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  • 11
    Electronic Resource
    Electronic Resource
    Phase-II trial of idarubicin, fludarabine, cytosine arabinoside, and filgrastim (Ida-FLAG) for treatment of refractory, relapsed, and secondary AML (1999)
    Springer
    Annals of hematology 78 (1999), S. 418-425 
    Details
    ISSN: 1432-0584
    Keywords: Key words High-risk acute myeloid leukemia ; Idarubicin ; Fludarabine ; rhG-CSF ; Priming concept
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The current phase-II trial was initiated to assess the efficacy and toxicity of the Ida-FLAG regimen in patients with poor-risk acute myeloid leukemia (AML). Three subgroups of patients with AML were eligible for the study: (a) refractory, (b) first relapse, or (c) secondary AML (i.e., signs of trilineage myelodysplasia at diagnosis or the history of a myelodysplasia or myeloproliferative disorder). Fifty-seven fully evaluable patients were included in the study. Twenty patients received a second course of Ida-FLAG. Complete remission was achieved by 1/14 patients with refractory AML, 12/15 patients with relapsed AML, and 17/28 patients with secondary AML. The median duration of ANC 〈1000/μl was 17 days (10–36); of platelets 〈30,000/μl 23 days (9–65); of days with fever 〉38.0  °C 6 days (1–33). Thirteen patients (22.8%) died within 42 days of severe infection or hemorrhage. Overall survival at 20 weeks in the subgroups was 24% for patients with refractory, 78% for patients with relapsed, and 55% for patients with secondary AML. The toxicity of the first cycle of Ida-FLAG is moderate. The feasibility and subjective tolerance of the Ida-FLAG regimen are acceptable. There is no evidence for an increase of atypical infections. The efficacy for patients with secondary AML and especially those with first relapse of AML is good, with a high rate of complete remissions. Remission duration seems to be short. Therefore, an intensified post-remission therapy seems necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050541
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  • 12
    Electronic Resource
    Electronic Resource
    Anaemia, thrombocytopenia and coagulopathy due to occult diffuse infantile haemangiomatosis of spleen and pancreas (1999)
    Springer
    European journal of pediatrics 158 (1999), S. 379-383 
    Details
    ISSN: 1432-1076
    Keywords: Key words Antithrombin III ; Coagulation ; Haemangiomatosis ; Kasabach-Merrit syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Diffuse infantile haemangiomatosis of the spleen is a very rare lesion. Large haemangiomas may cause trapping of platelets and coagulation disorders known as Kasabach-Merrit syndrome. We here report the case of an infant with splenic and pancreatic haemangiomatosis presenting with life-threatening thrombocytopenia, anaemia and intravascular coagulation. Diagnosis was hampered by reactive erythroblastosis and non-conclusive radiological findings. While treatment with corticosteroids was ineffective, administration of antithrombin III improved coagulation parameters. After splenectomy the child recovered promptly and has remained free of disease for 3 years to date. Conclusion Occult visceral haemangiomatosis without visible cutaneous haemangiomas should be included in the differential diagnosis of thrombocytopenia, anaemia and consumption coagulopathy. Antithrombin III treatment may be considered to overcome bleeding problems in patients with Kasabach-Merrit syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310051096
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  • 13
    Electronic Resource
    Electronic Resource
    The orion-IRc2 outflow observed in COJ=4-3 (1995)
    Springer
    Astrophysics and space science 224 (1995), S. 143-149 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A CO J=4-3 map of the Orion-IRc2 region (size 80″, beam 15″) is presented. The outflow has a bipolar structure observed nearly pole-on. We interpret our observations in terms of an hierarchy of “tubes” where the fastest gas proceeds through the narrowest, innermost cone. The gas has an inhomogeneous temperature distribution and must be highly clumped. Most of the properties derived comply with the picture developed for the few known extreme high velocity outflows; however, this outflow contains exceptionally dense gas ( 〉 106 cm−3).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00667837
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  • 14
    Electronic Resource
    Electronic Resource
    New fluorescent dyes in the red region for biodiagnostics (1995)
    Springer
    Journal of fluorescence 5 (1995), S. 247-261 
    Details
    ISSN: 1573-4994
    Keywords: Fluorescence ; photochemistry ; rhodamine dyes ; time-resolved spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The increased sensitivity together with the advent of low-cost optical sources and detectors in the visible-near IR region has led us to current efforts to develop new efficient fluorescent labels for biodiagnostics with absorption and emission beyond 600 nm. In view of the general fluorescence decrease with increasing emission wavelength, we investigated the possibility to shift the absorption of rhodamine dyes toward the region 620–670 nm. The hydrophobic nature of all known long-wavelength dyes results in the tendency to form intra- and intermolecular aggregates in hydrophilic solvents, especially in aqueous environment. Due to the aggregation with biological materials, fluorescence quenching of the dyes is often observed. New strategies for prevention of these processes are considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00723896
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  • 15
    Electronic Resource
    Electronic Resource
    Plasmodesmal widening accompanies the short-term increase in symplasmic phloem unloading in pea root tips under osmotic stress (1995)
    Springer
    Protoplasma 188 (1995), S. 22-37 
    Details
    ISSN: 1615-6102
    Keywords: Osmotic stress ; Phloem unloading ; Pisum sativum ; Plasmodesmata ; Symplasmic transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Root tips ofPisum sativum seedlings were exposed to 350 mM mannitol, which was shown to effect a transient but dramatic increase in phloem unloading, and investigated by electron microscopy. After chemical fixation and embedding, extremely thin sections of the root extension zone were examined. Outer, inner, and desmotubule diameters of 830 primary plasmodesmata in transverse walls of cortical cells were measured. Statistical analysis indicated that the majority of plasmodesmata had no neck constriction during osmoregulation. Compared to controls, a highly significant increase in mean plasmodesmata diameter was found, but the desmotubule diameter remained unchanged. Both loss of neck constriction and widening of the cytoplasmic sleeve indicate an increase in effective passage area of plasmodesmata. Spokes between plasma membrane and desmotubule were preserved. Continued exposure of the root tips to mannitol led to a return to control values for plasmodesmal diameters. In contrast to these responses, plasmolysis of cortical cells by 1,000 mM sucrose, diminishing phloem unloading, was accompanied by a reduction in those plasmodesmata classified as open. This is the first report showing a correlation between the ultrastructure of plasmodesmata and the rate of symplasmic transport. The role of the different plasmodesmal components in controlling the passage area of symplasmic transport is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276793
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  • 16
    Electronic Resource
    Electronic Resource
    Using virtual reality techniques in maxillofacial surgery planning (1999)
    Springer
    Virtual reality 4 (1999), S. 213-222 
    Details
    ISSN: 1434-9957
    Keywords: Surgery planning ; Volume segmentation ; Virtual tools ; Force feedback ; Intra-operative navigation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract The primary goal of our research has been to implement an entirely computer-based maxillofacial surgery planning system [1]. An important step toward this goal is to make virtual tools available to the surgeon in order to carry out a three-dimensional (3D) cephalometrical analysis and to interactively define bone segments from skull and jaw bones. An easy-to-handle user interface employs visual and force-feedback devices to define subvolumes of a patient's volume dataset [2]. The defined subvolumes, together with their spatial arrangements based on the cephalometrical results, eventually lead to an operation plan. We have evaluated modern low-cost, force-feedback devices with regard to their ability to emulate the surgeon's working procedure. Once the planning of the procedure is complete, the planning results are transferred to the operating room. In our intra-operative concept the visualisation of planning data is speech controlled by the surgeon and correlated with the patient's position by an electromagnetic 3D sensor system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01418157
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  • 17
    Electronic Resource
    Electronic Resource
    Nichtinvasive Beatmung bei akuter respiratorischer Insuffizienz (1999)
    Springer
    Intensivmedizin und Notfallmedizin 36 (1999), S. 156-162 
    Details
    ISSN: 1435-1420
    Keywords: Key words Noninvasive mechanical ventilation ; acute respiratory failure ; intensive care unit ; nasal ventilation ; Schlüsselwörter Nichtinvasive Beatmung ; Maskenbeatmung ; akute respiratorische Insuffizienz ; Intensivmedizin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die nichtinvasive Beatmung über eine Maske ermöglicht bei vielen Patienten eine effiziente Beatmung unter Vermeidung der Risiken und Nebenwirkungen der endotrachealen Intubation. Für die chronisch-obstruktive Lungenerkrankung sind die Vorteile der Maskenbeatmung im Hinblick auf Beatmungsdauer, Dauer der Intensivbehandlung, Prognose und Behandlungskosten inzwischen relativ gut durch Studien belegt. Bei anderen Indikationen erlauben die verfügbaren Daten noch kein gesichertes Urteil, rechtfertigen aber einen Behandlungsversuch auch außerhalb von Studien in der täglichen klinischen Routine. Nachteilig sind der tendenziell höhere personelle Betreuungsaufwand bei der nichtinvasiven Beatmung sowie die starke Erfahrungsabhängigkeit der Ergebnisse. Die wichtigste Voraussetzung für eine erfolgreiche nichtinvasive Beatmung in der Intensivmedizin ist die Bereitschaft von Ärzten und Pflegepersonal, eine ungewohnte Beatmungsphilosophie zu akzeptieren und die relativ einfache Technik der Maskenbeatmung zu erlernen.
    Notes: Summary Noninvasive positive pressure ventilation provides effective ventilatory support for many patients with acute respiratory failure and avoids the risks and side effects of endotracheal intubation. Controlled clinical studies demonstrate improved outcome and cost effectiveness for patients with acute exacerbations of chronic obstructive pulmonary disease. The data on use of noninvasive ventilation for other forms of acute respiratory failure are less clear, but justify a consideration of mask ventilation in many clinical situations. Noninvasive ventilation tends to be more time-consuming and more dependent on experienced ICU staff than conventional mechanical ventilation. It is essential for the success of this “new” therapy that physicians and nursing staff try to become familiar not only with the technique but also with a different approach to mechanical ventilation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003900050222
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  • 18
    Electronic Resource
    Electronic Resource
    Parameter zur Diagnose und Verlaufsbeurteilung von Infektionen in der Intensivmedizin (1997)
    Springer
    Intensivmedizin und Notfallmedizin 34 (1997), S. 466-471 
    Details
    ISSN: 1435-1420
    Keywords: Key words Procalcitonin ; C-reactive protein ; sepsis ; acute phase response ; Schlüsselwörter Procalcitonin ; Akute-Phase-Reaktion ; CRP ; Sepsis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In dieser Übersichtsarbeit wird eine kritische Bewertung der zur Verfügung stehenden infektiologischen Laborparameter vorgenommen. Dies geschieht unter besonderer Berücksichtigung der intensivmedizinischen Situation. Die bisher etablierten infektiologischen Parameter (BSG, BB, CRP) werden dem neuen ,,Sepsis-Marker`` Procalcitonin (PCT) gegenüber gestellt. Zum jetzigen Zeitpunkt läßt sich die zukünftige Rolle des PCT noch nicht abschließend einschätzen. Möglicherweise bestehen jedoch wesentliche diagnostische Vorteile bei leberinsuffizienten, neutropenen und anderweitig immunkompromitierten (transplantierten) Patienten.
    Notes: Summary Diagnosis of bacterial infection and/or sepsis in critically ill patients is a common problem in intensive care medicine. White blood count, C-reactive protein (CRP), and the erythrocyte sedimentation rate (ESR) are often used in the differential diagnosis of infection versus SIRS (systemic inflammatory response syndrome) due to noninfectious causes. There is a number of non-infectious stimuli to cause leucocytosis and CRP elevation. In the last 3 years, Procalcitonin (PCT) was determined to be a marker of severe bacterial infection, especially sepsis. PCT appears to have several advantages; it is of non-hepatic (yet unknown) origin and useful in patients with hepatic insufficiency. There is no PCT-increase in acute graft-rejection, viral disease, and autoimmune disorders. Some studys showed a prognostic value of PCT in sepsis due to peritonitis and pancreatitis. PCT appears to be a new and helpful tool in the diagnosis and treatment of critically ill patients. Further studies are needed to finally established PCT in the daily management of critically ill patients. At this time significantly higher costs are the major detraction to daily or frequent measurements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003900050074
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