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  • 1
    Electronic Resource
    Electronic Resource
    Successful antidepressant treatment for five terminally ill cancer patients with major depression, suicidal ideation and a desire for death (1999)
    Springer
    Supportive care in cancer 7 (1999), S. 432-436 
    Details
    ISSN: 1433-7339
    Keywords: Key words Suicidal thought ; Desire for death ; Major depression ; Antidepressant ; Terminally ill cancer patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In the debate on euthanasia and physician-assisted suicide, we have to exclude terminally ill patients in whom the desire for death is caused by major depression. However, it is still not clear to what degree major depression can be treated by psychiatric intervention in this setting. We evaluated the effect of antidepressant treatment in terminally ill cancer patients. Six cancer patients with suicidal ideas thought to be due to major depression were treated with tricyclic antidepressants. Three had requested terminal sedation to relieve them from their suffering. The median survival of five of these patients was 4 weeks after diagnosis; one was lost to follow-up. The efficacy of the antidepressant treatment was assessed using the Hamilton Rating Scale for Depression (HRSD). One week after the start of treatment with antidepressants, five of the six patients showed a marked improvement in their mood and showed no further suicidal thoughts or requests for terminal sedation. The average reduction in the HRSD score was 23.4 points (14–38; SD = 9.9). Antidepressant treatment can be effective in alleviating the desire for death due to major depression, even in terminally ill cancer patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005200050305
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  • 2
    Electronic Resource
    Electronic Resource
    TJS-010, a new prescription of oriental medicine, enhances 8-OH-DPAT-induced effects in rats (1996)
    Springer
    Journal of neural transmission 103 (1996), S. 69-75 
    Details
    ISSN: 1435-1463
    Keywords: Kampo ; hypothermia ; flat body posture ; 5-HT-1A receptors ; anxiety
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We evaluated the effect of TJS-010, a new prescription of oriental medicine, on hypothermia and flat body posture in rats, induced by activation of serotonin (5-HT)-1A receptors by (±)-8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT). Hypothermia was induced by 8-OH-DPAT in a dose and time-dependent manner. The hypothermia induced by O.1mg/kg 8-OH-DPAT was enhanced by 500 and 750mg/kg of TJS-010. At the concentration of O.1 mg/kg, 8-OH-DPAT also produced flat body posture in rats, and 750mg/ kg TJS-010 increased the flat body posture. These results suggest that TJS-010 facilitates the 5-HT-1A receptors in the central nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292617
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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