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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 136 (1997), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We performed a randomized double-blind study within-group comparison in 11 patients to study the effect of subcutaneous injections of botulinum A toxin in focal hyperhidrosis of the palms. A total dose of 120 mU (mouse units) of botulinum A toxin (Dysport®) was injected into six different sites on one palm, whereas the other was injected with sterile saline. Objective quantification of sweat production was performed using digitized ninhydrin-staincd sheets. Three weeks after treatment, the mean reduction of sweat production in the botulinum A toxin-treated palms was 26% (P〈0·001). after 8 weeks 26% (P= 0·002) and after 13 weeks 31% (P〈0·001).Subjective assessment of sweat production by the patients using a visual analogue scale showed a 38% improvement in the botulinum A toxin-treated palms at 3 weeks (P=0·002). 40% at 8 weeks (P=0·002) and 38% at 13 weeks (P= 0·002). Neither the objective measurement nor the subjective rating showed a statistically significant reduction of sweating in the placebo-treated palms. Three patients reported reversible minor weakness of powerful handgrip after injection at the toxin-treated site, lasting between 2 and 5 weeks.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Torticollis spasmodicus ; Blepharospasmus ; Hemifazialer Spasmus ; Therapien ; Botulinumtoxin ; Key words Spasmodic torticollis ; Blepharospasm ; Hemifacial spasm ; Therapies ; Botulinum toxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Injections with botulinum toxin type A (BTX) are considered the first-line treatment for spasmodic torticollis (ST), blepharospasm (BL) and hemifacial spasm (HFS). Because BTX brings only temporary and partial relief, patients frequently try other additional therapies to minimize their symptoms. The subjective rating of all therapies ever tried by patients with ST, BL and HFS was evaluated by using a simple questionnaire. Two hundred questionnaires were considered (112 TS, 54 BL, 34 HFS). BTX was rated subjectively the best therapy in all three diagnostic groups (median: 2=good effect). Despite Citalopram and physiotherapy (median: 3=average effect), all other therapies were rated with a median of ≥4 (=minimal effect). Patients with ST tried 7.7, patients with BL 2.4 and patients with HFS 2.6 different types of therapy. In conclusion, BTX is the most effective treatment for patients with ST, BL and HFS, as rated subjectively. Further evaluation of therapies additional to BTX injections is recommended.
    Notes: Zusammenfassung Die Botulinumtoxinbehandlung (BTX) gilt als Therapie der Wahl bei Torticollis spasmodicus (TS), Blepharospasmus (BL) und hemifazialem Spasmus (HFS). Da bestehende Beschwerden mit BTX meist nur vorübergehend und manchmal nicht im ganzen Ausmaß beseitigt werden können, werden von Patienten immer wieder andere Behandlungsformen versucht. Mit einem einfachen Fragebogen wurde von Patienten mit TS, BL und HFS eine subjektive Beurteilung aller bisher versuchten Therapien eingeholt. Ausgewertet wurden 200 Fragebögen (112 TS, 54 BL, 34 HFS). BTX wurde in allen drei Diagnosegruppen als subjektiv wirksamste Therapie bewertet (Median: 2=gute Wirkung). Abgesehen von Citalopram und Physiotherapie (Median: 3=durchschnittliche Wirkung) beim TS wurden alle anderen Therapien mit einem Median von ≥4 (=minimale Wirkung) bewertet. Patienten mit TS haben im Durchschnitt 7,7, Patienten mit BL 2,4 und mit HFS 2,6 Behandlungsformen ausprobiert. Zusammenfassend ist BTX die subjektiv wirksamste Behandlung bei Patienten mit TS, BL und HFS. Weitere Untersuchungen über ergänzende Begleittherapien zur BTX-Behandlung sind erforderlich.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0942-0940
    Keywords: Keywords: Aneurysmal subarachnoid haemorrhage; long-term effects; quality of life; rehabilitation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Although physical and emotional dysfunction appears to be quite frequent even among independent survivors of aneurysmal subarachnoid haemorrhage (SAH), these symptoms may easily be missed on routine follow-up examinations. To assess the long-term functional effects of SAH and to outline possible treatment approaches, a cross-sectional study using multidimensional measures of relevant areas of function was performed on 40 independent survivors. After an average follow-up period of 22 months, patients were selected and enrolled following a pre-designed protocol. The comprehensive test battery consisted of subjective and objective measures of physical, psychological and social function and relationships between the different levels of assessment were calculated. We found a considerable proportion of cognitive, emotional and physical dysfunction in this sample, but on the subjective level, the majority of the patients stated satisfaction with life in general. Mild cognitive dysfunction was frequently missed and causes distress in the family. Mild to moderate depression was underdiagnosed, although such an emotional dysfunction influences working capacity and quality of life. Referral to rehabilitation centers appears to be restricted to patients with severe impairments. Our results help to alert the neurosurgeon to these possible symptoms and show the urgent need for a prospective, interdisciplinary and multidimensional follow-up of SAH survivors.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 231 (1984), S. 79-82 
    ISSN: 1432-1459
    Keywords: Gangliosides ; Denervation atrophy ; Skeletal muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer Publikation wurde berichtet, daß es nach experimenteller Denervierung des Kaninchenskelettmuskels zu einem Anstieg der Gangliosidkonzentration komme. Wir untersuchten Gangliosid-, DNS-, Gesamtlipidund Proteinkonzentrationen bei experimenteller Denervierung des Musculus gastrocnemius des Kaninchens und bei neurogener Atrophie des menschlichen Skelettmuskels. Bei schwerer neurogener Atrophie kam es zu einer statistisch signifikanten Zunahme der Gesamtgangliosid-, DNS-und Gesamtlipidkonzentration, während die Proteinkonzentration im Vergleich zu den Kontrollen signifikant abnahm. Das Gangliosidmuster bei schwerer neurogener Atrophie zeigte signifikante Zunahme eines GT1b-ähnlichen bzw. eine relativ deutliche Abnahme eines GM1-ähnlichen Gangliosids. Die Untersuchungen bei experimenteller Denervierung des Kaninchenskelettmuskels brachten ähnliche Ergebnisse wie bei der neurogenen Atrophie des Menschen: signifikante Zunahme der Gesamtgangliosidkonzentration, Zunahme des GT1b-ähnlichen und signifikante Abnahme des GM1-ähnlichen Gangliosids.
    Notes: Summary In experimental denervation of rabbit skeletal muscle, an increase of gangliosides has been reported. Ganglioside, DNA, total lipid and protein levels were studied in experimental denervation of rabbit gastrocnemius muscle and in human skeletal muscle with denervation atrophy. In severe human denervation atrophy total ganglioside, DNA and total lipid levels were increased, and protein levels decreased as compared with controls. The ganglioside pattern was changed in severe human denervation atrophy and showed a significant increase of a GT1b-like and moderate decrease of a GM1-like compound. Findings in experimentally denervated rabbit muscle resembled results obtained in human denervation atrophy, showing a significant increase of total ganglioside levels as well as a moderate increase of GT1b-like and decrease of GM1-like compounds.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1459
    Keywords: Spinal subarachnoid haemorrhage ; Juxtamedullary cavernous haemangioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Innerhalb von 13 Monaten traten bei einem 24 Jahre alten Studenten vier Attacken von Subarachnoidalblutung auf. Ein juxtamedulläres kavernöses Hämangiom bei Th2 war die Ursache der rezidivierenden spinalen Subarachnoidalblutung.
    Notes: Summary Within a period of 13 months a 24-year-old male student experienced four attacks of subarachnoid haemorrhage. An intradural-extramedullary haemangioma at the level of the second thoracic segment was found to be the cause of the repeated bleeding.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1984), S. 275-280 
    ISSN: 1433-8491
    Keywords: Cerebro-vascular disease ; Stroke ; Prognosis ; Zerebrovaskuläre Erkrankung ; zerebraler Insult ; Prognose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 57 von 70 Patienten, die vor dem 40. Lebensjahr erstmals zerebrale Durchblutungsstörungen auf ischämischer Basis erlitten hatten, wurde der weitere Verlauf über durchschnittlich 84 Monate verfolgt. Innerhalb von 48 Monaten nach dem initialen Ereignis kam es bei 22 von 51 Patienten (43,1%) mit Spontanverlauf zu weiteren Manifestationen (Rezidivquote fur Patienten mit transitorischischämischen Attacken 78,6%, für Patienten mit prolongierten reversiblen Defekten 33,3%, für Patienten mit kompletten Schlaganfällen 28,6%), wobei 31,5% aller Patienten schon innerhalb des ersten Jahres neuerliche zerebrale Durchblutungsstörungen erlitten, die meisten sogar innerhalb der ersten wenigen Monate. Trotz der wesentlich höheren Rezidivrate waren Patienten mit initialen passageren zerebralen Durchblutungsstörungen am Ende des Beobachtungszeitraums (BZR) in sozialer Hinsicht weniger beeinträchtigt als Patienten mit kompletten Schlaganfällen als Erstmanifestation. 78,4% aller Patienten waren am Ende des BZR voll arbeitsfähig. Bei 72,2% der patienten mit neuerlichen zerebralen Durchblutungsstörungen war das Herdgeschehen einem anderen als dem urspriinglich betroffenen Gefäßgebiet zuzuordnen. Patienten mit arterieller Hypertonic im BZR halten eine etwas ungünstigere Langzeitprognose, während Nikotinkonsum wie auch relatives Körpergewicht auf den Schweregrad der sozialen Beeinträchtigung keinen Einfluß hatte. Trotz der eher günstigen Langzeitprognose weisen unsere Ergebnisse — besonders im Hinblick auf die hohe Rezidivquote innerhalb der ersten Monate nach der initialen Attacke — auf die Notwendigkeit einer unverzüglichen umfassenden diagnostischen Abklärung und Einleitung einer individuellen Therapie bei Patienten mit „juvenilem Insult” hin.
    Notes: Summary Seventy patients suffering from ischemic cerebrovascular disease had had their first attack before the age of 40 years. Of these patients 57 were re-examined 84 months (mean) after the initial event. Within 48 months, 22 of 51 patients (43.1%) without surgical treatment had recurrent ischemic events (78.6% patients with transient ischemic attacks, 33.3% patients with protracted reversible deficits, 28.6% patients with completed stroke). Of all patients 31.5% had their first recurrent attack during the first year, most of them during the first few months after the initial event. In spite of the considerably higher recurrence rate, patients with initial transient ischemic attacks or protracted reversible deficits had a lower degree of social disability at the end of the follow-up period than patients with an initial completed stroke. In 72.2% of the patients with recurrent events the ischemic focus was found in a vascular area different from the one originally concerned. Patients with arterial hypertension during the follow-up period had a somewhat less-favorable long-term prognosis, but nicotine abuse or relative body weight had no influence on the degree of social disability at the end of the follow-up period. In general, long-term prognosis was rather favorable, 78.4% of the patients being fully capable of work at the end of the follow-up period. Nevertheless, results point to the necessity of complete diagnostic evaluation without delay and introduction of individual therapy for patients suffering from “juvenile stroke.”
    Type of Medium: Electronic Resource
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