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  • 1
    Electronic Resource
    Electronic Resource
    Silicon emitter for field desorption mass spectrometry (1979)
    s.l. : American Chemical Society
    Analytical chemistry 51 (1979), S. 69-72 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac50037a025
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  • 2
    Electronic Resource
    Electronic Resource
    Impairment of skin barrier function in NC/Nga Tnd mice as a possible model for atopic dermatitis (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 144 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  The pathogenesis and aetiology of atopic dermatitis (AD) remain unclear. Establishment of suitable animal models should aid elucidation of the pathogenesis and development of therapy. Objectives  We focused on biophysical and biochemical parameters in the skin of NC/Nga Tnd mice to evaluate similarities to and differences from AD. Methods  Biophysical (transepidermal water loss and skin surface conductance) and biochemical parameters (ceramide contents and activity of ceramide-metabolizing enzymes) were measured in NC/Nga Tnd mice in which spontaneous dermatitis appeared under ambient laboratory conditions (ALC). Results  Biophysical parameters suggested impairment of water retention properties and barrier function. The amount of ceramide in NC/Nga Tnd mice under ALC decreased significantly. These dermatological features resembled those of AD, as did the clinical signs and histological changes. Conclusions  The results described here and previous immunological studies on AD suggest that the NC/Nga Tnd mouse may be a suitable model for certain aspects of AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.03946.x
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  • 3
    Electronic Resource
    Electronic Resource
    Large near-resonance third-order nonlinearity in an azobenzene-functionalized polymer film (1998)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 72 (1998), S. 1021-1023 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The third-order nonlinear optical response of a thin film containing the azobenzene dye Disperse Red 1 was studied using the z-scan technique with tunable picosecond pulses. A nonlinear refractive index of −5.0 cm2/GW, corresponding to a Re χ(3)=−3.0×10−15 m2/V2 (2.1×10−7 esu), has been measured at 570 nm. The observed nonlinearity is attributed to the change in refractive index induced by the trans-cis transition in the dye molecule. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.120977
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  • 4
    Electronic Resource
    Electronic Resource
    Calculation of nuclear spin–spin couplings. VIII. Vicinal proton–proton coupling constants in ethane (1995)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 103 (1995), S. 6597-6600 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Ab initio self-consistent-field (SCF) and electron correlation calculations have been carried out for the dihedral angle dependence of the vicinal proton–proton coupling constants, 3JHH, in ethane molecule. The four contributions to 3JHH, (JFC, JSD, JOP, and JOD) have been computed with the three different basis sets, [5s2p1d/2s1p], [5s3p1d/3s1p], and [7s4p2d/5s2p]. The Fermi contact (FC) contribution was largest and the spin–dipole (SD) contribution was smallest. The FC and orbital paramagnetic (OP) contributions showed large basis set dependence, but the SD and orbital diamagnetic (OD) contributions presented little basis set dependence. The calculated total SCF contribution to 3JHH was higher than the experimental coupling. Using the Møller–Plesset perturbation theory we have introduced electron correlation effects on the FC and OP terms. The correlation effects on the OP term was shown to be negligible. The second-order correlation in the FC term was very large and amounted to half of its SCF value in magnitude with opposite sign. However, the third-order correlation in the FC contribution was small. Unfortunately, the calculated 3JHH value including correlation corrections through third order was too small compared to the experimental one. The poor agreement between calculation and experiment is claimed to be due to higher than third-order correlations in the FC term. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.470388
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  • 5
    Electronic Resource
    Electronic Resource
    Calculation of nuclear magnetic shieldings. XI. Vibrational motion effects (1996)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 105 (1996), S. 4692-4699 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Nuclear magnetic shieldings in first- and second-row hydrides were calculated with electron correlation taken into account through third order. The calculation was performed using London's gauge-invariant atomic orbitals (GIAOs) and finite-field Møller–Plesset perturbation theory (FF-MPPT). Furthermore, the vibrational motion corrections to the magnetic shieldings were evaluated. It was shown that the calculated isotropic shielding constants at the experimental geometries are higher than the experimental values, but that vibrational corrections are generally negative and improve the calculated shielding constants. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.472310
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  • 6
    Electronic Resource
    Electronic Resource
    C5b-8 Step Lysis of Swine Endothelial Cells by Human Complement and Functional Feature of Transfected CD59 (1996)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 43 (1996), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The authors established several swine endothelial cell (SEC) lines expressing human CD59 by transfection of cDNA, and assessed the function of the transfectant molecules in comparison with those of membrane cofactor protein (MCP) and decay-accelerating factor (DAF) in an in vitro hyperacute rejection model of swine to human discordant xenograft. At the usual expression rate, DAF and MCP protected SEC from human complement mediated cell lysis, but CD59 did not block human complement attack on SEC. However, CD59 protects SEC from cell lysis when sufficiently expressed as in human umbilical vein (HUVEC). The authors examined why CD59 needed so many molecules to protect human complement-mediated SEC lysis and found that SEC underwent lysis by human C5b-8. The degree of C5b-8 step lysis of SEC was approximately 70% of the total activity (C5b-9). Additionally, CD59 protected human complement activation less efficiently at the C5b-8 step than at the C9-step. Therefore, to overcome human complement mediated SEC lysis, C8 activity must be inhibited by dense expression of CD59.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.1996.d01-50.x
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  • 7
    Electronic Resource
    Electronic Resource
    Alterations of p16/CDKN2, p53 and ras genes in oral squamous cell carcinomas and premalignant lesions (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 25 (1996), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Exons 1–3 of the p16/CDKN2 gene, exons 4–9 of the p53 gene and exons 1 and 2 of H-, K- and N-ras genes were screened for mutations by a combination of immunohistochemistry and single-strand conformational polymorphism (SSCP) analyses of polymerase chain reaction products from human surgical samples of both frank oral squamous cell carcinomas and premalignant lesions. The samples included 20 squamous cell carcinomas. 10 epithelial dysplasias and 10 epithelial hyperplasias. No identifiable gene mutations were detected in any of the dysplasias or hyperplasias, while 2 (10%) deletions and 2 (10%) mutations of p16/CDKN2, along with 5 (25%) p53 mutations were found in the advanced carcinomas, yielding characteristic p16/CDKN2 and p53 changes. A mutation in the K-ras gene was found in single carcinoma and dysplastic samples. From the data, it can be argued that p16/CDKN2 and p53 mutations are relatively late occurrences in human oral tumorigenesis and that genetic alterations of the ras genes may not play a significant role in squamous neoplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1996.tb01377.x
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  • 8
    Electronic Resource
    Electronic Resource
    ENDOTHELINS CONTRACT GUINEA-PIG PULMONARY ARTERY AND ENHANCE ITS ADRENERGIC RESPONSE VIA ETA RECEPTORS (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 23 (1996), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. This study has pharmacologically characterized endothelin (ET) receptor subtype(s) mediating contraction and enhancement of adrenergic contraction in guinea-pig pulmonary artery. Isometric tension of the isolated endothelium-denuded ring preparations was measured in the presence of indomethacin (10−5 mol/L) and NG-nitro-L-arginine methyl ester (l-NAME; 3X10−4 mol/L) to exclude a mechanism via endothelium, cyclo-oxygenase-generated eicosanoids and nitric oxide.2. In the additional presence of tetrodotoxin (TTX; 3X10−7 mol/L), ET-1 (10−11-10−7 mol/L) concentration-dependently contracted the preparations. The rank order of potency to contract the preparations among ET receptor agonists was ET-1, sarafotoxin (STX) 6b〉ET-3〉IRL 1620, STX 6c. BQ-123 (7X10−7-7X10−6 mol/L) concentration-dependently shifted the concentration-contraction curve for ET-1 to the right in a parallel manner. Pretreatment with STX 6c (3X10−7 mol/L for 30 min) did not significantly desensitize contractions to ET-1, ET-3 or IRL 1620 (P〉0.05; t-test, 10 d. f.).3. ET-1 (10−10-10−9 mol/L) and STX 6b (10−9-10−8 mol/L) significantly enhanced the electrical field stimulation-induced contraction in a BQ-123-sensitive manner (P〈0.05; t-test, 24–38 d.f.), while ET-3 (10−11-10−8 mol/L) and STX 6c (10−11-10−7 mol/L) did not affect contractions. ET-1 (10−11 mol/L) significantly enhanced contractions to exogenous nor-adrenaline in the presence of TTX (3X10−7 mol/L) (P〈0.05; t-test, 16 d.f.).4. These data indicate that the BQ-123-sensitive ETA receptor mediates both contraction and enhancement of adrenergic contractions in the guinea-pig pulmonary artery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1996.tb02745.x
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  • 9
    Electronic Resource
    Electronic Resource
    A new analytical system for quantification scratching behaviour in mice (2004)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 150 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Scratching behaviour is an important component of human atopic dermatitis. The duration of scratching determines the extent of skin damage and thus the rash, but quantification of this is difficult. Establishment of a method for measuring the duration of scratching is important in order to make objective assessments of the factors that may cause the itch and also the efficacy of new antipruritic drugs.Objectives  A novel method for assessing the duration of scratching in mice was evaluated, based on the time course changes in the distance between the animal's hind limbs and the back of the neck during scratching behaviour.Methods  Compound 48/80 was administered intradermally to the back of ICR mice and their scratching behaviour was recorded on digital videotape. The distance between the back and the hind limb was measured continuously using an image analysis system.Results  Measurement of the frequency and duration when the mouse's hind limb came into contact with the back of the neck provided an accurate method of quantitating scratching behaviour.Conclusions  This system provides a new method of quantifying scratching behaviour in a mouse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2004.05744.x
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  • 10
    Electronic Resource
    Electronic Resource
    1,8-Bis(2-thienyl)-1,3,5,7-octatetrayne (1998)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 54 (1998), S. 1519-1521 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270198005605
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