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  • 1
    Electronic Resource
    Electronic Resource
    Annealing characteristics and electrical properties of 1-MeV arsenic-ion-implanted layers in silicon (1990)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 68 (1990), S. 5555-5563 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Arsenic ions have been implanted in (100)Si at an incident energy of 1 MeV to a dose of 1×1015/cm2. Rutherford backscattering measurements with a 1.5-MeV He-ion beam have shown that a buried amorphous layer is formed in the Si substrate which is implanted at a low ion-beam current of 0.8 μA and that considerable annealing occurs when implantation is carried out at a high ion-beam current of 2 μA. The implantation-induced amorphous layer recrystallizes after annealing above 550 °C, but a high density of lattice defects still remains in the substrate even after annealing at 1000 °C. Defect observations using a cross-sectional transmission electron microscope have revealed that those defects are located at the two depths corresponding to the initial transition regions where the crystallinity is changed from the amorphous to nonamorphized states in the substrate. In addition, secondary defects also exist in a particular region inside the initial buried amorphous layer. The recrystallization of the buried amorphous layer during post-implant annealing is initiated not only from the deeper part of the substrate but also from the nonamorphized surface layer. From a series of isothermal annealing studies, it has been shown that the recrystallization rates at 550 °C are 140 and 180 A(ring)/min on the frontside and backside of the buried amorphous layer, respectively. Electrical profile measurements, using the differential Hall method, have shown that a highly doped, buried conductive layer with a peak carrier concentration of around 2×1019/cm3 can be formed by annealing above 800 °C.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.347193
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  • 2
    Electronic Resource
    Electronic Resource
    Low-duty pulsed PIG source in HIMAC : International conference on ion sources (1990)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 61 (1990), S. 466-468 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A low-duty pulsed PIG source has been developed for the injector (e/m= (1)/(7) – 1/4 ) of HIMAC. This source is of an indirectly heated PIG type. The requirement for this source is a high current with a low repetition rate and a low-duty factor. To obtain good stability during pulsed operation, the source is operated in a positive arc impedance range. Pulsed operation also allows the arc voltage to be high (1.4 kV), resulting in a high yield of multiply charged ions. With an arc pulse width of 500 μs (1 Hz and a duty of 0.05%), a useful beam pulse width of 200 μs with a peak intensity of 120 μA for Ar6+ has been obtained at an optimum gas pressure of 10−3 Torr. This intensity is higher than for cw mode by a factor of 5. A 90% emittance has also been measured to be 250π mm mrad in both the X and Y directions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1141275
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  • 3
    Electronic Resource
    Electronic Resource
    Performance of a low-duty pulsed Penning source for the medical synchrotron facility at NIRS : Proceedings of the fourth International Conference on Ion Sources (1992)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 63 (1992), S. 2904-2906 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A low-duty pulsed Penning source has been developed for the injector of the medical synchrotron facility at NIRS. The repetition rate is 1 Hz, with a duty factor of 4×10−4. The lifetime of the cathodes has been evaluated to be longer than two months, and that of the filament (cw) longer than one week. The intensity of multiply charged ions was increased by a factor of 10 compared with that obtained under dc operation. The reliability and stability were also improved. The results concerning the performance and some improvements of the source are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1142794
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  • 4
    Electronic Resource
    Electronic Resource
    High-pressure Brillouin study of solid HBr at pressures up to 7 GPa (1999)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 111 (1999), S. 10617-10621 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: High-pressure Brillouin scattering measurements have been carried out in orientationally disordered (OD) phases I and I′ of solid HBr, which yielded the first determination of acoustic velocities for all directions, the refractive index, the polarizability, the density, adiabatic elastic constants (C11, C12, and C44), bulk modulus, and the elastic anisotropy as a function of pressure up to 7 GPa and at room temperature. The I→I′ phase transition in solid HBr was confirmed on the discontinuous pressure dependence at P=2.3 GPa for average errors of the least-squares fit by the analysis of in situ Brillouin spectroscopy. These elastic properties of solid HBr are compared with recent results in the OD phase I of solid HCl. We suggest that the form of the potential energy function for intermolecular forces in solid HBr is similar to that in HCl. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.480414
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  • 5
    Electronic Resource
    Electronic Resource
    The relationship between maximal jaw opening and size of skeleton: a cephalometric study (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 23 (1996), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: summary The purpose of this study was to investigate the correlation between maximal mouth opening and size of the skeleton. The subjects were dental students at the Dental School of the Health Sciences University of Hokkaido with no functional disorders of the masticatory system. The stature and maximal mouth opening were recorded in 29 males and 31 females. These subjects agreed to have a lateral cephalogram taken at the closed and maximal mouth opening positions. The correlations between the maximal mouth opening and the body height, mandibular length and mandibular angle were significant. The correlation between the maximal mouth opening and the movement of the condyle was also significant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1996.tb00807.x
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  • 6
    Electronic Resource
    Electronic Resource
    Phenytoin partially antagonized L-type Ca2+ current in glucagon-secreting tumor cells (ITC-1) (1992)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 345 (1992), S. 78-84 
    Details
    ISSN: 1432-1912
    Keywords: ITC-1 cell ; Low-threshold and transient Ca2+ (T-type) current ; High-threshold and long-lasting Ca2+ (L-type) current ; 5,5-diphenylhydantoin (phenytoin)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Transmembrane Ca2+ currents were investigated by means of a whole-cell clamp technique in a hamster glucagon-secreting tumor cell line (ITC-1). Two types of Ca2+ current were identified in ITC-1 cells. The low-threshold and transient (T-type) current became detectable above the potential level around −60 mV and decayed rapidly with an inactivation time constant of 95 ms (at −40 mV and 23°C), while the high-threshold and long-lasting (L-type) one was activated by depolarization more positive to −30 mV with non-inactivating kinetics. The voltage dependence and kinetics of these currents were identical to those reported in guinea-pig pancreatic α2 cells. Both currents were augmented by equimolar substitution of Ca2+ with Ba2+ and completely abolished by adding 1 μM La3+. Phenytoin, a well known anti-epileptic drug and a postulated T-type specific Ca2+ current antagonist, surprisingly blocked the L-type current without affecting the T-type current in ITC-1 cells. While phenytoin antagonized the L-type Ba2+ current selectively, 60% of the current remained even in supramaximal concentration range over 500 μM. The residual component of the L-type current was completely abolished by adding nifedipine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175473
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  • 7
    Electronic Resource
    Electronic Resource
    Congenital prepubic sinus (1994)
    Springer
    Pediatric surgery international 9 (1994), S. 287-289 
    Details
    ISSN: 1437-9813
    Keywords: Prepubic sinus ; Duplication of urethra ; Infants and children ; Embryology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Congenital prepubic sinus is a rare anomaly: only five pediatric cases have to our knowledge been reported to date. We report two further cases with the sinus extending from the overlying skin through the rectus fascia to the anterior bladder wall. In our first case the opening of the sinus was just 3 cm below the midline inferior to the navel, with concentric, thin smooth-muscle layers. This lesion may represent a mild forme fruste of a midline closure defect. In our second case, the sinus was lined by transitional epithelium in its distal portion with stratified squamous epithelium near the surface, and was also surrounded by a thin smooth-muscle layer. These two cases may represent a variant of epispadiac urethral duplication. Our observations suggest that congenital prepubic sinus and urethral duplication are related embryologically.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00832260
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  • 8
    Electronic Resource
    Electronic Resource
    Immunohistochemical analysis of rat and human respiratory cilia with anti-dynein antibody: comparison between normal cilia and pathological cilia in primary ciliary dyskinesia (1995)
    Springer
    Virchows Archiv 427 (1995), S. 401-406 
    Details
    ISSN: 1432-2307
    Keywords: Immunostaining ; Primary ciliary dyskinesia ; Kartagener's syndrome ; Immotile cilia syndrome ; WIC-Hyd rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Wistar Imamichi rat and human respiratory cilia were examined with anti-dynein antibody (AD2), which is specific for sea urchin sperm flagellar dynein. AD2-labelled fresh-frozen normal rat and human cilia stained clearly by immunofluorescence and the peroxidase-antiperoxidase (PAP) technique. On immunoelectron microscopy, AD2 labelled the outer dynein arms of normal human cilia. Paraffin-embedded normal human cilia also stained by immunofluorescence, although not always clearly. Neither the cilia of WIC-Hyd male rats, an animal model of Kartagener's syndrome, nor human cilia from patients with primary ciliary dyskinesia (PCD) reacted positively by the immunofluorescence or PAP technique. Western blots of normal rat cilia yielded a single band of about 450 kDa. In conclusion, AD2 recognizes the outer arm dynein heavy chains of healthy cilia and may be useful in diagnosing and classifying PCD light microscopically especially when only paraffin-embedded specimens are available. This approach may be of potential use for better defining and classifying PCD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199389
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  • 9
    Electronic Resource
    Electronic Resource
    Serum MIP-1α and IL-8 in septic patients (1996)
    Springer
    Intensive care medicine 22 (1996), S. 1169-1175 
    Details
    ISSN: 1432-1238
    Keywords: Macrophage inflammatory protein-1 alpha (MIP-1α) kwInterleukin-8 (IL-8) ; Sepsis ; Disseminated intravascular Coagulation (DIC)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied blood MIP-1α and IL-8 in 38 septic patients and 5 healthy volunteers. Both chemokines were undetectable in the healthy volunteers. In sepsis, serum MIP-1α was detected in 45% of the patients and IL-8 in 84%. The levels of MIP-1α, but not of IL-8, correlated with CRP, IL-6 and TNFα levels. Complication, including various organ failures and mortality, showed no correlation with serum MIP-1α levels. In contrast, we found increased levels of serum IL-8 in septic patients with disseminated intravascular coagulation, central nervous system (CNS) dysfunction or renal failure, and the mortality rate was higher in the IL-8-detectable group than in the IL-8 undetectable group (50% vs 0%,p〈0.05). In conclusion, the production of both MIP-1α and IL-8 was increased and initially detectable levels of circulating IL-8 predicted high mortality in sepsis. Objective To determine the significance of the C-C chemokine MIP-1α and the C-X-C chemokine IL-8 in sepsis. Design Prospective study. Setting Clinical investigation, emergency department and general intensive care unit of university hospital. Patients and participants 38 septic patients and 5 healthy volunteers were studied. Sepsis was diagnosed following the criteria formulated by ACCP/SCCM. Interventions 10–20 ml of blood was drawn from each patient at the time of initial diagnosis of sepsis. Measurements and results MIP-1α and IL-8 were determined by sand-wich ELISA. Both chemokines were undetectable in the healthy volunteers. In sepsis, serum MIP-1α was detected in 45% of the patients and IL-8 was detected in 84%. The levels of MIP-1α, but not of IL-8, correlated with CRP, IL-6 and TNFα levels. Complications, including various organ failures and mortality, showed no correlation with serum MIP-1α levels. In contrast, we found increased levels of serum IL-8 in patients with disseminated intravascular coagulation (DIC) (p〈0.05), central nervous system (CNS) dysfunction (p〈0.05), renal failure (p〈0.01) and the mortality rates were higher in the IL-8 detectable group than in the IL-8 undetectable group (50% vs 0%,p〈0.05). Conclusions The production of MIP-1α and IL-8 was increased in sepsis. Furthermore, an initially detectable level of circulating IL-8, but not MIP-1α, predicted a high mortality in sepsis diagnosed according to the ACCP/SCCM criteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709331
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  • 10
    Electronic Resource
    Electronic Resource
    Serum MIP-1α and IL-8 in septic patients (1996)
    Springer
    Intensive care medicine 22 (1996), S. 1169-1175 
    Details
    ISSN: 1432-1238
    Keywords: Key words Macrophage inflammatory protein-1alpha (MIP-1α) ; Interleukin-8 (IL-8) ; Sepsis ; Disseminated intravascular Coagulation (DIC)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Structured Abstract   Objective: To determine the significance of the C–C chemokine MIP-1α and the C–X–C chemokine IL-8 in sepsis. Design: Prospective study. Setting: Clinical investigation, emergency department and general intensive care unit of university hospital. Patients and participants: 38 septic patients and 5 healthy volunteers were studied. Sepsis was diagnosed following the criteria formulated by ACCP/SCCM. Interventions: 10–20 ml of blood was drawn from each patient at the time of initial diagnosis of sepsis. Measurements and results: MIP-1α and IL-8 were determined by sandwich ELISA. Both chemokines were undetectable in the healthy volunteers. In sepsis, serum MIP-1α was detected in 45% of the patients and IL-8 was detected in 84%. The levels of MIP-1α, but not of IL-8, correlated with CRP, IL-6 and TNFα levels. Complications, including various organ failures and mortality, showed no correlation with serum MIP-1α levels. In contrast, we found increased levels of serum IL-8 in patients with disseminated intravascular coagulation (DIC) (p〈0.05), central nervous system (CNS) dysfunction (p〈0.05), renal failure (p〈0.01) and the mortality rates were higher in the IL-8 detectable group than in the IL-8 undetectable group (50% vs 0%, p〈0.05). Conclusions: The production of MIP-1α and IL-8 was increased in sepsis. Furthermore, an initially detectable level of circulating IL-8, but not MIP-1α, predicted a high mortality in sepsis diagnosed according to the ACCP/SCCM criteria.
    Notes: Abstract  We studied blood MIP-1α and IL-8 in 38 septic patients and 5 healthy volunteers. Both chemokines were undetectable in the healthy volunteers. In sepsis, serum MIP-1α was detected in 45% of the patients and IL-8 in 84%. The levels of MIP-1α, but not of IL-8, correlated with CRP, IL-6 and TNFα levels. Complications, including various organ failures and mortality, showed no correlation with serum MIP-1α levels. In contrast, we found increased levels of serum IL-8 in septic patients with disseminated intravascular coagulation, central nervous system (CNS) dysfunction or renal failure, and the mortality rate was higher in the IL-8-detectable group than in the IL-8 undetectable group (50% vs 0%, p〈0.05). In conclusion, the production of both MIP-1α and IL-8 was increased and initially detectable levels of circulating IL-8 predicted high mortality in sepsis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709331
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