Fiber Reinforced Ti-6Al-4V Alloy (2000)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 183-187 (Apr. 2000), p. 1243-1248 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/45/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.183-187.1243.pdf
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Cadmium, Copper, and Zinc Levels in Rice and Soil of Japan, Indonesia, and China by Soil Type (2000)
    Springer
    Bulletin of environmental contamination and toxicology 64 (2000), S. 33-39 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001289910006
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Secondary tethered cord syndrome in spinal dysraphism (2000)
    Springer
    Child's nervous system 16 (2000), S. 457-461 
    Details
    ISSN: 1433-0350
    Keywords: Keywords Spinal dysraphism ; Complication ; Secondary tethered cord syndrome ; Dural graft
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Secondary tethered cord syndrome following initial repair for spinal dysraphism is an important area of interest. In this study, 32 cases with spinal dysraphism in the lumbosacral region were enrolled, in whom radical repair with autologous material had been carried out in the early stage soon after birth. During the follow-up period of up to 19 years 10 months, surgery was considered to be indicated in 2 of the 8 lipomeningocele cases and in 6 of the 24 meningocele and meningomyelocele cases, because of the presence of tethered cord syndrome 4–19 years after the primary operation. In all 8 of these cases, MR imaging demonstrated tethered spinal cord in the form of low conus medullaris. In 6 of the 8 operated cases surgery was followed by improvement of the spinal neurological deterioration. According to our experience, early untethering for secondary tethered cord syndrome is essential. In addition, since the complications of Silastic duraplasty at untethering were all minor and the operative outcome was satisfactory, the use of silicone rubber sheeting as a dural substitute might be recommended to prevent adhesion of the spinal cord.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007291
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Expression of apoptosis-related proteins (p53, p21WAF1, bcl-2, and bax) and sensitivity to chemotherapy in squamous cell carcinoma of the esophagus (2000)
    Springer
    International journal of clinical oncology 5 (2000), S. 89-96 
    Details
    ISSN: 1437-7772
    Keywords: Key words Esophageal carcinoma ; Chemotherapy ; p53 ; p21 ; bcl-2 ; bax
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. Chemotherapy is an important component of the multimodal approach to the treatment of advanced esophageal squamous cell carcinoma. Methods. We investigated the associations between p53, p21 (Waf1), bcl-2, and bax expression and response to chemotherapy (cisplatin + 5-fluorouracil + leucovorin) in 43 patients with advanced esophageal squamous cell carcinoma. The expression of p53, p21 (Waf1), bcl-2, and bax proteins was analyzed immunohistologically in pretreatment biopsy and post-treatment resected specimens. Results. The 23 patients who had objective evidence of either a complete response (CR) or a partial response (PR) to chemotherapy survived for significantly longer than the 20 patients who had no response (NR). The expression of p53, p21 (Waf1), bcl-2, and bax was detected in 26 (61%), 12 (28%), 6 (14%), and 19 (44%) of the pretreatment biopsy specimens, respectively. The response to chemotherapy was not independently associated with the expression of any of these proteins. However, in the 26 patients with p53-expressing tumors, the response rate was 80% in patients whose tumor also expressed p21, whereas it was 19% in those whose tumor did not coexpress p21. No change in p53 expression was observed before and after chemotherapy, except in 1 patient; however, p21 expression appeared to be induced by chemotherapy in 5 patients. Patient survival was also not independently associated with the expression of any of these proteins. However, patients with p53-negative or p21-positive tumors had a better response to chemotherapy and survived for longer than those with p53-positive and p21-negative tumors. Conclusion. p53 and p21 expression in biopsy specimens obtained before chemotherapy could be useful predictors of response and survival in patients with advanced esophageal squamous cell carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101470050097
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Expression of transforming growth factor (TGF)-β1 mRNA and contractility of extracellular matrices in three-dimensional culture of rat peritoneal fibroblasts (2000)
    Springer
    Clinical and experimental nephrology 4 (2000), S. 105-113 
    Details
    ISSN: 1437-7799
    Keywords: Key words Peritoneal dialysis ; Fibrotic process ; Collagen gel contraction ; Cytokines ; IL-6 ; TGF-β1 ; RT-PCR ; Wound healing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. In a fibrotic process the interaction between resident cells and extracellular matrices is important in the control of cell function. Our preliminary experiments indicated that concentrated peritoneal dialysis effluent caused contraction of collagen matrices by peritoneal fibroblasts. In this study we attempted to mimic the inflammatory milieu present during peritoneal inflammation and assessed its effect on fibroblast activation. Methods. Rat peritoneal fibroblasts (RPFB) were isolated by a time-elapsed differential subculture from mixtures of primary cultures of peritoneal resident cells, and then cultured in collagen matrices. Various inflammatory mediators, known to be present in the peritoneal cavity during inflammation, (i.e., interleukin-6 [IL-6], IL-1β, and tumor necrosing factor (TNF)α were added to three-dimensional-RPFB cultures (1 × 105/ml) prior to their incubation for either 48 h or 10 days. The contractility of collagen matrices over this time period was monitored, as was the expression of transforming growth factor (TGF)-β1 mRNA. Experimental conditions were: (i) control gels, (ii) gels with IL-6, (iii) gels with IL-1β, (iv) gels with TNFα, (v) gels with each cytokine plus glucose (90 mM). Results. With 48 h stimulation, a greater than tenfold increase in TGF-β1 mRNA expression (measured as the ratio to TGF-β1/glyceraldehyde 3-phosphate dehydrogenase [GAPDH] mRNA) was observed compared with the control, and this was accompanied by gel contraction. With 10-day stimulation, both IL-1β and TNFα suppressed the expression of TGF-β1 mRNA as well as suppressing gel contraction. There was a 30% to 40% gel contraction accompanied by elongation of RPFB morphology in the IL-6 and control groups. The addition of glucose promoted the extension of RPFB and gel contraction by up to 60% in both the IL-1β- and TNFα-supplemented groups. Conclusion. These in vitro findings suggest that a balance of inflammatory cytokines influences rat peritoneal fibroblast (RPFB) gene expression, causing changes in the interaction between extracellular matrices and peritoneal fibroblasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00012160
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Usefulness of uracil loading test for detecting 5-fluorouracil metabolic enzyme deficiencies in humans (2000)
    Springer
    International journal of clinical oncology 5 (2000), S. 171-173 
    Details
    ISSN: 1437-7772
    Keywords: Key words 5-Fluorouracil (5-FU) ; Dihydropyrimidine dehydrogenase (DPD) ; Dihydropyrimidinase (DHPase) ; Uracil loading test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. We investigated the usefulness of the uracil loading test to detect human carriers of dihydropyrimidine dehydrogenase (DPD) and dihydropyrimidinase (DHPase) deficiencies. Methods. Our subjects consisted of family A (including a patient, a 37-year-old man with a urinary dihydrouracil (DHU) level of 185.4 μmol/mmol creatinine [Cre]); family B (including a patient, a 3-month-old girl with a DHU level of 154.3 μmol/mmol Cre); and ten healthy volunteers. Oral loading tests were performed with 10 mg/kg of uracil to examine changes in the serum and urinary levels of uracil and dihydrouracil in the subjects. Results. The uracil loading test showed the highest levels of urinary DHU 120 min after loading in the mother and father of the patient in family A (52.2 and 65.4 μmol/mmol Cre, respectively) and the mother of the patient in family B (66.4 μmol/mmol Cre). Conclusion. These urinary DHU levels were higher than those in the ten healthy adults, which led us to diagnose these individuals with high DHU levels as human carriers of DHPase deficiencies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00012033
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Identification of a novel 23 kDa protein encoded by putative open reading frame 2 of TT virus (TTV) genotype 1 different from the other genotypes (2000)
    Springer
    Archives of virology 145 (2000), S. 1385-1398 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary.  We report the entire open reading frames (ORFs) sequences of four TT virus (TTV) isolates, one genotype 2 (G2) and three G4 isolates. Despite a DNA virus, TTV possesses high rate of amino acid (aa) substitution: the aa sequence homology of ORF1 and 2 is lower than the nucleotide homology. The partial ‘N22’ region of ORF1 is suitable for genotyping of ‘prototype TTV’ isolates, because the phylogenetic tree from partial ‘N22’ sequence is consistent with that from the entire ORF1. Based on our sequence data, ORF2 from most isolates excluding G1 encode truncated 49 aa (pORF2a) because of an in-frame stop codon, although ORF2s from most G1 isolates encode 202 aa (pORF2ab). Just downstream the stop codon, another ORF encoding a protein of approximately 150 aa (pORF2b) is found, whose homology is quite low among these genotypes. Our in vitro transcription/translation study supports that all G1a and a part of G1b without an in-frame stop codon dominantly encode pORF2ab, a novel 23 kDa protein, whereas the other genotypes with an in-frame stop codon encode pORF2b (17 kDa). Our data indicate TTV G1a and a part of G1b should have different characteristics from the other genotypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007050070097
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...