ISSN:
0887-624X
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Three commercial heparins of different molecular weights and anticoagulant activities were dinitrophenylated (DNP) with 2,4-dinitrofluorobenzene under aqueous conditions. The absorption spectra observed for DNP heparins in a 1% NaHCO3 solution consisted of the two absorption spectra characteristic of DNP - amino (N - DNP) and DNP - hydroxyl (O - DNP) groups. The number of N - DNP, O - DNP, and (N + O) - DNP groups were determined as well as the number of N - DNP groups per heparin chain; different values (i.e., 0.16, 0.17, and 0.55) for the latter were obtained with the three heparins. Further calculations showed that two of the heparins had approximately two (N + O) - DNP groups per chain (i.e., 2.1 and 1.8) whilst the third sample, considered to be a “cruder” heparin, had a value of 1.4.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/pola.1986.080240509
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