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  • 1
    Electronic Resource
    Electronic Resource
    Mikrowellenhyperthermie und Onkolyse durch Clostridien (1975)
    Springer
    Naturwissenschaften 62 (1975), S. 541-542 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609084
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  • 2
    Electronic Resource
    Electronic Resource
    Almost sure asymptotics for the continuous parabolic Anderson model (2000)
    Springer
    Probability theory and related fields 118 (2000), S. 547-573 
    Details
    ISSN: 1432-2064
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract. We consider the parabolic Anderson problem ∂ t u = κΔu + ξ(x)u on ℝ+×ℝ d with initial condition u(0,x) = 1. Here κ 〉 0 is a diffusion constant and ξ is a random homogeneous potential. We concentrate on the two important cases of a Gaussian potential and a shot noise Poisson potential. Under some mild regularity assumptions, we derive the second-order term of the almost sure asymptotics of u(t, 0) as t→∞.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008754
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  • 3
    Electronic Resource
    Electronic Resource
    Histamin in der Interstitialflüssigkeit der befallenen und klinisch nicht befallenen Haut bei chronisch rezidivierender Urticaria (1979)
    Springer
    Archives of dermatological research 266 (1979), S. 269-276 
    Details
    ISSN: 1432-069X
    Keywords: Chronic urticaria ; Histamine ; Interstitial fluid ; Histamine determination with autoanalyzer technique ; Chronisch rezidivierende Urticaria ; Histamin ; Interstitialflüssigkeit ; Histamin-Bestimmung mit Autoanalyzer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 8 Patienten mit idiopathischer chronisch rezidivierender Urticaria wurden in der Periumbilicalregion Saugblasen gleichzeitig auf frischen urticariellen Herden und der unveränderten Haut daneben produziert und Histamin in der Blasenflüssigkeit bestimmt. Hierzu wurde die von Siraganian entwickelte Methode der Autoanalyzer-Technik in modifizierter Form verwendet. Die Histaminspiegel lagen bei diesen Patienten in unveränderter Haut in derselben Größenordnung wie bei 10 Normalpersonen, während alle 8 Urticaria-Patienten höhere Histamin-Werte in den Urticae verglichen mit der nicht befallenen Haut aufwiesen; bei 4 der Patienten waren diese Unterschiede jedoch nur gering ausgeprägt.
    Notes: Summary In 8 patients with idiopathic chronic urticaria suction blisters were produced simultaneously on lesional and perilesional skin in the periumbilical area without application of heat. The suction pressure was 250 mm Hg, and thus the blister production lasted from 60–120 min. The blister fluid histamine was determined with a modified autoanalyzer technique developed by Siraganian. In this method the extraction of histamine, the condensation of o-phthaldialdehyde with histamine and the measurement of the fluorochrome is automated. With the described method it is possible to measure values less than 0.5 ng/ml. Histamine levels in perilesional skin were nearly in the same range as in the periumbilical skin of 10 normal persons. The range of the normal tissue fluid histamine levels was 0–15 ng/ml and they did not differ significantly from the plasma levels. In all 8 patients with chronic urticaria the histamine values were higher in lesional than in perilesional skin. In 1 patient the lesional blister fluid histamine value reached 35.5 ng/ml. Four of the patients showed only low differences (less than 3 ng/ml).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418572
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  • 4
    Electronic Resource
    Electronic Resource
    The impact of diabetes mellitus on survival after myocardial infarction: can it be modified by drug treatment? (2000)
    Springer
    Diabetologia 43 (2000), S. 218-226 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Diabetes mellitus, acute myocardial infarction, 28-day mortality, long-term survival, population-based register, secondary prevention.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Mortality of diabetic patients after myocardial infarction remains high despite recent improvement in their management. This study population-based evaluates the impact of cardiovascular drug therapy on mortality within 28 days and during 5-year follow-up in diabetic compared with non-diabetic patients.¶Methods. Using the MONICA Augsburg register from 1985 to 1992, 2210 inpatients with incident Q-wave myocardial infarction aged 25–74 years were included, of whom 468 had diabetes. Primary end point was mortality within 28 days and over 5 years. General linear model procedures were used for age-adjustment, controlling for sex, and testing significance; hazard risk ratios were calculated using multivariable Cox proportional hazards model procedures.¶Results. During the 5-year follow-up, 598 subjects died (396 diabetic, 202 non-diabetic). The mortality rate within 28 days was 12.6 % in diabetic patients (women 18.0 %, men 9.9 %) and 7.3 % in non-diabetic patients (p = 0.001). Mortality in diabetic patients over 5 years was increased by 64 % (95 % confidence interval 1.39–1.95) compared with non-diabetic patients. This was considerably reduced (p 〈 0.001) in patients treated with thrombolytic drugs (risk ratio: diabetes 0.57, no diabetes 0.65) and with beta blockers (0.62 and 0.64) and antiplatelets (0.76 and 0.74) at hospital discharge. Mortality of diabetic patients treated with these drugs was reduced to that of non-diabetic patients without such treatment (risk ratio 1.01 to 1.27; p 〉 0.1).¶Conclusion/interpretation. Diabetic patients after myocardial infarction are at particularly high risk of dying, but benefit clearly from treatment with thrombolytics, beta blockers and antiplatelets. This study does not, however, allow any inferences to be drawn for treatment with angiotensin converting enzyme inhibitors or the impact of left ventricular function. [Diabetologia (2000) 43: 218–226]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050032
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  • 5
    Electronic Resource
    Electronic Resource
    Stoffwechselprodukte von Mikroorganismen (1976)
    Springer
    Archives of microbiology 107 (1976), S. 143-160 
    Details
    ISSN: 1432-072X
    Keywords: New nucleoside-peptide antibiotic ; Chitin biosynthesis ; Structure elucidation ; Mass spectrometry ; Streptomyces tendae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Der Streptomycet Tü 901, Streptomyces tendae, bildet ein antifungisch wirkendes Nukleosid-Antibioticum, Nikkomycin. Als Angriffsort kommt die Chitinsynthese in Frage. Mit Hilfe der Massenspektrometrie und des chemischen Abbaus konnten Uracil, eine Aminohexuronsäure und eine neue, einen Pyridinring enthaltende Aminosäure nachgewiesen werden.
    Notes: Abstract From the fermentation broth of Streptomyces tendae Tü 901 a substance was isolated, which inhibits the growth of several fungi. The new antibiotic affects the chitchin biosynthesis. Its structure was identified by mass spectrometry of the products obtained after chemical degradation. Nikkomycin is a nucleoside-peptide antibiotic consisting of uracil, an amino hexuronic acid and a new amino acid containing a pyridin ring.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446834
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  • 6
    Electronic Resource
    Electronic Resource
    Stoffwechselprodukte von Mikroorganismen (1976)
    Springer
    Archives of microbiology 107 (1976), S. 249-256 
    Details
    ISSN: 1432-072X
    Keywords: Antibiotic derivatisation ; Yeast antibiotic ; Tryptanthrin ; Tryptophan metabolism ; Candia lipolytica
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Candida lipolytica synthetisiert das Antibioticum Tryptanthrin aus 1 Mol Tryptophan und 1 Mol Anthranilsäure. Bei Verfütterung von Tryptophan und substituierter Anthranilsäure, bzw. substituiertem Tryptophan und Anthranilsäure, konnten die zu erwartenden Tryptanthrinderivate isoliert und identifiziert werden. Die Enzyme der Tryptanthrinbiosynthese wiesen in bezug auf diese Substrate, mit Ausnahme von Bromtryptophan, keine Spezifität auf. Parallel zu diesen Versuchen wurden durch chemische Synthese substituierte Tryptanthrine hergestellt. Die Dierivate wurden auf ihre antibiotische Wirksamkeit geprüft; als besonders wirksam erwiesen sich die halogenierten Verbindungen.
    Notes: Abstract Candida lipolytica synthesizes the antibiotic tryptanthrin from 1 mole tryptophan and 1 mole anthranilic acid. When feeding tryptophan and substituted anthranilic acids, or substituted tryptophans and anthranilic acid, we could isolate and identify the expected derivatives of tryptanthrin. The enzymes of the biosynthesis of tryptanthrin, with the exception of bromotryptophan, had no specifity for these substrates. In addition to these experiments substituted tryptanthrines were chemically synthesized. We checked them for antibiotic action; the halogen compounds turned out to be especially effective.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00425335
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  • 7
    Electronic Resource
    Electronic Resource
    Gas-chromatographische Trennung von diastereomeren Aminosäureestern an chiralen stationären Phasen (1976)
    Springer
    Chromatographia 9 (1976), S. 72-73 
    Details
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Eine quantitative Analyse des Razemisierungsgrades von Aminosäuren durch gas-chromatographische Trennung der diastereomeren Aminosäureester an nicht-chiralen stationären Phasen ist ungenau, wenn optisch unreine Reagentien zur Herstellung der Derivate Verwendung finden. Dieses Problem kann durch den Einsatz chiraler stationärer Phasen, an denen alle optischen Isomeren getrennt werden, überwunden werden.
    Notes: Summary A quantitative analysis of racemic amino acids by gas chromatographic separation of diastereoisomeric esters on non-chiral stationary phases is inaccurate when optically impure reagents are used for the formation of derivatives. This problem can be solved by using a chiral stationary phase, on which all optical isomers are separated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02269222
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  • 8
    Electronic Resource
    Electronic Resource
    Zum Mechanismus der gas-chromatographischen Trennung enantiomerer Aminosäurederivate (1976)
    Springer
    Chromatographia 9 (1976), S. 331-332 
    Details
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Trennung enantiomerer Aminosäurederivate an chiralen stationären Phasen wird bisher weitgehend auf die Ausbildung unterschiedlich stabiler Wasserstoffbrücken-Assoziate zwischen stationärer Phase und den darin gelösten Enantiomeren zurückgeführt. Die Trennung von D- und L-Aminosäuren an einer stationären Phase, die keine Wasserstoffbrückenbindung zwischen den beteiligten Partnern zuläßt, beweist, daß andere Wechselwirkungskräfte als Wasserstoffbrückenbindungen für die Enantiomerentrennung verantwortlich zu machen sind.
    Notes: Summary The separation of enantiomeric amino acid derivatives on chiral stationary phases is believed to be predominantly due to the formation of hydrogen bond complexes between the stationary phase and the, enantiomeric solutes. The separation of D-and L-amino acids on a stationary phase which does not allow the formation of hydrogen bonds between solvent and solutes indicates that interactions other than hydrogen bonding are responsible for enantiomeric separations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02268837
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  • 9
    Electronic Resource
    Electronic Resource
    Far-infrared absorption of the superionic conductor Li3N. temperature and isotope effects (1979)
    Springer
    The European physical journal 32 (1979), S. 375-378 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The far-infrared absorption spectrum (20–250cm−1) of the superionic conductor Li3N —with6Li- and7Li-isotopes in the starting material—has been measured for different polarizations and temperatures (4–150 K). TheE ⊥c spectrum yields two lines near 80 and 140 cm−1, which are not observed forE ⊥c. From the isotopic frequency ratio (ω 6/ω 7≃1.07) and from the comparison to lattice dynamics it is concluded that these lines are due to resonant modes, weakly coupled to the lattice. Measurements of the isotope effects on the dielectric properties (10 Hz to 1 MHz) establish that the local diffusive type motion in shallow potentials and the low lying resonant modes originate from the same defect system (including Li-ions in non-regular positions).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02109466
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  • 10
    Electronic Resource
    Electronic Resource
    Positron spectra from internal pair conversion observed in 238U + 181Ta collisions (2000)
    Springer
    The European physical journal 9 (2000), S. 55-61 
    Details
    ISSN: 1434-601X
    Keywords: PACS. 14.60.Cd Electrons and positrons – 23.20.Ra Internal pair production – 25.70.Bc Elastic and quasielastic scattering – 25.70.De Coulomb excitation – 25.70.Hi Transfer reactions – 29.30.Aj Charged particle spectrometers: electric and magnetic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: We present new results from measurements and simulations of positron spectra, originating from 238U + 181Ta collisions at beam energies close to the Coulomb barrier. The measurements were performed using an improved experimental setup at the double-Orange spectrometer of GSI. Particular emphasis is put on the signature of positrons from Internal-Pair-Conversion (IPC) processes in the measured e+-energy spectra, following the de-excitation of electromagnetic transitions in the moving Ta-like nucleus. It is shown by Monte Carlo simulations that, for the chosen current sweeping procedure used in the present experiments, positron emission from discrete IPC transitions can lead to rather narrow line structures in the measured energy spectra. The measured positron spectra do not show evidence for line structures within the statistical accuracy achieved, although expected from the intensities of the observed γ-transitions ( E γ∼ 1250-1600 keV) and theoretical conversion coefficients. This is due to the reduced detection efficiency for IPC positrons, caused by the limited spatial and momentum acceptance of the spectrometer. A comparison with previous results, in which lines have been observed, is presented and the implications are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100500070055
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