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  • 1
    Electronic Resource
    Electronic Resource
    Long-term outcome of patients with headache and drug abuse after inpatient withdrawal: five-year follow-up (1996)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 16 (1996), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Thirty-eight patients with “chronic daily” headache and ergotamine and/or analgesics abuse according to the criteria proposed by the international Headache Society were re-investigated 5 years after inpatient drug withdrawal. At the end of the observation period, 19 patients (50.0%) had their headaches on only 8 days per month or less, 18 patients (47.4%) were free of symptoms or had only mild headaches. A close correlation was found between the frequency of headache and the duration of drug abuse, as well as between the intensity of headache and the number of tablets taken per month. Frequency and intensity of headache had changed within the first 2 years after withdrawal, but remained stable afterwards. Fifteen patients (39.5%) reported on recurrent drug abuse. Patients with migraine showed a tendency towards a better prognosis compared to patients with tension-type headache or with combined migraine and tension-type headache. The results of this study highlight the long-term efficacy of inpatient drug withdrawal in patients with headache and ergotamine and/or analgesics abuse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1996.1607481.x
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  • 2
    Electronic Resource
    Electronic Resource
    Use and abuse of analgesics in tension-type headache (1994)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 14 (1994), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Eighty patients suffering from tension-type headache for an average of 21 years were asked to report on all drugs they had ever taken (type, dosage, duration of intake, efficacy) or were taking currently. The patients had consumed on average 6.3 different drugs. The cumulative doses of derivatives of para-aminophenol, pyrazolone, and salicylic acid in some cases reached a maximum of several kilograms. Most drugs were classified by the patients as “moderately effective”. The rating “very effective” was assigned primarily to barbiturates; however, barbiturates are no longer used as components of compound analgesic drugs in Austria. At the time of investigation, patients consumed 2.5 (mean) different drugs, primarily as compound preparations. Seventeen patients (21%) showed signs of possible analgesics- or ergotamine-induced headache and were therefore advised to undergo withdrawal therapy. Our results show that patients with tension-type headache are at considerable risk of becoming drug-dependent and of acquiring analgesics-induced headache.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1994.1402162.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Botulinum A toxin injection in Focal hyperhidrosis (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb07974.x
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  • 4
    Electronic Resource
    Electronic Resource
    Treatment of focal hyperhidrosis with botulinum toxin type A: long-term follow-up in 61 patients (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 145 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background The blocking action of botulinum toxin type A (BTX-A) on cholinergically innervated sweat glands has been used successfully to treat patients with focal hyperhidrosis. Objectives To investigate the long-term efficacy and safety of intradermal injections of BTX-A. Methods We performed an open-label study in 61 patients treated over a period of 3 years for axillary or palmar hyperhidrosis. A total dose of 400 mU BTX-A (Dysport®) was injected into both axillae or 460 mU BTX-A (Dysport®) into both palms. The injections were repeated after relapse. Objective quantification of sweat production was performed using digitized ninhydrin-stained sheets. Results Four weeks after BTX-A treatment the median reduction in sweat production was 71% compared with baseline (P 〈 0·001) in the axillary group and 42% (P = 0·005) in the palmar group. Subjective assessment of sweat production by the patients using a visual analogue scale (0, no sweating; 100, the most severe sweating) showed a significant reduction in both the axillary (P 〈 0·001) and palmar groups (P 〈 0·001). Secondary disturbances due to focal hyperhidrosis interfering with daily activities were markedly improved in both groups. The median time interval between the sets of injections was 34 weeks for axillary hyperhidrosis and 25 weeks for palmar hyperhidrosis. The treatment of palmar hyperhidrosis was complicated by transient but not disabling weakness of the small hand muscles in nine of 21 patients. Conclusions Repeated intradermal injections of BTX-A in patients with axillary and palmar hyperhidrosis are as effective as first treatments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04349.x
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  • 5
    Electronic Resource
    Electronic Resource
    Double-blind trial of botulinum A toxin for the treatment of focal hyperhidrosis of the palms (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 136 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We performed a randomized double-blind study within-group comparison in 11 patients to study the effect of subcutaneous injections of botulinum A toxin in focal hyperhidrosis of the palms. A total dose of 120 mU (mouse units) of botulinum A toxin (Dysport®) was injected into six different sites on one palm, whereas the other was injected with sterile saline. Objective quantification of sweat production was performed using digitized ninhydrin-staincd sheets. Three weeks after treatment, the mean reduction of sweat production in the botulinum A toxin-treated palms was 26% (P〈0·001). after 8 weeks 26% (P= 0·002) and after 13 weeks 31% (P〈0·001).Subjective assessment of sweat production by the patients using a visual analogue scale showed a 38% improvement in the botulinum A toxin-treated palms at 3 weeks (P=0·002). 40% at 8 weeks (P=0·002) and 38% at 13 weeks (P= 0·002). Neither the objective measurement nor the subjective rating showed a statistically significant reduction of sweating in the placebo-treated palms. Three patients reported reversible minor weakness of powerful handgrip after injection at the toxin-treated site, lasting between 2 and 5 weeks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1997.d01-1233.x
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  • 6
    Electronic Resource
    Electronic Resource
    Dose thresholds and local anhidrotic effect of botulinum A toxin injections (Dysport®) (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 145 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04366.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Torticollis spasmodicus, Blepharospasmus und hemifazialer Spasmus Subjektive Bewertung der Therapie durch Patienten (1999)
    Springer
    Der Nervenarzt 70 (1999), S. 903-908 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Torticollis spasmodicus ; Blepharospasmus ; Hemifazialer Spasmus ; Therapien ; Botulinumtoxin ; Key words Spasmodic torticollis ; Blepharospasm ; Hemifacial spasm ; Therapies ; Botulinum toxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Injections with botulinum toxin type A (BTX) are considered the first-line treatment for spasmodic torticollis (ST), blepharospasm (BL) and hemifacial spasm (HFS). Because BTX brings only temporary and partial relief, patients frequently try other additional therapies to minimize their symptoms. The subjective rating of all therapies ever tried by patients with ST, BL and HFS was evaluated by using a simple questionnaire. Two hundred questionnaires were considered (112 TS, 54 BL, 34 HFS). BTX was rated subjectively the best therapy in all three diagnostic groups (median: 2=good effect). Despite Citalopram and physiotherapy (median: 3=average effect), all other therapies were rated with a median of ≥4 (=minimal effect). Patients with ST tried 7.7, patients with BL 2.4 and patients with HFS 2.6 different types of therapy. In conclusion, BTX is the most effective treatment for patients with ST, BL and HFS, as rated subjectively. Further evaluation of therapies additional to BTX injections is recommended.
    Notes: Zusammenfassung Die Botulinumtoxinbehandlung (BTX) gilt als Therapie der Wahl bei Torticollis spasmodicus (TS), Blepharospasmus (BL) und hemifazialem Spasmus (HFS). Da bestehende Beschwerden mit BTX meist nur vorübergehend und manchmal nicht im ganzen Ausmaß beseitigt werden können, werden von Patienten immer wieder andere Behandlungsformen versucht. Mit einem einfachen Fragebogen wurde von Patienten mit TS, BL und HFS eine subjektive Beurteilung aller bisher versuchten Therapien eingeholt. Ausgewertet wurden 200 Fragebögen (112 TS, 54 BL, 34 HFS). BTX wurde in allen drei Diagnosegruppen als subjektiv wirksamste Therapie bewertet (Median: 2=gute Wirkung). Abgesehen von Citalopram und Physiotherapie (Median: 3=durchschnittliche Wirkung) beim TS wurden alle anderen Therapien mit einem Median von ≥4 (=minimale Wirkung) bewertet. Patienten mit TS haben im Durchschnitt 7,7, Patienten mit BL 2,4 und mit HFS 2,6 Behandlungsformen ausprobiert. Zusammenfassend ist BTX die subjektiv wirksamste Behandlung bei Patienten mit TS, BL und HFS. Weitere Untersuchungen über ergänzende Begleittherapien zur BTX-Behandlung sind erforderlich.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050594
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