Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Immunogenicity of HILDA/LIF either in a Soluble or in a Membrane Anchored Form expressed In Vivo by Recombinant Vaccinia Viruses (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 38 (1993), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Insertion of various cDN As in the genome of the vaccinia virus (VV) enables the in vivo and in vitro study of the functional role and/or the immunogenicity of the virally encoded recombinant proteins. We have prepared a recombinant VV expressing the cDNA of the human cytokine HILDA/LTF (human interleukin for DA cells/leukaemia inhibitory factor), and used this virus to immunize mice against this protein, which is very homologous to its murine counterpart (∼80% homology). We also constructed and expressed by the same system a chimeric gene encoding the HILDA/LIF protein fused to the 37 COOH-terminal amino-acids of the human decay accelerating factor (DAF). This sequence proved to be sufficient for the targeting of the fusion protein to the cell membrane, where it is linked to the phosphatidylinositols. Both recombinant VVs induced cytokine-specific antibodies in mice as analysed with an FLISA where the recombinant HILDA/LIF was plastic-coated and a cytofluorometric assay where the LIF-DAF molecule was present at the cell surface of stably transfected PS15. In the latter case HILDA/LIF remained biologically active suggesting that it was expressed in its native form. The LIF-DAF fusion protein was found to exhibit a better capacity to elicit an antibody response against the native form of the cytokine as detected in cytofluorometric assays. Whatever the recombinant virus used to immunize the mice, the MoAbs obtained were positive either in the ELISA or in the cytofluorometric assays but one, which suggested that the plastic coating induced a conformationa1 change of HILDA/LIF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1993.tb01728.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Immune repertoire of graft-invading T cells (1990)
    Springer
    Transplant international 3 (1990), S. 176-180 
    Details
    ISSN: 1432-2277
    Keywords: T-cell repertoire ; Organ transplantation, T-cell repertoire ; Rejection, T-cell repertoire
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The immune repertoire of T lymphocytes invading human allografts is of fundamental importance both at the operational level, in order to achieve relevant matching, and at the functional level, since the unique capacity of T and B cells to specifically recognize allogeneic components restricts the origin of the signals leading to rejection by these cells. In this paper, the authors review their own work, as well as other contributions in this domain, with special reference to the frequency and function of donor-committed cells among the infiltrate and the relationship between T-cell receptor gene rearrangements and repertoire.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00355467
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    0.5 T MRI of small renal masses: value of T2-weighted and Gd-DOTA-enhanced images (1993)
    Springer
    European radiology 3 (1993), S. 447-452 
    Details
    ISSN: 1432-1084
    Keywords: Gadolinium ; Kidney, benign tumours ; Kidney, cysts ; Kidney, MRI studies ; Kidney, neoplasms ; MRI, contrast enhancement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We compared the value of T2-weighted and Gd-DOTA-enhanced T1-weighted images for the detection and characterisation of 33 small renal masses (14 clear cell carcinomas, 6 angiomyolipomas, 3 angiomyomas, 4 adenomas, 3 papillary carcinomas, 3 oncocytomas, 1 haemorrhagic cyst). Dynamic enhanced MRI was performed to study the tumoral vascular supply (19 cases). MRI depicted all the masses more than 1 cm in diameter, but missed all the lesions less than 1 cm (4 false-negative). The results of T2-weighted images and Gd-DOTA-enhanced images were similar as regards detection; however, Gd-DOTA-enhanced images depicted more clearly the tumours smaller than 2 cm (11 cases). MRI enabled the characterisation of only 3 masses (2 angiomyolipomas, 1 haemorrhagic cyst). New MRI features are described for oncocytomas (low signal intensity on T1-weighted images, high signal intensity on T2-weighted images, early and marked enhancement on dynamic enhanced MRI). Dynamic enhanced MRI did not contribute to the differentiation of benign from malignant tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221422
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Distinct presentations of radiocontrast-induced sialadenitis in renal insufficients and in patients with normal renal function (1994)
    Springer
    European radiology 4 (1994), S. 254-257 
    Details
    ISSN: 1432-1084
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report two incide ntal observations of radiocontrast-induced sialadenitis which occurred in a patient with normal renal function and in another patient undergoing chronic haemodialysis. Our first observation consisted of parotid gland, enlargement noted 1 h after contrast injection and which presaged anaphy lactoid shock. In the second cast salivary gland enlargement developed 3 days after administration of iodinated agent. A review of the literature based on 27 published observations. In dicates that two different presentations of iodide-induced sialadenitis canbe recognisedaccording totheirpathogenesis. In patients with normally functioning kidneys, the occurrence of sialadenitis after a shortdelay(5 min to 24 h) evokes an anaphylactoidmechanism. Conversely, in patients with impaired renal function, the delayed onset (1–5 days) of this adverse reaction suggest a toxic effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606456
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    On the Transition from Tin-Rich to Antimony-Rich European White Soda-Glass Trade Beads for the Senecas of Northeastern North America (2000)
    Springer
    Journal of radioanalytical and nuclear chemistry 244 (2000), S. 559-566 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract It has been shown that several modifications occurred, over the span of the 17th to 19th centuries, in the agents used to opacify European-made white soda-glass beads that were transmitted as trade goods to northeastern North America. Tin was used at the beginning of the 17th century, followed by Sb later in the century, and then by As during the 18th and 19th centuries. In an attempt to define more closely the transition from Sn-rich to Sb-rich white beads, we analyzed 198 white glass beads from a number of archaeological sites in western New York State. Chemical analysis shows that the arrival of Sb-white soda-glass trade beads began in this region during the period from approximately A.D. 1625–1640, and that they had completely replaced Sn-white beads by A.D. 1675. Specific bead chemistries link a number of the archaeological sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006767930385
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Non-Destructive Analysis of European Cobalt Blue Glass Trade Beads (2000)
    Springer
    Journal of radioanalytical and nuclear chemistry 244 (2000), S. 567-573 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Chemical analyses were made of royal blue glass trade beads from two early 17th century, archaeological sites in southern Ontario, Canada and from a glass beadmaking house in Amsterdam, The Netherlands. The results confirm that these beads were all mixed alkali — lime — silica glasses, coloured with Co and with opaque varients opacified with Sn. The groupings by chemistry tend to segregate by bead shapes, so that oval beads group together and circular shaped beads group together. Although the 2 Canadian sites are about 190 km apart, they produced 2 different sets of oval beads of similar chemistry, possibly helping confirm the contemporaneity of the people at both sites. An As/Co atomic ratio of about two may fit with the possible source of Co as a cobalt-arsenide ore (of common name smaltite) from the Hartz Mountains of eastern Germany, a source not far from either Amsterdam or Venice, both well known glass beadmaking centres of the period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006705014455
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...