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  • 2000-2004  (13)
  • 1985-1989  (18)
  • 1970-1974  (10)
  • 1960-1964  (6)
  • 1930-1934  (7)
  • 1925-1929  (13)
  • 1915-1919  (1)
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  • 11
    Electronic Resource
    Electronic Resource
    Alverine citrate fails to relieve the symptoms of irritable bowel syndrome: results of a double-blind, randomized, placebo-controlled trial (2002)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 16 (2002), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Alverine citrate has been used in the treatment of irritable bowel syndrome for many years.Aims : To compare the efficacy and safety of a new formulation of alverine citrate, a 120-mg capsule, with placebo given three times daily for 12 weeks.Methods : One hundred and seven patients with irritable bowel syndrome were entered into this three-centre, double-blind, randomized, placebo-controlled, parallel group trial. The primary end-point was relief of abdominal pain indicated by improvement in the scores for severity and frequency. Secondary efficacy variables included scores for other clinical symptoms and for overall well-being.Results : The severity and frequency of abdominal pain improved in 66% and 68% of patients treated with alverine citrate vs. 58% and 69% of the placebo group, but these differences were not significant. The mean percentage reduction in the scores for abdominal pain from baseline to the final assessment, although greater in the alverine citrate group (43.7%) compared with the placebo group (33.3%), was not statistically significant.Conclusions : Alverine citrate is no better than placebo at relieving the symptoms of irritable bowel syndrome. Future trials should be designed to take into account the high and persistent placebo response seen in this condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2002.01277.x
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  • 12
    Electronic Resource
    Electronic Resource
    Randomized comparison of photodynamic therapy with topical 5-fluorouracil in Bowen's disease (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 148 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background Bowen's disease (BD; intraepithelial squamous cell carcinoma) is therapeutically challenging because lesions, which may be multiple, are frequently located at sites that heal poorly. There is a small risk of progression to invasive carcinoma. Photodynamic therapy (PDT) is an effective treatment for certain non melanoma skin cancers, but comparison studies with other, better-established therapies are limited. Objectives To compare the efficacy and tolerability of PDT and topical 5-fluorouracil (5-FU) in BD. Methods Forty patients from two centres were randomized to either topical PDT or 5-FU. The PDT group was treated with 20% 5-aminolaevulinic acid (ALA) applied 4 h before illumination with 100 J cm−2 narrowband red light (630 ± 15 nm). 5-FU was applied to lesions for 4 weeks. A repeat treatment cycle was performed after 6 weeks if required. Results Twenty-nine of 33 (88%) lesions treated with PDT initially responded completely, compared with 22 of 33 (67%) after 5-FU. After 12 months, two recurrences in the PDT group and six in the 5-FU group reduced complete clinical clearance rates to 82% and 48%, respectively. PDT was significantly more effective (P = 0·006, odds ratio 4·78, 95% confidence interval 1·56–14·62). In the 5-FU group, severe eczematous reactions developed around seven lesions, ulceration in three and erosions in two. No such reactions occurred following PDT. There was no difference in overall pain experienced during each therapy. Conclusions Topical ALA-PDT is more effective than topical 5-FU in the treatment of BD, with fewer adverse events. ALA-PDT should be considered one of the first-line therapeutic options for BD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05033.x
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  • 13
    Electronic Resource
    Electronic Resource
    Abnormal Crimping in Merino and Polwarth Wools (1960)
    [s.l.] : Nature Publishing Group
    Nature 187 (1960), S. 960-961 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1. Crimp deterioration in fine Merino and Polwarth wools in changing from normal (1) to 'doggy' (3) In changing from normal to doggy, fine and medium Merino and Polwarth wools pass through an intermediate phase with secondary waves superimposed on the normal crimp ; in strong Merino wool the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/187960a0
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  • 14
    Electronic Resource
    Electronic Resource
    Demonstration of Strain-hardening of Steel (1915)
    [s.l.] : Nature Publishing Group
    Nature 94 (1915), S. 589-589 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE accompanying photograph (Fig. 1) represents the side of a steel bar. The bar was first marked by a punch in the way shown, and the punch marks were afterwards completely filed out. The side was then polished and the bar pulled in a testing machine beyond the elastic limit of the material. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/094589c0
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  • 15
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    A possible basis for individual differences in magnitude-estimation behaviour (1974)
    London, etc. : Periodicals Archive Online (PAO)
    British journal of psychology. 65 (1974) 85 
    Details
    ISSN: 0007-1269
    Topics: Psychology
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0047-1974-065-00-000010
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  • 16
    Electronic Resource
    Electronic Resource
    Meal size in nymphs of Locusta migratoria (1972)
    Springer
    Entomologia experimentalis et applicata 15 (1972), S. 399-410 
    Details
    ISSN: 1570-7458
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Die Nahrungsmenge, die von einer Larve der Wanderheuschrecke, Locusta migratoria L., im fünften Entwicklungsstadium bei einer einzigen Mahlzeit verzehrt wird, wurde ermittelt, indem ihr Darm und Darminhalt sofort nach dem Fressen gewogen wurden. In der Mitte des Entwicklungsstadiums wurden größere Mengen verzehrt, Weibchen fraßen mehr als Männchen, jedoch sind die weiblichen Larven ja auch größer. Die Menge der aufgenommenen Nahrung vergrößerte sich mit der Dauer künstlichen Futterentzuges. Sie erreichte ihren Höhepunkt nach sechs Stunden, nach welcher Zeit der Vorderdarm absolut leer war. Die verzehrten Mengen waren je nach der Art der Nahrung unterschiedlich. Auch stellten die Insekten sich so ein, daß sie von einer bestimmten Nahrung mehr zu sich nahmen, wenn sie daran aufgezogen worden waren. Nach längeren Zeitspannen der Isolierung hatten sie die Tendenz, weniger zu fressen. Temperatur und Feuchtigkeit hatten keinen Einfluß auf die Mengen, die verzehrt wurden, außer bei 40°, bei welcher Temperatur sich das gesamte Verhalten zum Fressen ändert.
    Notes: Abstract Meal size in fifth-instar nymphs of Locusta migratoria L. has been investigated by weighing the gut and its contents immediately after feeding. Larger meals are taken in mid-instar, while females eat more in one meal than males under the same conditions. Bigger meals are also eaten after longer periods of food deprivation, but after deprivation for two hours or less, corresponding with the normal interfeed length, meals are smaller than would be expected from the potential maximum foregut volume. The maximum volume attained varies with the type of food available to the insects and is influenced by previous conditioning. Temperature and humidity do not affect meal size except at 40°, at which temperature the usual pattern of feeding is completely altered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293604
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  • 17
    Electronic Resource
    Electronic Resource
    The yrast spectroscopy of neutron-rich nuclei produced in deep-inelastic processes (2003)
    Springer
    The European physical journal 20 (2003), S. 111-112 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. The highly sensitive GASP array at the INFN Legnaro Laboratory was used to study the $\gamma$ -ray de-excitation of neutron-rich nuclei produced in the deep-inelastic processes which occur when 230 MeV 36S ions interact with a target of 176Yb. Yrast decay schemes were identified in over forty target-like fragments and in over twenty projectile-like fragments. Analysis of the data has resulted in extensions to the yrast decay sequences of the target-like species, 176Hf, 166Er, 172Yb, and 152Sm. New transitions have also been observed in a number of projectile-like species including 34P and 41Cl. Experimental results are compared with the results of shell model calculations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epja/i2002-10334-y
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  • 18
    Electronic Resource
    Electronic Resource
    Use of the64Ni(36S,34Si)66Zn reaction to measure the mass of34Si (1985)
    Springer
    The European physical journal 321 (1985), S. 119-123 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The reaction64Ni(36S,34Si)66Zn atE=198 MeV has been used to measure the mass excess of34Si; a value of −19.971 −0.044 +0.037 MeV was obtained. This result which is in agreement with the previous value (−19.85±0.30 MeV) is in excellent agreement with recent shell-model mass predictions. The result is discussed within the context of the proposed region of deformation aroundZ=11,N=20.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411955
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  • 19
    Electronic Resource
    Electronic Resource
    Insect behavior at the leaf surface and learning as aspects of host plant selection (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 215-222 
    Details
    ISSN: 1420-9071
    Keywords: Behavior ; learning ; leaf surface ; wax ; insects ; food selection ; secondary compounds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Direct observations on the feeding behavior of insect herbivores are uncommon, but important. The important aspects of host-plant selection by phytophagous insects that have been revealed by such observations are the role of chemicals in the leaf surface, and learning. There are few detailed reports of behavior at the leaf surface, but these indicate that many, if not all, insects exhibit behavior pattenrs that can be interpreted as an examination of the quality of the surface and acceptance or rejection may follow without further testing. A number of experiments show that chemicals from the leaf surface commonly contribute to the acceptability or otherwise of a plant and in most cases so far the active chemicals are of widespread occurrence, not having a specific association with the host plant. Some experiments show that the association between surface chemicals and plant palatability is learned, but in other cases there is evidence of an innate response. Habituation to deterrent chemicals has been demonstrated in the laboratory, but not in the field. Food aversion learning also occurs and may be important in dietary switching by polyphagous insects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951806
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  • 20
    Electronic Resource
    Electronic Resource
    The regulation of feeding in Locusta migratoria: Internal inhibitory mechanisms (1973)
    Springer
    Entomologia experimentalis et applicata 16 (1973), S. 329-342 
    Details
    ISSN: 1570-7458
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Alle Hauptnerven des Mund- und Rachennervensystems wurden kontrolliert reseziert. Erst wenn die rückwärtigen Rachennerven zerschnitten werden, nehmen die Insekten wesentlich mehr Nahrung zu sich. Solche Insekten versuchen längere Zeit zu fressen. Wenn sich während des Fressens der Vorderdarm füllt, wird keine Nahrung an den Mitteldarm weitergegeben und sein Vorderende ist der letzte Teil, der sich vollständig ausdehnt. Nach Durchtrennung der rückwärtigen Rachennerven sind alle Teile des Vorderdarms offen-sichtlich mehr gedehnt. Eine solche erhöhte Nahrungsaufnahme tritt aber nicht ein, wenn die Nahrung relativ ungünstig ist. Das Abbinden des Kropfes verursacht beim nachträglichen Fressen keine übermäßige Ausdehnung des Vorderteiles. Die Nahrungsaufnahme hat keinen Unterschied im Körpervolumen zur Folge und das Durchtrennen des ventralen Nervenstranges bleibt ohne Einfluß auf die nachträglich aufgenommenen Nahrungsmengen. Das vergrößerte Darmvolumen wird durch Kollaps des Luftsackes kompensiert.
    Notes: Abstract During the course of a meal by insects with an empty gut, food is held in the foregut and the midgut remains empty. The last part of the foregut to fill is the extreme anterior end of the crop, and stretch receptors in this region control the amount eaten. Cutting the posterior pharyngeal nerves isolates these receptors from the frontal garglion and results in hyperphagia pharyngeal nerves isolates these receptors from the frontal garglion and results in hyperphagia during one meal. On unfavourable food, when smaller amounts are eaten, distension of the foregut is not involved in regulating meal size. Feedback from receptors in the body wall is not important in regulating meal size; most of the increase in gut volume resulting from feeding is taken up by the collapse of the air sacs so that there is little or no change in the body volume.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334244
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