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  • 1
    Electronic Resource
    Electronic Resource
    RADIOMETRIC DETERMINATION AND CHICK BIOASSAY OF FOLACIN IN FORTIFIED AND UNFORTIFIED FROZEN FOODS (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 45 (1980), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A radiometric assay for food folacin based on the competitive protein binding procedure was developed. The method is rapid, reliable and comparable to the microbiological assay. Cooking and storage did not significantly affect the folacin content of frozen fortified or unfortified frozen dinners and pies. Food folacin availability was measured by chick bioassay. The procedure involves feeding semi-purified diets containing various levels of folic acid and/or cooked or uncooked frozen convenience foods and measuring plasma and RBC folacin. Levels were directly related to folic acid intake from semipurified diets. Availability of folacin acid added to TV dinners and pies was demonstrated by elevation of plasma and RBC folacin, but fortification of vegetables did not cause consistent elevation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1980.tb03867.x
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  • 2
    Electronic Resource
    Electronic Resource
    Rapid amplification of a retrotransposon subfamily is evolving the mouse genome (1998)
    [s.l.] : Nature America Inc.
    Nature genetics 20 (1998), S. 288-290 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Retrotransposition affects genome structure by increasing repetition and producing insertional mutations. Dispersion of the retrotransposon L1 throughout mammalian genomes suggests that L1 activity might be an important evolutionary force. Here we report that L1 retrotransposition contributes ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/3104
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  • 3
    Electronic Resource
    Electronic Resource
    Genetics LINEs in mind (2005)
    [s.l.] : Nature Publishing Group
    Nature 435 (2005), S. 890-891 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Barbara McClintock won the Nobel Prize in Physiology or Medicine in 1983 for predicting the existence of mobile elements, pieces of DNA that move from one place in the genome to another. McClintock called them ‘controlling elements’ and proposed that they could account for developmental ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/435890a
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  • 4
    Electronic Resource
    Electronic Resource
    Visual evoked potentials as an aid in evaluating brain dysfunction following concussional injury: An animal model (1980)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 215 (1980), S. 105-111 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Visuell evozierte Potentiale wurden in dichter Folge vor und nach Kopfbeschleunigungen an Kaninchen über dauernd epidural implantierte Elektroden abgeleitet. Die Amplitude des nach der Läsion abgeleiteten VEPs war vermindert und die Erholungszeit verlängert. Beide Schädigungsfolgen waren umso ausgeprägter, je stärker die Beschleunigung und je deutlicher die später histologisch erfaßbaren Hirnveränderungen waren. In der Erwartung, daß das VEP bei Patienten mit Schädel-Hirnverletzungen wichtige Hinweise auf die Schwere der Verletzung und somit für die Behandlung liefern kann, waren diese Untersuchungen notwendig, um geeignete Untersuchungsmethoden und grundlegende Parameter zu finden.
    Notes: Abstract Visual evoked potentials were recorded sequentially, using permanent epidurally implanted electrodes, before and after accelerating the heads of rabbits. The amplitude of VEP, recorded after lesioning, was diminished and recovery time was prolonged depending on the amount of acceleration and the extent of brain lesions found later in histological examinations. VEP reflected damage to the brain more precisely than EEG or somatosensory evoked potentials, thus giving values for judging the extent of lesions in patients with brain injuries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414468
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  • 5
    Electronic Resource
    Electronic Resource
    Gene therapy for glioblestome multiforme: in vivo tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir (1997)
    Springer
    Journal of molecular medicine 75 (1997), S. 300-304 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050116
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  • 6
    Electronic Resource
    Electronic Resource
    Neuronavigation Computerassistierte Neurochirurgie (1999)
    Springer
    Der Nervenarzt 70 (1999), S. 517-521 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Neuronavigation ; Computer-assistierte Neurochirurgie ; Bildgestütztes Operieren ; Rahmenlose Stereotaxie ; Gliomchirurgie ; Key words Neuronavigation ; Computer-assisted neurosurgery ; Image-guided surgery ; Frameless stereotaxy ; Glioma surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The use of stereotactic methods for the resection of subcortical lesions is heavily advoacted in clinical neurosurgery introducing the term „neuronavigation”. Though being an unequivacally elegant technique for the localisation and delineation of pathological lesions in the central nervous system neuronavigation has not been validated by any prospective randomized controlled trial. The method is prone to significant errors as to the intraoperative localisation based upon preoperative threedimensional images. The maximum error can be up to 2.6 cm depending on the extent of the so-called brain shift. In comparison classical frame based stereotaxy has a mean error of ±1 mm and remains the gold standard for the exact threedimensional localisation of a given lesion. The value of neuronavigation is evident for small deep seated vascular lesions. For metastatic tumors or skull base tumors the usefullness is rather marginal because alternative therapies are available with proven and equivalent efficacy and reduced morbidity on one hand, and because of the anatomy of the tumor which makes neuronavigation unnecessary. For the currently most common application of neuronavigation, i.e. surgery of gliomas, no significant improvements of therapeutic results can be expected from neuronavigation. The biology of gliomas limits any mechanical approaches.
    Notes: Zusammenfassung Die Anwendung der stereotaktischen Methode für die Resektion von tiefliegenden Prozessen wird unter dem Begriff „Neuronavigation” in der klinischen Neurochirurgie vehement propagiert. Der Wert dieses unstrittig eleganten Verfahrens zur Lokalisation und Abgrenzung pathologischer Prozesse im ZNS ist bislang nicht durch prospektiv-kontrollierte, randomisierte Studien belegt. Die Methode ist mit einer erheblichen Fehlerbreite bzgl. der intraoperativen Lokalisation auf der Basis präoperativer dreidimensionaler Bilder behaftet („brain shift”). Dem gegenüber ist die klassische rahmengeführte Stereotaxie mit einer Genauigkeit von ±1 mm weiterhin der Gold-Standard für die exakte dreidimensionale Lokalisation eines Prozesses. Wenngleich der Wert der Neuronavigation für kleine, tiefsitzende, insbesondere vaskuläre Prozesse einleuchtet, ist der Wert bei Metastasen und Schädelbasistumoren nur sehr relativ, da hier entweder alternative Therapieverfahren mit gleicher Effizienz bei geringer Morbidität vorliegen oder weil aufgrund anatomischer Gegebenheiten die Neuronavigation entbehrlich ist. Für die derzeit häufigste Anwendung der Neuronavigation, der Gliomchirurgie, ist aus bekannten Gründen, die in der Biologie der Gliome liegen, keine Verbesserung der Operations-ergebnisse zu erwarten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050474
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  • 7
    Electronic Resource
    Electronic Resource
    Stereotaktische Behandlung der Bewegungsstörungen (1997)
    Springer
    Der Nervenarzt 68 (1997), S. 477-484 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Bewegungsstörungen ; M. Parkinson ; Stereotaxie ; Tremor ; Hirnstimulation ; Key words Stereotactic surgery ; Parkinson’s disease ; Movement disorders ; Thalamotomy ; Pallidotomy ; Brain ; Stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Stereotactic surgery for movement disorders is currently undergoing a re-evaluation. A new understanding of the pathophysiology makes the surgical lesion a logical step for the aleviation of both hyperkinetic symptoms such as tremor and hypokinetic symptoms like bradykinesia. Advances in imaging and electrophysiological control render these procedures more accurate and safer. Indications are medically refractory, Parkinsonean tremor, essential tremor, cerebellar tremor, bradykinesia and L-Dopa induced dyskinesis. The standard procedure is ablative surgery, i.e. thalamotomy for tremors and pallidotomy for bradykinesia, dystonia and L-Dopa induced dyskinesias. Deep brain stimulation is a novel alternative for selected patients which is currently evaluated. Neural transplantation of autologus, fetal or genetically manipulated cell suspensions into the striatum for the time being is experimental.
    Notes: Zusammenfassung Die chirurgische, d.h. stereotaktische Behandlung von Bewegungsstörungen erfährt derzeit eine Neubewertung. Neue Einsichten in die Pathophysiologie der Bewegungsstörungen haben dazu geführt, daß der stereotaktische Eingriff als begründeter therapeutischer Schritt angesehen wird. Die Nebenwirkungen stereotaktischer Eingriffe sind durch neue operative Techniken, digitale Bildgebung und elektrophysiologische Kontrollen geringer geworden. Die hauptsächlichen Indikationen sind Parkinson-Tremor und Rigidität, essentieller Tremor und zerebellärer Tremor. Als etablierte Routinemethode wird die stereotaktische Elektrokoagulation im Thalamus für alle Tremorformen weiterhin bevorzugt. Für die Behandlung von Akinesie und Bradykinesie, besonders auch der Dopa-induzierten Hyperkinesien, gewinnt die Pallidotomie rasch wieder an Bedeutung. Die chronische Stimulation durch Implantation von Hirnelektroden ist in Einzelfällen indiziert. Die Transplantation autologer, fetaler oder gentechnisch manipulierter Zellen wird derzeit in ihrer Bedeutung für die Therapie untersucht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050150
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  • 8
    Electronic Resource
    Electronic Resource
    Angiomyolipoma of the kidney and lymph nodes (1999)
    Springer
    World journal of urology 17 (1999), S. 123-125 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Angiomyolipoma (AML) is a benign mesenchymal tumor predominantly occurring in the kidney. Despite its low incidence of 0.07–0.3% in an unselected population, this tumor is well known, because the typical AML can be diagnosed without histological confirmation by a combination of ultrasound (US) and computerized tomography (CT) imaging in up to 95% of cases. In contrast, simultaneous involvement of the kidney and the regional lymph nodes is less known and might be confused with metastasizing malignant tumor. We report a case of the very uncommon simultaneous involvement of the kidney and the lymph nodes in AML.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003450050117
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  • 9
    Electronic Resource
    Electronic Resource
    European society for stereotactic and functional neurosurgery Abstracts Selected for Presentation at the 12th Congress in Milan, Italy, on June 12–15,1996 (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 597-654 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411184
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  • 10
    Electronic Resource
    Electronic Resource
    European Society for Stereotactic and Functional Neurosurgery (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 837-877 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050188
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