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  • 1
    Electronic Resource
    Electronic Resource
    Alkylating properties of phosphate esters. 1. Oxygen .fwdarw. nitrogen methyl transfer in dimethyl (2-pyridylmethyl) phosphate (1986)
    s.l. : American Chemical Society
    The @journal of organic chemistry 51 (1986), S. 265-267 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00352a033
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  • 2
    Electronic Resource
    Electronic Resource
    Photoisomerizations in the α-Tropolone Series: The Mechanistic Path of the α-Tropolone Methyl Ether to Methyl 4-Oxo-2-cyclopentenylacetate Conversion1 (1963)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 85 (1963), S. 2616-2621 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00900a021
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  • 3
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    Kearns, R., "Das Traditionsgefüge um den Menschensohn. Ursprüngliche Gestalt und älteste Veränderung im Urchristentum" (Book Review) (1989)
    Leiden : Periodicals Archive Online (PAO)
    Journal for the Study of Judaism in the Persian, Hellenistic, and Roman Period. 20 (1989) 238-240 
    Details
    ISSN: 0047-2212
    Topics: History , Theology and Religious Studies
    Notes: Reviews
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:v021-1989-020-00-000031
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  • 4
    Electronic Resource
    Electronic Resource
    Alosetron repeat dose pharmacokinetics, effects on enzyme activities, and influence of demographic factors (2004)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 20 (2004), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim : To assess the pharmacokinetics of alosetron, its effect on in vivo enzyme activities, and influence of demographic factors during repeated dosing.Methods : Thirty healthy men and women received 1 mg oral alosetron twice-daily for 29.5 days and a single oral dose of a metabolic probe cocktail before and on the last day of alosetron dosing. Serum alosetron concentrations were measured on days 1, 8, 15, 22 and 29. Probe-substrate and metabolite concentrations were measured after each cocktail dose.Results : Alosetron accumulation in serum was negligible. Exposure to alosetron did not alter probe-metabolite/substrate ratios associated with CYP2C19, 2E1, 2C9, or 3A4 activity, but modestly decreased those associated with CYP1A2 and N-acetyltransferase activity. Systemic exposure to alosetron was higher in women, positively correlated with age and body mass index, and negatively correlated with CYP1A2 activity. Incidence of constipation was higher in women, but not associated with alosetron concentration.Conclusions : Single dose data can reliably predict the pharmacokinetics of alosetron after repeated doses. Alosetron exhibits limited potential for inhibition of cytochrome P450-mediated metabolism. Interindividual differences in alosetron pharmacokinetics associated with demographic factors may be related to strong dependence on metabolism by CYP1A2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2004.02031.x
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  • 5
    Electronic Resource
    Electronic Resource
    155. Zur Immuntherapie der akuten Tetanuserkrankung (1969)
    Springer
    Langenbeck's archives of surgery 325 (1969), S. 952-954 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Unter den 32 Patienten, die in der Zeit zwischen 1966 und 1968 mit manifester Tetanuserkrankung zur stationären Behandlung kamen, waren 21 weder aktiv noch passiv immunisiert worden. Die übrigen 11 hatten teils Tetanol, teils heterologes Serum oder eine Kombination beider erhalten. Nach der stationären Aufnahme wurden alle aktiv immunisiert und mit heterologem oder homologem Serum behandelt. Bestimmungen des neutralisierenden Antitoxintiters zeigten bei vergleichbarer Dosierung die Überlegenheit des humanen Hyperimmunglobulins. Aus immunologischen Überlegungen wird bei manifester Erkrankung die Gabe von homologem Serum empfohlen.
    Notes: Summary Amongst the 32 patients, who came to us for hospital treatment for manifest tetanus between 1966 and 1968, 21 were neither actively nor passively immunised. The remaining 11 had received either Tetanol or heterologous serum or a combination of the two. After admission to hospital, they were all actively immunised and treated with either heterologous or homologous serum. Determination of the neutralising antitoxin titres demonstrated the superiority of the human hyper-immunoglobulin using comparative dosage. As a result of immunological consideration, we would recommend administration of homologous serum in cases, where the disease is manifest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01256051
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  • 6
    Electronic Resource
    Electronic Resource
    Isomerism in parabutylchloral; x-ray crystallographic determinations of 2,4,6-tris(1′,1′,2′-trichloropropyl)-1,3,5-trioxanes (1985)
    Springer
    Journal of chemical crystallography 15 (1985), S. 333-349 
    Details
    ISSN: 1572-8854
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract α-Parabutylchloral (2,4,6-tris(1′,1′,2′-trichloropropyl)-1,3,5-trioxane, C12H15Cl9O3) crystallizes in the orthorhombic space groupP212121 (No. 19) witha=12.165(6),b=9.964(5),c=17.433(9) Å,Z=4. The finalR value is 0.043 for 1667 observed reflections.β-Parabutylchloral crystallizes in the orthorhombic space groupPna21 (No. 33), witha=12.387(6),b=10.488(5),c=16.605(8) Å,Z=4. The finalR value is 0.047 for 1417 observed reflections. Unlike the geometric isomersα- andβ-parachloral (CCl3CHO)3 which exist in boat andcis,cis-chair conformations, theα- andβ-forms of parabutylchloral (CH3CHClCCl2CHO)3 are now shown by X-ray crystallography not to be geometric isomers. Both forms exist incis,cis-chair conformations and the isomerism arises from the chirality of the side chains at theβ-carbon atoms. In theα-form only two of the side chains have the same chirality, but in theβ-form the chirality at all theβ-carbon atoms is the same. The X-ray results are supplemented by1H and13C nuclear magnetic resonance spectroscopy and by mass spectrometry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01160726
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  • 7
    Electronic Resource
    Electronic Resource
    Pion absorption reactions on N, Ar and Xe (2000)
    Springer
    The European physical journal 9 (2000), S. 537-552 
    Details
    ISSN: 1434-601X
    Keywords: PACS. 25.80.Ls Pion inclusive scettering and absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: The absorption of π+ on Ar was studied at pion energies of 70, 118, 162, 239 and 330MeV, and on N and Xe at 239MeV. Twenty-six absorption reaction channels with at least two energetic charged particles in the final state have been evaluated. Partial cross-sections have been determined according to the number of protons, neutrons and deuterons in the final state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100500070010
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  • 8
    Electronic Resource
    Electronic Resource
    Erythropoietin und Hypertonie (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 914-919 
    Details
    ISSN: 1432-1440
    Keywords: Erythropoietin ; Hypertension ; Erythropoietin ; Hypertonie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Wirksamkeit von rekombinantem humanem Erythropoietin (rhEpo) bei der Korrektur der Anämie des terminal niereninsuffizienten dialysepflichtigen Patienten ist in mehreren Studien belegt. Eine deutliche Verbesserung der physischen Leistungsfähigkeit konnte durch ergometrische Untersuchungen dokumentiert werden. Neben seltenen Shunt-Thrombosen ist die einzige relevante unerwünschte Wirkung von rhEpo die Entwicklung oder Aggravierung einer Hypertonie bei etwa 30% der behandelten Patienten. Bei ca. 2% der Patienten kam es zur hypertensiven Enzephalopathie mit zentralnervöser Symptomatik. Als Ursache für diese Hypertonie-Entwicklung ist ein Anstieg des peripheren Widerstands anzunehmen. Belege dafür sind Messungen des regionalen Blutflusses mit Plethysmographie vor und nach Anämie-Korrektur mit rhEpo. Ursache für den Widerstandsanstieg wiederum dürfte eine Zunahme der Vollblutviskosität und eine Abnahme der peripheren hypoxiebedingten Vasodilatation sein. Zur Prävention der hypertensiven Komplikationen bei rhEpo-Therapie werden eine langsame Hämatokrit-Korrektur über 12–16 Wochen und eine Begrenzung des Ziel-Hämatokrits auf 30–35 Vol. % bei strikter Blutdruck- und Volumenkontrolle empfohlen.
    Notes: Summary Recombinant human erythropoietin (rhEpo) has been demonstrated in several studies to be effective in correcting the anemia of regular dialysis patients. This was accompanied by a significant improvement of the physical work capacity shown by exercise testing. The main side effect of rhEpo treatment has been the development or aggravation of hypertension in approximately 30% of the treated patients. In 2% hypertensive encephalopathy and convulsions occured. Data obtained by measurements of regional blood flow indicate the peripheral resistance did increase probably due to rise of blood viscosity and reversal of preexisting hypoxic vasodilatation. To avoid hypertensive complications anemia should be corrected slowly over a period of 12–16 weeks. Target hematocrit should not exceed 30–35 vol. %. Blood pressure and volume status should be monitored closely.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728954
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  • 9
    Electronic Resource
    Electronic Resource
    Effekte einer Captopriltherapie auf die Natrium- und Wasserausscheidung bei Patienten mit Leberzirrhose und Aszites (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 774-783 
    Details
    ISSN: 1432-1440
    Keywords: Liver cirrhosis ; Ascites ; Renin-angictensin-aldosterone-system ; Renal functional impairment ; Sodium excretion ; Captopril
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ascites in patients with cirrhosis of the liver frequently is refractory to diuretic treatment. It was postulated that vasoconstriction of the renal cortex, mediated by activation of the renin-angiotensin-aldosterone-system (RAAS), may be one course of the disturbed sodium- and water-excretion in these patients. We therefore investigated in 14 cirrhotic patients with ascites under constant diuretic treatment the effects of low-dose captopril therapy on urinary sodium- and potassium-excretion, body weight, abdominal girth, serum-sodium,-potassium, creatinine-clearance, plasma-renin-activity (PRA), plasma-aldosterone (PA) and mean arterial pressure (MAP). After a control period of 4 days the patients received 2 × 6.25 mg/d captopril for 5 days and 4 × 6.25 mg/d for further 5 days. Treatment was followed by a second control period without captopril. PRA increased significantly after 2 days of captopril treatment. 2 × 6.25 mg/d captopril induced a significant increase in sodium excretion and a significant decrease of body weight. MAP decreased slightly but significantly without clinical signs of hypotension. 4 × 6.25 mg/d captopril resulted in a further reduction of body weight and a further enhancement of sodium excretion. Three days after withdrawal of captopril sodium output was significantly reduced again. Conclusion: In cirrhotic patients low-dose captopril seems to be efficient in the treatment of ascites resistant to diuretics without causing major side effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745350
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  • 10
    Electronic Resource
    Electronic Resource
    Die Behandlung gynäkologischer Karzinome mit Iridium-192-Kurzzeit-Afterloading (1987)
    Springer
    Archives of gynecology and obstetrics 242 (1987), S. 444-446 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die AL-Bestrahlungstechnik bei 71 Patientinnen wies eine geringe Nebenwirkungsrate auf, es gabkeine strahlungsbedingten Fisteln, die Tumorprogredienzrate war günstig. Wegen der kurzen Behandlungsdauer von 10–15 min konnte die Bestrahlungenambulant ohne Anästhesie durchgeführt werden, es gab keine Embolien. Frühkomplikationen bestanden zumeist aus Blasenstörungen nach Einlage der intravesicalen Meßsonde. Selten gab es Darmblutungen oder Diarrhoen. Nach unseren Ergebnissen ist die Afterloading-Methode der herkömmlichen Radium-Bestrahlung deutlich überlegen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01783204
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