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  • 1995-1999  (5)
  • Triassic  (2)
  • 25.40  (1)
  • Demenz  (1)
  • Epiphyseal plate  (1)
Materialart
Erscheinungszeitraum
  • 1995-1999  (5)
Jahr
Schlagwörter
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Der Nervenarzt 69 (1998), S. 639-646 
    ISSN: 1433-0407
    Schlagwort(e): Schlüsselwörter S100B ; Demenz ; Trisomie 21 ; Multiple Sklerose ; Key words S100B ; Dementia ; Down syndrome ; Multiple sclerosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary S100B is a multifunctional member of the S100-calmodulin-troponin superfamily of proteins and can modulate the activity of other intracellular proteins following binding of calcium. S100B has been shown to exhibit regulatory effects on cell growth and differentiation as well as on cell shape and energy metabolism. S100B has neurotrophic properties and stimulates glial cell proliferation in vitro and in vivo. Overexpression of S100B has been proposed as a pathogenetic factor in plaque formation in patients with Alzheimerís disease and Down syndrome. Furthermore, S100B-specific T-lymphocytes have been shown to be encephalitogenic in the animal model of experimental autoimmune panencephalitis (EAP). Phenotypically and functionally similar S100B-specific T-cells can also be recovered from the peripheral blood of humans making S100B a potential candidate autoantigen in multiple sclerosis. Here the basic biochemical, molecular and functional properties of S100B are reviewed with special regard to the potential pathogenetic role of S100B in Alzheimerís disease, Down syndrome and multiple sclerosis.
    Notizen: Zusammenfassung S100B ist ein Mitglied der S100-Calmodulin-Troponin-Superfamilie, das nach Bindung von Kalzium in der Lage ist, mit anderen intrazellulären Proteinen zu interagieren. S100B übt auf diese Weise eine Vielzahl regulativer Funktionen bei intrazellulären Wachstums-, Differenzierungs- und Stoffwechselvorgängen aus. S100B hat neurotrophe Eigenschaften auf neuronale und astrozytäre Zellpopulationen in vitro und in vivo und ist möglicherweise an der Pathogenese der Plaqueentstehung und reaktiven Astrogliose bei der Alzheimerschen Erkrankung und Trisomie 21 beteiligt. Tierexperimentell konnte gezeigt werden, daß S100B-spezifische T-Lymphozyten enzephalitogen sind (experimentelle autoimmune Panenzephalitis, EAP). Phänotypisch und funktionell ähnliche S100B-spezifische T-Zellen lassen sich auch beim Menschen nachweisen. In Analogie zum EAP-Modell kann S100B daher als mögliches Autoantigen bei multipler Sklerose angesehen werden. In der folgenden Übersicht werden die wichtigsten biochemischen, molekularen und funktionellen Eigenschaften von S100B dargestellt. Ein besonderes Augenmerk gilt der möglichen pathogenetischen Rolle von S100B bei der Alzheimer Demenz, der Trisomie 21 sowie der Multiplen Sklerose.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    International journal of earth sciences 85 (1996), S. 293-302 
    ISSN: 1437-3262
    Schlagwort(e): Iran ; palaeomagnetism ; Triassic ; Cretaceous ; Central Iran ; geotectonics ; palaeoreconstruction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie
    Notizen: Abstract New pole positions for Triassic and Cretaceous times have been obtained from volcanic and sedimentary sequences in Central Iran. These new results confirm the general trend of the Apparent Polar Wander Path (APWP) of the Central-East-Iran microplate (CEIM) from the Triassic through the Tertiary as published by Soffel and Förster (1983, 1984). Two new palaeopoles for the Triassic of the CEIM have been obtained; limestones and tuffs from the Nakhlak region yield a mean direction of 094.0°/25.0°, N=12, k=4.1,α 95=24.7°, after bedding correction, corresponding to a palaeopole position of 310.8°E; 3.9°S, and volcanic rocks from the Sirjan regions yield a mean direction of 114.5°/35.1°, N=44, k=45.9,α 95=3.2° after bedding correction and a palaeopole position of 295.8°E; 10.3°N. Combining these with the two previously published results yields a new palaeopole position of 317.5°E; 12.7°N, for the Triassic of the CEIM, thus confirming that large counterclockwise rotations of the CEIM have occurred since the Triassic time. New results have also been obtained from Cretaceous limestones from the Saghand region of the CEIM. The mean direction of 340.7°/26.3°, N=33, k=44.3,α 95=3.8°, and the corresponding palaeopole position of 283.1°E; 64.4°N, is in agreement with previously determined Cretaceous palaeopole positions of the CEIM. Furthermore, results have also been obtained from Triassic dolomite, limestone, sandstone and siltstone from the Natanz region, which is located to the west of the CEIM. A total of 161 specimens from 44 cores taken at five sites gave a mean direction of the five sites at 033.3°/25.1°, N=5, k=69.0,α 95=9.3° and a palaeopole position of 167.2°E; 53.7°N. They pass the positive fold test of McElhinny (1964) on the level of 99% confidence. This pole position is in fairly good agreement with the mean Triassic pole position of the Turan Plate (149°E; 49°N). It indicates that the area of Natanz has not undergone the large counterclockwise rotation relative to the Turan plate since the Triassic, which has been shown for the CEIM. A Triassic palaeogeographic reconstruction of Iran, Arabia (Gondwana) and the Turan Plate (Eurasia) is also presented.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1432-2102
    Schlagwort(e): Schlüsselwörter Fraktur im Kindesalter ; Epiphyse ; Triplanare Fraktur ; MRT ; Key words Fracture in children ; Epiphyseal plate ; Triplane fracture ; MRI
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary Plain film radiography often underestimates the extent of injury in children with epiphyseal fracture. Especially Salter-Harris V fractures (crush fracture of the epiphyseal plate) are often primarily not detected. MRI of the ankle was performed in 10 children aged 9–17 (mean 14) years with suspected epiphyseal injury using 1.0-T Magnetom Expert. The fractures were classified according to the Salter-Harris-Rang-Odgen classification and compared with the results of plain radiography. In one case MRI could exclude epiphyseal injury; in four cases the MRI findings changed the therapeutic management. The visualisation of the fracture in three orthogonal planes and the possibility of detection of cartilage and ligamentous injury in MR imaging makes this method superior to conventional radiography and CT. With respect to radiation exposure MRI instead of CT should be used for the dignosis of epiphyseal injuries in children.
    Notizen: Zusammenfassung Die konventionelle Röntgendiagnostik unterschätzt häufig das Ausmaß der kindlichen Extremitätenfrakturen mit Epiphysenbeteiligung (Typ Salter-Harris). Insbesondere werden die Kompressionsfrakturen der Wachstumsfuge (Salter-Harris V) primär häufig nicht erkannt. Prospektiv wurden 10 Kinder im Alter von 9–17 Jahren (Durchschnittsalter=14 J.) mit Verdacht auf eine epiphysäre Fraktur der distalen Tibia magnetresonanztomographisch (1.0-Tesla Magnetom Expert), untersucht. Die MRT-Ergebnisse wurden auf der Basis der Klassifikation nach Salter-Harris-Rang-Odgen mit den konventionellen Röntgenbildern verglichen. In einem Fall, bei einem 15jährigen Patienten, gelang durch die MRT der Ausschluß einer epiphysären Verletzung. In 7 Fällen führte der MRT-Einsatz zu einer Änderung der Klassifikation nach Salter-Harris. Hieraus resultierte bei 4 Patienten ein Therapiewechsel. Da Frakturen, die sie begleitenden Knorpelläsionen und ligamentäre Verletzungen multiplanar dargestellt werden können, weist die MRT deutliche Vorteile gegenüber jeder anderen diagnostischen Methode (z.B. konventionelle Röntgendiagnostik, CT) auf. Im Hinblick auf die Strahlenexposition ist sie besonders bei Kindern eindeutig zu bevorzugen.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Geologische Rundschau 85 (1996), S. 293-302 
    ISSN: 0016-7835
    Schlagwort(e): Key words Iran ; palaeomagnetism ; Triassic ; Cretaceous ; Central Iran ; geotectonics ; palaeoreconstruction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie
    Notizen: Abstract  New pole positions for Triassic and Cretaceous times have been obtained from volcanic and sedimentary sequences in Central Iran. These new results confirm the general trend of the Apparent Polar Wander Path (APWP) of the Central-East-Iran microplate (CEIM) from the Triassic through the Tertiary as published by Soffel and Förster (1983, 1984). Two new palaeopoles for the Triassic of the CEIM have been obtained; limestones and tuffs from the Nakhlak region yield a mean direction of 094.0°/25.0°, N=12, k=4.1, α95=24.7°, after bedding correction, corresponding to a palaeopole position of 310.8°E; 3.9°S, and volcanic rocks from the Sirjan regions yield a mean direction of 114.5°/35.1°, N=44, k=45.9, α95=3.2° after bedding correction and a palaeopole position of 295.8°E; 10.3°N. Combining these with the two previously published results yields a new palaeopole position of 317.5°E; 12.7°N, for the Triassic of the CEIM, thus confirming that large counterclockwise rotations of the CEIM have occurred since the Triassic time. New results have also been obtained from Cretaceous limestones from the Saghand region of the CEIM. The mean direction of 340.7°/26.3°, N=33, k=44.3, α95=3.8°, and the corresponding palaeopole position of 283.1°E; 64.4°N, is in agreement with previously determined Cretaceous palaeopole positions of the CEIM. Furthermore, results have also been obtained from Triassic dolomite, limestone, sandstone and siltstone from the Natanz region, which is located to the west of the CEIM. A total of 161 specimens from 44 cores taken at five sites gave a mean direction of the five sites at 033.3°/25.1°, N= 5, k=69.0, α95=9.3° and a palaeopole position of 167.2°E; 53.7°N. They pass the positive fold test of McElhinny (1964) on the level of 99% confidence. This pole position is in fairly good agreement with the mean Triassic pole position of the Turan Plate (149°E; 49°N). It indicates that the area of Natanz has not undergone the large counterclockwise rotation relative to the Turan plate since the Triassic, which has been shown for the CEIM. A Triassic palaeogeographic reconstruction of Iran, Arabia (Gondwana) and the Turan Plate (Eurasia) is also presented.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    The European physical journal 351 (1995), S. 229-236 
    ISSN: 1434-601X
    Schlagwort(e): 25.40
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Excitation functions and forward-backward anisotropies have been measured for the7Li(p, γ)8Be capture reaction over the proton energy rangeE p =100 to 1500 keV, using a 4π summing crystal and Ge(Li) detectors, respectively. The data show at all energies the presence of El and M1 capture amplitudes arising from the direct capture (DC) process and theE R =441 and 1030 keV resonances, respectively. Due to the observed DC process, the present data increase significantly the reaction rates (up to a factor of 110) compared to values given in the compilation. The data and their analyses remove the recent criticism on DC model calculations, which had implied a significant reduction in the extrapolated S(E) factor for7Be(p,γ)B and thus in the predicted flux of high-energy solar neutrinos; thus, the solar neutrino problem is still with us.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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